Anna Elisabetta Boccaccio
Research staff
Degree in Physics conferred by the Faculty of Mathematics, Physics and Natural Sciences of the University of Genoa (1996), PhD in Physics at the Technical University of Munich, Germany (TUM, 2001).
From 1998 to 2001 PhD student at the Molecular and Cellular Neuropharmacology Group of the Max-Planck Institute for Experimental Medicine, Göttingen, Germany.
From 2002 to 2008 post-doc and later researcher at the Neurobiology sector of the International School of Advanced Studies (SISSA) of Trieste. From 2008 to 2010 post-doc senior at the Italian Institute of Technology (IIT), Genoa.
Researcher at the Institute of Biophysics in Genoa since 2010
orcid://0000-0002-6219-2285, ncbi://40667148
Contact:
- Email anna.boccaccio@ibf.cnr.it
- Phone +39-010-6475891
- Location Genova
Website:
https://www.researchgate.net/profile/Anna_Boccaccio
Research interests:
- Study of the Ca2+-activated chloride channels and phospholipid scramblases of the TMEM16/Anoctamin family (Principal investigator)
- Characterization of LRRC8 volume regulated anion channels
Further collaborations:
- Anna Menini (SISSA, Trieste)
- Paola Pedarzani (UCL,London, UK)
Key publications:
Boccaccio A and Pusch M. TMEM16 Ca2+ activated Cl- channels and CLC chloride channels and transporters. In Handbook of Neuronal Ion Channels. Oxford University Press in press
Di Zanni E, Gradogna A, Scholz-Starke J, Boccaccio A. Gain of function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia. Cellular and Molecular Life Sciences 2018 May;75(9):1657-1670. doi: 10.1007/s00018-017-2704-9
Pietra G, Dibattista M, Menini A, Reisert J, Boccaccio A. The Ca2+ -activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. The Journal of General Physiology 2016. Oct 148 (4) 293-311; doi: 10.1085/jgp.201611622
Cherian OL, Menini A and Boccaccio A* Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta-Biomembrane.2015 Apr;1848(4):1005-13. doi:10.1016/j.bbamem.2015.01.009
Boccaccio A, Scholz-Starke J, Hamamoto S, Larisch N, Festa M, Gutla PV, Costa A, Dietrich P, Uozumi N, Carpaneto A. The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells. Cellular and Molecular Life Sciences 2014 Apr 26. doi: 10.1007/s00018-014-1623-2.
Publications (22):
Phospholipid scrambling by a TMEM16 homolog of Arabidopsis thalianaBoccaccio, ANNA ELISABETTA; Picco, Cristiana; DI ZANNI, Eleonora; Joachim, Scholzstarke
THE FEBS JOURNAL (PRINT), 289, 2022
DOI: 10.1111/febs.16279
The cyclic AMP signaling pathway in the rodent main olfactory system
Boccaccio A.; Menini A.; Pifferi S.
cell & tissue research (internet)issn: 1432-0878springer, 383, 2021
DOI: 10.1007/s00441-020-03391-7
TMEM16E/ANO5 mutations related to bone dysplasia or muscular dystrophy cause opposite effects on lipid scrambling
Di Zanni, Eleonora; Gradogna, Antonella; Picco, Cristiana; Scholz-Starke, Joachim; Boccaccio, Anna
Human Mutation, 41, 2020
DOI: 10.1002/humu.24006
Lifting the veils on TMEM16E function
Boccaccio A, Di Zanni E, Gradogna A, Scholz-Starke J
Channels, 13, 2019
DOI: 10.1080/19336950.2018.1557470
Gain of function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia
Di Zanni E, Gradogna A, Scholz-Starke J, Boccaccio A
Cellular and molecular life sciences , 75, 2018
DOI: 10.1007/s00018-017-2704-9
Mechano-sensitization of mammalian neuronal networks through expression of the bacterial large-conductance mechanosensitive ion channel
Soloperto A, Boccaccio A, Contestabile A, Moroni M, Hallinan GI, Palazzolo G, Chad J, Deinhardt K, Carugo D, Difato F
Journal of cell science (online), 131, 2018
DOI: 10.1242/jcs.210393
Cisplatin activates volume sensitive LRRC8 channel mediated currents in Xenopus oocytes
Gradogna A.; Gaitan-Penas H.; Boccaccio A.; Estevez R.; Pusch M.
Channels , 11, 2017
DOI: 10.1080/19336950.2017.1284717
Subunit-dependent oxidative stress sensitivity of LRRC8 volume-regulated anion channels
Gradogna A, Gavazzo P, Boccaccio A, Pusch M
Journal of physiology , 595, 2017
DOI: 10.1113/JP274795
The long tale of the calcium activated Cl- channels in olfactory transduction
Dibattista M, Pifferi S, Boccaccio A, Menini A, Reisert J
Channels , 11, 2017
DOI: 10.1080/19336950.2017.1307489
The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H exchange activity.
Carpaneto A, Boccaccio A, Lagostena L, Di Zanni E, Scholz-Starke J
EMBO reports, 18, 2017
DOI: 10.15252/embr.201643814
The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons
Pietra G, Dibattista M, Menini A, Reisert J, Boccaccio A
Journal of general physiology, 148, 2016
DOI: 10.1085/jgp.201611622
Circuit formation and function in the olfactory bulb of mice with reduced spontaneous afferent activity.
Lorenzon, P.; Redolfi, N.; Podolsky, M.J.; Zamparo, I.; Franchi, S.A.; Pietra, G.; Boccaccio, A.; Menini, A.; Murthy, V.N.; Lodovichi, C.
Journal of neuroscience, 35, 2015
DOI: 10.1523/JNEUROSCI.0613-14.2015
Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons
Amjad, Asma; Hernandez-Clavijo, Andres; Pifferi, Simone; Maurya, Devendra Kumar; Boccaccio, Anna; Franzot, Jessica; Rock, Jason; Menini, Anna
Journal of general physiology, 145, 2015
DOI: 10.1085/jgp.201411348
Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel
Cherian, O.L., Menini, A., Boccaccio, A.
Biochimica et biophysica acta. Biomembranes , 1848, 2015
DOI: 10.1016/j.bbamem.2015.01.009
Flash Photolysis of Caged Compounds in the Cilia of Olfactory Sensory Neurons
Boccaccio Anna;Sagheddu C;Menini Anna
Journal of visualized experiments , 55, 2014
DOI: 10.3791/3195
Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel
Betto, Giulia; Cherian, O. Lijo; Pifferi, Simone; Cenedese, Valentina; Boccaccio, Anna; Menini, Anna
Journal of general physiology, 143, 2014
DOI: 10.1085/jgp.201411182
The phosphoinositide PI(3,5)P-2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells
Boccaccio, Anna; Scholz-Starke, Joachim; Hamamoto, Shin; Larisch, Nina; Festa, Margherita; Gutla, Paul Vijay Kanth; Costa, Alex; Dietrich, Petra; Uozumi, Nobuyuki; Carpaneto, Armando
Cellular and molecular life sciences , 71, 2014
DOI: 10.1007/s00018-014-1623-2
A Dynamical Feedback Model for Adaptation in the Olfactory Transduction Pathway
De Palo G; Boccaccio A; Miri A; Menini A; Altafini C
Biophysical journal, 102, 2012
Modulation of plant TPC channels by polyunsaturated fatty acids
Gutla PV; Boccaccio A; De Angeli A; Gambale F; Carpaneto A
Journal of experimental botany, 63, 2012
DOI: 10.1093/jxb/ers272
Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T.
Sagheddu C, Boccaccio A, Dibattista M, Montani G, Tirindelli R, Menini A
Journal of physiology, 588, 2010
Cyclic nucleotide-gated ion channels in sensory transduction.
Simone Pifferi, Simone; Boccaccio, Anna; Menini, Anna
The FEBS journal, 2006
DOI: 10.1016/j.febslet.2006.03.086
Electrophysiological properties and modeling of murine vomeronasal sensory neurons in acute slice preparations.
Shimazaki, Ranken ; Boccaccio, Anna ; Mazzatenta, Andrea ; Pinato, Giulietta ; Migliore, Michele ; Menini, Anna
CHEMICAL SENSES, 31, 2006
DOI: 10.1093/chemse/bjj047