Winterstein L.-M.; Kukovetz K.; Hansen U.-P.; Schroeder I.; van Etten J.L.; Moroni A.; Thiel G.; Rauh O.
the journal of general physiologyissn: 0022-1295rockefeller institute for medical research,, 153, 2021
DOI: 10.1085/JGP.202012731
Gating movements and ion permeation in HCN4 pacemaker channels
Saponaro A.; Bauer D.; Giese M.H.; Swuec P.; Porro A.; Gasparri F.; Sharifzadeh A.S.; Chaves-Sanjuan A.; Alberio L.; Parisi G.; Cerutti G.; Clarke O.B.; Hamacher K.; Colecraft H.M.; Mancia F.; Hendrickson W.A.; Siegelbaum S.A.; DiFrancesco D.; Bolognesi M.; Thiel G.; Santoro B.; Moroni A.
molecular cell (online), 81, 2021
DOI: 10.1016/j.molcel.2021.05.033
The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency
Jenewein, Tina; Kanner, Scott A.; Bauer, Daniel; Hertel, Brigitte; Colecraft, Henry M.; Moroni, Anna; Thiel, Gerhard; Kauferstein, Silke
Channels, 14, 2020
DOI: 10.1080/19336950.2020.1751522
A small viral potassium ion channel with an inherent inward rectification
Eckert, D. and Schulze, T. and Stahl, J. and Rauh, O. and Van Etten, J.L. and Hertel, B. and Schroeder, I. and Moroni, A. and Thiel, G.
channels (austin tex.), 13, 2019
DOI: 10.1080/19336950.2019.1605813
The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
Porro, A. and Saponaro, A. and Gasparri, F. and Bauer, D. and Gross, C. and Pisoni, M. and Abbandonato, G. and Hamacher, K. and Santoro, B. and Thiel, G. and Moroni, A.
elife, 8, 2019
DOI: 10.7554/eLife.49672
A light-gated potassium channel for sustained neuronal inhibition
Alberio, L. and Locarno, A. and Saponaro, A. and Romano, E. and Bercier, V. and Albadri, S. and Simeoni, F. and Moleri, S. and Pelucchi, S. and Porro, A. and Marcello, E. and Barsotti, N. and Kukovetz, K. and Boender, A.J. and Contestabile, A. and Luo, S. and Moutal, A. and Ji, Y. and Romani, G. and Beltrame, M. and Del Bene, F. and Di Luca, M. and Khanna, R. and Colecraft, H.M. and Pasqualetti, M. and Thiel, G. and Tonini, R. and Moroni, A.
nature methods, 15, 2018
DOI: 10.1038/s41592-018-0186-9
A synthetic peptide that prevents camp regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
Saponaro, A. and Cantini, F. and Porro, A. and Bucchi, A. and Difrancesco, D. and Maione, V. and Donadoni, C. and Introini, B. and Mesirca, P. and Mangoni, M.E. and Thiel, G. and Banci, L. and Santoro, B. and Moroni, A.
elife, 7, 2018
DOI: 10.7554/eLife.35753
Biofilm formation - what we can learn from recent developments
Bjarnsholt, T., Buhlin, K., Dufrêne, Y.F., Gomelsky, M., Moroni, A., Ramstedt, M., Rumbaugh, K.P., Schulte, T., Sun, L., Åkerlund, B., Römling, U.
journal of internal medicine (print), 284, 2018
DOI: 10.1111/joim.12782
Directional K+channel insertion in a single phospholipid bilayer: Neutron reflectometry and electrophysiology in the joint exploration of a model membrane functional platform
Rondelli V, Del Favero E, Brocca P, Fragneto G, Trapp M, Mauri L, Ciampa MG, Romani G, Braun CJ5, Winterstein L, Schroeder I, Thiel G, Moroni A, Cantu' L
Biochimica et biophysica acta. G, General subjects, 1862, 2018
DOI: 10.1016/j.bbagen.2018.05.007
Ionizing radiation induces morphological changes and immunological modulation of Jurkat cells
Voos, P.a, Fuck, S.a, Weipert, F.b, Babel, L.a, Tandl, D.a, Meckel, T.a, Hehlgans, S.b, Fournier, C.c, Moroni, A.d, Rödel, F.b, Thiel, G
frontiers in immunology, 9, 2018
DOI: 10.3389/fimmu.2018.00922
Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel
Gross, C. and Saponaro, A. and Santoro, B. and Moroni, A. and Thiel, G. and Hamacher, K.
the journal of biological chemistry (print), 293, 2018
DOI: 10.1074/jbc.RA118.002139
Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers
Winterstein, L.-M. and Kukovetz, K. and Rauh, O. and Turman, D.L. and Braun, C. and Moroni, A. and Schroeder, I. and Thiel, G.
the journal of general physiology, 150, 2018
DOI: 10.1085/jgp.201711904
Conversion of an instantaneous activating K+ channel into a slow activating inward rectifier
Baumeister D, Hertel B, Schroeder I, Gazzarrini S, Kast SM, Van Etten JL, Moroni A, Thiel G
FEBS letters, 591, 2017
DOI: 10.1002/1873-3468.12536
Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins
Saponaro A, Porro A, Chaves-Sanjuan A, Nardini M, Rauh O, Thiel G, Moroni A
The Plant cell, 29, 2017
DOI: 10.1105/tpc.17.00375
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
Tonelli M, Naesens L, Gazzarrini S, Santucci M, Cichero E, Tasso B, Moroni A, Costi MP, Loddo R
European journal of medicinal chemistry, 135, 2017
DOI: 10.1016/j.ejmech.2017.04.070
Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K+ Channels
Rauh O, Urban M, Henkes LM, Winterstein T, Greiner T, Van Etten JL, Moroni A, Kast SM, Thiel G, Schroeder I
Journal of the American Chemical Society, 139, 2017
DOI: 10.1021/jacs.7b01158
Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus
Barniol-Xicota M, Gazzarrini S, Torres E, Hu Y, Wang J, Naesens L, Moroni A, Vázquez S
Journal of medicinal chemistry, 60, 2017
DOI: 10.1021/acs.jmedchem.6b01758
The small neurotoxin apamin blocks not only small conductance Ca2+ activated K+ channels (SK type) but also the voltage dependent Kv1.3 channel
Voos P, Yazar M, Lautenschläger R, Rauh O, Moroni A, Thiel G
European biophysics journal, 46, 2017
DOI: 10.1007/s00249-016-1196-0
Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function
Biel S.; Aquila M.; Hertel B.; Berthold A.; Neumann T.; DiFrancesco D.; Moroni A.; Thiel G.; Kauferstein S.
Pflügers Archiv, 468, 2016
DOI: 10.1007/s00424-016-1870-1
Engineering a Ca++-Sensitive (Bio) Sensor from the Pore-Module of a Potassium Channel
DiFrancesco, Mattia Lorenzo; Gazzarrini, Sabrina; Arrigoni, Cristina; Romani, Giulia; Thiel, Gerhard; Moroni, Anna
Sensors , 15, 2015
DOI: 10.3390/s150304913
Large dsDNA chloroviruses encode diverse membrane transport proteins
Thiel G.; Greiner T.; Dunigan D.D.; Moroni A.; Van Etten J.L.
Virology , 479-480, 2015
DOI: 10.1016/j.virol.2015.02.025
Low-dose photon irradiation alters cell differentiation via activation of hIK channels
Roth B.; Gibhardt C.S.; Becker P.; Gebhardt M.; Knoop J.; Fournier C.; Moroni A.; Thiel G.
Pflügers Archiv , 467, 2015
DOI: 10.1007/s00424-014-1601-4
New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode
Rey-Carrizo M.; Gazzarrini S.; Llabres S.; Frigole-Vivas M.; Juarez-Jimenez J.; Font-Bardia M.; Naesens L.; Moroni A.; Luque F.J.; Vazquez S.
European journal of medicinal chemistry , 96, 2015
DOI: 10.1016/j.ejmech.2015.04.030
Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
Leiva R.; Gazzarrini S.; Esplugas R.; Moroni A.; Naesens L.; Sureda F.X.; Vazquez S.
Tetrahedron letters, 56, 2015
DOI: 10.1016/j.tetlet.2015.01.160
The sorting of a small potassium channel in mammalian cells can be shifted between mitochondria and plasma membrane
von Charpuis C.; Meckel T.; Moroni A.; Thiel G.
Cell calcium , 58, 2015
DOI: 10.1016/j.ceca.2014.09.009
X-ray irradiation activates K+ channels via H2O2 signaling
Gibhardt, Christine S.; Roth, Bastian; Schroeder, Indra; Fuck, Sebastian; Becker, Patrick; Jakob, Burkhard; Fournier, Claudia; Moroni, Anna; Thiel, Gerhard
Scientific reports , 5, 2015
DOI: 10.1038/srep13861
Azapropellanes with Anti-Influenza A Virus Activity
Torres, Eva; Leiva, Rosana; Gazzarrini, Sabrina; Rey-Carrizo, Matias; Frigole-Vivas, Marta; Moroni, Anna; Naesens, Lieve; Vazquez, Santiago
ACS medicinal chemistry letters, 5, 2014
DOI: 10.1021/ml500108s
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness
Lolicato, Marco; Bucchi, Annalisa; Arrigoni, Cristina; Zucca, Stefano; Nardini, Marco; Schroeder, Indra; Simmons, Katie; Aquila, Marco; DiFrancesco, Dario; Bolognesi, Martino; Schwede, Frank; Kashin, Dmitry; Fishwick, Colin W. G.; Johnson, A. Peter; Thiel
Nature chemical biology, 10, 2014
DOI: 10.1038/NCHEMBIO.1521
Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels
Moeller, Stefan; Alfieri, Andrea; Bertinetti, Daniela; Aquila, Marco; Schwede, Frank; Lolicato, Marco; Rehmann, Holger; Moroni, Anna; Herberg, Friedrich W.
ACS chemical biology, 9, 2014
DOI: 10.1021/cb400904s
Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes
DiFrancesco, Mattia L.; Hansen, Ulf-Peter; Thiel, Gerhard; Moroni, Anna; Schroeder, Indra
PloS one, 9, 2014
DOI: 10.1371/journal.pone.0107406
Pseudo painting/air bubble technique for planar lipid bilayers
Braun, Christian J.; Baer, Tom; Moroni, Anna; Thiel, Gerhard
Journal of neuroscience methods, 233, 2014
DOI: 10.1016/j.jneumeth.2014.05.031
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function
Saponaro, Andrea; Pauleta, Sofia R.; Cantini, Francesca; Matzapetakis, Manolis; Hammann, Christian; Donadoni, Chiara; Hu, Lei; Thiel, Gerhard; Banci, Lucia; Santoro, Bina; Moroni, Anna
Proceedings of the National Academy of Sciences of the United States of America, 111, 2014
DOI: 10.1073/pnas.1410389111
Viral potassium channels as a robust model system for studies of membrane-protein interaction
Braun, Christian J.; Lachnit, Christine; Becker, Patrick; Henkes, Leonhard M.; Arrigoni, Cristina; Kast, Stefan M.; Moroni, Anna; Thiel, Gerhard; Schroeder, Indra
Biochimica et biophysica acta. Biomembranes, 1838, 2014
DOI: 10.1016/j.bbamem.2013.06.010
A virus-encoded potassium ion channel is a structural protein in the chlorovirus Paramecium bursaria chlorella virus 1 virion
Romani G, Piotrowski A, Hillmer S, Gurnon J, Van Etten JL, Moroni A, Thiel G, Hertel B
Journal of general virology, 94, 2013
DOI: 10.1099/vir.0.055251-0
Creation of a Reactive Oxygen Species-Insensitive Kcv Channel
Schroeder I, Gazzarrini S, Ferrara G, Thiel G, Hansen UP, Moroni A
Biochemistry, 52, 2013
DOI: 10.1021/bi3016197
The voltage-sensing domain of a phosphatase gates the pore of a potassium channel
Cristina Arrigoni, Indra Schroeder, Giulia Romani, James L. Van Etten, Gerhard Thiel, and Anna Moroni
Journal of general physiology (online), 141, 2013
DOI: 10.1085/jgp.201210940
Relevance of Lysine Snorkeling in the Outer Transmembrane Domain of Small Viral Potassium Ion Channels
Gebhardt M; Henkes LM; Tayefeh S; Hertel B; Greiner T; Van Etten JL; Baumeister D; Cosentino C; Moroni A; Kast SM; Thiel G
Biochemistry , 51, 2012
Structural Organization of DNA in Chlorella Viruses
Wulfmeyer T; Polzer C; Hiepler G; Hamacher K; Shoeman R; Dunigan DD; Van Etten JL; Lolicato M; Moroni A; Thiel G; Meckel T
PloS one, 7, 2012
Functional HAK/KUP/KT-like potassium transporter encoded by chlorella viruses
Greiner T, Ramos J, Alvarez MC, Gurnon JR, Kang M, Van Etten JL, Moroni A, Thiel G
Plant journal, 68, 2011
Membrane anchoring and interaction between transmembrane domains are crucial for K+ channel function
Gebhardt M, Hoffgaard F, Hamacher K, Kast SM, Moroni A, Thiel G
Journal of biological chemistry, 286, 2011
Minimal art: Or why small viral K(+) channels are good tools for understanding basic structure and function relations
Thiel G, Baumeister D, Schroeder I, Kast SM, Van Etten JL, Moroni A
Biochimica et biophysica acta. Biomembranes, 1808, 2011
TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites
Santoro B, Hu L, Liu H, Saponaro A, Pian P, Piskorowski RA, Moroni A, Siegelbaum SA
Journal of neuroscience, 31, 2011
A functional calcium transporting ATPase encoded by Chlorella viruses.
Bonza MC, Martin H, Kang M, Lewis G, Greiner T, Giacometti S, Van Etten JL, De Michelis MI, Thiel G, Moroni A
Journal of general virology, 91, 2010
The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel.
Henkel M, Mitzner D, Henklein P, Meyer-Almes FJ, Moroni A, DiFrancesco ML, Henkes LM, Kreim M, Kast SM, Schubert U, Thiel G
Plos one, 5, 2010
Chlorella virus ATCV1 encodes a functional potassium channel of eighty-two amino acids.
Gazzarrini S, Kang M, Abenavoli A, Romani G, Olivari C, Gaslini D, Ferrara G, Van Etten JL, Kreim M, Kast SM, Thiel G, Moroni A
Biochemical journal, 420, 2009
DOI: 10.1042/BJ20090095
Chlorella Viruses Prevent Multiple Infections by Depolarizing the Host Membrane.
Greiner T, Frohns F, Kang M, Van Etten J, Käsmann A, Moroni A, Hertel B, Thiel G
Journal of general virology, 90, 2009
DOI: 10.1099/vir.0.010629-0
Fast and slow gating are inherent properties of the K+ channel pore module.
Abenavoli A, Di Francesco ML, Schroeder I, Epimashko S; Gazzarrini S, Hansen UP, Thiel G, Moroni A
Journal of general physiology, 134, 2009
Model development for the viral Kcv potassium channel.
Tayefeh S, Kloss T, Kreim M, Gebhardt M, Baumeister D, Hertel B, Richter C, Schwalbe H, Moroni A, Thiel G, Kast SM
Biophysical journal, 96, 2009
DOI: 10.1016/j.bpj.2008.09.050
Selection of inhibitor-resistant viral potassium channels identifies a common change that affects barium and amantadine block
Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL
Plos one, 4, 2009
14-3-3 proteins regulate the K+ channel KAT1 by a dual mode.
Sottocornola B.; Gazzarrini S.; Olivari C.; Romani G.; Valbuzzi P.; Thiel G.; and Moroni A.
Plant biology , 10, 2008
DOI: 10.1111/j.1438-8677.2007.00028.x
Chlorella viruses evoke a rapid release of K(+) from host cells during the early phase of infection
Neupärtl M; Meyer C; Woll I; Frohns F; Kang M; Van Etten JL; Kramer D; Hertel B; Moroni A; Thiel G.
Virology , 372, 2008
DOI: 10.1016/j.virol.2007.10.024
Transmembrane Domain Length of Viral Potassium Ion Channels is a Signal for Mitochondria Targeting
Balss J.; Papatheodorou P.; Mehmel M.; Baumeister D.; Hertel B.; Delaroque N.; Chatelain F.C.; Minor D.L. Jr; Van Etten J.L.; Rassow J.; Moroni A.; Thiel G..
Proceedings of the National Academy of Sciences of the United States of America, 105, 2008
DOI: 10.1073/pnas.0805709105
A plant homolog of animal chloride intracellular channels (CLICs) generates an ion conductance in heterologous systems.
Elter A; Hartel A; Sieben C; Hertel B; Fischer-Schliebs E; Lüttge U; Moroni A; Thiel G.
Journal of biological chemistry, 282, 2007
DOI: 10.1074/jbc.M607241200
Electrokinetics of smallest K+ channel: Open state V-sensitivity and inhibition by K+ driving force.
Gazzarrini S., Abenavoli A., Gradmann D., Thiel G., Moroni A.
Journal of membrane biology, 214, 2007
Molecular Dynamics Simulation Study of the Cytosolic Mouth in Kcv-type Potassium Channels.
Tayefeh S., Kloss T., Thiel G., Hertel B., Moroni A., and Kast S.M.
Biochemistry, 46, 2007
Molecular properties of Kcv, a virus encoded K+ channel.
Pagliuca C, Goetze TA, Wagner R, Thiel G, Moroni A, Parcej D.
Biochemistry, 46, 2007
Plant neurobiology: no brain, no gain?
Alpi, A., Amrhein, N., Bertl, A. , Blatt, M.R., Blumwald, E., Cervone, F., Dainty, J., De Michelis, M.I., Epstein, E., Galston, A.W., Goldsmith, M.H.M., Hawes, C., Hell, R., Hetherington, H., Hofte, H., Juergens, G., Leaver, C.J., Moroni, A., et al
Trends in plant science, 12, 2007
Chlorella virus MT325 encodes water and potassium channels that interact synergistically.
Gazzarrini S., Kang M., Epimashko S., Van Etten J. L., Dainty J., Thiel G., Moroni A.
Proceedings of the National Academy of Sciences of the United States of America, 103, 2006
Elongation of outer transmembrane domain alters function of miniature K+ channel Kcv.
Hertel B., Tayefeh S., Mehmel M., Kast S.M., Van Etten J., Moroni A. Thiel G.
Journal of Membrane Biology, 210, 2006
Flip-flopping salt bridges gate an ion channel.
Moroni A. and G. Thiel.
Nature chemical biology, 2, 2006
H+ pumping rhodopsin from the marine alga Acetabularia.
Tsunoda S.P., D. Ewers, S. Gazzarrini, A. Moroni, D. Gradmann, P. Hegemann.
Biophysical journal, 91, 2006
Potassium ion channels of chlorella viruses cause rapid depolarization of host cells during infection.
Frohns F., Kasmann A., Kramer D., Schafer B., Mehmel M., Kang M., Van Etten J. L., Gazzarrini S., Moroni A., Thiel G.
Journal of virology, 80, 2006
The potassium channel KAT1 is activated by plant and animal 14-3-3 proteins.
Sottocornola B, S. Visconti, S. Orsi, S. Gazzarrini, S. Giacometti, C. Olivari, A. Abenavoli, L. Camoni, P. Aducci, M. Marra, G. Thiel and A. Moroni.
Journal of biological chemistry, 281, 2006
Anna Moroni
orcid://0000-0002-1860-406X,
Publications (63):
Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel functionWinterstein L.-M.; Kukovetz K.; Hansen U.-P.; Schroeder I.; van Etten J.L.; Moroni A.; Thiel G.; Rauh O.
the journal of general physiologyissn: 0022-1295rockefeller institute for medical research,, 153, 2021
DOI: 10.1085/JGP.202012731
Gating movements and ion permeation in HCN4 pacemaker channels
Saponaro A.; Bauer D.; Giese M.H.; Swuec P.; Porro A.; Gasparri F.; Sharifzadeh A.S.; Chaves-Sanjuan A.; Alberio L.; Parisi G.; Cerutti G.; Clarke O.B.; Hamacher K.; Colecraft H.M.; Mancia F.; Hendrickson W.A.; Siegelbaum S.A.; DiFrancesco D.; Bolognesi M.; Thiel G.; Santoro B.; Moroni A.
molecular cell (online), 81, 2021
DOI: 10.1016/j.molcel.2021.05.033
The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency
Jenewein, Tina; Kanner, Scott A.; Bauer, Daniel; Hertel, Brigitte; Colecraft, Henry M.; Moroni, Anna; Thiel, Gerhard; Kauferstein, Silke
Channels, 14, 2020
DOI: 10.1080/19336950.2020.1751522
A small viral potassium ion channel with an inherent inward rectification
Eckert, D. and Schulze, T. and Stahl, J. and Rauh, O. and Van Etten, J.L. and Hertel, B. and Schroeder, I. and Moroni, A. and Thiel, G.
channels (austin tex.), 13, 2019
DOI: 10.1080/19336950.2019.1605813
The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
Porro, A. and Saponaro, A. and Gasparri, F. and Bauer, D. and Gross, C. and Pisoni, M. and Abbandonato, G. and Hamacher, K. and Santoro, B. and Thiel, G. and Moroni, A.
elife, 8, 2019
DOI: 10.7554/eLife.49672
A light-gated potassium channel for sustained neuronal inhibition
Alberio, L. and Locarno, A. and Saponaro, A. and Romano, E. and Bercier, V. and Albadri, S. and Simeoni, F. and Moleri, S. and Pelucchi, S. and Porro, A. and Marcello, E. and Barsotti, N. and Kukovetz, K. and Boender, A.J. and Contestabile, A. and Luo, S. and Moutal, A. and Ji, Y. and Romani, G. and Beltrame, M. and Del Bene, F. and Di Luca, M. and Khanna, R. and Colecraft, H.M. and Pasqualetti, M. and Thiel, G. and Tonini, R. and Moroni, A.
nature methods, 15, 2018
DOI: 10.1038/s41592-018-0186-9
A synthetic peptide that prevents camp regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
Saponaro, A. and Cantini, F. and Porro, A. and Bucchi, A. and Difrancesco, D. and Maione, V. and Donadoni, C. and Introini, B. and Mesirca, P. and Mangoni, M.E. and Thiel, G. and Banci, L. and Santoro, B. and Moroni, A.
elife, 7, 2018
DOI: 10.7554/eLife.35753
Biofilm formation - what we can learn from recent developments
Bjarnsholt, T., Buhlin, K., Dufrêne, Y.F., Gomelsky, M., Moroni, A., Ramstedt, M., Rumbaugh, K.P., Schulte, T., Sun, L., Åkerlund, B., Römling, U.
journal of internal medicine (print), 284, 2018
DOI: 10.1111/joim.12782
Directional K+channel insertion in a single phospholipid bilayer: Neutron reflectometry and electrophysiology in the joint exploration of a model membrane functional platform
Rondelli V, Del Favero E, Brocca P, Fragneto G, Trapp M, Mauri L, Ciampa MG, Romani G, Braun CJ5, Winterstein L, Schroeder I, Thiel G, Moroni A, Cantu' L
Biochimica et biophysica acta. G, General subjects, 1862, 2018
DOI: 10.1016/j.bbagen.2018.05.007
Ionizing radiation induces morphological changes and immunological modulation of Jurkat cells
Voos, P.a, Fuck, S.a, Weipert, F.b, Babel, L.a, Tandl, D.a, Meckel, T.a, Hehlgans, S.b, Fournier, C.c, Moroni, A.d, Rödel, F.b, Thiel, G
frontiers in immunology, 9, 2018
DOI: 10.3389/fimmu.2018.00922
Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel
Gross, C. and Saponaro, A. and Santoro, B. and Moroni, A. and Thiel, G. and Hamacher, K.
the journal of biological chemistry (print), 293, 2018
DOI: 10.1074/jbc.RA118.002139
Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers
Winterstein, L.-M. and Kukovetz, K. and Rauh, O. and Turman, D.L. and Braun, C. and Moroni, A. and Schroeder, I. and Thiel, G.
the journal of general physiology, 150, 2018
DOI: 10.1085/jgp.201711904
Conversion of an instantaneous activating K+ channel into a slow activating inward rectifier
Baumeister D, Hertel B, Schroeder I, Gazzarrini S, Kast SM, Van Etten JL, Moroni A, Thiel G
FEBS letters, 591, 2017
DOI: 10.1002/1873-3468.12536
Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins
Saponaro A, Porro A, Chaves-Sanjuan A, Nardini M, Rauh O, Thiel G, Moroni A
The Plant cell, 29, 2017
DOI: 10.1105/tpc.17.00375
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
Tonelli M, Naesens L, Gazzarrini S, Santucci M, Cichero E, Tasso B, Moroni A, Costi MP, Loddo R
European journal of medicinal chemistry, 135, 2017
DOI: 10.1016/j.ejmech.2017.04.070
Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K+ Channels
Rauh O, Urban M, Henkes LM, Winterstein T, Greiner T, Van Etten JL, Moroni A, Kast SM, Thiel G, Schroeder I
Journal of the American Chemical Society, 139, 2017
DOI: 10.1021/jacs.7b01158
Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus
Barniol-Xicota M, Gazzarrini S, Torres E, Hu Y, Wang J, Naesens L, Moroni A, Vázquez S
Journal of medicinal chemistry, 60, 2017
DOI: 10.1021/acs.jmedchem.6b01758
The small neurotoxin apamin blocks not only small conductance Ca2+ activated K+ channels (SK type) but also the voltage dependent Kv1.3 channel
Voos P, Yazar M, Lautenschläger R, Rauh O, Moroni A, Thiel G
European biophysics journal, 46, 2017
DOI: 10.1007/s00249-016-1196-0
Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function
Biel S.; Aquila M.; Hertel B.; Berthold A.; Neumann T.; DiFrancesco D.; Moroni A.; Thiel G.; Kauferstein S.
Pflügers Archiv, 468, 2016
DOI: 10.1007/s00424-016-1870-1
Engineering a Ca++-Sensitive (Bio) Sensor from the Pore-Module of a Potassium Channel
DiFrancesco, Mattia Lorenzo; Gazzarrini, Sabrina; Arrigoni, Cristina; Romani, Giulia; Thiel, Gerhard; Moroni, Anna
Sensors , 15, 2015
DOI: 10.3390/s150304913
Large dsDNA chloroviruses encode diverse membrane transport proteins
Thiel G.; Greiner T.; Dunigan D.D.; Moroni A.; Van Etten J.L.
Virology , 479-480, 2015
DOI: 10.1016/j.virol.2015.02.025
Low-dose photon irradiation alters cell differentiation via activation of hIK channels
Roth B.; Gibhardt C.S.; Becker P.; Gebhardt M.; Knoop J.; Fournier C.; Moroni A.; Thiel G.
Pflügers Archiv , 467, 2015
DOI: 10.1007/s00424-014-1601-4
New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode
Rey-Carrizo M.; Gazzarrini S.; Llabres S.; Frigole-Vivas M.; Juarez-Jimenez J.; Font-Bardia M.; Naesens L.; Moroni A.; Luque F.J.; Vazquez S.
European journal of medicinal chemistry , 96, 2015
DOI: 10.1016/j.ejmech.2015.04.030
Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
Leiva R.; Gazzarrini S.; Esplugas R.; Moroni A.; Naesens L.; Sureda F.X.; Vazquez S.
Tetrahedron letters, 56, 2015
DOI: 10.1016/j.tetlet.2015.01.160
The sorting of a small potassium channel in mammalian cells can be shifted between mitochondria and plasma membrane
von Charpuis C.; Meckel T.; Moroni A.; Thiel G.
Cell calcium , 58, 2015
DOI: 10.1016/j.ceca.2014.09.009
X-ray irradiation activates K+ channels via H2O2 signaling
Gibhardt, Christine S.; Roth, Bastian; Schroeder, Indra; Fuck, Sebastian; Becker, Patrick; Jakob, Burkhard; Fournier, Claudia; Moroni, Anna; Thiel, Gerhard
Scientific reports , 5, 2015
DOI: 10.1038/srep13861
Azapropellanes with Anti-Influenza A Virus Activity
Torres, Eva; Leiva, Rosana; Gazzarrini, Sabrina; Rey-Carrizo, Matias; Frigole-Vivas, Marta; Moroni, Anna; Naesens, Lieve; Vazquez, Santiago
ACS medicinal chemistry letters, 5, 2014
DOI: 10.1021/ml500108s
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness
Lolicato, Marco; Bucchi, Annalisa; Arrigoni, Cristina; Zucca, Stefano; Nardini, Marco; Schroeder, Indra; Simmons, Katie; Aquila, Marco; DiFrancesco, Dario; Bolognesi, Martino; Schwede, Frank; Kashin, Dmitry; Fishwick, Colin W. G.; Johnson, A. Peter; Thiel
Nature chemical biology, 10, 2014
DOI: 10.1038/NCHEMBIO.1521
Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels
Moeller, Stefan; Alfieri, Andrea; Bertinetti, Daniela; Aquila, Marco; Schwede, Frank; Lolicato, Marco; Rehmann, Holger; Moroni, Anna; Herberg, Friedrich W.
ACS chemical biology, 9, 2014
DOI: 10.1021/cb400904s
Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes
DiFrancesco, Mattia L.; Hansen, Ulf-Peter; Thiel, Gerhard; Moroni, Anna; Schroeder, Indra
PloS one, 9, 2014
DOI: 10.1371/journal.pone.0107406
Pseudo painting/air bubble technique for planar lipid bilayers
Braun, Christian J.; Baer, Tom; Moroni, Anna; Thiel, Gerhard
Journal of neuroscience methods, 233, 2014
DOI: 10.1016/j.jneumeth.2014.05.031
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function
Saponaro, Andrea; Pauleta, Sofia R.; Cantini, Francesca; Matzapetakis, Manolis; Hammann, Christian; Donadoni, Chiara; Hu, Lei; Thiel, Gerhard; Banci, Lucia; Santoro, Bina; Moroni, Anna
Proceedings of the National Academy of Sciences of the United States of America, 111, 2014
DOI: 10.1073/pnas.1410389111
Viral potassium channels as a robust model system for studies of membrane-protein interaction
Braun, Christian J.; Lachnit, Christine; Becker, Patrick; Henkes, Leonhard M.; Arrigoni, Cristina; Kast, Stefan M.; Moroni, Anna; Thiel, Gerhard; Schroeder, Indra
Biochimica et biophysica acta. Biomembranes, 1838, 2014
DOI: 10.1016/j.bbamem.2013.06.010
A virus-encoded potassium ion channel is a structural protein in the chlorovirus Paramecium bursaria chlorella virus 1 virion
Romani G, Piotrowski A, Hillmer S, Gurnon J, Van Etten JL, Moroni A, Thiel G, Hertel B
Journal of general virology, 94, 2013
DOI: 10.1099/vir.0.055251-0
Creation of a Reactive Oxygen Species-Insensitive Kcv Channel
Schroeder I, Gazzarrini S, Ferrara G, Thiel G, Hansen UP, Moroni A
Biochemistry, 52, 2013
DOI: 10.1021/bi3016197
The voltage-sensing domain of a phosphatase gates the pore of a potassium channel
Cristina Arrigoni, Indra Schroeder, Giulia Romani, James L. Van Etten, Gerhard Thiel, and Anna Moroni
Journal of general physiology (online), 141, 2013
DOI: 10.1085/jgp.201210940
Relevance of Lysine Snorkeling in the Outer Transmembrane Domain of Small Viral Potassium Ion Channels
Gebhardt M; Henkes LM; Tayefeh S; Hertel B; Greiner T; Van Etten JL; Baumeister D; Cosentino C; Moroni A; Kast SM; Thiel G
Biochemistry , 51, 2012
Structural Organization of DNA in Chlorella Viruses
Wulfmeyer T; Polzer C; Hiepler G; Hamacher K; Shoeman R; Dunigan DD; Van Etten JL; Lolicato M; Moroni A; Thiel G; Meckel T
PloS one, 7, 2012
Functional HAK/KUP/KT-like potassium transporter encoded by chlorella viruses
Greiner T, Ramos J, Alvarez MC, Gurnon JR, Kang M, Van Etten JL, Moroni A, Thiel G
Plant journal, 68, 2011
Membrane anchoring and interaction between transmembrane domains are crucial for K+ channel function
Gebhardt M, Hoffgaard F, Hamacher K, Kast SM, Moroni A, Thiel G
Journal of biological chemistry, 286, 2011
Minimal art: Or why small viral K(+) channels are good tools for understanding basic structure and function relations
Thiel G, Baumeister D, Schroeder I, Kast SM, Van Etten JL, Moroni A
Biochimica et biophysica acta. Biomembranes, 1808, 2011
TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites
Santoro B, Hu L, Liu H, Saponaro A, Pian P, Piskorowski RA, Moroni A, Siegelbaum SA
Journal of neuroscience, 31, 2011
A functional calcium transporting ATPase encoded by Chlorella viruses.
Bonza MC, Martin H, Kang M, Lewis G, Greiner T, Giacometti S, Van Etten JL, De Michelis MI, Thiel G, Moroni A
Journal of general virology, 91, 2010
The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel.
Henkel M, Mitzner D, Henklein P, Meyer-Almes FJ, Moroni A, DiFrancesco ML, Henkes LM, Kreim M, Kast SM, Schubert U, Thiel G
Plos one, 5, 2010
Chlorella virus ATCV1 encodes a functional potassium channel of eighty-two amino acids.
Gazzarrini S, Kang M, Abenavoli A, Romani G, Olivari C, Gaslini D, Ferrara G, Van Etten JL, Kreim M, Kast SM, Thiel G, Moroni A
Biochemical journal, 420, 2009
DOI: 10.1042/BJ20090095
Chlorella Viruses Prevent Multiple Infections by Depolarizing the Host Membrane.
Greiner T, Frohns F, Kang M, Van Etten J, Käsmann A, Moroni A, Hertel B, Thiel G
Journal of general virology, 90, 2009
DOI: 10.1099/vir.0.010629-0
Fast and slow gating are inherent properties of the K+ channel pore module.
Abenavoli A, Di Francesco ML, Schroeder I, Epimashko S; Gazzarrini S, Hansen UP, Thiel G, Moroni A
Journal of general physiology, 134, 2009
Model development for the viral Kcv potassium channel.
Tayefeh S, Kloss T, Kreim M, Gebhardt M, Baumeister D, Hertel B, Richter C, Schwalbe H, Moroni A, Thiel G, Kast SM
Biophysical journal, 96, 2009
DOI: 10.1016/j.bpj.2008.09.050
Selection of inhibitor-resistant viral potassium channels identifies a common change that affects barium and amantadine block
Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL
Plos one, 4, 2009
14-3-3 proteins regulate the K+ channel KAT1 by a dual mode.
Sottocornola B.; Gazzarrini S.; Olivari C.; Romani G.; Valbuzzi P.; Thiel G.; and Moroni A.
Plant biology , 10, 2008
DOI: 10.1111/j.1438-8677.2007.00028.x
Chlorella viruses evoke a rapid release of K(+) from host cells during the early phase of infection
Neupärtl M; Meyer C; Woll I; Frohns F; Kang M; Van Etten JL; Kramer D; Hertel B; Moroni A; Thiel G.
Virology , 372, 2008
DOI: 10.1016/j.virol.2007.10.024
Transmembrane Domain Length of Viral Potassium Ion Channels is a Signal for Mitochondria Targeting
Balss J.; Papatheodorou P.; Mehmel M.; Baumeister D.; Hertel B.; Delaroque N.; Chatelain F.C.; Minor D.L. Jr; Van Etten J.L.; Rassow J.; Moroni A.; Thiel G..
Proceedings of the National Academy of Sciences of the United States of America, 105, 2008
DOI: 10.1073/pnas.0805709105
A plant homolog of animal chloride intracellular channels (CLICs) generates an ion conductance in heterologous systems.
Elter A; Hartel A; Sieben C; Hertel B; Fischer-Schliebs E; Lüttge U; Moroni A; Thiel G.
Journal of biological chemistry, 282, 2007
DOI: 10.1074/jbc.M607241200
Electrokinetics of smallest K+ channel: Open state V-sensitivity and inhibition by K+ driving force.
Gazzarrini S., Abenavoli A., Gradmann D., Thiel G., Moroni A.
Journal of membrane biology, 214, 2007
Molecular Dynamics Simulation Study of the Cytosolic Mouth in Kcv-type Potassium Channels.
Tayefeh S., Kloss T., Thiel G., Hertel B., Moroni A., and Kast S.M.
Biochemistry, 46, 2007
Molecular properties of Kcv, a virus encoded K+ channel.
Pagliuca C, Goetze TA, Wagner R, Thiel G, Moroni A, Parcej D.
Biochemistry, 46, 2007
Plant neurobiology: no brain, no gain?
Alpi, A., Amrhein, N., Bertl, A. , Blatt, M.R., Blumwald, E., Cervone, F., Dainty, J., De Michelis, M.I., Epstein, E., Galston, A.W., Goldsmith, M.H.M., Hawes, C., Hell, R., Hetherington, H., Hofte, H., Juergens, G., Leaver, C.J., Moroni, A., et al
Trends in plant science, 12, 2007
Chlorella virus MT325 encodes water and potassium channels that interact synergistically.
Gazzarrini S., Kang M., Epimashko S., Van Etten J. L., Dainty J., Thiel G., Moroni A.
Proceedings of the National Academy of Sciences of the United States of America, 103, 2006
Elongation of outer transmembrane domain alters function of miniature K+ channel Kcv.
Hertel B., Tayefeh S., Mehmel M., Kast S.M., Van Etten J., Moroni A. Thiel G.
Journal of Membrane Biology, 210, 2006
Flip-flopping salt bridges gate an ion channel.
Moroni A. and G. Thiel.
Nature chemical biology, 2, 2006
H+ pumping rhodopsin from the marine alga Acetabularia.
Tsunoda S.P., D. Ewers, S. Gazzarrini, A. Moroni, D. Gradmann, P. Hegemann.
Biophysical journal, 91, 2006
Potassium ion channels of chlorella viruses cause rapid depolarization of host cells during infection.
Frohns F., Kasmann A., Kramer D., Schafer B., Mehmel M., Kang M., Van Etten J. L., Gazzarrini S., Moroni A., Thiel G.
Journal of virology, 80, 2006
The potassium channel KAT1 is activated by plant and animal 14-3-3 proteins.
Sottocornola B, S. Visconti, S. Orsi, S. Gazzarrini, S. Giacometti, C. Olivari, A. Abenavoli, L. Camoni, P. Aducci, M. Marra, G. Thiel and A. Moroni.
Journal of biological chemistry, 281, 2006