Personal Card



Pier Luigi San Biagio

Associate

Pier Luigi San Biagio has coordinated the research activity in the field of Biophysics at the CNR-IAIF since its creation in 1980. After more than one year spent working at NIH (Bethesda, MD, USA), he returned in Italy and set up a lab with outstanding equipment for the characterization of biomolecular aggregation. He was Director of the IAIF from 1998 to 2002 when the Institute became part of the Biophysics Institute as Palermo U.O.S.. Since then, he has been in charge of U.O.S. (2002-2015) and director of the research group “Processi di Aggregazione Biomolecolare”. Its research activity is based on complementary approaches to the study of biomolecular aggregation at microscopic and mesoscopic level.

orcid://0000-0002-4622-7361,

Contact:

- Email pierluigi.sanbiagio@ibf.cnr.it
- Phone +39-091-6809311
- Location Palermo

Research interests:

- Biomolecular Aggregation Processes (Principal investigator)
- Protein aggregation and the onset of neurodegenerative diseases (Principal investigator)
- Structure and Functionality of Molecular chaperones
- Polysaccharides Substitutes for Gluten-Free Baking
- Insulin drug delivery in neurodegeneration
- Study of natural and chemically modified natural polymers for biotechnological applications
- Development of bio-adhesives for wet environments from marine mussels
- Laboratory of protein engineering for production of recombinant proteins.
- Extraction and characterization of polyphenols from complex systems of agri-food origin; study of antioxidant properties and of neuroprotective and anti-amyloidogenic effects in neurodegenerative processes

Further collaborations:

- F. Cappello (Università di Palermo, BIONEC e IEMEST)
- A. Padova (Fondazione Ri.MED)
- A. Pastore (Dip. Medicina Molecolare, Università di Pavia )
- M. Leone (Dipartimento di Fisica e Chimica, Università di Palermo)

Financial support:

- Avviso 11/2017 Rafforzare l'occupabilità nel sistema R&S e la nascita di spin off di ricerca in Sicilia – P.O. FSE 2014/2020

Key publications:

P. Picone, G. Porcelli, C. Caruso Bavisotto, D. Nuzzo, G. Galizzi, P. L. San Biagio, D. Bulone, M. Di Carlo, Synaptosomes: new vesicles for neuronal mitochondrial transplantation, . J Nanobiotechnol. (2021)

L. A. Ditta, D. Bulone, P. L. San Biagio, R. Marino, D. Giacomazza, R. Lapasin, The degree of compactness of the incipient High Methoxyl Pectin networks. A rheological insight at the sol-gel transition. Intl. J. Biol. Macromol. 158 (2020) 985–993.

R. Santonocito et al., Recombinant mussel protein Pvfp-5beta: a potential tissue bioadhesive. J Biol Chem 294 (2019) 12826 – 12835.

D. Bulone, P.L. San Biagio, T. Quinones-Ruix, M.R. Alomar, I.K. Lednev, F.T. Robb, E. Conway de Macario, A.J. Macario, A multipronged method for assessing the effects of mutations on chaperone molecules causing human chaperonopathies, in: C.M. Gomes (Ed.) Protein Misfolding Diseases: Methods and Protocols, Springer (2019) pp. 69-92.

S. Vilasi, D. Bulone, C. Caruso Bavisotto, C. Campanella, A.M. Gammazza, P.L. San Biagio, F. Cappello, E. Conway de Macario, A.J. Macario, Chaperonin of Group I: Oligomeric spectrum and biochemical-biological implications, Frontiers in Molecular Biosciences, 4 (2018) 1 - 14.

Publications (127):

Synaptosomes: new vesicles for neuronal mitochondrial transplantation
Picone Pasquale; Porcelli Gaetana; Bavisotto Celeste Caruso; Nuzzo Domenico; Galizzi Giacoma; San Biagio Pier Luigi; Bulone Donatella; Di Carlo Marta;
Journal of nanobiotechnology, 2021
DOI: 10.1186/s12951-020-00748-6

Agarose/ -carrageenan-based hydrogel !lm enriched with natural plant extracts for the treatment of cutaneous wounds
Lorena Anna Ditta (a) , Estella Rao(a) , Fiorenza Provenzano (a) , Jesús Lozano Sánchez (b,c), Radha Santonocito (a), Rosa Passantino (a), Maria Assunta Costa (a), Maria Antonietta Sabatino (d), Clelia Dispenza (a, d), Daniela Giacomazza (a), Pier Luigi San Biagio (a), Romano Lapasin (e)
International journal of biological macromolecules, 2020
DOI: 10.1016/j.ijbiomac.2020.08.170

The degree of compactness of the incipient High Methoxyl Pectin networks. A rheological insight at the sol-gel transition
L.A. Ditta (a), D. Bulone (a), P.L. San Biagio (a), R. Marino, D (b). Giacomazza (a), R. Lapasin (c)
International journal of biological macromolecules, 2020
DOI: 10.1016/j.ijbiomac.2020.05.019

Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Dispenza Clelia; Todaro Simona; Sabatino Maria Antonietta; Martino Delia; Martorana Vincenzo; San Biagio Pier Luigi; Maffei Paola and Bulone Donatella
Cellulose (Lond.), 2020
DOI: 10.1007/s10570-020-03004-0

Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Dispenza, Clelia; Todaro, Simona; Sabatino, Maria Antonietta; Martino, Delia; Martorana, Vincenzo; San Biagio, Pier Luigi; Maffei, Paola; Bulone, Donatella
Cellulose (Lond.), 2020
DOI: 10.1007/s10570-020-03004-0

Amyloid jams: Mechanical and dynamical properties of an amyloid fibrillar network
Martorana V, Raccosta S, Giacomazza D, Ditta LA, Noto R, Biagio PLS, Manno M
Biophysical chemistry (Print), 2019
DOI: 10.1016/j.bpc.2019.106231

Recombinant mussel protein Pvfp-5beta: a potential tissue bioadhesive
Santonocito R, Venturella F, Dal Piaz F, Morando MA, Provenzano A, Rao E, Costa MA, Bulone D, San Biagio PL, Giacomazza D, Sicorello A, Alfano C, Passantino R, Pastore A
Journal of biological chemistry (Online), 2019
DOI: 10.1074/jbc.RA119.009531

Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics
Caruso Bavisotto C, Cipolla C, Graceffa G, Barone R, Bucchieri F, Bulone D, Cabibi D, Campanella C, Marino Gammazza A, Pitruzzella A, Porcasi R, San Biagio PL, Tomasello G, Conway de Macario E, Macario AJL, Cappello F, Rappa F
International journal of molecular sciences (Online), 2019
DOI: 10.3390/ijms20184496

Water extract of cryphaea heteromalla (Hedw.) d. mohr bryophyte as a natural powerful source of biologically active compounds
Provenzano F, Sánchez JL, Rao E, Santonocito R, Ditta LA, Borrás Linares I, Passantino R, Campisi P, Dia MG, Costa MA, Segura-Carretero A, San Biagio PL, Giacomazza D
International journal of molecular sciences (Print), 2019
DOI: 10.3390/ijms20225560

Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus indica and its potential biological activity
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K
Phytochemistry, 2018
DOI: 10.1016/j.phytochem.2018.06.015

The precious content of the olive mill wastewater: The protective effects of the antioxidant fraction in cell cultures
Giacomazza D, D'Andrea D, Provenzano A, Picone P, Provenzano F, Guarrasi V, Raimondo M, San Biagio PL, Passantino R, Mangione MR, Di Carlo M, Costa MA
CyTA: journal of food (Online), 2018
DOI: 10.1080/19476337.2018.1458752

Data concerning the rheological behavior of high methoxyl pectin during gelation process
Giacomazza D, Bulone D, San Biagio PL, Marino R, Lapasin R
Data in brief, 2018
DOI: 10.1016/j.dib.2018.04.064

Chaperonin of Group I: Oligomeric spectrum and biochemical and biological implications
Vilasi S, Bulone D, Caruso Bavisotto C, Campanella C, Marino Gammazza A, San Biagio PL, Cappello F, Conway de Macario E, Macario AJL
Frontiers in Molecular Biosciences, 2018
DOI: 10.3389/fmolb.2017.00099

The role of sucrose concentration in self-assembly kinetics of high methoxyl pectin
Giacomazza D, Bulone D, San Biagio PL, Marino R, Lapasin R
International journal of biological macromolecules, 2018
DOI: 10.1016/j.ijbiomac.2018.02.103

Nose-to-brain delivery of insulin enhanced by a nanogel carrier
Picone P, Sabatino MA, Ditta LA, Amato A, San Biagio PL, Mulè F, Giacomazza D, Dispenza C, Di Carlo M
Journal of controlled release, 2018
DOI: 10.1016/j.jconrel.2017.11.040

Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 2017
DOI: 10.1039/c7ra05300b

Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection
Presti G, Guarrasi V, Gulotta E, Provenzano F, Provenzano A, Giuliano S, Monfreda M, Mangione MR, Passantino R, San Biagio PL, Costa MA, Giacomazza D
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.09.002

Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.07.008

Pectin from Opuntia ficus indica: Optimization of microwave-assisted extraction and preliminary characterization
Lefsih K, Giacomazza D, Dahmoune F, Mangione MR, Bulone D, San Biagio PL, Passantino R, Costa MA, Guarrasi V, Madani K
Food chemistry, 2017
DOI: 10.1016/j.foodchem.2016.10.073

Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction
Dispenza C, Todaro S, Bulone D, Sabatino MA, Ghersi G, San Biagio PL, Lo Presti C
Materials science & engineering. C, Biomimetic materials, sensors and systems (Print), 2017
DOI: 10.1016/j.msec.2016.09.045

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog
Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT
Biochemistry and Biophysics Reports, 2017
DOI: 10.1016/j.bbrep.2017.07.011

Data concerning the proteolytic resistance and oxidative stress in LAN5 cells after treatment with BSA hydrogels.
Picone P, Navarra G, Peres C, Contardi M, San Biagio PL, Di Carlo M, Giacomazza D, Militello V
Data in brief, 2016
DOI: 10.1016/j.dib.2016.08.065

Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.010

Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019

The complex mechanism of HM pectin self-assembly: A rheological investigation
Giacomazza D.; Bulone D.; San Biagio P.L.; Lapasin R.
Carbohydrate polymers, 2016
DOI: 10.1016/j.carbpol.2016.03.046

Heat- and pH-induced BSA conformational changes, hydrogel formation and application as 3D cell scaffold
Navarra G, Peres C, Contardi M, Picone P, San Biagio PL, Di Carlo M, Giacomazza D, Militello V
Archives of biochemistry and biophysics (Print), 2016
DOI: 10.1016/j.abb.2016.07.020

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging (Albany, N.Y. Online), 2016
DOI: 10.18632/aging.101004

Ionizing Radiation-Engineered Nanogels as Insulin Nanocarriers for the Development of a New Strategy for the Treatment of Alzheimer's Disease
Pasquale Picone, Lorena Anna Ditta, Maria Antonietta Sabatino, Valeria Militello, Pier Luigi San Biagio, Maria Laura Di Giacinto, Laura Cristaldi, Domenico Nuzzo, Clelia Dispenza, Daniela Giacomazza, Marta Di Carlo
Biomaterials, 2016
DOI: 10.1016/j.biomaterials.2015.11.057

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, C. and Ortore, M.G. and Vilasi, S. and Carrotta, R. and Mangione, M.R. and Bulone, D. and Librizzi, F. and Spinozzi, F. and Burgio, G. and Amenitsch, H. and San Biagio, P.L.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Temperature-induced self-assembly of degalactosylated xyloglucan at low concentration
Todaro S.; Dispenza C.; Sabatino M.A.; Ortore M.G.; Passantino R.; San Biagio P.L.; Bulone D.
Journal of polymer science. Part B, Polymer physics (Online), 2015
DOI: 10.1002/polb.23895

insertion in liposomes containing GM1-cholesterol domains
Nicastro, M. C. Spigolon, D. Librizzi, F. Moran, Oscar Ortore, M. G. Bulone, D. San Biagio, P. L. Carrotta, R.
Biophysical chemistry (Print), 2015
DOI: 10.1016/j.bpc.2015.07.010

Temperature-induced self-assembly of degaloctosylated xyloglucan at low concentration
Todaro, S. Dispenza, C. Sabatino, M. A. Ortore, M. G. Passantino, R. San Biagio, P. L. Bulone, D.
Journal of polymer science. Part B, Polymer physics (Online), 2015

Photo-inhibition of Ab fibrillation mediated by a newly designed fluorinated oxadiazole
M.R. Mangione1, A. Palumbo Piccionello1,2,3, C. Marino1,4, M.G. Ortore5, P. Picone6, S. Vilasi1, M. Di Carlo6, S. Buscemi1,2, D. Bulone1 and P.L. San Biagio1
RSC advances, 2015
DOI: 10.1039/c4ra13556c

Characterization of fruits of four different lemon cultivars, Collected in the northern coast of sicily
Cupane M.; Guarrasi V.; Palazzolo E.; San Biagio P.L.; Germana M.A.
Acta horticulturae, 2015
DOI: 10.17660/ActaHortic.2015.1065.215

Custom system for single molecule force spectroscopy
1 E. Landini, 2 S. Raccosta, 2 F. D'Anca, 3 M. Zora, 3 S. Mazzola, 2 P.L. Sanbiagio, 2 V. Martorana, 1 M. Vassalli
Microscopie, 2014

Monitoring the shelf-life of minimally processed fresh-cut apple slices by physical-chemical analysis and electronic nose
V. Guarrasi (1), D. Giacomazza (1), M.A. Germanà (2), M. Amenta (3), P.L. San Biagio PL(1)
Agrotechnology, 2014

Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.
Marino Gammazza, Antonella; Rizzo, Manfredi; Citarrella, Roberto; Rappa, Francesca; Campanella, Claudia; Bucchieri, Fabio; Patti, Angelo; Nikolic, Dragana; Cabibi, Daniela; Amico, Giandomenico; Conaldi, Pier Giulio; San Biagio, Pier Luigi; Montalto, Giuseppe; Farina, Felicia; Zummo, Giovanni; Conway de Macario, Everly; Macario, Alberto J L; Cappello, Francesco
Cell stress & chaperones (Online), 2014
DOI: 10.1007/s12192-013-0460-9

Seasonal variations of antimicrobial activity and chemical composition of essential oils extracted from three Citrus limon L. Burm. cultivars
Settanni, L. and Randazzo, W. and Palazzolo, E. and Moschetti, M. and Aleo, A. and Guarrasi, V. and Mammina, C. and San Biagio, P. L. and Marra, F. P. and Moschetti, G. and Germanà, M. A.
Natural product research (Print), 2014

Maltose-conjugated chitosans induce macroscopic gelation of pectin solutions at neutral pH
Giacomazza, D.; Sabatino, M. A.; Catena, A.; Leone, M.; San Biagio, P. L.; Dispenza, C.
Carbohydrate polymers, 2014
DOI: 10.1016/j.carbpol.2014.08.014

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657

alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes
Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi
The journal of physical chemistry letters, 2014
DOI: 10.1021/jz501570m

Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes
Canale, Claudio; Seghezza, Silvia; Vilasi, Silvia; Carrotta, Rita; Bulone, Donatella; Diaspro, Alberto; Biagio, Pier Luigi San; Dante, Silvia
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2013.07.010

Inhibiting effect of alpha(s1)-casein on A beta(1-40) fibrillogenesis
Carrotta R; Canale C; Diaspro A; Trapani A; San Biagio PL; Bulone D
Biochimica et biophysica acta. G, General subjects (Print), 2012
DOI: 10.1016/j.bbagen.2011.11.010

alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp307417x

Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter (Print), 2012
DOI: 10.1088/0953-8984/24/24/244103

Alzheimer's disease: biological aspects, therapeutic perspectives and diagnostic tools
M Di Carlo, D Giacomazza, P L San Biagio
Journal of physics. Condensed matter (Online), 2012
DOI: 10.1088/0953-8984/24/24/244102

Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases?
Di Carlo M, Giacomazza D, Picone P, Nuzzo D, San Biagio PL.
Free radical research (Online), 2012
DOI: 10.3109/10715762.2012.714466

A close connection: Alzheimer's disease and type 2 diabetes.
Di Carlo M.; Gacomazza G.; Picone P.; Nuzzo D.; Vasto S.; Accardi G.; Caruso C.; San Biagio PL
Current Topics in Biochemical Research, 2012

Rheological characterization and release properties of inulin-based hydrogels
Pitarresi G; Giacomazza D; Triolo D; Giammona G; San Biagio PL
Carbohydrate polymers, 2012
DOI: 10.1016/j.carbpol.2012.01.059

Multivariate data analysis of thermally treated Sicilian extravirgin olive oils. Coupling of electronic nose, gas chromatography-mass spectroscopy and rheology techniques
M. Amenta, M.E. Monge, L. Lizzarraga, D. Giacomazza, V. Guarrasi, P.L. San Biagio, D. Bulone
The Open food science journal, 2012
DOI: 10.2174/1874256401206010024

Insulin activated Akt rescues Ab oxidative stress induced cell death by orchestrating molecules trafficking
Picone P.; Giacomazza D.; Vetri V.; Carrotta R.; Militello V.; San Biagio P.L.; Di Carlo M.
Aging cell (Online), 2011
DOI: 10.1111/j.1474-9726.2011.00724.x

Amyloid gels: precocious appearance of elastic properties during the formation of an insulin fibrillar network
Manno M.(1); D. Giacomazza (1); J. Newman; V. Martorana (1) and P.L. San Biagio (1)
Langmuir, 2010
DOI: 10.1021/la903340v

Irreversible gelation of thermally unfolded lysozyme: structural and mechanical properties of lysozyme aggregates
Raccosta S.; Manno M. (1); Bulone D. (1); Giacomazza D. (1); Militello V.; Martorana V. (1); San Biagio P. L. (1)
European biophysics journal, 2010
DOI: 10.1007/s00249-009-0503-4

Naso elettronico con sensori MOS per discriminare 3 cultivar di Eriobotrya japonica Lindl
Guarrasi V., Farina V., San Biagio P.L., Germanà M.A.

Naso Elettonico con sensori MOS per discriminare 3 cultivar di Eriobotrya japonica Lindl
Guarrasi, Valeria and Farina, v. and San Biagio, P. L. and Germanà, M. A.
Acta Italus hortus, 2010

Insulin promotes survival of amyloid-beta oligomers neuroblastoma damaged cells via caspase 9 inhibition and Hsp70 upregulation
Di Carlo, M., P. Picone, R. Carrotta, D. Giacomazza, P. L. San Biagio.
Journal of Biomedicine and Biotechnology (Online), 2010
DOI: 10.1155/2010/147835

A beta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures.
Picone P; Carrotta R; Montana G; Nobile MR; San Biagio PL; Di Carlo M.
Biophysical journal (Print), 2009
DOI: 10.1016/j.bpj.2008.11.056

Thermal aggregation and ion-induced cold-gelation of Bovine Serum Albumin
Navarra G; Giacomazza D (1); Leone M; Librizzi F; Militello V; San Biagio PL. (1)
European biophysics journal, 2009
DOI: 10.1007/s00249-008-0389-6

Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin.
Carrotta R; Manno M; Giordano FM; Longo A; Portale G; Martorana V; San Biagio PL.
PCCP. Physical chemistry chemical physics (Print), 2009
DOI: 10.1039/b818687a

Kinetics of different processes in human insulin amyloid formation.
Manno M.; Craparo E.F.; Podestà A.; Bulone D.; Carrotta R.; Martorana V.; Milani P.; Tiana G.; San Biagio P.L.
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2006.11.008

A statistical light scattering approach to separating fast and slow dynamics.
Barthès J.; D. Bulone(1); M. Manno(1); V. Martorana (1); P. L. San Biagio. (1)
European biophysics journal, 2007
DOI: 10.1007/s00249-007-0163-1

Large size fibrillar bundles of the alzheimer amyloid beta-protein.
Carrotta R.; J. Barthès; A. Longo; V. Martorana; M. Manno; G. Portale; P. L. San Biagio.
European biophysics journal, 2007
DOI: 10.1007/s00249-007-0164-0

Relation between structural and release properties in a polysaccharide gel system.
Mangione M. R.(1); D. Giacomazza (1); G. Cavallaro; D. Bulone (1); V. Martorana (1); P. L. San Biagio (1).
Biophysical chemistry (Print), 2007
DOI: 10.1016/j.bpc.2007.04.013

Employment of Cationic Solid-Lipid nanoparticles as RNA carriers
Montana G.; Bondì M.L.; Carrotta R.; Picone P.; Craparo E.F.; San Biagio P.L.; Giammona G.; Di Carlo M.
Bioconjugate chemistry, 2007
DOI: 10.1021/bc0601166

Toxicity of recombinant beta-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus.
Carrotta R.; Di Carlo M.; Manno M.; Montana G.; Picone P.; Romancino D.; San Biagio P.L.
The FASEB journal, 2006
DOI: 10.1096/fj.06-5716fje

Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation.
Manno M.; Craparo E.F.; Martorana V.; Bulone D.; San Biagio P.L.
Biophysical journal (Print), 2006
DOI: 10.1529/biophysj.105.077636

Toxicity of recombinant beta-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus.
Carrotta R.; Di Carlo M.; Manno M.; Montana G.; Picone P.; Romancino D.; San Biagio P.L.
The FASEB journal, 2006

The interplay between polyQ and protein context delays aggregation by forming a reservoir of protofibrils
Bulone Donatella (2); Masino Laura (1); Thomas David J. (3); San Biagio Pier Luigi (2); Pastore Annalisa (1);
PloS one, 2006
DOI: 10.1371/journal.pone.0000111

Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.
Carrotta R.; Manno M.; Bulone D.; Martorana V.; San Biagio P.L.;
The Journal of biological chemistry (Print), 2005
DOI: 10.1074/jbc.M500052200

K+ and Na+ effects on the gelation properties of k-Carrageenan.
Mangione M.R. (1); Giacomazza D. (1); Bulone D. (1); Martorana V. (1); Cavallaro G.; San Biagio P.L. (1)
Biophysical chemistry (Print), 2005
DOI: 10.1016/j.bpc.2004.08.005

Role of charges and solvent on the conformational properties of poly(galacturonic acid) chains: a Molecular Dynamics study.
Noto R.; Martorana V.; Bulone D.; San Biagio P. L.
Biomacromolecules, 2005
DOI: 10.1021/bm050280g

The role of pH on instability and aggregation of sickle cell hemoglobin solutions.
Manno M.; San Biagio P.L.; Palma M.U.
Proteins (Print), 2004
DOI: 10.1002/prot.10648

Ordering of agarose near the macroscopic gelation point.
Bulone D.; Giacomazza D.; Martorana V.; Newman J.; San Biagio P.L.
Physical review. E, Statistical, nonlinear, and soft matter physics (Print), 2004
DOI: 10.1103/PhysRevE.69.041401

Thermodynamic instability and off-critical slowing down in supersaturated lysozyme solutions
Manno M. (1); Bulone D. (1); Martorana V. (1); San Biagio P. L. (1)
Journal of physics. Condensed matter (Print), 2004
DOI: 10.1088/0953-8984/16/42/017

Ergodic to non-ergodic transition monitored by scattered light intensity statistics
Manno M. (1); Bulone D. (1); Martorana V. (1); San Biagio P. L. (1)
Physica. A (Print), 2004
DOI: 10.1016/j.physa.2004.04.107

Deposito della beta-amiloide sulla membrana cellulare: ruolo degli ioni metallici e dei radicali liberi
Gianfranco Menestrina, Mauro Dalla Serra, Massimiliano Comai, Rossella Tomazzoli, Cristina Potrich, Pier Luigi San Biagio, Mauro Manno, Donatella Bulone, Antonella Graiff, Floriana Giraudo, Lorenzo Gasperi
Punto Omega, 2004

Thermodynamic instability in supersaturated lysozyme solutions: effect of salt and role of concentration fluctuations.
Manno M. 1, Xiao C. 2, Bulone D. 1, Martorana V. 1, San_Biagio P.L. 1
Physical review. E, Statistical, nonlinear and soft matter physics (Online), 2003
DOI: 10.1103/PhysRevE.68.011904

Thermoreversible gelation of k-Carrageenan: relation between conformational transition and aggregation.
Mangione M.R. 1,2, Giacomazza D. 1, Bulone D. 1, Martorana V. 1, San Biagio P.L. 1
Biophysical chemistry (Print), 2003
DOI: 10.1016/S0301-4622(02)00341-1

Role of sucrose in pectin gelation: Static and dynamic light scattering experiments
Bulone D. 1, Martorana V. 1, Xiao C. 2, San Biagio P.L. 1
Macromolecules (Print), 2002
DOI: 10.1021/ma0205109

Salt effects on gelation of agarose aqueous solutions
Newman J., Martorana V., Bulone D., San Biagio P. L.
Biophysical journal (Print), 2002

Effects of intermediates on aggregation of native bovine serum albumin.
Bulone D., Martorana V., San Biagio PL.
Biophysical chemistry (Print), 2001
DOI: 10.1016/S0301-4622(01)00155-7

Nel mondo dei biopolimeri
Bulone, D., M. Dalla Serra, R. Felicioli, M. Gonnelli, G. Menestrina, and P. L. San Biagio
Sapere (Bari), 2001

Cinque per uno
Forti, G., F. Gambale, F. Lenci, G. Manestrina, and P. L. San Biagio
Sapere (Bari), 2001

Interaction of processes on different length scales in a bioelastomer capable of performing energy conversion.
Manno, M., A. Emanuele, V. Martorana, P. L. San Biagio, D. Bulone, M. B. Palma-Vittorelli, D. T. McPherson, J. Xu, T. M. Parker, and D. W. Urry
Biopolymers (Print), 2001

Novel hydrogels based on a polyasparthydrazide. Synthesis and characterization
Pitarresi, G., G. Cavallaro, B. Carlisi, G. Giammona, D. Bulone, and P. L. San Biagio
Macromolecular chemistry and physics (Print), 2000

Potential of mean force between two ions in a sucrose rich aqueous solution
Martorana, V., L. La Fata, D. Bulone, and P. L. San Biagio
Chemical physics letters (Print), 2000

Effects of electric charges on hydrophobic forces II
Bulone D., Martorana V., San Biagio P.L., Palma-Vittorelli M.B.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2000

Multiple interactions between molecular and supramolecular ordering
Manno M., Emanuele A., Martorana V., Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1999

Below the threshold of macroscopic gelation
Bulone D., Martorana V., San Biagio P.L.
Trends in Chemical Physics, 1999

Effects of solvent perturbation on gelation driven by spinodal demixing
Bulone D., Emanuele A., San Biagio P.L.
Biophysical chemistry (Print), 1999

Solvent-induced free energy landscape and solute-solvent dynamic coupling in a multielement solute
San Biagio P.L., Martorana V., Bulone D., Palma-Vittorelli M.B., Palma M.U.
Biophysical journal (Print), 1999

Interacting processes in protein coagulation
San Biagio P.L., Martorana V., Emanuele A., Vaiana S.M., Manno M., Bulone D., Palma-Vittorelli M.B., Palma M.U.
Proteins (Print), 1999

Actin filaments are structurally weakened by binding of the N-terminal (S1-3) portion of gelsolin
Lincoln B., San Biagio P.L., Bulone D., Newman J., Selden L.A., Hurwitz C., Kinosian H.J., Estes J.E., Gershman L.C.
Biophysical journal (Print), 1998

Physics and biophysics of solvent induced forces: hydrophobic interactions and context-dependent hydration
San Biagio P.L., Bulone D., Martorana V., Palma-Vittorelli M.B., Palma M.U.
European Biophysical Journal, 1998

Preparation, characterization and in vitro antimicrobial activity of ampicillin-loaded polyethylcyanoacrylate nanoparticles
Fontana G., Pitarresi G., Tomarchio V., Carlisi B., San Biagio P.L.
Biomaterials, 1998

Collective properties of hydration: long range and specificity of hydrophobic interactions
Martorana V., Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Biophysical journal (Print), 1997

Mesoscopic gels at low agarose concentration: perturbation effects on ethanol
Bulone D., Newman J., San Biagio P.L.
Biophysical journal (Print), 1997

Effects of electric charges on hydrophobic forces
Bulone D., Martorana V., San Biagio P.L., Palma-Vittorelli M.B.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1997

Self-assembly of biopolymeric structures below the threshold of random cross-link percolation
San Biagio P.L., Bulone D., Emanuele A., Palma M.U.
Biophysical journal (Print), 1996

Spontaneous symmetry-breaking pathways: Time-resolved study of agarose gelation
San Biagio P.L., Bulone D., Emanuele A., Palma-Vittorelli M.B., Palma M.U.
Food hydrocolloids, 1996

Mesoscopic gel at low agarose concentration in water: a dynamic light scattering study
Bulone D., San Biagio P.L.
Biophysical journal (Print), 1995

Transputer-based upgrading of a differential scanning calorimeter
Bulone D., Fornili L.G., Fornili S.L., Lapis M., San Biagio P.L.
Measurement science & technology (Print), 1994

The role of water in hemoglobin function and stability
Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Science (New York, N.Y.), 1993

The role of solvent-induced forces in bimolecular function and stability
Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Nuovo cimento della Società italiana di fisica. D Condensed matter, atomic, molecular and chemical physics, biophysics (Testo stamp.), 1993

Water-mediated interactions of biosolutes - Aspects of dynamics, structure and configuration lifetime of the solvent
Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Journal of molecular liquids (Print), 1993

Solvent-induced forces, and fluctuations: a novel comparison of human hemoglobins S and A.
San Biagio P.L., Palma M.U.
Comments on theoretical biology, 1992

Time-resolved study of network self-organization from a biopolymeric solution
A. Emanuele, L. Di Stefano, D. Giacomazza, M. Trapanese, M.B. Palma-Vittorelli and M.U. Palma
Biopolymers (Print), 1991
DOI: 10.1002/bip.360310706

Spinodal lines and Flory-Huggins free-energies for solutions of human hemoglobins HbS and HbA
San Biagio P.L., Palma M.U.
Biophysical journal (Print), 1991

Dynamic Light Scattering from spatially injhomogeneous cross-linked actin gels
San Biagio P.L., Newman J., Schick K.L.
Macromolecules (Print), 1991

Microgel regions in dilute agarose solutions: the notion of non-gelling concentration and the role of spinodal demixing
Bulone D., San Biagio P.L.
Chemical physics letters (Print), 1991

Spinodal demixing, percolation and gelation of biostructural polymers
San Biagio P.L., Bulone D., Emanuele A., Madonia F., Di Stefano M., Giacomazza D., Trapanese M., Palma-Vittorelli M.B., Palma M.U.
Makromolekulare Chemie. Theory and simulations, 1990

Current perspectives on the kinetics of hemoglobin S gelation
San Biagio P.L., Hofrichter J., Mozzarelli A., Henry E.R., Eaton W.A.
Annals of the New York Academy of Sciences, 1989

Co-solute control of the selfassembly of a biopolymeric supramolecular structure
San Biagio P.L., Newman J., Madonia F., Palma M.U.
Chemical physics letters (Print), 1989

New photon correlator design based on transputer array concurrency
Brugé F., San Biagio P.L., Fornili S.L.
Review of scientific instruments, 1989

Transputer-based upgrading of a laser photon correlator
Brugè F., San Biagio P.L., Fornili S.L.
Review of scientific instruments, 1989

Overlap of elastomeric polypeptide coils in solution required for single phase elastogenesis
San Biagio P.L., Madonia F., Trapane T.L., Urry D.W., Palma M.U.
Chemical physics letters (Print), 1988

A sol-sol structural transition of aqueous agarose systems
San Biagio P.L., Madonia F., Newman J., Palma M.U.
Biopolymers (Print), 1986

A sol-sol transition as the first step in the gelation of agarose sold
San Biagio P.L., Madonia F., Newman J., Palma M.U.
Journal of biomolecular structure & dynamics, 1986

Cooperative interaction of polysaccharide molecules in water: a role of connectivity properties of Hbonds within the solvent
San Biagio P.L., Madonia F., Sciortino F., Palma-Vittoreli M.B., Palma M.U.
Journal de physique, 1984

Biomolecular-solvent stereodynamic coupling probed by deuteration
Fornili S.L., Leone M., Madonia F., Migliore M., Palma-Vittorelli M.B., Palma M.U., San Biagio P.L.
Journal of biomolecular structure & dynamics, 1983

Photon scattering as a probe of microviscosity and channel size in gels such as sickle haemoglobin
Madonia F., San Biagio P.L., Palma M.U., Schiliro G., Musumeci S., Russo G.
Nature (Lond.), 1983

Temperature dependence of the effects of some monohydric alcohols on the oxygen affinity of hemoglobin: determination and analysis of thermodynamic parameters
Cordone L., Cupane A., San Biagio P.L., Vitrano E.
Biopolymers (Print), 1981

Effect of some organic cosolvents on the reaction of hemoglobin with oxygen
Cordone L., Cupane A., San Biagio P.L., Vitrano E.
Biopolymers (Print), 1981

Thermal stability of Poly(A) and Poly(U) complexes in H2O and D2O: isotopic effects on critical temperatures and transitions width
Cupane A., Vitrano E., San Biagio P.L., Madonia F., Palma M.U.
Progress in nucleic acid research, 1980

Effect of some monohydric alcohols on the oxygen affinity on hemoglobin: relevance of solvent dielectric constant and hydrophobicity
Cordone L., Cupane A., San Biagio P.L., Vitrano E.
Biopolymers (Print), 1979

Temperature induced difference spectra of oxy and deoxy hemoglobin in the near IR, visible and Soret regions
San Biagio P.L., Vitrano E., Cupane A., Madonia F., Palma M.U.
Biochemical and biophysical research communications (Print), 1977