Carla Marchetti
Carla Marchetti graduated in Physics (1980, Genoa, Italy). She worked at MPI (Munich, Germany, 1984) and Texas Medical Center (Houston, USA, 1985-87). Since 1984, she is a permanent researcher at Institute of Biophysics (IBF), National Research Council, Genoa, Italy, and senior researcher since 2001. She has been coordinator of national and international research projects, supervisor of pre-doctoral and doctoral thesis and acts as peer referee for international journals and for research projects for the Italian Ministry of Research (MIUR). She has contributed more than 50 papers to peer-reviewed international journals with H-index=25 (Scopus).
orcid://0000-0001-9219-1825,
Research interests:
- Characterization of the mechanism of action of plant polyphenols from green-tea (Principal investigator)
- Ca2+ dynamics in prostate cancer cells of increasing malignancy (Principal investigator)
- Multitarget bioactive polyphenols as modulators of cytosolic calcium (Principal investigator)
Further collaborations:
- Bruno Burlando (University of Genoa)
- Laura Cornara (University of Genoa)
Key publications:
Marchetti C. (2021) Green tea catechins and intracellular calcium dynamics in prostate cancer cells. AIMS Molecular Science 8(1):1-12. doi: 10.3934/molsci.2021001
Marchetti C, Gavazzo P, Burlando B.(2020) Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release. Life Sci. 258:118232. doi: 10.1016/j.lfs.2020.118232.
Cornara L, Pastorino G, ., Borghesi B, Salis A, Clericuzio M, Marchetti C, Damonte G, Burlando B. (2018) Posidonia oceanica (L.) Delile ethanolic extract modulates cell activities with skin health applications. Marine Drugs 16(1): 21
Pastorino G, Marchetti C, Borghesi B, Cornara L, Ribulla S, Burlando B (2017). Biological activities of the legume crops Melilotus officinalis and Lespedeza capitata for skin care and pharmaceutical applications. Industrial Crops and Products, 96:158-164
Marchetti C, Ribulla S, Patrone M, Magnelli V, Burlando B. (2016). Resveratrol induces intracellular Ca2+ rise via T-type Ca2+ channels in a mesothelioma cell line. Life Sciences 148:125-131
Publications (21):
Green tea catechins and intracellular calcium dynamics in prostate cancer cellsMarchetti, Carla
aims molecular science, 8, 2021
DOI: 10.3934/molsci.2021001
Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release
Marchetti, C., Gavazzo, P., Burlando, B.
Life Sciences, 258, 2020
DOI: 10.1016/j.lfs.2020.118232
Posidonia oceanica (L.) delile ethanolic extract modulates cell activities with skin health applications
Cornara L, Pastorino G, Borghesi B, Salis A, Clericuzio M, Marchetti C, Damonte G, Burlando B
Marine drugs, 16, 2018
DOI: 10.3390/md16010021
Biological activities of the legume crops Melilotus officinalis and Lespedeza capitata for skin care and pharmaceutical applications
Pastorino G, Marchetti C, Borghesi B, Cornara L, Ribulla S, Burlando B
Industrial crops and products, 96, 2017
DOI: 10.1016/j.indcrop.2016.11.047
Resveratrol induces intracellular Ca2+ rise via T-type Ca2+ channels in a mesothelioma cell line
Marchetti C.; Ribulla S.; Magnelli V.; Patrone M.; Burlando B.
Life sciences , 148, 2016
DOI: 10.1016/j.lfs.2016.01.048
Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
Scudieri, Paolo; Caci, Emanuela; Venturini, Arianna; Sondo, Elvira; Pianigiani, Giulia; Marchetti, Carla; Ravazzolo, Roberto; Pagani, Franco; Galietta, Luis J. V.
Journal of physiology , 593, 2015
DOI: 10.1113/JP270691
Oleuropein-Olive Leaf Extract Affects Calcium Dynamics and Impairs Viability of Malignant Mesothelioma Cells
Marchetti C, Clericuzio M, Borghesi B, Cornara L, Ribulla S, Gosetti F, Marengo E, Burlando B
Evidence-based complementary and alternative medicine, 2015, 2015
DOI: 10.1155/2015/908493
EPIGALLOCATECHIN-3-GALLATE ELICITS Ca2+ SPIKE IN MCF-7 BREAST CANCER CELLS: ESSENTIAL ROLE OF Cav3.2 CHANNELS
Ranzato E, Magnelli V., Martinotti S., Waheed Z., Cain S.M., Snutch T.P., Marchetti C, Burlando B
Cell calcium , 2014
DOI: 10.1016/j.ceca.2014.09.002
Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases
Marchetti Carla
BioMetals , 27, 2014
DOI: 10.1007/s10534-014-9791-y
Multiple effects of copper on NMDA receptor currents
Marchetti, Carla; Baranowska-Bosiacka, Irena; Gavazzo, Paola
Brain research, 1542, 2014
DOI: 10.1016/j.brainres.2013.10.029
Role of Calcium Channels in Heavy Metal Toxicity
Marchetti Carla
ISRN Toxicology , 2013, 2014
DOI: 10.1155/2013/184360
Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead
Baranowska-Bosiacka, Irena; Gutowska, Izabela; Marchlewicz, Mariola; Marchetti, Carla; Kurzawski, Mateusz; Dziedziejko, Viotetta; Kolasa, Agnieszka; Olszewska, Maria; Rybicka, Marta; Safranow, Krzysztof; Nowacki, Przemyslaw; (Wiszniewska, Barbara; Chlubek
Brain research, 1435, 2012
Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA
Gavazzo P, Vella S, Marchetti C, Nizzari M, Cancedda R, Pagano A
Journal of neurochemistry, 119, 2011
Altered energy status of primary cerebellar granule neuronal cultures from rats exposed to lead in the pre- and neonatal period
Baranowska-Bosiacka I, Gutowska I, Marchetti C, Rutkowska M, Marchlewicz M, Kolasa A, Prokopowicz A, Wiernicki I, Piotrowska K, Bakiewicz M, Safranow K, Wiszniewska B, Chlubek D
Toxicology, 280, 2011
Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-d-aspartate receptor channels
Gavazzo P, Tedesco M, Chiappalone M, Zanardi I, Marchetti C
Neuroscience, 177, 2011
South African plants used in traditional medicine to treat epilepsy have an antagonistic effect on NMDA receptor currents
Marchetti C, Gavazzo P, Stafford GI, Van Staden J
Journal of ethnopharmacology, 137, 2011
The influence of Calcium ions on Nickel modulation of NMDA receptor currents
Gavazzo P, Guida P, Marchetti C
Metallomics, 3, 2011
Molecular determinants of multiple effects of Nickel on NMDA receptor channels
Gavazzo P, Guida P, Zanardi I, Marchetti C
Neurotoxicity resear, 15, 2009
Molecular determinants of Pb2+ interaction with NMDA receptor channels.
Gavazzo P.; Zanardi I.; Baranowska-Bosiacka I.; Marchetti C.
Neurochemistry international, 52, 2008
DOI: 10.1016/j.neuint.2007.07.003
Nickel differentially affects NMDA receptor channels in developing cultured rat neurons
Paola Gavazzo; Monica Mazzolini; Mariateresa Tedesco; Carla Marchetti
Brain research, 1078, 2006
DOI: 10.1016/j.brainres.2006.01.059
Susceptibility of insulinoma cells to Cadmium and modulation by L-type calcium channels.
Gavazzo P.; Morelli E.; Marchetti C.
BIOMETALS, 18, 2005
DOI: 10.1007/s10534-004-5789-1