Characterization of LRRC8 volume regulated anion channels

In collaboration with Raul Estevez (University of Barcelona) we have biophysically and pharmacologically characterized the newly identified family of LRRC8 proteins that underlie the volume-regulated anion channel, VRAC. We are continuing on the structure-function analysis of these channels.

Members:
Anna Elisabetta Boccaccio
Paolo Gualtieri
Michael Pusch (Principal investigator)