Personal Card

Maria Rosalia Mangione

Research staff

From 2008 Technologist at IBF - Palermo
2006 Research Project for “realizzazione di un centro regionale per il controllo di qualità di oli vergini d' oliva”.
2004 PhD on “Technologies of biologically active substances” Faculty of Pharmacia – Palermo
1999 Degree cum laude on " Pharmaceutical Chemistry and Technology”



- Email
- Phone +39-091-6809334
- Location Palermo

Research interests:

- Amyloid aggregation processes and their inhibition (Principal investigator)
- Extraction, identification and characterization of naturally occurring compounds and study of their biological activity on cell lines.
- Model Membrane Systems and Interaction Studies
- Liposome as drug delivery system
- Production, Purification, Mutagenesis and Characterization of proteins expressed in E. coli

Financial support:

- Progetto FSE 2014/2020 “Percorsi formative nei settori Biotecnologia, Biomedicina e Agroalimentare”.
- Progetto istituzionale CNR/IBF SIVA “Caratterizzazione del fattore Heat Shock Factor 1 (HSF1) e suoi complessi molecolari”.
- Progetto istituzionale CNR/IBF “Stabilità e funzione di proteine”.

Key publications:

Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R (2018) Biophysical characterization of asolectin-squalene liposomes. Colloids and Surface B: Biointerfaces 170:479-487

Mangione MR, Vilasi S, Marino C, et al. (2016) Hsp60, amateur chaperone in amyloid-beta fibrillogenesis. Biochimica et Biophysica Acta (BBA)-General Subjects 1860(11):2474-2483

Mangione MR, Palumbo Piccionello A, Marino C, et al. (2015) Photo-inhibition of Abeta fibrillation mediated by a newly designed fluorinated oxadiazole. RSC Advances 5(21):16540-16548

Guarrasi V, Mangione MR, Sanfratello V, et al. (2011) Quantification of underivatized fatty acids from vegetable oils by HPLC with UV detection. Journal of Chromatography Science 48(8):663-668

Mangione MR, Giacomazza D, Bulone D, et al. (2003) Thermoreversible gelation of K-Carrageenan: relation between conformational transition and aggregation. Biophysical Chemistry 104(1):95-105

Publications (26):

Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
The journal of physical chemistry. B, 2019
DOI: 10.1021/acs.jpcb.8b11719

Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 2019
DOI: 10.1021/acschemneuro.9b00183

Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus indica and its potential biological activity
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K
Phytochemistry, 2018
DOI: 10.1016/j.phytochem.2018.06.015

The precious content of the olive mill wastewater: The protective effects of the antioxidant fraction in cell cultures
Giacomazza D, D'Andrea D, Provenzano A, Picone P, Provenzano F, Guarrasi V, Raimondo M, San Biagio PL, Passantino R, Mangione MR, Di Carlo M, Costa MA
CyTA: journal of food (Online), 2018
DOI: 10.1080/19476337.2018.1458752

Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces (Print), 2018
DOI: 10.1016/j.colsurfb.2018.06.032

Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 2017
DOI: 10.1039/c7ra05300b

Simultaneous Determination of Caffeine and Chlorogenic Acids in Green Coffee by UV/Vis Spectroscopy
Navarra G, Moschetti M, Guarrasi V, Mangione MR, Militello V, Leone M
Journal of Chemistry, 2017
DOI: 10.1155/2017/6435086

Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection
Presti G, Guarrasi V, Gulotta E, Provenzano F, Provenzano A, Giuliano S, Monfreda M, Mangione MR, Passantino R, San Biagio PL, Costa MA, Giacomazza D
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.09.002

Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.07.008

Pectin from Opuntia ficus indica: Optimization of microwave-assisted extraction and preliminary characterization
Lefsih K, Giacomazza D, Dahmoune F, Mangione MR, Bulone D, San Biagio PL, Passantino R, Costa MA, Guarrasi V, Madani K
Food chemistry, 2017
DOI: 10.1016/j.foodchem.2016.10.073

Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019

Temporal control of xyloglucan self-assembly into layered structures by radiation-induced degradation
Todaro S, Sabatino MA, Mangione MR, Picone P, Di Giacinto ML, Bulone D, Dispenza C
Carbohydrate polymers, 2016
DOI: 10.1016/j.carbpol.2016.07.005

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, C. and Ortore, M.G. and Vilasi, S. and Carrotta, R. and Mangione, M.R. and Bulone, D. and Librizzi, F. and Spinozzi, F. and Burgio, G. and Amenitsch, H. and San Biagio, P.L.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions
Dispenza C, Sabatino MA, Grimaldi N, Mangione MR, Walo M, Murugan E, Jonsson M
RSC advances, 2016
DOI: 10.1039/c5ra23926e

Photo-inhibition of Ab fibrillation mediated by a newly designed fluorinated oxadiazole
M.R. Mangione1, A. Palumbo Piccionello1,2,3, C. Marino1,4, M.G. Ortore5, P. Picone6, S. Vilasi1, M. Di Carlo6, S. Buscemi1,2, D. Bulone1 and P.L. San Biagio1
RSC advances, 2015
DOI: 10.1039/c4ra13556c

Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans
Todaro, S.; Sabatino, M. A.; Walo, M.; Mangione, M. R.; Bulone, D.; Dispenza, C.
Radiation physics and chemistry (1993), 2014
DOI: 10.1016/j.radphyschem.2013.05.055

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657

The Tempered Polymerization of Human Neuroserpin
Noto R; Santangelo MG; Ricagno S; Mangione MR; Levantino M; Pezzullo M; Martorana V; Cupane A; Bolognesi M; Manno M
PloS one, 2012
DOI: 10.1371/journal.pone.0032444

On the molecular structure of human neuroserpin polymers
Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M
Proteins (Print), 2012
DOI: 10.1002/prot.23197

Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter (Print), 2012
DOI: 10.1088/0953-8984/24/24/244103

Quantification of underivatized fatty acids from vegetable oils by HPLC with UV Detection
Guarrasi V.; Mangione M.R.; Sanfratello V.; Martorana V.; Bulone D.
Journal of chromatographic science, 2010
DOI: 10.1093/chromsci/48.8.663

Synergistic interaction of Locust Bean Gum and Xanthan investigated by rheology and light scattering
Sandolo C.; Bulone D.; Mangione M.R.; Margheritelli S.; Di Meo C.; Alhaique F.; Matricardi P.; Coviello T.
Carbohydrate polymers, 2010
DOI: 10.1016/j.carbpol.2010.05.044

Relation between structural and release properties in a polysaccharide gel system.
Mangione M. R.(1); D. Giacomazza (1); G. Cavallaro; D. Bulone (1); V. Martorana (1); P. L. San Biagio (1).
Biophysical chemistry (Print), 2007
DOI: 10.1016/j.bpc.2007.04.013

K+ and Na+ effects on the gelation properties of k-Carrageenan.
Mangione M.R. (1); Giacomazza D. (1); Bulone D. (1); Martorana V. (1); Cavallaro G.; San Biagio P.L. (1)
Biophysical chemistry (Print), 2005
DOI: 10.1016/j.bpc.2004.08.005

Thermoreversible gelation of k-Carrageenan: relation between conformational transition and aggregation.
Mangione M.R. 1,2, Giacomazza D. 1, Bulone D. 1, Martorana V. 1, San Biagio P.L. 1
Biophysical chemistry (Print), 2003
DOI: 10.1016/S0301-4622(02)00341-1