Personal Card



Carla Marchetti

Carla Marchetti graduated in Physics (1980, Genoa, Italy). She worked at MPI (Munich, Germany, 1984) and Texas Medical Center (Houston, USA, 1985-87). Since 1984, she is a permanent researcher at Institute of Biophysics (IBF), National Research Council, Genoa, Italy, and senior researcher since 2001. She has been coordinator of national and international research projects, supervisor of pre-doctoral and doctoral thesis and acts as peer referee for international journals and for research projects for the Italian Ministry of Research (MIUR). She has contributed more than 50 papers to peer-reviewed international journals with H-index=25 (Scopus).

orcid://0000-0001-9219-1825,

Research interests:

- Characterization of the mechanism of action of plant polyphenols from green-tea (Principal investigator)
- Ca2+ dynamics in prostate cancer cells of increasing malignancy (Principal investigator)
- Multitarget bioactive polyphenols as modulators of cytosolic calcium (Principal investigator)

Further collaborations:

- Bruno Burlando (University of Genoa)
- Laura Cornara (University of Genoa)

Key publications:

Marchetti C. (2021) Green tea catechins and intracellular calcium dynamics in prostate cancer cells. AIMS Molecular Science 8(1):1-12. doi: 10.3934/molsci.2021001

Marchetti C, Gavazzo P, Burlando B.(2020) Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release. Life Sci. 258:118232. doi: 10.1016/j.lfs.2020.118232.

Cornara L, Pastorino G, ., Borghesi B, Salis A, Clericuzio M, Marchetti C, Damonte G, Burlando B. (2018) Posidonia oceanica (L.) Delile ethanolic extract modulates cell activities with skin health applications. Marine Drugs 16(1): 21

Pastorino G, Marchetti C, Borghesi B, Cornara L, Ribulla S, Burlando B (2017). Biological activities of the legume crops Melilotus officinalis and Lespedeza capitata for skin care and pharmaceutical applications. Industrial Crops and Products, 96:158-164

Marchetti C, Ribulla S, Patrone M, Magnelli V, Burlando B. (2016). Resveratrol induces intracellular Ca2+ rise via T-type Ca2+ channels in a mesothelioma cell line. Life Sciences 148:125-131

Publications (54):

Green tea catechins and intracellular calcium dynamics in prostate cancer cells
Marchetti Carla
AIMS Molecular Science, 2021
DOI: 10.3934/molsci.2021001

Epigallocatechin-3-gallate mobilizes intracellular Ca 2+ in prostate cancer cells through combined Ca 2+ entry and Ca 2+ -induced Ca 2+ release
Carla Marchetti, Paola Gavazzo, Bruno Burlando
Life sciences (1973), 2020
DOI: 10.1016/j.lfs.2020.118232

Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca(2+)release
Marchetti, Carla and Gavazzo, Paola and Burlando, Bruno
Life sciences (1973), 2020
DOI: 10.1016/j.lfs.2020.118232

Posidonia oceanica (L.) delile ethanolic extract modulates cell activities with skin health applications
Cornara L, Pastorino G, Borghesi B, Salis A, Clericuzio M, Marchetti C, Damonte G, Burlando B
Marine drugs, 2018
DOI: 10.3390/md16010021

Biological activities of the legume crops Melilotus officinalis and Lespedeza capitata for skin care and pharmaceutical applications
Pastorino G, Marchetti C, Borghesi B, Cornara L, Ribulla S, Burlando B
Industrial crops and products (Print), 2017
DOI: 10.1016/j.indcrop.2016.11.047

Resveratrol induces intracellular Ca2+ rise via T-type Ca2+ channels in a mesothelioma cell line
Marchetti C.; Ribulla S.; Magnelli V.; Patrone M.; Burlando B.
Life sciences (1973), 2016
DOI: 10.1016/j.lfs.2016.01.048

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
Scudieri, Paolo; Caci, Emanuela; Venturini, Arianna; Sondo, Elvira; Pianigiani, Giulia; Marchetti, Carla; Ravazzolo, Roberto; Pagani, Franco; Galietta, Luis J. V.
Journal of physiology (Lond., Print), 2015
DOI: 10.1113/JP270691

Oleuropein-Olive Leaf Extract Affects Calcium Dynamics and Impairs Viability of Malignant Mesothelioma Cells
Marchetti C, Clericuzio M, Borghesi B, Cornara L, Ribulla S, Gosetti F, Marengo E, Burlando B
Evidence-based complementary and alternative medicine (Print), 2015
DOI: 10.1155/2015/908493

Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases
Marchetti Carla
BioMetals (Dordr., Online), 2014
DOI: 10.1007/s10534-014-9791-y

EPIGALLOCATECHIN-3-GALLATE ELICITS Ca2+ SPIKE IN MCF-7 BREAST CANCER CELLS: ESSENTIAL ROLE OF Cav3.2 CHANNELS
Ranzato E, Magnelli V., Martinotti S., Waheed Z., Cain S.M., Snutch T.P., Marchetti C, Burlando B
Cell calcium (Sheff.), 2014
DOI: 10.1016/j.ceca.2014.09.002

Multiple effects of copper on NMDA receptor currents
Marchetti, Carla; Baranowska-Bosiacka, Irena; Gavazzo, Paola
Brain research, 2014
DOI: 10.1016/j.brainres.2013.10.029

Role of Calcium Channels in Heavy Metal Toxicity
1.Marchetti C
ISRN Toxicology (Online), 2013
DOI: 10.1155/2013/184360

Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead
Baranowska-Bosiacka, Irena; Gutowska, Izabela; Marchlewicz, Mariola; Marchetti, Carla; Kurzawski, Mateusz; Dziedziejko, Viotetta; Kolasa, Agnieszka; Olszewska, Maria; Rybicka, Marta; Safranow, Krzysztof; Nowacki, Przemyslaw; (Wiszniewska, Barbara; Chlubek, Dariusz
Brain research, 2012
DOI: 10.1016/j.brainres.2011.11.062

Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-d-aspartate receptor channels
Gavazzo P, Tedesco M, Chiappalone M, Zanardi I, Marchetti C
Neuroscience, 2011

Altered energy status of primary cerebellar granule neuronal cultures from rats exposed to lead in the pre- and neonatal period
Baranowska-Bosiacka I, Gutowska I, Marchetti C, Rutkowska M, Marchlewicz M, Kolasa A, Prokopowicz A, Wiernicki I, Piotrowska K, Bakiewicz M, Safranow K, Wiszniewska B, Chlubek D
Toxicology (Amst.), 2011

South African plants used in traditional medicine to treat epilepsy have an antagonistic effect on NMDA receptor currents
Marchetti C, Gavazzo P, Stafford GI, Van Staden J
Journal of ethnopharmacology, 2011

Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA
Gavazzo P, Vella S, Marchetti C, Nizzari M, Cancedda R, Pagano A
Journal of neurochemistry, 2011
DOI: 10.1111/j.1471-4159.2011.07492.x

The influence of Calcium ions on Nickel modulation of NMDA receptor currents
Gavazzo P, Guida P, Marchetti C
Metallomics (Print), 2011

Molecular determinants of multiple effects of Nickel on NMDA receptor channels
Gavazzo P.; Guida P.; Zanardi I.; Marchetti C.
Neurotoxicity resarch, 2009
DOI: 10.1007/s12640-009-9003-7

Molecular determinants of Pb2+ interaction with NMDA receptor channels.
Gavazzo P.; Zanardi I.; Baranowska-Bosiacka I.; Marchetti C.
Neurochemistry international, 2008
DOI: 10.1016/j.neuint.2007.07.003

Nickel differentially affects NMDA receptor channels in developing cultured rat neurons
Paola Gavazzo; Monica Mazzolini; Mariateresa Tedesco; Carla Marchetti
Brain research, 2006
DOI: 10.1016/j.brainres.2006.01.059

Calcium accumulation in neurites and cell bodies of rat cerebellar granule cells in culture: effects on GABAA receptors function.
Cupello A; Esposito A.; Marchetti C.; Pellistri F; Robello M.
Amino acids (Wien, Print), 2005
DOI: 10.1007/s00726-005-0165-1

Two-photon analysis of lead accumulation in rat cerebellar granule cells
Esposito A.; Robello M.; Pellistri F; Marchetti C.
Neurochemical research, 2005
DOI: 10.1007/s11064-005-5980-y

Susceptibility of insulinoma cells to Cadmium and modulation by L-type calcium channels.
Gavazzo P.; Morelli E.; Marchetti C.
BioMetals (Oxf.), 2005
DOI: 10.1007/s10534-004-5789-1

NMDA receptors as targets of heavy metal interaction and toxicity.
Marchetti C.; Gavazzo P.
Neurotoxicity resarch, 2005
DOI: 10.1007/BF03033978

Two photon imaging of calcium accumulation in rat cerebellar granule cells.
Pellistri F; Cupello A; Esposito A.; Marchetti C.; Robello M.
NeuroReport (Oxf.), 2004

Subunit-dependent effects of nickel on NMDA receptor channels.
Marchetti C. 1, Gavazzo P. 1
Molecular brain research, 2003

Molecular targets of lead in brain neurotoxicity.
Marchetti C.

Lead inhibition of NMDA channels in native and recombinant receptors.
Gavazzo P. , Gazzoli A. , Mazzolini M. , Marchetti C.
NeuroReport (Oxf.), 2001

Multiple pathways of Pb(2+) permeation in rat cerebellar granule neurones.
Mazzolini M. 1, Traverso S. 1, Marchetti C. 1
Journal of neurochemistry, 2001

Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-?
Galietta L. J. V., Folli C., Marchetti C., Romano L., Carpani D., Conese M., Zegarra-Moran O.
American journal of physiology. Lung cellular and molecular physiology, 2000

Pathways of Cadmium Influx in Mammalian Neurons
Usai C., Barberis A., Moccagatta L., Marchetti C.
Journal of neurochemistry, 1999
DOI: 10.1046/j.1471-4159.1999.0722154.x

Expression of CD38 Increases Intracellular Calcium Concentration and Reduces Doubling Time in HeLa and 3T3 Cells
Zocchi E., Daga A., Usai C., Franco L., Guida L., Bruzzone S., Costa A., Marchetti C., De Flora A
The Journal of biological chemistry (Print), 1998
DOI: 10.1074/jbc.273.14.8017

Ectocellular in vitro and in vivo metabolism of cADP-ribose in cerebellum
De Flora A, Guida L, Franco L, Zocchi E, Pestarino M, Usai C, Marchetti C, Fedele E, Fontana G, Raiteri M
Biochemical journal (Lond., 1984), 1996

High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rat cerebellar granule neurons
Marchetti C., Usai C.
Neuroscience letters (Print), 1996
DOI: 10.1016/0304-3940(96)12492-7

PHARMACOLOGICAL TYPES OF CALCIUM CHANNELS AND THEIR MODULATION BY BACLOFEN IN CEREBELLAR GRANULES
Amico C; Marchetti C; Nobile M; Usai C
The Journal of neuroscience, 1995

Functional characterization of the effect of nimodipine on the calcium current in rat cerebellar granule cells
Marchetti C; Amico C; Usai C
Journal of neurophysiology, 1995

INACTIVATION OF VOLTAGE-DEPENDENT CALCIUM CURRENT IN AN INSULINOMA CELL-LINE
Marchetti C, Amico C, Podestà D, Robello M
European biophysics journal, 1994

The patch-recording technique: different approaches in a clonal pancreatic ?-cell line
Marchetti, Carla and Amico, Carolina and Robello, Mauro
Physica medica (Testo stamp.), 1993

Voltage-dependent calcium currents in dissociated granule cells from rat cerebellum
Marchetti C; Carignani C; Robello M
Neuroscience, 1991

A transient outward current dependent on external calcium in rat cerebellar granule cells
Carignani C; Robello M; Marchetti C; Maga L
The journal of membrane biology (Print), 1991
DOI: 10.1007/BF01871426

Voltage-dependent calcium currents in rat gonadotropes separated by centrifugal elutriation
Marchetti C; Childs GV; Brown AM
American journal of physiology: endocrinology and metabolism, 1990

A transient voltage-dependent outward current in cultured cerebellar granules
Robello, Mauro and Carignani, Corrado and Marchetti, Carla
Bioscience reports, 1989
DOI: 10.1007/BF01117047

Guanosine-5'-O-(3-thiotriphosphate) modifies kinetics of voltage-dependent calcium current in chick sensory neurons
Marchetti C, Robello M
Biophysical journal (Print), 1989

A whole-cell and single-channel study of the voltage-dependent outward potassium current in avian hepatocytes
Marchetti C, Premont RT, Brown AM
The Journal of general physiology, 1988

Protein kinase activator 1-oleoyl-2-acetyl-sn-glycerol inhibits two types of calcium currents in GH3 cells
Marchetti C, Brown AM
The American journal of physiology, 1988

Membrane currents of identified isolated rat corticotropes and gonadotropes
Marchetti C, Childs GV, Brown AM
The American journal of physiology, 1987

Secretion from corticotropes after avidin-fluorescein stains for biotinylated ligands (CRF or AVP)
Childs GV, Unabia G, Burke JA, Marchetti C
The American journal of physiology, 1987

Involvement of sodium channels and two types of calcium channels in the regulation of adrenocorticotropin release
Childs GV, Marchetti C, Brown AM
Endocrinology (Philadelphia), 1987
DOI: 10.1210/endo-120-5-2059

Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick
Marchetti C, Carbone E, Lux HD
Pflügers Archiv, 1986
DOI: 10.1007/BF00586670

Effect of gangliosides on phospholipid bilayers: a study with the lipophilic ions relaxation method
Usai C, Robello M, Gambale F, Marchetti C
The journal of membrane biology (Print), 1984
DOI: 10.1007/BF01870728

GM1 micelles modify the transport properties of the ionophore gramicidin D in artificial planar bilayers
Gambale F, Marchetti C, Usai C, Robello M, Gorio A
Journal of neuroscience research, 1984
DOI: 10.1002/jnr.490120222

Capacitance--voltage relationship in phospholipid bilayers containing gangliosides
Usai C, Marchetti C, Gambale F, Robello M, Gorio A
FEBS letters (Print), 1983

Properties of ionic transport through phospholipid-glycolipid artificial bilayers
Gambale F, Robello M, Usai C, Marchetti C
Biochimica et biophysica acta (Print), 1982