Zuccolini Paolo; Ferrera Loretta; Remigante Alessia; Picco Cristiana; Barbieri Raffaella; Bertelli Sara; Moran Oscar; Gavazzo Paola; Pusch Michael
British journal of pharmacology, 2022
DOI: 10.1111/bph.15810
Small Angle X-ray Scattering Sensing Membrane Composition: The Role of Sphingolipids in Membrane-Amyloid beta-Peptide Interaction
Carrotta Rita; Mangione Maria Rosalia; Librizzi Fabio; Moran Oscar
Biology (Basel), 2022
DOI: 10.3390/biology11010026
Modulator Combination Improves In Vitro the Microrheological Properties of the Airway Surface Liquid of Cystic Fibrosis Airway Epithelia
Ludovico Alessandra; Moran Oscar and Baroni Debora
International journal of molecular sciences (Online), 2022
DOI: 10.3390/ijms231911396
Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart
Zechini Luigi, Camilleri-Brennan Julian, Walsh Jonathan, Beaven Robin, Moran Oscar, Hartley Paul S. S., Diaz Mary and Denholm Barry
Frontiers in physiology, 2022
DOI: 10.3389/fphys.2022.1003999
The application of bicarbonate recovers the chemical-physical properties of airway surface liquid in cystic fibrosis epithelia models
Ferrera L.; Capurro V.; Delpiano L.; Gianotti A.; Moran O.
Biology (Basel), 2021
DOI: 10.3390/biology10040278
Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis
Brandas C.; Ludovico A.; Parodi A.; Moran O.; Millo E.; Cichero E.; Baroni D.
Biomolecules, 2021
DOI: 10.3390/biom11101417
Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore M.; Picco C.; Moran O.
Scientific reports (Nature Publishing Group), 2020
DOI: 10.1038/s41598-020-65287-4
Small molecule anion carriers correct abnormal airway surface liquid properties in cystic fibrosis airway epithelia
Gianotti A.; Capurro V.; Delpiano L.; Mielczarek M.; Garcia-valverde M.; Carreira-barral I.; Ludovico A.; Fiore M.; Baroni D.; Moran O.; Quesada R.; Caci E.
International journal of molecular sciences (Print), 2020
DOI: 10.3390/ijms21041488
WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
Carusone, Teresa Maria; Cardiero, Giovanna; Cerreta, Mariangela; Mandrich, Luigi; Moran, Oscar; Porzio, Elena; Catara, Giuliana; Lacerra, Giuseppina; Manco, Giuseppe
Cell death and disease, 2020
DOI: 10.1038/s41419-020-2504-2
The different anion transport capability of prodiginine- and tambjamine-like molecules
Fiore M.; Garcia-Valverde M.; Carreira-Barral I.; Moran O.
European journal of pharmacology, 2020
DOI: 10.1016/j.ejphar.2020.173592
Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra and Capurro, Valeria and Delpiano, Livia and Mielczarek, Marcin and Garcia-Valverde, Maria and Carreira-Barral, Israel and Ludovico, Alessandra and Fiore, Michele and Baroni, Debora and Moran, Oscar and Quesada, Roberto and Caci, Emanuela
International journal of molecular sciences (Online), 2020
DOI: 10.3390/ijms21041488
Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore Michele; Picco Cristiana and Moran Oscar
Scientific reports (Nature Publishing Group), 2020
DOI: 10.1038/s41598-020-65287-4
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
The journal of physical chemistry. B, 2019
DOI: 10.1021/acs.jpcb.8b11719
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 2019
DOI: 10.1111/bph.14649
Lumacaftor-rescued F508del-CFTR has a modified bicarbonate permeability
Ferrera Loretta; Baroni Debora; Moran Oscar
Journal of cystic fibrosis, 2019
DOI: 10.1016/j.jcf.2019.01.012
Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors
Amico Giulia; Brandas Chiara; Moran Oscar; Baroni Debora
International journal of molecular sciences (Online), 2019
DOI: 10.3390/ijms20215463
Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 2018
DOI: 10.3389/fphar.2018.00852
Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R
Scientific reports (Nature Publishing Group), 2018
DOI: 10.1038/s41598-018-20708-3
A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Human mutation, 2018
DOI: 10.1002/humu.23589
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces (Print), 2018
DOI: 10.1016/j.colsurfb.2018.06.032
The gating of the CFTR channel
Moran O.
Cellular and molecular life sciences (Print. ed.), 2017
DOI: 10.1007/s00018-016-2390-z
The biophysics, biochemistry and physiology of CFTR
Moran O.
Cellular and molecular life sciences (Print. ed.), 2017
DOI: 10.1007/s00018-016-2384-x
Mutation E87Q of the beta 1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Scientific reports (Nature Publishing Group), 2017
DOI: 10.1038/s41598-017-10645-y
Pharmacological rescue of mutant CFTR protein improves the viscoelastic properties of CF mucus
Gianotti A, Capurro V, Scudieri P, Galietta LJ, Moran O, Zegarra-Moran O
Journal of cystic fibrosis, 2016
DOI: 10.1016/j.jcf.2015.11.003
Structure of wild type and mutant F508del CFTR: A small-angle X-ray scattering study of the protein-detergent complexes
Pollock NL, Satriano L, Zegarra-Moran O, Ford RC, Moran O
Journal of structural biology (Online), 2016
DOI: 10.1016/j.jsb.2016.02.004
Intermolecular interactions in the TMEM16A dimer controlling channel activity
Scudieri P, Musante I, Gianotti A, Moran O, Galietta L
Scientific reports (Nature Publishing Group), 2016
DOI: 10.1038/srep38788
Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.010
Differential gene expression profiles of two excitable rat cell lines after over-expression of WT- and C121W-?1 sodium channel subunits
Baroni, D.; Moran, O.
Neuroscience, 2015
DOI: 10.1016/j.neuroscience.2015.03.052
Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS
Baroni, Debora; Zegarra-Moran, Olga; Moran, Oscar
Cellular and molecular life sciences (Print. ed.), 2015
DOI: 10.1007/s00018-014-1747-4
On the interactions between nucleotide binding domains and membrane spanning domains in cystic fibrosis transmembrane regulator: A molecular dynamic study
Belmonte, Luca; Belmonte, Luca; Moran, Oscar
Biochimie (Print), 2015
DOI: 10.1016/j.biochi.2015.01.010
On the multiple roles of the voltage gated sodium channel beta1 subunit in genetic diseases.
Baroni, Debora; Moran, Oscar
Frontiers in Pharmacology, 2015
DOI: 10.3389/fphar.2015.00108
On the structural organization of the intracellular domains of CFTR
Moran O.
International journal of biochemistry & cell biology, 2014
DOI: 10.1016/j.biocel.2014.01.024
Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression
Baroni, Debora; Picco, Cristiana; Barbieri, Raffaella; Moran, Oscar
Biology of the cell, 2014
DOI: 10.1111/boc.201300040
Direct interaction of a cftr potentiator and a cftr corrector with phospholipid bilayers
Baroni D.; Zegarra-Moran O.; Svensson A.; Moran O.
European biophysics journal, 2014
DOI: 10.1007/s00249-014-0956-y
Characterisation of the salmon cystic fibrosis transmembrane conductance regulator protein for structural studies.
Pollock,Naomi L, Moran,Oscar, Baroni,Debora, Zegarra-Moran,Olga, Ford,Robert,C.
AIMS Molecular Science, 2014
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR
Marasini C; Galeno L; Moran O
Cellular and molecular life sciences (Print. ed.), 2013
DOI: 10.1007/s00018-012-1172-5
Visualization of single proteins from stripped native cell membranes: A protocol for high-resolution atomic force microscopy
C. Marasini, E. Jacchetti, M. Moretti, C. Canale, O. Moran, M. Vassalli
Microscopy research and technique (Online), 2013
DOI: 10.1002/jemt.22223
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR
Marasini C, Galeno L, Moran O
Cellular and molecular life sciences (Print. ed.), 2013
Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels
Moran O, Grottesi A, Chadburn AJ, Tammaro P.
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2012.10.006
Functional modulation of voltage-dependent sodium channel expression by wild type and mutated C121W-?1 subunit
Baroni, Debora; Barbieri, Raffaella; Picco, Cristiana; Moran, Oscar
Journal of bioenergetics and biomembranes, 2013
DOI: 10.1007/s10863-013-9510-3
A potentiator induces conformational changes on the recombinant CFTR nucleotide binding domains in solution.
Galfre' E; Galeno L.; Moran O.
Cellular and molecular life sciences (Print. ed.), 2012
DOI: 10.1007/s00018-012-1049-7
Thermodynamic study of the native and phosphorylated regulatory domain of the CFTR
Marasini, C.; Galeno, L.; Moran, O.
Biochemical and biophysical research communications (Print), 2012
DOI: 10.1016/j.bbrc.2012.05.165
Identification of an intra-molecular disulfide bond in the sodium channel beta 1-subunit
Barbieri R; Baroni D; Moran O
Biochemical and biophysical research communications (Print), 2012
DOI: 10.1016/j.bbrc.2012.02.163
Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution
Galeno L, Galfrè E, Moran O
European biophysics journal, 2011
Molecular differential expression of voltage-gated sodium channel ± and ² subunit mRNAs in five different mammalian cell lines
Baroni D, Moran O
Journal of bioenergetics and biomembranes, 2011
Molecular differential expression of voltage-gated sodium channel ? and ? subunit mRNAs in five different mammalian cell lines
Baroni, Debora; Moran, Oscar
Journal of bioenergetics and biomembranes, 2011
DOI: 10.1007/s10863-011-9399-7
Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution
Galeno, Lauretta; Galfre, Elena; Moran, Oscar
European biophysics journal, 2011
DOI: 10.1007/s00249-011-0692-5
Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1.
Bisignano P; Moran O.
Biochimie (Print), 2010
DOI: 10.1016/j.biochi.2009.09.007
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators.
Moran O.
Journal of theoretical biology, 2010
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators
Moran, Oscar
Journal of theoretical biology, 2010
DOI: 10.1016/j.jtbi.2009.08.032
ATP binding to the C-terminus of the Arabidopsis thaliana, AtCLCa, regulates nitrate transport into plant vacuoles.
De Angeli A.; Moran O.; Wege S.; Filleur S.; Ephritikhine G.; Thomine S.; Barbier-Brygoo H.; Gambale F.
The Journal of biological chemistry (Print), 2009
DOI: 10.1074/jbc.M109.005132
Molecular determinants of ammonia and urea conductance in plant aquaporin homologs.
Dynowski M, Mayer M, Moran O, Ludewig U.
FEBS letters (Print), 2008
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering.
Moran O.; Roessle M.W.; Mariuzza R.A.; Dimasi N.
Biophysical journal (Print), 2008
DOI: 10.1529/biophysj.107.116590
Plant plasma membrane water channels conduct the signaling molecule H2O2.
Dynowski M; Schaaf G; Loque D; Moran O; Ludewig U.
Biochemical journal (Lond., 1984), 2008
DOI: 10.1042/BJ20080287
On the measurement of the functional properties of the CFTR
Moran O, Zegarra-Moran, O.
Journal of cystic fibrosis, 2008
Plant plasma membrane water channels conduct the signalling molecule H2O2
M. Dynowski, G. Schaaf, D. Loque, O. Moran, U. Ludewig
Biochemical journal (Lond., 1984), 2008
On the measurement of the functional properties of the CFTR
Moran, Oscar; Zegarra-Moran, Olga
Journal of cystic fibrosis, 2008
DOI: 10.1016/j.jcf.2008.05.003
Functional analysis of mutations in the putative binding site for cystic fibrosis transmembrane conductance regulator potentiators: Interaction between activation and inhibition.
Zegarra-Moran O; Monteverde M; Galietta LJ; Moran O
The Journal of biological chemistry (Print), 2007
DOI: 10.1074/jbc.M611411200
Molecular analysis and solution structure from small-angle X-ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a)
Dimasi N., Roessle M., Moran O, Candiano G., Svergun D.I. and Biassoni R.
International journal of biological macromolecules, 2007
Leishmania amazonensis: Anionic currents expressed in oocytes upon microinjection of mRNA from the parasite.
Lagos M LF, Moran O, Camacho M.
Experimental parasitology, 2007
Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel.
Pedemonte N; Boido D; Moran O; Giampieri ; Mazzei M; Ravazzolo R; Galietta LJ.
Molecular pharmacology (Print), 2007
DOI: 10.1124/mol.107.034702
The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1.
Márquez JA; Galfré E; Dupeux F; Flot D; Moran O; Dimasi N.
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2007.01.011
Characterizazion of a 7,8-benzoflavone double effect on CFTR CI- channel activity.
Ferrera L, Pincin C, Moran O.
The journal of membrane biology (Internet), 2007
beta1 subunit modulates the Nav1.4 sodium channel by changing the surface charge.
Ferrera L., Moran O.
Experimental brain research, 2006
Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains.
Moran O.; Galietta L.J.V.; Zegarra-Moran O.
Cellular and molecular life sciences (Print. ed.), 2005
DOI: 10.1007/s00018-004-4422-3
A quantitative description of the activation and inhibition of CFTR by potentiators: Genistein.
Moran Oscar; Zegarra-Moran Olga
FEBS letters (Print), 2005
DOI: 10.1016/j.febslet.2005.06.026
Minimal sodium channel pore consisting of S5-P-S6 segments preserves intracellular pharmacology
Pincin C., Ferrera L., Moran O.
Biochemical and biophysical research communications (Print), 2005
Effects of Intracellular Magnesium on Kv1.5 and Kv2.1 Potassium Channels.
Tammaro P., Smirnov S., Moran O.
European biophysics journal, 2005
Identification of an antigenic domain near the C-terminus of human granulocyte-macrophage colony-stimulating factor and its spatial localization.
Chiarini R., Moran O., Revoltella R.
The Journal of biological chemistry (Print), 2004
Identification of cftr activators and inhibitors: chance or design?
Galietta L.J.V., Moran O.
Current opinion in pharmacology (Print), 2004
Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in mammalian cells.
Moran O. ; Picollo A. ; Conti F.
Biophysical journal (Print), 2003
Sodium channel heterologous expression in mammalian cells and the role of the endogenous b1-subunits.
Moran O., Conti F., Tammaro P.
Neuroscience letters (Print), 2003
Molecular modeling of p-chlorophenoxyacetic acid binding to the ClC-0 channel.
Moran O. 1, Traverso S. 1, Elia L. 1, Pusch M. 1
Biochemistry (Easton), 2003
Modulation of sodium current in mammalian cells by an epilepsy-correlated beta 1-subunit mutation
P. Tammaro, F. Conti, O. Moran,
Biochemical and biophysical research communications (Print), 2002
DOI: 10.1006/bbrc.2002.6570
Conduction properties of arctic fish peripheral nerves
O. Moran, R. Melani
Polar biology (Print), 2001
Molecular simulation of the interaction of kappa-conotoxin-PVIIa with the shaker potassium channel pore
O. Moran
European biophysics journal, 2001
Skeletal muscle sodium channel is affected by an epileptogenic beta1 subunit mutation
O. Moran, F. Conti
Biochemical and biophysical research communications (Print), 2001
Modulation of the rSKM1 sodium channel ?-subunit by the ?1-subunit does not modify the inactivation kinetics
O. Moran,
Neuroscience research communications (Print), 2000
Functional properties of sodium channels do not depend on the cytoskeleton integrity
O. Moran, P. Tammaro, M. Nizzari, F. Conti
Biochemical and biophysical research communications (Print), 2000
Endogenous expression of the ?1a sodium channel subunit in HEK-293 cells
O. Moran, M. Nizzari, F. Conti
FEBS letters (Print), 2000
DOI: 10.1016/S0014-5793(00)01518-0
Conduction of nervous impulse at low temperature in Polar fishes
O. Moran
The Italian journal of zoology (Modena), 2000
KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs
M. Piccini, F. Vitelli, M. Seri, L .J. Galietta, O. Moran, A. Bulfone, S. Banfi, B. Pober, A. Renieri,
Genomics (S. Diego Calif.), 1999
Characterization of a murine gene homologous to the bovine cacc chloride channel
L. Romio, L. Musante, R. Cinti, M. Seri, O. Moran, O. Zegarra-Moran, L .J. Galietta
Gene (Amst.), 1999
Myopathic mutations affect differently the inactivation of the two gating modes of sodium channel
O. Moran, M. Nizzari, F. Conti,
Journal of bioenergetics and biomembranes, 1999
Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore region
A. Boccaccio, O. Moran, K. Imoto, F. Conti
Biophysical journal (Print), 1999
Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation
M. Aiello, O. Moran, M. Pisciotta, F. Gambale
European biophysics journal, 1998
Calcium dependent shifts of Na+ channel activation correlated with the state-dependence of calcium-binding to the pore
A. Boccaccio, O. Moran, F. Conti
European biophysics journal, 1998
Fast- and slow-gating modes of the sodium channel are altered by a paramyotonia congenita-linked mutation
O. Moran, R. Melani, M. Nizzari, F. Conti
Journal of bioenergetics and biomembranes, 1998
Characterization of the conduction properties in mediterranean fish peripheral nerves
R. Melani, O. Moran
The Italian journal of zoology (Modena), 1998
Inactivation defects produced by a myopathic ii-s6 mutation of the muscle sodium channe
O. Moran, M. Nizzari, F. Conti
Biochemical and biophysical research communications (Print), 1998
Simulation of action potential damping produced by anticonvulsant drugs
G. Rauch, O. Moran, M. Nobile
Pharmacological research (Print), 1997
Accumulation of long-lasting inactivation in rat brain K+ channel
A. Bertoli, O. Moran, F. Conti
Experimental brain research, 1996
Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism
F. Conti, A. Gheri, M. Pusch, O. Moran
Biophysical journal (Print), 1996
Prediction of polypeptide secondary structures analysing the oscillation of the hydropathy profile
G. Rauch, O. Moran
Computer methods and programs in biomedicine (Print), 1995
Properties of the Kv1.1 rat brain potassium channels expressed in mammalian cells: temperature effects
O. Moran, F. Conti
Biochemical and biophysical research communications (Print), 1995
Inward rectifier potassium channels in plants differ from their animal counterparts in response to voltage and channel modulators
R. Hedrich, O. Moran, F. Conti, H. Busch, D. Becker, F. Gambale, I. Dreyer, A. Küch, K. Neuwinger, K. Palme
European biophysics journal, 1995
DOI: 10.1007/BF00211406
On the structure of mitochondrial porins and its homologies with bacterial porins
G. Rauch, O. Moran
Biochemical and biophysical research communications (Print), 1994
DOI: 10.1006/bbrc.1994.1536
Activation and deactivation properties of rat brain K+ channels of the shaker-related subfamily
A. Bertoli, O. Moran, F. Conti
European biophysics journal, 1994
Proline mutations on the S4 segment of brain sodium channel II
O. Moran, A. Gheri, O. Zegarra-Moran, K. Imoto, F. Conti,
Biochemical and biophysical research communications (Print), 1994
Properties of the transient potassium currents in cerebellar granule cells
O. Zegarra-Moran, O. Moran
Experimental brain research, 1994
Currents activated by GABA and their modulation by Zn2+ in cerebellar granule cells in culture
G. Kilic, O. Moran, E. Cherubini
European journal of neuroscience (Print), 1993
Channels in mitochondrial membranes: knowns, unknowns, and prospects for the future
M .C. Sorgato, O. Moran
Critical reviews in biochemistry and molecular biology, 1993
DOI: 10.3109/10409239309086793
Modulation of voltage-dependent calcium channels by glutamate in rat cerebellar granule cells in culture
O. Zegarra-Moran, O. Moran
Experimental brain research, 1993
Physical characterization of the pore forming cytolysine from gardnerella vaginalis
O. Moran, O. Zegarra-Moran, C. Virginio, L. Gusmani, G .D. Rottini
FEMS microbiology immunology, 1992
High-conductance pathways in mitochondrial membranes
O. Moran, M .C. Sorgato
Journal of bioenergetics and biomembranes, 1992
Ionic permeability of the mitochondrial outer membrane
O. Moran, M. Sciancalepore, G. Sandri, E. Panfili, R. Bassi, C. Ballarin, M .C. Sorgato
European biophysics journal, 1992
Development of voltage-dependent ionic currents in rat cerebellar granule cells grown in primary culture
Z. Galdzicki, F. Lin, O. Moran, A. Novelli, G. Puia, M. Sciancalepore
International Journal of Neuroscience, 1991
N-methyl-d-aspartate receptor-mediated spontaneous activity in cerebellar granule cells in culture
G. Kili?, O. Moran, E. Cherubini
Neuroscience letters (Print), 1991
Competitive blockage of the sodium channel by intracellular magnesium ions in central mammalian neurones
F. Lin, F. Conti, O. Moran
European biophysics journal, 1991
Voltage dependent calcium channels in cerebellar granule cell primary cultures
O. Moran, F. Lin, O. Zegarra-Moran, M. Sciancalepore
European biophysics journal, 1991
Voltage-dependent cationic channels formed by a cytolytic toxin produced by gardnerella vaginalis
O. Moran, O. Zegarra-Moran, C. Virginio, G. Rottini
FEBS letters (Print), 1991
Voltage-dependent calcium currents in trigeminal chick neurons
Z. Ga?dzicki, G. Puia, M. Sciancalepore, O. Moran
Biochemical and biophysical research communications (Print), 1990
Voltage dependent sodium currents in cultured rat cerebellar granule cells
F. Lin, O. Moran
Bioscience reports, 1990
Kainate activated single channel currents as revealed by domoic acid
M. Sciancalepore, Z. Ga?dzicki, X. Zheng, O. Moran
European biophysics journal, 1990
Electrophysiological characterization of contact sites in brain mitochondria
O. Moran, G. Sandri, E. Panfili, W. Stühmer, M .C. Sorgato
European biophysics journal, 1990
Sodium ionic and gating currents in mammalian cells
O. Moran, F. Conti
European biophysics journal, 1990
Changes of n-methyl-d-aspartate activated channels of cerebellar granule cells with days in culture
M. Sciancalepore, L. Forti, O. Moran
Biochemical and biophysical research communications (Print), 1989
Further investigation on the high-conductance ion channel of the inner membrane of mitochondria
M .C. Sorgato, O. Moran, V. De Pinto, B .U. Keller, W. Stuehmer
Journal of bioenergetics and biomembranes, 1989
Requena La comunidad científica en Venezuela para 1983: Una descripción preliminar de su productividad
W. Lemoine, O. Moran, A. Valencia, J. Requena
Interciencia, 1988
A comparision of the effect of experimental anesthetics on nerve impulse blockade and on proteinatious target site
Requena, J., O. Moran, and Malavé, P. A
Biochemical and biophysical research communications (Print), 1988
Sistema de adquisición de datos y control para microcomputadoras personales
Lemoine, L. Moran,O. Requena J
Acta científica venezolana, 1988
An x-ray diffraction study of changes in myelin structure during experimental allergic neuritis
E. Vonasek, O. Moran, L. Mateu
Journal of neurocytology (Print), 1987
Generación del impulso nervioso: un modelo de simulación para microcomputadoras personales como herramienta auxiliar en la docencia universitaria
O. Moran, J.E. Smith, y J. Requena
Interciencia, 1986
Reversible changes in myelin membrane stucture and electrical activity during anesthesia in vivo
L. Mateu, O.Moran
Biochimica et biophysica acta (Print), 1986
Lossening of the paranodal myelin by the repetitive propagation of action potential
O. Moran, L. Mateu
Nature (Lond.), 1983
Variability of oxygen affinity of blood: human subjects native to high altitude
R .M. Winslow, C .C. Monge, N .J. Statham, C .G. Gibson, S. Charache, J. Whittembury, O. Moran, R .L. Berger
Journal of applied physiology (1985), 1981
Efectos hematologicos del veneno del Loxosceles laeta en ratones albinos
O. Moran, A. Zavaleta, R. Castro de la Mata
Boletín chileno de parasitología (Impr.), 1981
Oxygen transport in guinea pig native to high altitude (Junin, Peru - 4105)
Z. Turek, B. Ringnalda, O. Moran, F. Kreuzer
Pflügers Archiv, 1980
Oscar Moran
BSc in Biology (1978) e MSc in Biophysics (1979), Universidad Peruana Cayetano Heredia, Lima. PhSc Physiology and Biophysics, Instituto Venezolano de Investigaciones Cientificas, Caracas.
orcid://0000-0003-1287-6176, ncbi://47761049
Research interests:
- Genetic diseases caused by mutations of the auxiliary subunits of the sodium channel (Principal investigator)
- Molecular pharmacology of cystic fibrosis (Principal investigator)
Further collaborations:
- Loretta Ferrera (Istituto Giannina Gaslini, Genova)
- Luis J.V. Galietta (Tigem, Napoli)
Financial support:
- Identification of the binding sites of CFTR correctors. Progetto FFC#8/2016, Fondazione per la Ricerca sulla Fibrosi Cistica
- Transmembrane anion transporters as new chemotherapeutics for the treatment of cystic fibrosis.
- Grant agreement No 667079, European Union’s Horizon 2020 research and innovation programme.
Key publications:
Moran, Oscar. “The Biophysics, Biochemistry and Physiology of CFTR.” Cellular and Molecular Life Sciences: CMLS, October 4, 2016. https://doi.org/10.1007/s00018-016-2384-x.
Pollock, Naomi L., Letizia Satriano, Olga Zegarra-Moran, Robert C. Ford, and Oscar Moran. “Structure of Wild Type and Mutant F508del CFTR: A Small-Angle X-Ray Scattering Study of the Protein-Detergent Complexes.” Journal of Structural Biology 194, no. 1 (April 2016): 102–11. https://doi.org/10.1016/j.jsb.2016.02.004.
Fiore, Michele, Claudia Cossu, Valeria Capurro, Cristiana Picco, Alessandra Ludovico, Marcin Mielczarek, Israel Carreira-Barral, et al. “Small Molecule-Facilitated Anion Transporters in Cells for a Novel Therapeutic Approach to Cystic Fibrosis.” British Journal of Pharmacology 176, no. 11 (2019): 1764–79. https://doi.org/10.1111/bph.14649.
Gianotti, Ambra, Valeria Capurro, Paolo Scudieri, Luis J. V. Galietta, Oscar Moran, and Olga Zegarra-Moran. “Pharmacological Rescue of Mutant CFTR Protein Improves the Viscoelastic Properties of CF Mucus.” Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society 15, no. 3 (May 2016): 295–301. https://doi.org/10.1016/j.jcf.2015.11.003.
Baroni, Debora, Olga Zegarra-Moran, and Oscar Moran. “Functional and Pharmacological Induced Structural Changes of the Cystic Fibrosis Transmembrane Conductance Regulator in the Membrane Solved Using SAXS.” Cell Mol Life Sci 72, no. 7 (April 2015): 1363–75.
Publications (128):
The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca2+ in melanoma and pancreatic duct adenocarcinoma cell linesZuccolini Paolo; Ferrera Loretta; Remigante Alessia; Picco Cristiana; Barbieri Raffaella; Bertelli Sara; Moran Oscar; Gavazzo Paola; Pusch Michael
British journal of pharmacology, 2022
DOI: 10.1111/bph.15810
Small Angle X-ray Scattering Sensing Membrane Composition: The Role of Sphingolipids in Membrane-Amyloid beta-Peptide Interaction
Carrotta Rita; Mangione Maria Rosalia; Librizzi Fabio; Moran Oscar
Biology (Basel), 2022
DOI: 10.3390/biology11010026
Modulator Combination Improves In Vitro the Microrheological Properties of the Airway Surface Liquid of Cystic Fibrosis Airway Epithelia
Ludovico Alessandra; Moran Oscar and Baroni Debora
International journal of molecular sciences (Online), 2022
DOI: 10.3390/ijms231911396
Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart
Zechini Luigi, Camilleri-Brennan Julian, Walsh Jonathan, Beaven Robin, Moran Oscar, Hartley Paul S. S., Diaz Mary and Denholm Barry
Frontiers in physiology, 2022
DOI: 10.3389/fphys.2022.1003999
The application of bicarbonate recovers the chemical-physical properties of airway surface liquid in cystic fibrosis epithelia models
Ferrera L.; Capurro V.; Delpiano L.; Gianotti A.; Moran O.
Biology (Basel), 2021
DOI: 10.3390/biology10040278
Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis
Brandas C.; Ludovico A.; Parodi A.; Moran O.; Millo E.; Cichero E.; Baroni D.
Biomolecules, 2021
DOI: 10.3390/biom11101417
Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore M.; Picco C.; Moran O.
Scientific reports (Nature Publishing Group), 2020
DOI: 10.1038/s41598-020-65287-4
Small molecule anion carriers correct abnormal airway surface liquid properties in cystic fibrosis airway epithelia
Gianotti A.; Capurro V.; Delpiano L.; Mielczarek M.; Garcia-valverde M.; Carreira-barral I.; Ludovico A.; Fiore M.; Baroni D.; Moran O.; Quesada R.; Caci E.
International journal of molecular sciences (Print), 2020
DOI: 10.3390/ijms21041488
WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
Carusone, Teresa Maria; Cardiero, Giovanna; Cerreta, Mariangela; Mandrich, Luigi; Moran, Oscar; Porzio, Elena; Catara, Giuliana; Lacerra, Giuseppina; Manco, Giuseppe
Cell death and disease, 2020
DOI: 10.1038/s41419-020-2504-2
The different anion transport capability of prodiginine- and tambjamine-like molecules
Fiore M.; Garcia-Valverde M.; Carreira-Barral I.; Moran O.
European journal of pharmacology, 2020
DOI: 10.1016/j.ejphar.2020.173592
Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra and Capurro, Valeria and Delpiano, Livia and Mielczarek, Marcin and Garcia-Valverde, Maria and Carreira-Barral, Israel and Ludovico, Alessandra and Fiore, Michele and Baroni, Debora and Moran, Oscar and Quesada, Roberto and Caci, Emanuela
International journal of molecular sciences (Online), 2020
DOI: 10.3390/ijms21041488
Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore Michele; Picco Cristiana and Moran Oscar
Scientific reports (Nature Publishing Group), 2020
DOI: 10.1038/s41598-020-65287-4
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
The journal of physical chemistry. B, 2019
DOI: 10.1021/acs.jpcb.8b11719
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 2019
DOI: 10.1111/bph.14649
Lumacaftor-rescued F508del-CFTR has a modified bicarbonate permeability
Ferrera Loretta; Baroni Debora; Moran Oscar
Journal of cystic fibrosis, 2019
DOI: 10.1016/j.jcf.2019.01.012
Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors
Amico Giulia; Brandas Chiara; Moran Oscar; Baroni Debora
International journal of molecular sciences (Online), 2019
DOI: 10.3390/ijms20215463
Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 2018
DOI: 10.3389/fphar.2018.00852
Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R
Scientific reports (Nature Publishing Group), 2018
DOI: 10.1038/s41598-018-20708-3
A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Human mutation, 2018
DOI: 10.1002/humu.23589
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces (Print), 2018
DOI: 10.1016/j.colsurfb.2018.06.032
The gating of the CFTR channel
Moran O.
Cellular and molecular life sciences (Print. ed.), 2017
DOI: 10.1007/s00018-016-2390-z
The biophysics, biochemistry and physiology of CFTR
Moran O.
Cellular and molecular life sciences (Print. ed.), 2017
DOI: 10.1007/s00018-016-2384-x
Mutation E87Q of the beta 1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Scientific reports (Nature Publishing Group), 2017
DOI: 10.1038/s41598-017-10645-y
Pharmacological rescue of mutant CFTR protein improves the viscoelastic properties of CF mucus
Gianotti A, Capurro V, Scudieri P, Galietta LJ, Moran O, Zegarra-Moran O
Journal of cystic fibrosis, 2016
DOI: 10.1016/j.jcf.2015.11.003
Structure of wild type and mutant F508del CFTR: A small-angle X-ray scattering study of the protein-detergent complexes
Pollock NL, Satriano L, Zegarra-Moran O, Ford RC, Moran O
Journal of structural biology (Online), 2016
DOI: 10.1016/j.jsb.2016.02.004
Intermolecular interactions in the TMEM16A dimer controlling channel activity
Scudieri P, Musante I, Gianotti A, Moran O, Galietta L
Scientific reports (Nature Publishing Group), 2016
DOI: 10.1038/srep38788
Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.010
Differential gene expression profiles of two excitable rat cell lines after over-expression of WT- and C121W-?1 sodium channel subunits
Baroni, D.; Moran, O.
Neuroscience, 2015
DOI: 10.1016/j.neuroscience.2015.03.052
Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS
Baroni, Debora; Zegarra-Moran, Olga; Moran, Oscar
Cellular and molecular life sciences (Print. ed.), 2015
DOI: 10.1007/s00018-014-1747-4
On the interactions between nucleotide binding domains and membrane spanning domains in cystic fibrosis transmembrane regulator: A molecular dynamic study
Belmonte, Luca; Belmonte, Luca; Moran, Oscar
Biochimie (Print), 2015
DOI: 10.1016/j.biochi.2015.01.010
On the multiple roles of the voltage gated sodium channel beta1 subunit in genetic diseases.
Baroni, Debora; Moran, Oscar
Frontiers in Pharmacology, 2015
DOI: 10.3389/fphar.2015.00108
On the structural organization of the intracellular domains of CFTR
Moran O.
International journal of biochemistry & cell biology, 2014
DOI: 10.1016/j.biocel.2014.01.024
Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression
Baroni, Debora; Picco, Cristiana; Barbieri, Raffaella; Moran, Oscar
Biology of the cell, 2014
DOI: 10.1111/boc.201300040
Direct interaction of a cftr potentiator and a cftr corrector with phospholipid bilayers
Baroni D.; Zegarra-Moran O.; Svensson A.; Moran O.
European biophysics journal, 2014
DOI: 10.1007/s00249-014-0956-y
Characterisation of the salmon cystic fibrosis transmembrane conductance regulator protein for structural studies.
Pollock,Naomi L, Moran,Oscar, Baroni,Debora, Zegarra-Moran,Olga, Ford,Robert,C.
AIMS Molecular Science, 2014
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR
Marasini C; Galeno L; Moran O
Cellular and molecular life sciences (Print. ed.), 2013
DOI: 10.1007/s00018-012-1172-5
Visualization of single proteins from stripped native cell membranes: A protocol for high-resolution atomic force microscopy
C. Marasini, E. Jacchetti, M. Moretti, C. Canale, O. Moran, M. Vassalli
Microscopy research and technique (Online), 2013
DOI: 10.1002/jemt.22223
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR
Marasini C, Galeno L, Moran O
Cellular and molecular life sciences (Print. ed.), 2013
Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels
Moran O, Grottesi A, Chadburn AJ, Tammaro P.
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2012.10.006
Functional modulation of voltage-dependent sodium channel expression by wild type and mutated C121W-?1 subunit
Baroni, Debora; Barbieri, Raffaella; Picco, Cristiana; Moran, Oscar
Journal of bioenergetics and biomembranes, 2013
DOI: 10.1007/s10863-013-9510-3
A potentiator induces conformational changes on the recombinant CFTR nucleotide binding domains in solution.
Galfre' E; Galeno L.; Moran O.
Cellular and molecular life sciences (Print. ed.), 2012
DOI: 10.1007/s00018-012-1049-7
Thermodynamic study of the native and phosphorylated regulatory domain of the CFTR
Marasini, C.; Galeno, L.; Moran, O.
Biochemical and biophysical research communications (Print), 2012
DOI: 10.1016/j.bbrc.2012.05.165
Identification of an intra-molecular disulfide bond in the sodium channel beta 1-subunit
Barbieri R; Baroni D; Moran O
Biochemical and biophysical research communications (Print), 2012
DOI: 10.1016/j.bbrc.2012.02.163
Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution
Galeno L, Galfrè E, Moran O
European biophysics journal, 2011
Molecular differential expression of voltage-gated sodium channel ± and ² subunit mRNAs in five different mammalian cell lines
Baroni D, Moran O
Journal of bioenergetics and biomembranes, 2011
Molecular differential expression of voltage-gated sodium channel ? and ? subunit mRNAs in five different mammalian cell lines
Baroni, Debora; Moran, Oscar
Journal of bioenergetics and biomembranes, 2011
DOI: 10.1007/s10863-011-9399-7
Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution
Galeno, Lauretta; Galfre, Elena; Moran, Oscar
European biophysics journal, 2011
DOI: 10.1007/s00249-011-0692-5
Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1.
Bisignano P; Moran O.
Biochimie (Print), 2010
DOI: 10.1016/j.biochi.2009.09.007
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators.
Moran O.
Journal of theoretical biology, 2010
Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators
Moran, Oscar
Journal of theoretical biology, 2010
DOI: 10.1016/j.jtbi.2009.08.032
ATP binding to the C-terminus of the Arabidopsis thaliana, AtCLCa, regulates nitrate transport into plant vacuoles.
De Angeli A.; Moran O.; Wege S.; Filleur S.; Ephritikhine G.; Thomine S.; Barbier-Brygoo H.; Gambale F.
The Journal of biological chemistry (Print), 2009
DOI: 10.1074/jbc.M109.005132
Molecular determinants of ammonia and urea conductance in plant aquaporin homologs.
Dynowski M, Mayer M, Moran O, Ludewig U.
FEBS letters (Print), 2008
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering.
Moran O.; Roessle M.W.; Mariuzza R.A.; Dimasi N.
Biophysical journal (Print), 2008
DOI: 10.1529/biophysj.107.116590
Plant plasma membrane water channels conduct the signaling molecule H2O2.
Dynowski M; Schaaf G; Loque D; Moran O; Ludewig U.
Biochemical journal (Lond., 1984), 2008
DOI: 10.1042/BJ20080287
On the measurement of the functional properties of the CFTR
Moran O, Zegarra-Moran, O.
Journal of cystic fibrosis, 2008
Plant plasma membrane water channels conduct the signalling molecule H2O2
M. Dynowski, G. Schaaf, D. Loque, O. Moran, U. Ludewig
Biochemical journal (Lond., 1984), 2008
On the measurement of the functional properties of the CFTR
Moran, Oscar; Zegarra-Moran, Olga
Journal of cystic fibrosis, 2008
DOI: 10.1016/j.jcf.2008.05.003
Functional analysis of mutations in the putative binding site for cystic fibrosis transmembrane conductance regulator potentiators: Interaction between activation and inhibition.
Zegarra-Moran O; Monteverde M; Galietta LJ; Moran O
The Journal of biological chemistry (Print), 2007
DOI: 10.1074/jbc.M611411200
Molecular analysis and solution structure from small-angle X-ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a)
Dimasi N., Roessle M., Moran O, Candiano G., Svergun D.I. and Biassoni R.
International journal of biological macromolecules, 2007
Leishmania amazonensis: Anionic currents expressed in oocytes upon microinjection of mRNA from the parasite.
Lagos M LF, Moran O, Camacho M.
Experimental parasitology, 2007
Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel.
Pedemonte N; Boido D; Moran O; Giampieri ; Mazzei M; Ravazzolo R; Galietta LJ.
Molecular pharmacology (Print), 2007
DOI: 10.1124/mol.107.034702
The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1.
Márquez JA; Galfré E; Dupeux F; Flot D; Moran O; Dimasi N.
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2007.01.011
Characterizazion of a 7,8-benzoflavone double effect on CFTR CI- channel activity.
Ferrera L, Pincin C, Moran O.
The journal of membrane biology (Internet), 2007
beta1 subunit modulates the Nav1.4 sodium channel by changing the surface charge.
Ferrera L., Moran O.
Experimental brain research, 2006
Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains.
Moran O.; Galietta L.J.V.; Zegarra-Moran O.
Cellular and molecular life sciences (Print. ed.), 2005
DOI: 10.1007/s00018-004-4422-3
A quantitative description of the activation and inhibition of CFTR by potentiators: Genistein.
Moran Oscar; Zegarra-Moran Olga
FEBS letters (Print), 2005
DOI: 10.1016/j.febslet.2005.06.026
Minimal sodium channel pore consisting of S5-P-S6 segments preserves intracellular pharmacology
Pincin C., Ferrera L., Moran O.
Biochemical and biophysical research communications (Print), 2005
Effects of Intracellular Magnesium on Kv1.5 and Kv2.1 Potassium Channels.
Tammaro P., Smirnov S., Moran O.
European biophysics journal, 2005
Identification of an antigenic domain near the C-terminus of human granulocyte-macrophage colony-stimulating factor and its spatial localization.
Chiarini R., Moran O., Revoltella R.
The Journal of biological chemistry (Print), 2004
Identification of cftr activators and inhibitors: chance or design?
Galietta L.J.V., Moran O.
Current opinion in pharmacology (Print), 2004
Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in mammalian cells.
Moran O. ; Picollo A. ; Conti F.
Biophysical journal (Print), 2003
Sodium channel heterologous expression in mammalian cells and the role of the endogenous b1-subunits.
Moran O., Conti F., Tammaro P.
Neuroscience letters (Print), 2003
Molecular modeling of p-chlorophenoxyacetic acid binding to the ClC-0 channel.
Moran O. 1, Traverso S. 1, Elia L. 1, Pusch M. 1
Biochemistry (Easton), 2003
Modulation of sodium current in mammalian cells by an epilepsy-correlated beta 1-subunit mutation
P. Tammaro, F. Conti, O. Moran,
Biochemical and biophysical research communications (Print), 2002
DOI: 10.1006/bbrc.2002.6570
Conduction properties of arctic fish peripheral nerves
O. Moran, R. Melani
Polar biology (Print), 2001
Molecular simulation of the interaction of kappa-conotoxin-PVIIa with the shaker potassium channel pore
O. Moran
European biophysics journal, 2001
Skeletal muscle sodium channel is affected by an epileptogenic beta1 subunit mutation
O. Moran, F. Conti
Biochemical and biophysical research communications (Print), 2001
Modulation of the rSKM1 sodium channel ?-subunit by the ?1-subunit does not modify the inactivation kinetics
O. Moran,
Neuroscience research communications (Print), 2000
Functional properties of sodium channels do not depend on the cytoskeleton integrity
O. Moran, P. Tammaro, M. Nizzari, F. Conti
Biochemical and biophysical research communications (Print), 2000
Endogenous expression of the ?1a sodium channel subunit in HEK-293 cells
O. Moran, M. Nizzari, F. Conti
FEBS letters (Print), 2000
DOI: 10.1016/S0014-5793(00)01518-0
Conduction of nervous impulse at low temperature in Polar fishes
O. Moran
The Italian journal of zoology (Modena), 2000
KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs
M. Piccini, F. Vitelli, M. Seri, L .J. Galietta, O. Moran, A. Bulfone, S. Banfi, B. Pober, A. Renieri,
Genomics (S. Diego Calif.), 1999
Characterization of a murine gene homologous to the bovine cacc chloride channel
L. Romio, L. Musante, R. Cinti, M. Seri, O. Moran, O. Zegarra-Moran, L .J. Galietta
Gene (Amst.), 1999
Myopathic mutations affect differently the inactivation of the two gating modes of sodium channel
O. Moran, M. Nizzari, F. Conti,
Journal of bioenergetics and biomembranes, 1999
Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore region
A. Boccaccio, O. Moran, K. Imoto, F. Conti
Biophysical journal (Print), 1999
Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation
M. Aiello, O. Moran, M. Pisciotta, F. Gambale
European biophysics journal, 1998
Calcium dependent shifts of Na+ channel activation correlated with the state-dependence of calcium-binding to the pore
A. Boccaccio, O. Moran, F. Conti
European biophysics journal, 1998
Fast- and slow-gating modes of the sodium channel are altered by a paramyotonia congenita-linked mutation
O. Moran, R. Melani, M. Nizzari, F. Conti
Journal of bioenergetics and biomembranes, 1998
Characterization of the conduction properties in mediterranean fish peripheral nerves
R. Melani, O. Moran
The Italian journal of zoology (Modena), 1998
Inactivation defects produced by a myopathic ii-s6 mutation of the muscle sodium channe
O. Moran, M. Nizzari, F. Conti
Biochemical and biophysical research communications (Print), 1998
Simulation of action potential damping produced by anticonvulsant drugs
G. Rauch, O. Moran, M. Nobile
Pharmacological research (Print), 1997
Accumulation of long-lasting inactivation in rat brain K+ channel
A. Bertoli, O. Moran, F. Conti
Experimental brain research, 1996
Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism
F. Conti, A. Gheri, M. Pusch, O. Moran
Biophysical journal (Print), 1996
Prediction of polypeptide secondary structures analysing the oscillation of the hydropathy profile
G. Rauch, O. Moran
Computer methods and programs in biomedicine (Print), 1995
Properties of the Kv1.1 rat brain potassium channels expressed in mammalian cells: temperature effects
O. Moran, F. Conti
Biochemical and biophysical research communications (Print), 1995
Inward rectifier potassium channels in plants differ from their animal counterparts in response to voltage and channel modulators
R. Hedrich, O. Moran, F. Conti, H. Busch, D. Becker, F. Gambale, I. Dreyer, A. Küch, K. Neuwinger, K. Palme
European biophysics journal, 1995
DOI: 10.1007/BF00211406
On the structure of mitochondrial porins and its homologies with bacterial porins
G. Rauch, O. Moran
Biochemical and biophysical research communications (Print), 1994
DOI: 10.1006/bbrc.1994.1536
Activation and deactivation properties of rat brain K+ channels of the shaker-related subfamily
A. Bertoli, O. Moran, F. Conti
European biophysics journal, 1994
Proline mutations on the S4 segment of brain sodium channel II
O. Moran, A. Gheri, O. Zegarra-Moran, K. Imoto, F. Conti,
Biochemical and biophysical research communications (Print), 1994
Properties of the transient potassium currents in cerebellar granule cells
O. Zegarra-Moran, O. Moran
Experimental brain research, 1994
Currents activated by GABA and their modulation by Zn2+ in cerebellar granule cells in culture
G. Kilic, O. Moran, E. Cherubini
European journal of neuroscience (Print), 1993
Channels in mitochondrial membranes: knowns, unknowns, and prospects for the future
M .C. Sorgato, O. Moran
Critical reviews in biochemistry and molecular biology, 1993
DOI: 10.3109/10409239309086793
Modulation of voltage-dependent calcium channels by glutamate in rat cerebellar granule cells in culture
O. Zegarra-Moran, O. Moran
Experimental brain research, 1993
Physical characterization of the pore forming cytolysine from gardnerella vaginalis
O. Moran, O. Zegarra-Moran, C. Virginio, L. Gusmani, G .D. Rottini
FEMS microbiology immunology, 1992
High-conductance pathways in mitochondrial membranes
O. Moran, M .C. Sorgato
Journal of bioenergetics and biomembranes, 1992
Ionic permeability of the mitochondrial outer membrane
O. Moran, M. Sciancalepore, G. Sandri, E. Panfili, R. Bassi, C. Ballarin, M .C. Sorgato
European biophysics journal, 1992
Development of voltage-dependent ionic currents in rat cerebellar granule cells grown in primary culture
Z. Galdzicki, F. Lin, O. Moran, A. Novelli, G. Puia, M. Sciancalepore
International Journal of Neuroscience, 1991
N-methyl-d-aspartate receptor-mediated spontaneous activity in cerebellar granule cells in culture
G. Kili?, O. Moran, E. Cherubini
Neuroscience letters (Print), 1991
Competitive blockage of the sodium channel by intracellular magnesium ions in central mammalian neurones
F. Lin, F. Conti, O. Moran
European biophysics journal, 1991
Voltage dependent calcium channels in cerebellar granule cell primary cultures
O. Moran, F. Lin, O. Zegarra-Moran, M. Sciancalepore
European biophysics journal, 1991
Voltage-dependent cationic channels formed by a cytolytic toxin produced by gardnerella vaginalis
O. Moran, O. Zegarra-Moran, C. Virginio, G. Rottini
FEBS letters (Print), 1991
Voltage-dependent calcium currents in trigeminal chick neurons
Z. Ga?dzicki, G. Puia, M. Sciancalepore, O. Moran
Biochemical and biophysical research communications (Print), 1990
Voltage dependent sodium currents in cultured rat cerebellar granule cells
F. Lin, O. Moran
Bioscience reports, 1990
Kainate activated single channel currents as revealed by domoic acid
M. Sciancalepore, Z. Ga?dzicki, X. Zheng, O. Moran
European biophysics journal, 1990
Electrophysiological characterization of contact sites in brain mitochondria
O. Moran, G. Sandri, E. Panfili, W. Stühmer, M .C. Sorgato
European biophysics journal, 1990
Sodium ionic and gating currents in mammalian cells
O. Moran, F. Conti
European biophysics journal, 1990
Changes of n-methyl-d-aspartate activated channels of cerebellar granule cells with days in culture
M. Sciancalepore, L. Forti, O. Moran
Biochemical and biophysical research communications (Print), 1989
Further investigation on the high-conductance ion channel of the inner membrane of mitochondria
M .C. Sorgato, O. Moran, V. De Pinto, B .U. Keller, W. Stuehmer
Journal of bioenergetics and biomembranes, 1989
Requena La comunidad científica en Venezuela para 1983: Una descripción preliminar de su productividad
W. Lemoine, O. Moran, A. Valencia, J. Requena
Interciencia, 1988
A comparision of the effect of experimental anesthetics on nerve impulse blockade and on proteinatious target site
Requena, J., O. Moran, and Malavé, P. A
Biochemical and biophysical research communications (Print), 1988
Sistema de adquisición de datos y control para microcomputadoras personales
Lemoine, L. Moran,O. Requena J
Acta científica venezolana, 1988
An x-ray diffraction study of changes in myelin structure during experimental allergic neuritis
E. Vonasek, O. Moran, L. Mateu
Journal of neurocytology (Print), 1987
Generación del impulso nervioso: un modelo de simulación para microcomputadoras personales como herramienta auxiliar en la docencia universitaria
O. Moran, J.E. Smith, y J. Requena
Interciencia, 1986
Reversible changes in myelin membrane stucture and electrical activity during anesthesia in vivo
L. Mateu, O.Moran
Biochimica et biophysica acta (Print), 1986
Lossening of the paranodal myelin by the repetitive propagation of action potential
O. Moran, L. Mateu
Nature (Lond.), 1983
Variability of oxygen affinity of blood: human subjects native to high altitude
R .M. Winslow, C .C. Monge, N .J. Statham, C .G. Gibson, S. Charache, J. Whittembury, O. Moran, R .L. Berger
Journal of applied physiology (1985), 1981
Efectos hematologicos del veneno del Loxosceles laeta en ratones albinos
O. Moran, A. Zavaleta, R. Castro de la Mata
Boletín chileno de parasitología (Impr.), 1981
Oxygen transport in guinea pig native to high altitude (Junin, Peru - 4105)
Z. Turek, B. Ringnalda, O. Moran, F. Kreuzer
Pflügers Archiv, 1980