Bongiorno, Roberta; Ludovico, Alessandra; Moran, Oscar; Baroni, Debora
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 2023
DOI: 10.3390/ijms241612838
αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Paterna, A.; Santonicola, P.; Di Prima, G.; Rao, E.; Raccosta, S.; Zampi, G.; Russo, C.; Moran, O.; Manno, M.; Di Schiavi, E.; Librizzi, F.; Carrotta, R.
ACS CHEMICAL NEUROSCIENCE, 14, 2023
DOI: 10.1021/acschemneuro.3c00239
Small Angle X-ray Scattering Sensing Membrane Composition: The Role of Sphingolipids in Membrane-Amyloid beta-Peptide Interaction
Carrotta, Rita; Mangione, Maria Rosalia; Librizzi, Fabio; Moran, Oscar
biology (basel), 11, 2022
DOI: 10.3390/biology11010026
The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca2+ in melanoma and pancreatic duct adenocarcinoma cell lines
Zuccolini, Paolo; Ferrera, Loretta; Remigante, Alessia; Picco, Cristiana; Barbieri, Raffaella; Bertelli, Sara; Moran, Oscar; Gavazzo, Paola; Pusch, Michael
british journal of pharmacology, 2022
DOI: 10.1111/bph.15810
Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis
Brandas C.; Ludovico A.; Parodi A.; Moran O.; Millo E.; Cichero E.; Baroni D.
biomolecules, 11, 2021
DOI: 10.3390/biom11101417
The application of bicarbonate recovers the chemical-physical properties of airway surface liquid in cystic fibrosis epithelia models
Ferrera L.; Capurro V.; Delpiano L.; Gianotti A.; Moran O.
biology (basel)issn: 2079-7737mdpi, 10, 2021
DOI: 10.3390/biology10040278
Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore, Michele; Picco, Cristiana; Moran, Oscar
Scientific Reports, 10, 2020
DOI: 10.1038/s41598-020-65287-4
Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra; Capurro, Valeria; Delpiano, Livia; Mielczarek, Marcin; Garcia-Valverde, Maria; Carreira-Barral, Israel; Ludovico, Alessandra; Fiore, Michele; Baroni, Debora; Moran, Oscar; Quesada, Roberto; Caci, Emanuela
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21041488
The different anion transport capability of prodiginine- and tambjamine-like molecules
Michele Fiore, María García-Valverde, Israel Carreira-Barral, Oscar Moran
European Journal of Pharmacology, 889, 2020
DOI: 10.1016/j.ejphar.2020.173592
WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
Carusone, Teresa Maria; Cardiero, Giovanna; Cerreta, Mariangela; Mandrich, Luigi; Moran, Oscar; Porzio, Elena; Catara, Giuliana; Lacerra, Giuseppina; Manco, Giuseppe
Cell Death & Disease, 11, 2020
DOI: 10.1038/s41419-020-2504-2
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
Journal of physical chemistry b, 123, 2019
DOI: 10.1021/acs.jpcb.8b11719
Lumacaftor-rescued F508del-CFTR has a modified bicarbonate permeability
Ferrera L, Baroni D, Moran O
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18, 2019
DOI: 10.1016/j.jcf.2019.01.012
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 176, 2019
DOI: 10.1111/bph.14649
Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors
Amico G, Brandas C, Moran O, Baroni D
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20215463
A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Human mutation, 39, 2018
DOI: 10.1002/humu.23589
Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 9, 2018
DOI: 10.3389/fphar.2018.00852
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces, 170, 2018
DOI: 10.1016/j.colsurfb.2018.06.032
Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R
Scientific reports , 8, 2018
DOI: 10.1038/s41598-018-20708-3
Mutation E87Q of the beta 1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Scientific reports , 7, 2017
DOI: 10.1038/s41598-017-10645-y
The biophysics, biochemistry and physiology of CFTR
Moran O.
Cellular and molecular life sciences , 74, 2017
DOI: 10.1007/s00018-016-2384-x
The gating of the CFTR channel
Moran O.
Cellular and molecular life sciences , 74, 2017
DOI: 10.1007/s00018-016-2390-z
Amyloid ?-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.010
Intermolecular interactions in the TMEM16A dimer controlling channel activity
Scudieri P, Musante I, Gianotti A, Moran O, Galietta L
Scientific reports , 6, 2016
DOI: 10.1038/srep38788
Pharmacological rescue of mutant CFTR protein improves the viscoelastic properties of CF mucus
Gianotti A, Capurro V, Scudieri P, Galietta LJ, Moran O, Zegarra-Moran O
Journal of cystic fibrosis, 15, 2016
DOI: 10.1016/j.jcf.2015.11.003
Structure of wild type and mutant F508del CFTR: A small-angle X-ray scattering study of the protein-detergent complexes
Pollock NL, Satriano L, Zegarra-Moran O, Ford RC, Moran O
Journal of structural biology, 194, 2016
DOI: 10.1016/j.jsb.2016.02.004
Differential gene expression profiles of two excitable rat cell lines after over-expression of WT- and C121W-?1 sodium channel subunits
Baroni, D.; Moran, O.
Neuroscience , 297, 2015
DOI: 10.1016/j.neuroscience.2015.03.052
Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS
Baroni, Debora; Zegarra-Moran, Olga; Moran, Oscar
Cellular and molecular life sciences , 72, 2015
DOI: 10.1007/s00018-014-1747-4
On the interactions between nucleotide binding domains and membrane spanning domains in cystic fibrosis transmembrane regulator: A molecular dynamic study
Belmonte, Luca; Belmonte, Luca; Moran, Oscar
Biochimie , 111, 2015
DOI: 10.1016/j.biochi.2015.01.010
On the multiple roles of the voltage gated sodium channel beta1 subunit in genetic diseases.
Baroni, Debora; Moran, Oscar
Frontiers in Pharmacology , 6, 2015
DOI: 10.3389/fphar.2015.00108
Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression
Baroni, Debora; Picco, Cristiana; Barbieri, Raffaella; Moran, Oscar
Biology of the cell, 106, 2014
DOI: 10.1111/boc.201300040
Direct interaction of a cftr potentiator and a cftr corrector with phospholipid bilayers
Baroni D.; Zegarra-Moran O.; Svensson A.; Moran O.
European biophysics journal, 43, 2014
DOI: 10.1007/s00249-014-0956-y
On the structural organization of the intracellular domains of CFTR
Moran O.
International journal of biochemistry & cell biology, 52, 2014
DOI: 10.1016/j.biocel.2014.01.024
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR
Marasini C; Galeno L; Moran O
Cellular and molecular life sciences, 70, 2013
Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels
Moran O, Grottesi A, Chadburn AJ, Tammaro P.
Biophysical chemistry, 171, 2013
DOI: 10.1016/j.bpc.2012.10.006
Visualization of single proteins from stripped native cell membranes: A protocol for high-resolution atomic force microscopy
C. Marasini, E. Jacchetti, M. Moretti, C. Canale, O. Moran, M. Vassalli
Microscopy research and technique (online), 76, 2013
DOI: 10.1002/jemt.22223
A potentiator induces conformational changes on the recombinant CFTR nucleotide binding domains in solution.
Galfre' E; Galeno L.; Moran O.
Cellular and molecular life sciences, 69, 2012
Identification of an intra-molecular disulfide bond in the sodium channel beta 1-subunit
Barbieri R; Baroni D; Moran O
Biochemical and biophysical research communications, 420, 2012
Thermodynamic study of the native and phosphorylated regulatory domain of the CFTR
Marasini, C.; Galeno, L.; Moran, O.
Biochemical and biophysical research communications , 423, 2012
Molecular differential expression of voltage-gated sodium channel alpha and beta subunit mRNAs in five different mammalian cell lines
Baroni D, Moran O
Journal of bioenergetics and biomembranes, 43, 2011
Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution
Galeno L, Galfr? E, Moran O
European biophysics journal with biophysics letters, 40, 2011
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators.
Moran O
Journal of theoretical biology, 262, 2010
Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1.
Bisignano P, Moran O
Biochimie, 92, 2010
ATP binding to the C-terminus of the Arabidopsis thaliana, AtCLCa, regulates nitrate transport into plant vacuoles.
De Angeli A, Moran O, Wege S, Filleur S, Ephritikhine G, Thomine S, Barbier-Brygoo H, Gambale F
Journal of biological chemistry, 284, 2009
DOI: 10.1074/jbc.M109.005132
Molecular determinants of ammonia and urea conductance in plant aquaporin homologs.
Dynowski M, Mayer M, Moran O, Ludewig U.
FEBS letters, 582, 2008
On the measurement of the functional properties of the CFTR
Moran O, Zegarra-Moran, O.
Journal of cystic fibrosis, 7, 2008
Plant plasma membrane water channels conduct the signaling molecule H2O2.
Dynowski M; Schaaf G; Loque D; Moran O; Ludewig U.
Biochemical journal , 414, 2008
DOI: 10.1042/BJ20080287
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering.
Moran O.; Roessle M.W.; Mariuzza R.A.; Dimasi N.
Biophysical journal, 94, 2008
DOI: 10.1529/biophysj.107.116590
Characterizazion of a 7,8-benzoflavone double effect on CFTR CI- channel activity.
Ferrera L, Pincin C, Moran O.
Journal of membrane biology (internet), 220, 2007
Functional analysis of mutations in the putative binding site for cystic fibrosis transmembrane conductance regulator potentiators: Interaction between activation and inhibition.
Zegarra-Moran O; Monteverde M; Galietta LJ; Moran O
Journal of biological chemistry, 282, 2007
DOI: 10.1074/jbc.M611411200
Leishmania amazonensis: Anionic currents expressed in oocytes upon microinjection of mRNA from the parasite.
Lagos M LF, Moran O, Camacho M.
Experimental parasitology, 116, 2007
Molecular analysis and solution structure from small-angle X-ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a)
Dimasi N., Roessle M., Moran O, Candiano G., Svergun D.I. and Biassoni R.
International journal of biological macromolecules, 40, 2007
Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel.
Pedemonte N; Boido D; Moran O; Giampieri ; Mazzei M; Ravazzolo R; Galietta LJ.
Molecular pharmacology, 72, 2007
DOI: 10.1124/mol.107.034702
The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1.
Márquez JA; Galfré E; Dupeux F; Flot D; Moran O; Dimasi N.
Journal of Molecular Biology, 367, 2007
DOI: 10.1016/j.jmb.2007.01.011
beta1 subunit modulates the Nav1.4 sodium channel by changing the surface charge.
Ferrera L., Moran O.
Experimental brain research, 172, 2006
Minimal sodium channel pore consisting of S5-P-S6 segments preserves intracellular pharmacology
Pincin, C; Ferrera, L; Moran, O
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (PRINT), 334, 2005
Oscar Moran
BSc in Biology (1978) e MSc in Biophysics (1979), Universidad Peruana Cayetano Heredia, Lima. PhSc Physiology and Biophysics, Instituto Venezolano de Investigaciones Cientificas, Caracas.
orcid://0000-0003-1287-6176, ncbi://47761049
Research interests:
- Genetic diseases caused by mutations of the auxiliary subunits of the sodium channel (Principal investigator)
- Molecular pharmacology of cystic fibrosis (Principal investigator)
Further collaborations:
- Loretta Ferrera (Istituto Giannina Gaslini, Genova)
- Luis J.V. Galietta (Tigem, Napoli)
Financial support:
- Identification of the binding sites of CFTR correctors. Progetto FFC#8/2016, Fondazione per la Ricerca sulla Fibrosi Cistica
- Transmembrane anion transporters as new chemotherapeutics for the treatment of cystic fibrosis.
- Grant agreement No 667079, European Union’s Horizon 2020 research and innovation programme.
Key publications:
Moran, Oscar. “The Biophysics, Biochemistry and Physiology of CFTR.” Cellular and Molecular Life Sciences: CMLS, October 4, 2016. https://doi.org/10.1007/s00018-016-2384-x.
Pollock, Naomi L., Letizia Satriano, Olga Zegarra-Moran, Robert C. Ford, and Oscar Moran. “Structure of Wild Type and Mutant F508del CFTR: A Small-Angle X-Ray Scattering Study of the Protein-Detergent Complexes.” Journal of Structural Biology 194, no. 1 (April 2016): 102–11. https://doi.org/10.1016/j.jsb.2016.02.004.
Fiore, Michele, Claudia Cossu, Valeria Capurro, Cristiana Picco, Alessandra Ludovico, Marcin Mielczarek, Israel Carreira-Barral, et al. “Small Molecule-Facilitated Anion Transporters in Cells for a Novel Therapeutic Approach to Cystic Fibrosis.” British Journal of Pharmacology 176, no. 11 (2019): 1764–79. https://doi.org/10.1111/bph.14649.
Gianotti, Ambra, Valeria Capurro, Paolo Scudieri, Luis J. V. Galietta, Oscar Moran, and Olga Zegarra-Moran. “Pharmacological Rescue of Mutant CFTR Protein Improves the Viscoelastic Properties of CF Mucus.” Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society 15, no. 3 (May 2016): 295–301. https://doi.org/10.1016/j.jcf.2015.11.003.
Baroni, Debora, Olga Zegarra-Moran, and Oscar Moran. “Functional and Pharmacological Induced Structural Changes of the Cystic Fibrosis Transmembrane Conductance Regulator in the Membrane Solved Using SAXS.” Cell Mol Life Sci 72, no. 7 (April 2015): 1363–75.
Publications (55):
Elexacaftor Mediates the Rescue of F508del CFTR Functional Expression Interacting with MSD2Bongiorno, Roberta; Ludovico, Alessandra; Moran, Oscar; Baroni, Debora
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 2023
DOI: 10.3390/ijms241612838
αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Paterna, A.; Santonicola, P.; Di Prima, G.; Rao, E.; Raccosta, S.; Zampi, G.; Russo, C.; Moran, O.; Manno, M.; Di Schiavi, E.; Librizzi, F.; Carrotta, R.
ACS CHEMICAL NEUROSCIENCE, 14, 2023
DOI: 10.1021/acschemneuro.3c00239
Small Angle X-ray Scattering Sensing Membrane Composition: The Role of Sphingolipids in Membrane-Amyloid beta-Peptide Interaction
Carrotta, Rita; Mangione, Maria Rosalia; Librizzi, Fabio; Moran, Oscar
biology (basel), 11, 2022
DOI: 10.3390/biology11010026
The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca2+ in melanoma and pancreatic duct adenocarcinoma cell lines
Zuccolini, Paolo; Ferrera, Loretta; Remigante, Alessia; Picco, Cristiana; Barbieri, Raffaella; Bertelli, Sara; Moran, Oscar; Gavazzo, Paola; Pusch, Michael
british journal of pharmacology, 2022
DOI: 10.1111/bph.15810
Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis
Brandas C.; Ludovico A.; Parodi A.; Moran O.; Millo E.; Cichero E.; Baroni D.
biomolecules, 11, 2021
DOI: 10.3390/biom11101417
The application of bicarbonate recovers the chemical-physical properties of airway surface liquid in cystic fibrosis epithelia models
Ferrera L.; Capurro V.; Delpiano L.; Gianotti A.; Moran O.
biology (basel)issn: 2079-7737mdpi, 10, 2021
DOI: 10.3390/biology10040278
Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore, Michele; Picco, Cristiana; Moran, Oscar
Scientific Reports, 10, 2020
DOI: 10.1038/s41598-020-65287-4
Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra; Capurro, Valeria; Delpiano, Livia; Mielczarek, Marcin; Garcia-Valverde, Maria; Carreira-Barral, Israel; Ludovico, Alessandra; Fiore, Michele; Baroni, Debora; Moran, Oscar; Quesada, Roberto; Caci, Emanuela
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21041488
The different anion transport capability of prodiginine- and tambjamine-like molecules
Michele Fiore, María García-Valverde, Israel Carreira-Barral, Oscar Moran
European Journal of Pharmacology, 889, 2020
DOI: 10.1016/j.ejphar.2020.173592
WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
Carusone, Teresa Maria; Cardiero, Giovanna; Cerreta, Mariangela; Mandrich, Luigi; Moran, Oscar; Porzio, Elena; Catara, Giuliana; Lacerra, Giuseppina; Manco, Giuseppe
Cell Death & Disease, 11, 2020
DOI: 10.1038/s41419-020-2504-2
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
Journal of physical chemistry b, 123, 2019
DOI: 10.1021/acs.jpcb.8b11719
Lumacaftor-rescued F508del-CFTR has a modified bicarbonate permeability
Ferrera L, Baroni D, Moran O
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18, 2019
DOI: 10.1016/j.jcf.2019.01.012
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 176, 2019
DOI: 10.1111/bph.14649
Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors
Amico G, Brandas C, Moran O, Baroni D
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20215463
A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Human mutation, 39, 2018
DOI: 10.1002/humu.23589
Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 9, 2018
DOI: 10.3389/fphar.2018.00852
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces, 170, 2018
DOI: 10.1016/j.colsurfb.2018.06.032
Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R
Scientific reports , 8, 2018
DOI: 10.1038/s41598-018-20708-3
Mutation E87Q of the beta 1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Scientific reports , 7, 2017
DOI: 10.1038/s41598-017-10645-y
The biophysics, biochemistry and physiology of CFTR
Moran O.
Cellular and molecular life sciences , 74, 2017
DOI: 10.1007/s00018-016-2384-x
The gating of the CFTR channel
Moran O.
Cellular and molecular life sciences , 74, 2017
DOI: 10.1007/s00018-016-2390-z
Amyloid ?-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.010
Intermolecular interactions in the TMEM16A dimer controlling channel activity
Scudieri P, Musante I, Gianotti A, Moran O, Galietta L
Scientific reports , 6, 2016
DOI: 10.1038/srep38788
Pharmacological rescue of mutant CFTR protein improves the viscoelastic properties of CF mucus
Gianotti A, Capurro V, Scudieri P, Galietta LJ, Moran O, Zegarra-Moran O
Journal of cystic fibrosis, 15, 2016
DOI: 10.1016/j.jcf.2015.11.003
Structure of wild type and mutant F508del CFTR: A small-angle X-ray scattering study of the protein-detergent complexes
Pollock NL, Satriano L, Zegarra-Moran O, Ford RC, Moran O
Journal of structural biology, 194, 2016
DOI: 10.1016/j.jsb.2016.02.004
Differential gene expression profiles of two excitable rat cell lines after over-expression of WT- and C121W-?1 sodium channel subunits
Baroni, D.; Moran, O.
Neuroscience , 297, 2015
DOI: 10.1016/j.neuroscience.2015.03.052
Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS
Baroni, Debora; Zegarra-Moran, Olga; Moran, Oscar
Cellular and molecular life sciences , 72, 2015
DOI: 10.1007/s00018-014-1747-4
On the interactions between nucleotide binding domains and membrane spanning domains in cystic fibrosis transmembrane regulator: A molecular dynamic study
Belmonte, Luca; Belmonte, Luca; Moran, Oscar
Biochimie , 111, 2015
DOI: 10.1016/j.biochi.2015.01.010
On the multiple roles of the voltage gated sodium channel beta1 subunit in genetic diseases.
Baroni, Debora; Moran, Oscar
Frontiers in Pharmacology , 6, 2015
DOI: 10.3389/fphar.2015.00108
Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression
Baroni, Debora; Picco, Cristiana; Barbieri, Raffaella; Moran, Oscar
Biology of the cell, 106, 2014
DOI: 10.1111/boc.201300040
Direct interaction of a cftr potentiator and a cftr corrector with phospholipid bilayers
Baroni D.; Zegarra-Moran O.; Svensson A.; Moran O.
European biophysics journal, 43, 2014
DOI: 10.1007/s00249-014-0956-y
On the structural organization of the intracellular domains of CFTR
Moran O.
International journal of biochemistry & cell biology, 52, 2014
DOI: 10.1016/j.biocel.2014.01.024
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR
Marasini C; Galeno L; Moran O
Cellular and molecular life sciences, 70, 2013
Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels
Moran O, Grottesi A, Chadburn AJ, Tammaro P.
Biophysical chemistry, 171, 2013
DOI: 10.1016/j.bpc.2012.10.006
Visualization of single proteins from stripped native cell membranes: A protocol for high-resolution atomic force microscopy
C. Marasini, E. Jacchetti, M. Moretti, C. Canale, O. Moran, M. Vassalli
Microscopy research and technique (online), 76, 2013
DOI: 10.1002/jemt.22223
A potentiator induces conformational changes on the recombinant CFTR nucleotide binding domains in solution.
Galfre' E; Galeno L.; Moran O.
Cellular and molecular life sciences, 69, 2012
Identification of an intra-molecular disulfide bond in the sodium channel beta 1-subunit
Barbieri R; Baroni D; Moran O
Biochemical and biophysical research communications, 420, 2012
Thermodynamic study of the native and phosphorylated regulatory domain of the CFTR
Marasini, C.; Galeno, L.; Moran, O.
Biochemical and biophysical research communications , 423, 2012
Molecular differential expression of voltage-gated sodium channel alpha and beta subunit mRNAs in five different mammalian cell lines
Baroni D, Moran O
Journal of bioenergetics and biomembranes, 43, 2011
Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution
Galeno L, Galfr? E, Moran O
European biophysics journal with biophysics letters, 40, 2011
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators.
Moran O
Journal of theoretical biology, 262, 2010
Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1.
Bisignano P, Moran O
Biochimie, 92, 2010
ATP binding to the C-terminus of the Arabidopsis thaliana, AtCLCa, regulates nitrate transport into plant vacuoles.
De Angeli A, Moran O, Wege S, Filleur S, Ephritikhine G, Thomine S, Barbier-Brygoo H, Gambale F
Journal of biological chemistry, 284, 2009
DOI: 10.1074/jbc.M109.005132
Molecular determinants of ammonia and urea conductance in plant aquaporin homologs.
Dynowski M, Mayer M, Moran O, Ludewig U.
FEBS letters, 582, 2008
On the measurement of the functional properties of the CFTR
Moran O, Zegarra-Moran, O.
Journal of cystic fibrosis, 7, 2008
Plant plasma membrane water channels conduct the signaling molecule H2O2.
Dynowski M; Schaaf G; Loque D; Moran O; Ludewig U.
Biochemical journal , 414, 2008
DOI: 10.1042/BJ20080287
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering.
Moran O.; Roessle M.W.; Mariuzza R.A.; Dimasi N.
Biophysical journal, 94, 2008
DOI: 10.1529/biophysj.107.116590
Characterizazion of a 7,8-benzoflavone double effect on CFTR CI- channel activity.
Ferrera L, Pincin C, Moran O.
Journal of membrane biology (internet), 220, 2007
Functional analysis of mutations in the putative binding site for cystic fibrosis transmembrane conductance regulator potentiators: Interaction between activation and inhibition.
Zegarra-Moran O; Monteverde M; Galietta LJ; Moran O
Journal of biological chemistry, 282, 2007
DOI: 10.1074/jbc.M611411200
Leishmania amazonensis: Anionic currents expressed in oocytes upon microinjection of mRNA from the parasite.
Lagos M LF, Moran O, Camacho M.
Experimental parasitology, 116, 2007
Molecular analysis and solution structure from small-angle X-ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a)
Dimasi N., Roessle M., Moran O, Candiano G., Svergun D.I. and Biassoni R.
International journal of biological macromolecules, 40, 2007
Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel.
Pedemonte N; Boido D; Moran O; Giampieri ; Mazzei M; Ravazzolo R; Galietta LJ.
Molecular pharmacology, 72, 2007
DOI: 10.1124/mol.107.034702
The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1.
Márquez JA; Galfré E; Dupeux F; Flot D; Moran O; Dimasi N.
Journal of Molecular Biology, 367, 2007
DOI: 10.1016/j.jmb.2007.01.011
beta1 subunit modulates the Nav1.4 sodium channel by changing the surface charge.
Ferrera L., Moran O.
Experimental brain research, 172, 2006
Minimal sodium channel pore consisting of S5-P-S6 segments preserves intracellular pharmacology
Pincin, C; Ferrera, L; Moran, O
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (PRINT), 334, 2005