Characterization of the mechanism of action of plant polyphenols from green-tea

Several evidences have suggested a negative correlation between prostate cancer (PCa) incidence and green tea consumption in Asian countries. In this project we study the effects on the main green tea flavonoid, (?)-epigallocatechin-3-gallate (EGCG), on proliferation and internal Ca2+ levels in metastatic androgen-insensitive DU145 and PC3 PCa cells and describe a mechanism that combined Ca2+ entry and Ca2+-induced Ca2+ release. The model also fits to green tea extract (GTE) effect, with obvious similarities, but also notable differences that argue for the synergic intervention of the other components.

Members:
Paola Gavazzo