Adamo, Giorgia; Picciotto, Sabrina; Santonicola, Pamela; Gargano, Paola; Rao, Estella; Paterna, Angela; Raccosta, Samuele; Smeraldi, Giulia; Paganini, Carolina; Romancino, Daniele; Salamone, Monica; Russo, Claudio; Arosio, Paolo; Di Schiavi, Elia; Manno, Mauro; Bongiovanni, Antonella
MATERIALS TODAY BIO, 37, 2026
DOI: 10.1016/j.mtbio.2026.102792
Extracellular vesicles from microalgae as natural bioactive agents for UVB protection, anti-aging, and skin depigmentation
Gargano, P; Picciotto, S; Paterna, A; Raccosta, S; Rao, E; Romancino, Dp; Smeraldi, G; Manno, M; Salamone, M; Zarovni, N; Adamo, G; Bongiovanni, A
BIOMEDICINE & PHARMACOTHERAPY, 194, 2026
DOI: 10.1016/j.biopha.2025.118961
Assessing enzyme activity to obtain a new functional prebiotic jam
Foti, P.; Romeo, F. V.; Amenta, M.; Papa, M.; Paterna, A.; Guarrasi, V.; Timpanaro, N.
FOOD BIOSCIENCE, 65, 2025
DOI: 10.1016/j.fbio.2025.106044
DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles
Adamo, Giorgia; Picciotto, Sabrina; Gargano, Paola; Paterna, Angela; Raccosta, Samuele; Rao, Estella; Romancino, Daniele Paolo; Ghersi, Giulio; Manno, Mauro; Salamone, Monica; Bongiovanni, Antonella
JOURNAL OF EXTRACELLULAR VESICLES, 14, 2025
DOI: 10.1002/jev2.70030
Effect of Circular‐Economy‐Derived Experimental Biostimulants on Growth and Development of Soilless Strawberry Plants in Greenhouse Conditions
Nazeer, Samreen; Agosti, Anna; Leto, Leandra; Amini, Ali; Remelli, Andrea; Di Fazio, Andrea; Turolla, Andrea; Paterna, Angela; Rao, Estella; Cirlini, Martina; Chiancone, Benedetta
JOURNAL OF SUSTAINABLE AGRICULTURE AND ENVIRONMENT, 4, 2025
DOI: 10.1002/sae2.70101
Loading Proteins into Extracellular Vesicles to Camouflage Protein Allergens
Rao, Estella; Paterna, Angela; Longo, Valeria; Aloi, Noemi; Adamo, Giorgia; Picciotto, Sabrina; Romancino, Daniele; Raccosta, Samuele; Bongiovanni, Antonella; Colombo, Paolo; Manno, Mauro
ACS OMEGA, 2025
DOI: 10.1021/acsomega.5c03419
Monoterpene Indole Alkaloids with Antimicrobial Activity Against Helicobacter pylori
Marques, Andreia T.; Tanoeiro, Luís; Paterna, Angela; Filomena Caeiro, Maria; Cardoso, David; Mulhovo, Silva; Vital, Joana S.; Carolina Pimentel, Ana; Ferreira, Maria-José U.; Vale, Filipa F.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26, 2025
DOI: 10.3390/ijms26167904
Optimizing sustainable production of high-quality microalgae-derived extracellular vesicles through batch-refeed perfusion cultivation
Picciotto, Sabrina; Belmonte, Dario; Gargano, Paola; Adamo, Giorgia; Paterna, Angela; Rao, Estella; Conlon, Thomas; Raccosta, Samuele; Romancino, Daniele Paolo; Smeraldi, Giulia; Salamone, Monica; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella
JOURNAL OF BIOTECHNOLOGY, 406, 2025
DOI: 10.1016/j.jbiotec.2025.07.016
Antioxidant properties and bioactivity of three marine microalgae on human cancer cell lines
Herbert, H.; Parkes, R.; Barone, M. E.; Mcdonnell, A.; Picciotto, S.; Adamo, G.; Paterna, A.; Manno, M.; Bongiovanni, A.; Touzet, N.; Campion, E.
Applied Phycology, 5, 2024
DOI: 10.1080/26388081.2024.2382146
Effects of Cultivation Stress on the Glaucophyte Cyanophora paradoxa and Bioactive Potential in Human Cancer Cell Lines
Herbert, H.; Parkes, R.; Barone, M. E.; Picciotto, S.; Adamo, G.; Paterna, A.; Manno, M.; Bongiovanni, A.; Campion, E.; Touzet, N.
PHYCOLOGIA, 63, 2024
DOI: 10.1080/00318884.2024.2330341
Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties
Adamo, Giorgia; Santonicola, Pamela; Picciotto, Sabrina; Gargano, Paola; Nicosia, Aldo; Longo, Valeria; Aloi, Noemi; Romancino, Daniele; Paterna, Angela; Rao, Estella; Raccosta, Samuele; Noto, Rosina; Salamone, Monica; Deidda, Irene; Costa, Salvatore; DI SANO, Caterina; Zampi, Giuseppina; Morsbach, Svenja; Landfester, Katharina; Colombo, Paolo; Wei, Mingxing; Bergese, Paolo; Touzet, Nicolas; Manno, Mauro; DI SCHIAVI, Elia; Bongiovanni, Antonella
COMMUNICATIONS BIOLOGY, 7, 2024
DOI: 10.1038/s42003-024-06612-9
alphaS1-Casein administration to a C. elegans model of Alzheimer's disease through proteoliposome delivery
Carrotta, Rita; Paterna, Angela; Santonicola, Pamela; DI PRIMA, Giulia; Rao, Estella; Raccosta, Samuele; Zampi, Giuseppina; Oscar, Moran; Manno, Mauro; DI SCHIAVI, Elia; Librizzi, Fabio
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 52, 2023
αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Paterna, A.; Santonicola, P.; Di Prima, G.; Rao, E.; Raccosta, S.; Zampi, G.; Russo, C.; Moran, O.; Manno, M.; Di Schiavi, E.; Librizzi, F.; Carrotta, R.
ACS CHEMICAL NEUROSCIENCE, 14, 2023
DOI: 10.1021/acschemneuro.3c00239
Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans
Picciotto, Sabrina; Santonicola, Pamela; Paterna, Angela; Rao, Estella; Raccosta, Samuele; Romancino Daniele, Paolo; Noto, Rosina; Touzet, Nicolas; Manno, Mauro; DI SCHIAVI, Elia; Bongiovanni, Antonella; Adamo, Giorgia
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10, 2022
DOI: 10.3389/fbioe.2022.830189
Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto, Sabrina; Barone, Maria E.; Fierli, David; Aranyos, Anita; Adamo, Giorgia; Bo?i?, Darja; Romancino, Daniele P.; Stanly, Christopher; Parkes, Rachel; Morsbach, Svenja; Raccosta, Samuele; Paganini, Carolina; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Capasso Palmiero, Umberto; Santonicola, Pamela; Igli?, Ales; Gai, Meiyu; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Landfester, Katharina; Liguori, Giovanna L.; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Manno, Mauro; Touzet, Nicolas; Bongiovanni, Antonella
biomaterials science (print)issn: 2047-4830royal society of chemistry, 9, 2021
DOI: 10.1039/d0bm01696a
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo, Giorgia; Fierli, David; Romancino, Daniele P.; Picciotto, Sabrina; Barone, Maria E.; Aranyos, Anita; Bo?i?, Darja; Morsbach, Svenja; Raccosta, Samuele; Stanly, Christopher; Paganini, Carolina; Gai, Meiyu; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Randazzo, Loredana; Parkes, Rachel; Capasso Palmiero, Umberto; Rao, Estella; Paterna, Angela; Santonicola, Pamela; Igli?, Ales; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Liguori, Giovanna L.; Landfester, Katharina; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella
journal of extracellular vesiclesissn: 2001-3078järfälla : co-action pub., 10, 2021
DOI: 10.1002/jev2.12081
Angela Paterna
Research staff
11/2019 - present PostDoc Fellowship at the CNR – IBF Palermo 04/2018 - 09/2019 Research Fellowship at the CNR – ICB Catania 05/2017 PhD in Pharmacy, Speciality in Pharmaceutical and Therapeutic Chemistry (SFRH/BD/77612/2011) at the Research Institute for Medicines (iMed.ULisboa, Lisbon) Faculty of Pharmacy, University of Lisbon (Natural Product Chemistry group). 05/2011-04/2012 Research fellowship (PTDC/QUI-QUI/099815/2008) at the Research Institute for Medicines (iMed.ULisboa, Lisbon) University of Lisbon. 10/2010 Master Degree in Chemistry and Pharmaceutical Technology at the Faculty of Pharmacy, University of Palermo, Italy.
orcid://0000-0002-4903-4143,
Contact:
- Email angela.paterna@ibf.cnr.it
- Phone +39-091-6809556
- Location Palermo
Research interests:
- Cell-based technologies and bioactives for research and innovation (Cell-Tech Hub)
Key publications:
Adamo et al. Journal of Extracellular Vesicles, 2021, 10(6), e12081
Raimundo et al. British Journal of Pharmacology, 2021, 178 (18), pp. 3627 - 3647
Sanfilippo et al. Bioorganic Chemistry, 2019, 93, 103325
Paterna et al. Bioorganic and Medicinal Chemistry, 2018, 26(2), pp. 421–434
Paterna et al. European Journal of Medicinal Chemistry, 2017, 128, pp. 247–257
Publications (16):
Engineered microalgal extracellular vesicles for efficient doxorubicin delivery and improved therapeutic efficacy in breast cancerAdamo, Giorgia; Picciotto, Sabrina; Santonicola, Pamela; Gargano, Paola; Rao, Estella; Paterna, Angela; Raccosta, Samuele; Smeraldi, Giulia; Paganini, Carolina; Romancino, Daniele; Salamone, Monica; Russo, Claudio; Arosio, Paolo; Di Schiavi, Elia; Manno, Mauro; Bongiovanni, Antonella
MATERIALS TODAY BIO, 37, 2026
DOI: 10.1016/j.mtbio.2026.102792
Extracellular vesicles from microalgae as natural bioactive agents for UVB protection, anti-aging, and skin depigmentation
Gargano, P; Picciotto, S; Paterna, A; Raccosta, S; Rao, E; Romancino, Dp; Smeraldi, G; Manno, M; Salamone, M; Zarovni, N; Adamo, G; Bongiovanni, A
BIOMEDICINE & PHARMACOTHERAPY, 194, 2026
DOI: 10.1016/j.biopha.2025.118961
Assessing enzyme activity to obtain a new functional prebiotic jam
Foti, P.; Romeo, F. V.; Amenta, M.; Papa, M.; Paterna, A.; Guarrasi, V.; Timpanaro, N.
FOOD BIOSCIENCE, 65, 2025
DOI: 10.1016/j.fbio.2025.106044
DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles
Adamo, Giorgia; Picciotto, Sabrina; Gargano, Paola; Paterna, Angela; Raccosta, Samuele; Rao, Estella; Romancino, Daniele Paolo; Ghersi, Giulio; Manno, Mauro; Salamone, Monica; Bongiovanni, Antonella
JOURNAL OF EXTRACELLULAR VESICLES, 14, 2025
DOI: 10.1002/jev2.70030
Effect of Circular‐Economy‐Derived Experimental Biostimulants on Growth and Development of Soilless Strawberry Plants in Greenhouse Conditions
Nazeer, Samreen; Agosti, Anna; Leto, Leandra; Amini, Ali; Remelli, Andrea; Di Fazio, Andrea; Turolla, Andrea; Paterna, Angela; Rao, Estella; Cirlini, Martina; Chiancone, Benedetta
JOURNAL OF SUSTAINABLE AGRICULTURE AND ENVIRONMENT, 4, 2025
DOI: 10.1002/sae2.70101
Loading Proteins into Extracellular Vesicles to Camouflage Protein Allergens
Rao, Estella; Paterna, Angela; Longo, Valeria; Aloi, Noemi; Adamo, Giorgia; Picciotto, Sabrina; Romancino, Daniele; Raccosta, Samuele; Bongiovanni, Antonella; Colombo, Paolo; Manno, Mauro
ACS OMEGA, 2025
DOI: 10.1021/acsomega.5c03419
Monoterpene Indole Alkaloids with Antimicrobial Activity Against Helicobacter pylori
Marques, Andreia T.; Tanoeiro, Luís; Paterna, Angela; Filomena Caeiro, Maria; Cardoso, David; Mulhovo, Silva; Vital, Joana S.; Carolina Pimentel, Ana; Ferreira, Maria-José U.; Vale, Filipa F.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26, 2025
DOI: 10.3390/ijms26167904
Optimizing sustainable production of high-quality microalgae-derived extracellular vesicles through batch-refeed perfusion cultivation
Picciotto, Sabrina; Belmonte, Dario; Gargano, Paola; Adamo, Giorgia; Paterna, Angela; Rao, Estella; Conlon, Thomas; Raccosta, Samuele; Romancino, Daniele Paolo; Smeraldi, Giulia; Salamone, Monica; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella
JOURNAL OF BIOTECHNOLOGY, 406, 2025
DOI: 10.1016/j.jbiotec.2025.07.016
Antioxidant properties and bioactivity of three marine microalgae on human cancer cell lines
Herbert, H.; Parkes, R.; Barone, M. E.; Mcdonnell, A.; Picciotto, S.; Adamo, G.; Paterna, A.; Manno, M.; Bongiovanni, A.; Touzet, N.; Campion, E.
Applied Phycology, 5, 2024
DOI: 10.1080/26388081.2024.2382146
Effects of Cultivation Stress on the Glaucophyte Cyanophora paradoxa and Bioactive Potential in Human Cancer Cell Lines
Herbert, H.; Parkes, R.; Barone, M. E.; Picciotto, S.; Adamo, G.; Paterna, A.; Manno, M.; Bongiovanni, A.; Campion, E.; Touzet, N.
PHYCOLOGIA, 63, 2024
DOI: 10.1080/00318884.2024.2330341
Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties
Adamo, Giorgia; Santonicola, Pamela; Picciotto, Sabrina; Gargano, Paola; Nicosia, Aldo; Longo, Valeria; Aloi, Noemi; Romancino, Daniele; Paterna, Angela; Rao, Estella; Raccosta, Samuele; Noto, Rosina; Salamone, Monica; Deidda, Irene; Costa, Salvatore; DI SANO, Caterina; Zampi, Giuseppina; Morsbach, Svenja; Landfester, Katharina; Colombo, Paolo; Wei, Mingxing; Bergese, Paolo; Touzet, Nicolas; Manno, Mauro; DI SCHIAVI, Elia; Bongiovanni, Antonella
COMMUNICATIONS BIOLOGY, 7, 2024
DOI: 10.1038/s42003-024-06612-9
alphaS1-Casein administration to a C. elegans model of Alzheimer's disease through proteoliposome delivery
Carrotta, Rita; Paterna, Angela; Santonicola, Pamela; DI PRIMA, Giulia; Rao, Estella; Raccosta, Samuele; Zampi, Giuseppina; Oscar, Moran; Manno, Mauro; DI SCHIAVI, Elia; Librizzi, Fabio
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 52, 2023
αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Paterna, A.; Santonicola, P.; Di Prima, G.; Rao, E.; Raccosta, S.; Zampi, G.; Russo, C.; Moran, O.; Manno, M.; Di Schiavi, E.; Librizzi, F.; Carrotta, R.
ACS CHEMICAL NEUROSCIENCE, 14, 2023
DOI: 10.1021/acschemneuro.3c00239
Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans
Picciotto, Sabrina; Santonicola, Pamela; Paterna, Angela; Rao, Estella; Raccosta, Samuele; Romancino Daniele, Paolo; Noto, Rosina; Touzet, Nicolas; Manno, Mauro; DI SCHIAVI, Elia; Bongiovanni, Antonella; Adamo, Giorgia
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10, 2022
DOI: 10.3389/fbioe.2022.830189
Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto, Sabrina; Barone, Maria E.; Fierli, David; Aranyos, Anita; Adamo, Giorgia; Bo?i?, Darja; Romancino, Daniele P.; Stanly, Christopher; Parkes, Rachel; Morsbach, Svenja; Raccosta, Samuele; Paganini, Carolina; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Capasso Palmiero, Umberto; Santonicola, Pamela; Igli?, Ales; Gai, Meiyu; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Landfester, Katharina; Liguori, Giovanna L.; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Manno, Mauro; Touzet, Nicolas; Bongiovanni, Antonella
biomaterials science (print)issn: 2047-4830royal society of chemistry, 9, 2021
DOI: 10.1039/d0bm01696a
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo, Giorgia; Fierli, David; Romancino, Daniele P.; Picciotto, Sabrina; Barone, Maria E.; Aranyos, Anita; Bo?i?, Darja; Morsbach, Svenja; Raccosta, Samuele; Stanly, Christopher; Paganini, Carolina; Gai, Meiyu; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Randazzo, Loredana; Parkes, Rachel; Capasso Palmiero, Umberto; Rao, Estella; Paterna, Angela; Santonicola, Pamela; Igli?, Ales; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Liguori, Giovanna L.; Landfester, Katharina; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella
journal of extracellular vesiclesissn: 2001-3078järfälla : co-action pub., 10, 2021
DOI: 10.1002/jev2.12081