Personal Card



Vincenzo Martorana

Research staff

Contact:

- Email vincenzo.martorana@ibf.cnr.it
- Phone +39-091-6809308
- Location Palermo

Research interests:

- Laboratory for Advanced and Scattering Technologies (LAST)
- Amyloid aggregation processes and their inhibition
- Production, Purification, Mutagenesis and Characterization of proteins expressed in E. coli
- Molecular bases of serpinopathies
- Characterisation of extracellular vescicles

Publications (66):

Dye-Derived Red-Emitting Carbon Dots for Lasing and Solid-State Lighting
Antonino Madonia, Gianluca Minervini, Angela Terracina, Ashim Pramanik, Vincenzo Martorana, Alice Sciortino, Carlo M. Carbonaro, Chiara Olla, Teresa Sibillano, Cinzia Giannini, Elisabetta Fanizza, Maria L. Curri, Annamaria Panniello, Fabrizio Messina, and Marinella Striccoli
ACS nano (Online), 2023
DOI: 10.1021/acsnano.3c05566

The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
Pizzo Federica, Mangione Maria Rosalia, Librizzi Fabio, Manno Mauro, Martorana Vincenzo, Noto Rosina and Vilasi Silvia
Life (Basel), 2022
DOI: 10.3390/life12030448

Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto Sabrina; Barone Maria E.; Fierli David; Aranyos Anita; Adamo Giorgia; Bo?i? Darja; Romancino Daniele P.; Stanly Christopher; Parkes Rachel; Morsbach Svenja; Raccosta Samuele; Paganini Carolina; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Capasso Palmiero Umberto; Santonicola Pamela; Igli? Ales; Gai Meiyu; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Landfester Katharina; Liguori Giovanna L.; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Manno Mauro; Touzet Nicolas; Bongiovanni Antonella
Biomaterials science (Print), 2021
DOI: 10.1039/d0bm01696a

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo Giorgia; Fierli David; Romancino Daniele P.; Picciotto Sabrina; Barone Maria E.; Aranyos Anita; Bo?i? Darja; Morsbach Svenja; Raccosta Samuele; Stanly Christopher; Paganini Carolina; Gai Meiyu; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Randazzo Loredana; Parkes Rachel; Capasso Palmiero Umberto; Rao Estella; Paterna Angela; Santonicola Pamela; Igli? Ales; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Liguori Giovanna L.; Landfester Katharina; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Touzet Nicolas; Manno Mauro; Bongiovanni Antonella;
Journal of extracellular vesicles, 2021
DOI: 10.1002/jev2.12081

Scaling concepts in serpin polymer physics
Raccosta S.; Librizzi F.; Jagger A.M.; Noto R.; Martorana V.; Lomas D.A.; Irving J.A.; Manno M.
Materials (Basel), 2021
DOI: 10.3390/ma14102577

Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Dispenza Clelia; Todaro Simona; Sabatino Maria Antonietta; Martino Delia; Martorana Vincenzo; San Biagio Pier Luigi; Maffei Paola and Bulone Donatella
Cellulose (Lond.), 2020
DOI: 10.1007/s10570-020-03004-0

Amyloid jams: Mechanical and dynamical properties of an amyloid fibrillar network
Martorana V, Raccosta S, Giacomazza D, Ditta LA, Noto R, Biagio PLS, Manno M
Biophysical chemistry (Print), 2019
DOI: 10.1016/j.bpc.2019.106231

Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 2019
DOI: 10.1021/acschemneuro.9b00183

Intermittent C1-Inhibitor Deficiency Associated with Recessive Inheritance: Functional and Structural Insight
Caccia S, Suffritti C, Carzaniga T, Berardelli R, Berra S, Martorana V, Fra A, Drouet C, Cicardi M
Scientific reports (Nature Publishing Group), 2018
DOI: 10.1038/s41598-017-16667-w

Palmitoylation is a post -translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles
Romancino, Daniele P.; Buffa, Valentina; Caruso, Stefano; Ferrara, Ines; Raccosta, Samuele; Notaro, Antonietta; Campos, Yvan; Noto, Rosina; Martorana, Vincenzo; Cupane, Antonio; Giallongo, Agata; d'Azzo, Alessandra; Manno, Mauro; Bongiovanni, Antonella
Biochimica et biophysica acta. G, General subjects (Print), 2018
DOI: 10.1016/j.bbagen.2018.09.004

Embelin binds to human neuroserpin and impairs its polymerisation
Saga, Giorgia; Sessa, Fabio; Barbiroli, Alberto; Santambrogio, Carlo; Russo, Rosaria; Sala, Michela; Raccosta, Samuele; Martorana, Vincenzo; Caccia, Sonia; Noto, Rosina; Moriconi, Claudia; Miranda, Elena; Grandori, Rita; Manno, Mauro; Bolognesi, Martino; Bolognesi, Martino; Ricagno, Stefano
Scientific reports (Nature Publishing Group), 2016
DOI: 10.1038/srep18769

Electrostatics promotes molecular crowding and selects the aggregation pathway in fibril-forming protein solutions
Raccosta, S. and Blanco, M. and Roberts, C.J. and Martorana, V. and Manno, M.
Il Nuovo cimento C (2009, Testo stamp.), 2016
DOI: 10.1393/ncc/i2016-16304-0

The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop
Noto R.; Randazzo L.; Raccosta S.; Caccia S.; Moriconi C.; Miranda E.; Martorana V.; Manno M.
Scientific reports (Nature Publishing Group), 2015
DOI: 10.1038/srep13666

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum
Moriconi C, Ordoñez A, Lupo G, Gooptu B, Irving JA, Noto R, Martorana V, Manno M, Timpano V, Guadagno NA, Dalton L, Marciniak SJ, Lomas DA, Miranda E
The FEBS journal (Online), 2015
DOI: 10.1111/febs.13517

Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics
Noto, Rosina; Santangelo, Maria Grazia; Levantino, Matteo; Cupane, Antonio; Mangione, Maria Rosalia; Parisi, Daniele; Ricagno, Stéfano; Bolognesi, Martino; Manno, Mauro; Martorana, Vincenzo
Biochimica et biophysica acta. Proteins and proteomics, 2015
DOI: 10.1016/j.bbapap.2014.10.002

Custom system for single molecule force spectroscopy
1 E. Landini, 2 S. Raccosta, 2 F. D'Anca, 3 M. Zora, 3 S. Mazzola, 2 P.L. Sanbiagio, 2 V. Martorana, 1 M. Vassalli
Microscopie, 2014

Protein-Protein Interactions in Dilute to Concentrated Solutions: alpha-Chymotrypsinogen in Acidic Conditions
Blanco, Marco A.; Perevozchikova, Tatiana; Martorana, Vincenzo; Manno, Mauro; Roberts, Christopher J.
The journal of physical chemistry. B, 2014
DOI: 10.1021/jp412301h

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657

The Tempered Polymerization of Human Neuroserpin
Noto R; Santangelo MG; Ricagno S; Mangione MR; Levantino M; Pezzullo M; Martorana V; Cupane A; Bolognesi M; Manno M
PloS one, 2012
DOI: 10.1371/journal.pone.0032444

On the molecular structure of human neuroserpin polymers
Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M
Proteins (Print), 2012
DOI: 10.1002/prot.23197

alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp307417x

Thermodynamic versus Conformational Metastability in Fibril-Forming Lysozyme Solutions
Raccosta S; Martorana V; Manno M
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp303430g

Amyloid fibrils formation of concanavalin A at basic pH
Carrotta R (1); Vetri V(2); Librizzi F (2); Martorana V (1); Militello V(2); Leone M (2)
The journal of physical chemistry. B (1997 : Online), 2011

Existence of metastable intermediate lysozyme conformation highlights the role of alcohols in altering protein stability
D'Amico M, Raccosta S, Cannas M, Martorana V, Manno M
The journal of physical chemistry. B, 2011
DOI: 10.1021/jp106748g

Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress
Andersen C. B.; Manno M.; Rischel C.; Thórólfsson M.; Martorana V.
Protein science (Print), 2010
DOI: 10.1002/pro.309

Quantification of underivatized fatty acids from vegetable oils by HPLC with UV Detection
Guarrasi V.; Mangione M.R.; Sanfratello V.; Martorana V.; Bulone D.
Journal of chromatographic science, 2010
DOI: 10.1093/chromsci/48.8.663

Amyloid gels: precocious appearance of elastic properties during the formation of an insulin fibrillar network
Manno M.(1); D. Giacomazza (1); J. Newman; V. Martorana (1) and P.L. San Biagio (1)
Langmuir, 2010
DOI: 10.1021/la903340v

Irreversible gelation of thermally unfolded lysozyme: structural and mechanical properties of lysozyme aggregates
Raccosta S.; Manno M. (1); Bulone D. (1); Giacomazza D. (1); Militello V.; Martorana V. (1); San Biagio P. L. (1)
European biophysics journal, 2010
DOI: 10.1007/s00249-009-0503-4

Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin.
Carrotta R; Manno M; Giordano FM; Longo A; Portale G; Martorana V; San Biagio PL.
PCCP. Physical chemistry chemical physics (Print), 2009
DOI: 10.1039/b818687a

Branching in amyloid fibril growth.
Andersen CB; Yagi H; Manno M; Martorana V; Ban T; Christiansen G; Otzen DE; Goto Y; Rischel C
Biophysical journal (Print), 2009
DOI: 10.1016/j.bpj.2008.11.024

Kinetics of different processes in human insulin amyloid formation.
Manno M.; Craparo E.F.; Podestà A.; Bulone D.; Carrotta R.; Martorana V.; Milani P.; Tiana G.; San Biagio P.L.
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2006.11.008

A statistical light scattering approach to separating fast and slow dynamics.
Barthès J.; D. Bulone(1); M. Manno(1); V. Martorana (1); P. L. San Biagio. (1)
European biophysics journal, 2007
DOI: 10.1007/s00249-007-0163-1

Large size fibrillar bundles of the alzheimer amyloid beta-protein.
Carrotta R.; J. Barthès; A. Longo; V. Martorana; M. Manno; G. Portale; P. L. San Biagio.
European biophysics journal, 2007
DOI: 10.1007/s00249-007-0164-0

Relation between structural and release properties in a polysaccharide gel system.
Mangione M. R.(1); D. Giacomazza (1); G. Cavallaro; D. Bulone (1); V. Martorana (1); P. L. San Biagio (1).
Biophysical chemistry (Print), 2007
DOI: 10.1016/j.bpc.2007.04.013

Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation.
Manno M.; Craparo E.F.; Martorana V.; Bulone D.; San Biagio P.L.
Biophysical journal (Print), 2006
DOI: 10.1529/biophysj.105.077636

Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.
Carrotta R.; Manno M.; Bulone D.; Martorana V.; San Biagio P.L.;
The Journal of biological chemistry (Print), 2005
DOI: 10.1074/jbc.M500052200

K+ and Na+ effects on the gelation properties of k-Carrageenan.
Mangione M.R. (1); Giacomazza D. (1); Bulone D. (1); Martorana V. (1); Cavallaro G.; San Biagio P.L. (1)
Biophysical chemistry (Print), 2005
DOI: 10.1016/j.bpc.2004.08.005

Role of charges and solvent on the conformational properties of poly(galacturonic acid) chains: a Molecular Dynamics study.
Noto R.; Martorana V.; Bulone D.; San Biagio P. L.
Biomacromolecules, 2005
DOI: 10.1021/bm050280g

NMR and molecular dynamics studies of the interaction of melatonin with calmodulin.
Turjanski A.G.; Estrin D.A.; Rosenstein R.E.; McCormick J.E.; Martin S.R.; Pastore A.; Biekofsky R.R.; Martorana V.
Protein science (Print), 2004
DOI: 10.1110/ps.04611404

Ordering of agarose near the macroscopic gelation point.
Bulone D.; Giacomazza D.; Martorana V.; Newman J.; San Biagio P.L.
Physical review. E, Statistical, nonlinear, and soft matter physics (Print), 2004
DOI: 10.1103/PhysRevE.69.041401

Thermodynamic instability and off-critical slowing down in supersaturated lysozyme solutions
Manno M. (1); Bulone D. (1); Martorana V. (1); San Biagio P. L. (1)
Journal of physics. Condensed matter (Print), 2004
DOI: 10.1088/0953-8984/16/42/017

Ergodic to non-ergodic transition monitored by scattered light intensity statistics
Manno M. (1); Bulone D. (1); Martorana V. (1); San Biagio P. L. (1)
Physica. A (Print), 2004
DOI: 10.1016/j.physa.2004.04.107

Thermodynamic instability in supersaturated lysozyme solutions: effect of salt and role of concentration fluctuations.
Manno M. 1, Xiao C. 2, Bulone D. 1, Martorana V. 1, San_Biagio P.L. 1
Physical review. E, Statistical, nonlinear and soft matter physics (Online), 2003
DOI: 10.1103/PhysRevE.68.011904

Thermoreversible gelation of k-Carrageenan: relation between conformational transition and aggregation.
Mangione M.R. 1,2, Giacomazza D. 1, Bulone D. 1, Martorana V. 1, San Biagio P.L. 1
Biophysical chemistry (Print), 2003
DOI: 10.1016/S0301-4622(02)00341-1

Tailoring of Physical and Chemical Properties of Macro- and Microhydrogels Based on Telechelic PVA
Paradossi G.; Cavalieri F. Chiessi E.; Ponassi V.; Martorana V.
Biomacromolecules, 2002
DOI: 10.1021/bm0256247

Role of sucrose in pectin gelation: Static and dynamic light scattering experiments
Bulone D. 1, Martorana V. 1, Xiao C. 2, San Biagio P.L. 1
Macromolecules (Print), 2002
DOI: 10.1021/ma0205109

Salt effects on gelation of agarose aqueous solutions
Newman J., Martorana V., Bulone D., San Biagio P. L.
Biophysical journal (Print), 2002

Effects of intermediates on aggregation of native bovine serum albumin.
Bulone D., Martorana V., San Biagio PL.
Biophysical chemistry (Print), 2001
DOI: 10.1016/S0301-4622(01)00155-7

Interaction of processes on different length scales in a bioelastomer capable of performing energy conversion.
Manno, M., A. Emanuele, V. Martorana, P. L. San Biagio, D. Bulone, M. B. Palma-Vittorelli, D. T. McPherson, J. Xu, T. M. Parker, and D. W. Urry
Biopolymers (Print), 2001

Potential of mean force between two ions in a sucrose rich aqueous solution
Martorana, V., L. La Fata, D. Bulone, and P. L. San Biagio
Chemical physics letters (Print), 2000

Effects of electric charges on hydrophobic forces II
Bulone D., Martorana V., San Biagio P.L., Palma-Vittorelli M.B.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2000

Multiple interactions between molecular and supramolecular ordering
Manno M., Emanuele A., Martorana V., Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1999

Below the threshold of macroscopic gelation
Bulone D., Martorana V., San Biagio P.L.
Trends in Chemical Physics, 1999

Solvent-induced free energy landscape and solute-solvent dynamic coupling in a multielement solute
San Biagio P.L., Martorana V., Bulone D., Palma-Vittorelli M.B., Palma M.U.
Biophysical journal (Print), 1999

Interacting processes in protein coagulation
San Biagio P.L., Martorana V., Emanuele A., Vaiana S.M., Manno M., Bulone D., Palma-Vittorelli M.B., Palma M.U.
Proteins (Print), 1999

Interaction of explicit solvent with hydrophobic/philic/charged residues of a protein: residue character vs. conformational context
V Martorana, G Corongiu, MU Palma
Proteins (Print), 1998

Physics and biophysics of solvent induced forces: hydrophobic interactions and context-dependent hydration
San Biagio P.L., Bulone D., Martorana V., Palma-Vittorelli M.B., Palma M.U.
European Biophysical Journal, 1998

Collective properties of hydration: long range and specificity of hydrophobic interactions
Martorana V., Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Biophysical journal (Print), 1997

Effects of electric charges on hydrophobic forces
Bulone D., Martorana V., San Biagio P.L., Palma-Vittorelli M.B.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1997

Correlated solvent-induced forces on a protein at single residue resolution: relation to conformation, stability, dynamics and function
V. Martorana (a), G. Corongiu ()b, M.U. Palma (c, d, e)
Chemical physics letters (Print), 1996

Comparison of the water perturbations induced by two small organic solutes: ab initio calculations and molecular dynamics simulation
Rosina Noto, Vincenzo Martorana, Antonio Emanuele, Sandro L Fornili
Journal of the Chemical Society. Faraday transactions (Print), 1995

A molecular dynamics study of large-scale reversible aggregation of anisotropic particles
F. Brugè (1), V. Martorana (2), S. L. Fornili (1), M. B. Palma-Vittorelli (1)
International journal of quantum chemistry, 1992

Demixing and polymerization in systems of anisotropic globular particles: A molecular dynamics simulation study
F. Brugè(1,2), V. Martorana(2), S. L. Fornili(1,2), M. B. Palma-Vittorelli(1,2)
Die Makromolekulare Chemie. Macromolecular symposia, 1991

Hydration of the Ammonium Ion: Monte Carlo Simulation
R. Noto (1), V. Martorana (1), M. Migliore (1), S.L. Fornili (1,2)
Zeitschrift für Naturforschung. Teil a, Physik, physikalische Chemie, Kosmophysik, 1991

An algorithm to find all paths between two nodes in a graph
M Migliore, V Martorana, F Sciortino
Journal of computational physics (Print), 1990

Concurrent Molecular Dynamics Simulation of ST2 Water on a Transputer Array
F. Brugè (1), V. Martorana (1) & S. L. Fornili (1,2)
Molecular simulation (Print), 1988