Raboni, S.; Fumagalli, F.; Ceccone, G.; La Spina, R.; Ponti, J.; Mehn, D.; Guerrini, G.; Bettati, S.; Mozzarelli, A.; D'Acunto, M.; Presciuttini, G.; Cristallini, C.; Gabellieri, E.; Cioni, P.
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 653, 2024
DOI: 10.1016/j.ijpharm.2024.123882
Post-Translational Modifications of Histone Variants in the Absence and Presence of a Methionine-Depleting Enzyme in Normal and Cancer Cells
Montalbano, S; Raboni, S; Sidoli, S; Mozzarelli, A; Bettati, S; Buschini, A
CANCERS, 15, 2023
DOI: 10.3390/cancers15020527
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction
De Bei O.; Marchetti M.; Ronda L.; Gianquinto E.; Lazzarato L.; Chirgadze D.Y.; Hardwick S.W.; Cooper L.R.; Spyrakis F.; Luisi B.F.; Campanini B.; Bettati S.
proceedings of the national academy of sciences of the united states of america (online), 119, 2022
DOI: 10.1073/pnas.2116708119
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties
Pavone, Marialaura; Raboni, Samanta; Marchetti, Marialaura; Annunziato, Giannamaria; Bettati, Stefano; Papotti, Bianca; Marchi, Cinzia; Carosati, Emanuele; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
RESULTS IN CHEMISTRY, 4, 2022
DOI: 10.1016/j.rechem.2022.100443
From hemoglobin allostery to hemoglobin-based oxygen carriers
Faggiano S.; Ronda L.; Bruno S.; Abbruzzetti S.; Viappiani C.; Bettati S.; Mozzarelli A.
molecular aspects of medicine, 84, 2022
DOI: 10.1016/j.mam.2021.101050
Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95
Giaccari R.; Marchesani F.; Compari C.; Fisicaro E.; Mozzarelli A.; Campanini B.; Bettati S.; Bruno S.; Faggiano S.
international journal of molecular sciences (print), 23, 2022
DOI: 10.3390/ijms23094959
Use of Exogenous in Human Therapy: Approved Drugs and Potential Applications
Cioni, Patrizia and Gabellieri, Edi and Campanini, Barbara and Bettati, Stefano and Raboni, Samanta
current medicinal chemistryissn: 0929-8673bentham science publishers, 29, 2022
DOI: 10.2174/0929867328666210713094722
A competitive o-acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex
Marchetti M.; De Angelis F.S.; Annunziato G.; Costantino G.; Pieroni M.; Ronda L.; Mozzarelli A.; Campanini B.; Cannistraro S.; Bizzarri A.R.; Bettati S.
catalystsissn: 2073-4344molecular diversity preservation international, 11, 2021
DOI: 10.3390/catal11060700
A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine gamma-Lyase
Raboni, Samanta and Montalbano, Serena and Stransky, Stephanie and Garcia, Benjamin A. and Buschini, Annamaria and Bettati, Stefano and Sidoli, Simone and Mozzarelli, Andrea
frontiers in molecular biosciences, 8, 2021
DOI: 10.3389/fmolb.2021.735303
A novel assay for phosphoserine phosphatase exploiting serine acetyltransferase as the coupling enzyme
Marchesani F.; Zangelmi E.; Bruno S.; Bettati S.; Peracchi A.; Campanini B.
life (basel)issn: 2075-1729molecular diversity preservation international, 11, 2021
DOI: 10.3390/life11060485
Discovery of substituted (2-aminooxazol-4-yl)isoxazole-3- carboxylic acids as inhibitors of bacterial serine acetyltransferase in the quest for novel potential antibacterial adjuvants
Magalhaes J.; Franko N.; Raboni S.; Annunziato G.; Tammela P.; Bruno A.; Bettati S.; Armao S.; Spadini C.; Cabassi C.S.; Mozzarelli A.; Pieroni M.; Campanini B.; Costantino G.
pharmaceuticals (basel)issn: 1424-8247mdpi, molecular diversity preservation international,, 14, 2021
DOI: 10.3390/ph14020174
Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase
Michielon A.; Marchesani F.; Faggiano S.; Giaccari R.; Campanini B.; Bettati S.; Mozzarelli A.; Bruno S.
biochimica et biophysica acta. proteins and proteomicsissn: 1570-9639elsevier, 1869, 2021
DOI: 10.1016/j.bbapap.2020.140544
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant
Annunziato G.; Spadini C.; Franko N.; Storici P.; Demitri N.; Pieroni M.; Flisi S.; Rosati L.; Iannarelli M.; Marchetti M.; Magalhaes J.; Bettati S.; Mozzarelli A.; Cabassi C.S.; Campanini B.; Costantino G.
acs infectious diseasesissn: 2373-8227acs publications, 7, 2021
DOI: 10.1021/acsinfecdis.0c00378
Revealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange MS
Rosa B.; Dickinson E.R.; Marchetti M.; Campanini B.; Pioselli B.; Bettati S.; Rand K.D.
molecular & cellular proteomicsissn: 1535-9476american society for biochemistry and molecular biology,, 20, 2021
DOI: 10.1016/j.mcpro.2021.100098
Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
Cooper, Chris E. and Bird, Matthew and Sheng, XiaoBo and Choi, Ji-Won and Silkstone, Gary G. A. and Simons, Michelle and Syrett, Natalie and Piano, Riccardo and Ronda, Luca and Bettati, Stefano and Paredi, Gianluca and Mozzarelli, Andrea and Reeder, Brandon J.
frontiers in chemistry, 9, 2021
DOI: 10.3389/fchem.2021.707797
The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase
Marchesani, F. and Gianquinto, E. and Autiero, I. and Michielon, A. and Campanini, B. and Faggiano, S. and Bettati, S. and Mozzarelli, A. and Spyrakis, F. and Bruno, S.
european journal of biochemistryissn: 1432-1033federation of european biochemical societies, 288, 2021
DOI: 10.1111/febs.15645
Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality
Cooper, Chris E.; Silkstone, Gary G. A.; Simons, Michelle; Gretton, Svetlana; Rajagopal, Badri S.; Allen-Baume, Victoria; Syrett, Natalie; Shaik, Thoufieq; Popa, Gina; Sheng, XiaoBo; Bird, Matthew; Choi, Ji-Won; Piano, Riccardo; Ronda, Luca; Bettati, Stef
Biomaterials Science, 8, 2020
DOI: 10.1039/c9bm01773a
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
Magalhaes, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Paivi; Bruno, Agostino; Bettati, Stefano; Mozzarelli, Andrea; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
Acs Medicinal Chemistry Letters, 11, 2020
DOI: 10.1021/acsmedchemlett.9b00627
Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development
Marchetti, Marialaura; De Bei, Omar; Bettati, Stefano; Campanini, Barbara; Kovachka, Sandra; Gianquinto, Eleonora; Spyrakis, Francesca; Ronda, Luca
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21062145
Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection ofStaphylococcus aureus
Ronda, Luca; Tonelli, Alessandro; Sogne, Elisa; Autiero, Ida; Spyrakis, Francesca; Pellegrino, Sara; Abbiati, Giorgio; Maffioli, Elisa; Schulte, Carsten; Piano, Riccardo; Cozzini, Pietro; Mozzarelli, Andrea; Bettati, Stefano; Clerici, Francesca; Milani, P
Sensors, 20, 2020
DOI: 10.3390/s20174977
SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling
Ronda, Luca; Faggiano, Serena; Paredi, Gianluca; Michielon, Annalisa; Sartor, Franco; Raschini, Annamaria Soliani; Cavatorta, Valeria; Sgarbi, Elisa; Bettati, Stefano; Mozzarelli, Andrea
Journal Of Molecular Liquids, 298, 2020
DOI: 10.1016/j.molliq.2019.111983
Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action
Rosa B, Marchetti M, Paredi G, Amenitsch H, Franko N, Benoni R, Giabbai B, De Marino MG, Mozzarelli A, Ronda L, Storici P, Campanini B, Bettati S
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20205219
Allosteric communication of tryptophan synthase: Functional and regulatory properties of the βS178P mutant
Marabotti, A.; De Biase, D.; Tramonti, A.; Bettati, S.; Mozzarelli, A.
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 2001
DOI: 10.1074/jbc.M011781200
Stefano Bettati
Publications (23):
Conjugation to gold nanoparticles of methionine gamma-lyase, a cancer-starving enzyme. Physicochemical characterization of the nanocomplex for prospective nanomedicine applicationsRaboni, S.; Fumagalli, F.; Ceccone, G.; La Spina, R.; Ponti, J.; Mehn, D.; Guerrini, G.; Bettati, S.; Mozzarelli, A.; D'Acunto, M.; Presciuttini, G.; Cristallini, C.; Gabellieri, E.; Cioni, P.
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 653, 2024
DOI: 10.1016/j.ijpharm.2024.123882
Post-Translational Modifications of Histone Variants in the Absence and Presence of a Methionine-Depleting Enzyme in Normal and Cancer Cells
Montalbano, S; Raboni, S; Sidoli, S; Mozzarelli, A; Bettati, S; Buschini, A
CANCERS, 15, 2023
DOI: 10.3390/cancers15020527
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction
De Bei O.; Marchetti M.; Ronda L.; Gianquinto E.; Lazzarato L.; Chirgadze D.Y.; Hardwick S.W.; Cooper L.R.; Spyrakis F.; Luisi B.F.; Campanini B.; Bettati S.
proceedings of the national academy of sciences of the united states of america (online), 119, 2022
DOI: 10.1073/pnas.2116708119
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties
Pavone, Marialaura; Raboni, Samanta; Marchetti, Marialaura; Annunziato, Giannamaria; Bettati, Stefano; Papotti, Bianca; Marchi, Cinzia; Carosati, Emanuele; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
RESULTS IN CHEMISTRY, 4, 2022
DOI: 10.1016/j.rechem.2022.100443
From hemoglobin allostery to hemoglobin-based oxygen carriers
Faggiano S.; Ronda L.; Bruno S.; Abbruzzetti S.; Viappiani C.; Bettati S.; Mozzarelli A.
molecular aspects of medicine, 84, 2022
DOI: 10.1016/j.mam.2021.101050
Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95
Giaccari R.; Marchesani F.; Compari C.; Fisicaro E.; Mozzarelli A.; Campanini B.; Bettati S.; Bruno S.; Faggiano S.
international journal of molecular sciences (print), 23, 2022
DOI: 10.3390/ijms23094959
Use of Exogenous in Human Therapy: Approved Drugs and Potential Applications
Cioni, Patrizia and Gabellieri, Edi and Campanini, Barbara and Bettati, Stefano and Raboni, Samanta
current medicinal chemistryissn: 0929-8673bentham science publishers, 29, 2022
DOI: 10.2174/0929867328666210713094722
A competitive o-acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex
Marchetti M.; De Angelis F.S.; Annunziato G.; Costantino G.; Pieroni M.; Ronda L.; Mozzarelli A.; Campanini B.; Cannistraro S.; Bizzarri A.R.; Bettati S.
catalystsissn: 2073-4344molecular diversity preservation international, 11, 2021
DOI: 10.3390/catal11060700
A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine gamma-Lyase
Raboni, Samanta and Montalbano, Serena and Stransky, Stephanie and Garcia, Benjamin A. and Buschini, Annamaria and Bettati, Stefano and Sidoli, Simone and Mozzarelli, Andrea
frontiers in molecular biosciences, 8, 2021
DOI: 10.3389/fmolb.2021.735303
A novel assay for phosphoserine phosphatase exploiting serine acetyltransferase as the coupling enzyme
Marchesani F.; Zangelmi E.; Bruno S.; Bettati S.; Peracchi A.; Campanini B.
life (basel)issn: 2075-1729molecular diversity preservation international, 11, 2021
DOI: 10.3390/life11060485
Discovery of substituted (2-aminooxazol-4-yl)isoxazole-3- carboxylic acids as inhibitors of bacterial serine acetyltransferase in the quest for novel potential antibacterial adjuvants
Magalhaes J.; Franko N.; Raboni S.; Annunziato G.; Tammela P.; Bruno A.; Bettati S.; Armao S.; Spadini C.; Cabassi C.S.; Mozzarelli A.; Pieroni M.; Campanini B.; Costantino G.
pharmaceuticals (basel)issn: 1424-8247mdpi, molecular diversity preservation international,, 14, 2021
DOI: 10.3390/ph14020174
Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase
Michielon A.; Marchesani F.; Faggiano S.; Giaccari R.; Campanini B.; Bettati S.; Mozzarelli A.; Bruno S.
biochimica et biophysica acta. proteins and proteomicsissn: 1570-9639elsevier, 1869, 2021
DOI: 10.1016/j.bbapap.2020.140544
Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant
Annunziato G.; Spadini C.; Franko N.; Storici P.; Demitri N.; Pieroni M.; Flisi S.; Rosati L.; Iannarelli M.; Marchetti M.; Magalhaes J.; Bettati S.; Mozzarelli A.; Cabassi C.S.; Campanini B.; Costantino G.
acs infectious diseasesissn: 2373-8227acs publications, 7, 2021
DOI: 10.1021/acsinfecdis.0c00378
Revealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange MS
Rosa B.; Dickinson E.R.; Marchetti M.; Campanini B.; Pioselli B.; Bettati S.; Rand K.D.
molecular & cellular proteomicsissn: 1535-9476american society for biochemistry and molecular biology,, 20, 2021
DOI: 10.1016/j.mcpro.2021.100098
Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
Cooper, Chris E. and Bird, Matthew and Sheng, XiaoBo and Choi, Ji-Won and Silkstone, Gary G. A. and Simons, Michelle and Syrett, Natalie and Piano, Riccardo and Ronda, Luca and Bettati, Stefano and Paredi, Gianluca and Mozzarelli, Andrea and Reeder, Brandon J.
frontiers in chemistry, 9, 2021
DOI: 10.3389/fchem.2021.707797
The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase
Marchesani, F. and Gianquinto, E. and Autiero, I. and Michielon, A. and Campanini, B. and Faggiano, S. and Bettati, S. and Mozzarelli, A. and Spyrakis, F. and Bruno, S.
european journal of biochemistryissn: 1432-1033federation of european biochemical societies, 288, 2021
DOI: 10.1111/febs.15645
Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality
Cooper, Chris E.; Silkstone, Gary G. A.; Simons, Michelle; Gretton, Svetlana; Rajagopal, Badri S.; Allen-Baume, Victoria; Syrett, Natalie; Shaik, Thoufieq; Popa, Gina; Sheng, XiaoBo; Bird, Matthew; Choi, Ji-Won; Piano, Riccardo; Ronda, Luca; Bettati, Stef
Biomaterials Science, 8, 2020
DOI: 10.1039/c9bm01773a
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
Magalhaes, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Paivi; Bruno, Agostino; Bettati, Stefano; Mozzarelli, Andrea; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
Acs Medicinal Chemistry Letters, 11, 2020
DOI: 10.1021/acsmedchemlett.9b00627
Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development
Marchetti, Marialaura; De Bei, Omar; Bettati, Stefano; Campanini, Barbara; Kovachka, Sandra; Gianquinto, Eleonora; Spyrakis, Francesca; Ronda, Luca
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21062145
Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection ofStaphylococcus aureus
Ronda, Luca; Tonelli, Alessandro; Sogne, Elisa; Autiero, Ida; Spyrakis, Francesca; Pellegrino, Sara; Abbiati, Giorgio; Maffioli, Elisa; Schulte, Carsten; Piano, Riccardo; Cozzini, Pietro; Mozzarelli, Andrea; Bettati, Stefano; Clerici, Francesca; Milani, P
Sensors, 20, 2020
DOI: 10.3390/s20174977
SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling
Ronda, Luca; Faggiano, Serena; Paredi, Gianluca; Michielon, Annalisa; Sartor, Franco; Raschini, Annamaria Soliani; Cavatorta, Valeria; Sgarbi, Elisa; Bettati, Stefano; Mozzarelli, Andrea
Journal Of Molecular Liquids, 298, 2020
DOI: 10.1016/j.molliq.2019.111983
Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action
Rosa B, Marchetti M, Paredi G, Amenitsch H, Franko N, Benoni R, Giabbai B, De Marino MG, Mozzarelli A, Ronda L, Storici P, Campanini B, Bettati S
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20205219
Allosteric communication of tryptophan synthase: Functional and regulatory properties of the βS178P mutant
Marabotti, A.; De Biase, D.; Tramonti, A.; Bettati, S.; Mozzarelli, A.
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 2001
DOI: 10.1074/jbc.M011781200