Laura Lagostena
Research staff
Degree in biology (1991) at the University of Genova (Italy). PhD in Neuroscience (2002) at The Open University, London (UK)
orcid://0000-0001-6440-3720,
Contact:
- Email laura.lagostena@ibf.cnr.it
- Phone +39-010-6475560
- Location Genova
Research interests:
- Recordings of electronic currents from plant cytochromes
- Functional and structural studies of human CLC protein complexes involved in genetic diseases
Key publications:
New Insights into the Mechanism of NO 3 - Selectivity in the Human Kidney Chloride Channel ClC-Ka and the CLC Protein Family L. Lagostena, G. Zifarelli, A. Picollo. J Am Soc Nephrol. 2019 Feb;30(2):293-302. doi: 10.1681/ASN.2018060593
Pathobiologic Mechanisms of Neurodegeneration in Osteopetrosis Derived From Structural and Functional Analysis of 14 ClC-7 Mutants E. Di Zanni , E. Palagano, L. Lagostena , D. Strina , A. Rehman, M. Abinun , L. De Somer, B. Martire, J. Brown, A. Kariminejad, S. Balasubramaniam, G. Baynam, F. Gurrieri , M.A. Pisanti , I. De Maggio, M.R. Abboud, R. Chiesa, C. P Burren, Anna Villa , C. Sobacchi, A. Picollo. Bone Miner Res. 2021 Mar;36(3):531-545. doi: 10.1002/jbmr.4200
GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels E. Jeworutzki, L. Lagostena , X. Elorza-Vidal, T. López-Hernández, R. Estévez, M. Pusch Biophys J. 2014 Sep 2;107(5):1105-1116.doi: 10.1016/j.bpj.2014.07.040.
The human two-pore channel 1 is modulated by cytosolic and luminal calcium L. Lagostena, M. Festa, M. Pusch, A. Carpaneto. Sci Rep. 2017 Mar 2;7:43900. doi: 10.1038/srep43900.
Publications (36):
Tonoplast cytochrome b561 is a transmembrane ascorbate-dependent monodehydroascorbate reductase: functional characterization of electron currents in plant vacuolesGradogna, Antonella; Lagostena, Laura; Beltrami, Sara; Tosato, Edoardo; Picco, Cristiana; Scholz-Starke, Joachim; Sparla, Francesca; Trost, Paolo; Carpaneto, Armando
New phytologist (Print), 2023
DOI: 10.1111/nph.18823
Functional characterisation of electron currents in plant vacuoles: direct recordings of cytochrome b561A activity
Carpaneto Armando; Gradogna Antonella; Lagostena Laura; Beltrami Sara; Tosato Edoardo; Picco Cristiana; Scholz-Starke Joachim; Sparla Francesca; Trost Paolo
European biophysics journal, 2023
Current Methods to Unravel the Functional Properties of Lysosomal Ion Channels and Transporters
Festa Margherita; Minicozzi Velia; Boccaccio Anna; Lagostena Laura; Gradogna Antonella; Qi Tianwen; Costa Alex; Larisch Nina; Hamamoto Shin; *Pedrazzini Emanuela; Milenkovic Stefan; Scholz-Starke Joachim; Ceccarelli Matteo; *Vitale Alessandro; Dietrich Petra; Uozumi Nobuyuki; Gambale Franco; Carpaneto Armando.
Cells, 2022
DOI: 10.3390/cells11060921
Pathobiologic Mechanisms of Neurodegeneration in Osteopetrosis Derived from Structural and Functional Analysis of 14 ClC-7 Mutants
Eleonora Di Zanni, Eleonora Palagano, Laura Lagostena, Dario Strina , Asma Rehman, Mario Abinun, Lien De Somer, Baldassarre Martire, Justin Brown, Ariana Kariminejad, Shanti Balasubramanian, Gareth Baynam, Fiorella Gurrieri, Maria A Pisanti, Ilaria De Maggio, Miguel R Abboud, Robert Chiesa, Christine P Burren, Anna Villa, Cristina Sobacchi, Alessandra Picollo
Journal of bone and mineral research, 2021
DOI: 10.1002/jbmr.4200
The mechanism and energetics of a ligand-controlled hydrophobic gate in a mammalian two pore channel
Milenkovic S.; Bodrenko I.V.; Lagostena L.; Gradogna A.; Serra G.; Bosin A.; Carpaneto A.; Ceccarelli M.
PCCP. Physical chemistry chemical physics (Print), 2020
DOI: 10.1039/d0cp00805b
Immature Dentate Granule Cells Require Ntrk2/Trkb for the Formation of Functional Hippocampal Circuitry
Badurek S.; Griguoli M.; Asif-Malik A.; Zonta B.; Guo F.; Middei S.; Lagostena L.; Jurado-Parras M.T.; Gillingwater T.H.; Gruart A.; Delgado-Garcia J.M.; Cherubini E.; Minichiello L.
I, science (Print), 2020
DOI: 10.1016/j.isci.2020.101078
New Insights into the Mechanism of NO3 - Selectivity in the Human Kidney Chloride Channel ClC-Ka and the CLC Protein Family
Lagostena L, Zifarelli G, Picollo A
Journal of the American Society of Nephrology, 2019
DOI: 10.1681/ASN.2018060593
A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin
Benkerrou D.; Minicozzi V.; Gradogna A.; Milenkovic S.; Bodrenko I. V.; Festa M.; Lagostena L.; Cornara L.; D'Amore A.; Ceccarelli M.; Filippini A.; Carpaneto A.
Biophysical chemistry (Print), 2019
DOI: 10.1016/j.bpc.2019.106246
The human two-pore channel 1 is modulated by cytosolic and luminal calcium
Lagostena L, Festa M, Pusch M, Carpaneto A
Scientific reports (Nature Publishing Group), 2017
DOI: 10.1038/srep43900
The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H exchange activity.
Carpaneto A, Boccaccio A, Lagostena L, Di Zanni E, Scholz-Starke J
EMBO reports (Print), 2017
DOI: 10.15252/embr.201643814
Electron current recordings in living cells
Trost P, Picco C, Scholz-Starke J, Festa M, Lagostena L, Costa A, Sparla F, Carpaneto A
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.05.006
Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis
Pafumi I, Festa M, Papacci F, Lagostena L, Giunta C, Gutla V, Cornara L, Favia A, Palombi F, Gambale F, Filippini A, Carpaneto A
Scientific reports (Nature Publishing Group), 2017
DOI: 10.1038/s41598-017-04974-1
Identification and Functional Characterization of CLCN1 Mutations Found in Nondystrophic Myotonia Patients
Vindas-Smith R.; Fiore M.; Vasquez M.; Cuenca P.; del Valle G.; Lagostena L.; Gaitan-Penas H.; Estevez R.; Pusch M.; Morales F.
Human mutation, 2016
DOI: 10.1002/humu.22916
Using the plant vacuole as a biological system to investigate the functional properties of exogenous channels and transporters
M. Festa , L. Lagostena , A. Carpaneto
Biochimica et biophysica acta. Biomembranes, 2016
DOI: 10.1016/j.bbamem.2015.09.022
Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex
Yekhlef, Latefa; Breschi, Gian Luca; Lagostena, Laura; Russo, Giovanni; Taverna, Stefano
Journal of neurophysiology, 2015
DOI: 10.1152/jn.00841.2014
GlialCAM, a CLC-2 Cl- Channel Subunit, Activates the Slow Gate of CLC Chloride Channels
Jeworutzki, Elena; Lagostena, Laura; Elorza-Vidal, Xabier; Lopez-Hernandez, Tania; Estevez, Raul; Pusch, Michael
Biophysical journal (Print), 2014
DOI: 10.1016/j.bpj.2014.07.040
The depolarizing action of GABA controls early network activity in the developing hippocampus
Cherubini, Enrico; Griguoli, Marilena; Safiulina, Victoria; Lagostena, Laura
Molecular neurobiology, 2011
DOI: 10.1007/s12035-010-8147-z
Modulatory effects of S 38232, a non ?-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus
Lagostena, Laura; Danober, Laurence; Challal, Sylvie; Lestage, Pierre; Mocaër, Elisabeth; Trocmé-Thibierge, Caryn; Cherubini, Enrico
Neuropharmacology, 2010
DOI: 10.1016/j.neuropharm.2009.12.003
In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction
Lagostena, Laura; Rosato-Siri, Marcelo; D'Onofrio, Mara; Brandi, Rossella; Arisi, Ivan; Capsoni, Simona; Franzot, Jessica; Cattaneo, Antonino; Cherubini, Enrico
The Journal of neuroscience, 2010
DOI: 10.1523/JNEUROSCI.3326-09.2010
The partial ?7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus
Lagostena, Laura; Trocme-Thibierge, Caryn; Morain, Philippe; Cherubini, Enrico
Neuropharmacology, 2008
DOI: 10.1016/j.neuropharm.2007.11.016
Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase.
Boccaccio Anna 1; Lagostena Laura 1; Hagen Volker 2; Menini Anna 1
The Journal of general physiology, 2006
DOI: 10.1085/jgp.200609555
Carbon nanotube substrates boost neuronal electrical signaling
Lovat, Viviana; Pantarotto, Davide; Lagostena, Laura; Cacciari, Barbara; Grandolfo, Micaela; Righi, Massimo; Spalluto, Giampiero; Prato, Maurizio; Ballerini, Laura
Nano letters (Print), 2005
DOI: 10.1021/nl050637m
Electrophysiological properties of mouse bone marrow c-kit+ cells co-cultured onto neonatal cardiac myocytes
Lagostena, Laura; Avitabile, Daniele; De Falco, Elena; Orlandi, Alessia; Grassi, Francesca; Iachininoto, Maria Grazia; Ragone, Gianluca; Fucile, Sergio; Pompilio, Giulio; Eusebi, Fabrizio; Pesce, Maurizio; Capogrossi, Maurizio C.
Cardiovascular research, 2005
DOI: 10.1016/j.cardiores.2005.01.018
Olfaction: from odorant molecules to the olfactory cortex.
Menini, Anna; Lagostena, Laura; Boccaccio, Anna
News in physiological sciences, 2004
DOI: 10.1152/nips.1507.2003
Whole-cell recordings and photolysis of caged compounds in olfactory sensory neurons isolated from the mouse
Lagostena, Laura; Menini, Anna
Chemical senses, 2003
DOI: 10.1093/chemse/bjg063
Purinergic control of intercellular communication between Hensen's cells of the guinea-pig cochlea
Lagostena, L; Ashmore, JF; Kachar, B; Mammano, F
Journal of physiology (Lond., Print), 2001
DOI: 10.1111/j.1469-7793.2001.0693h.x
Intracellular calcium dynamics and membrane conductance changes evoked by Deiters' cell purinoceptor activation in the organ of Corti
Lagostena, T; Mammano, F
Cell calcium (Edinburgh), 2001
DOI: 10.1054/ceca.2000.0183
Frequency dependence of electrical coupling in Deiters' cells of the guinea pig cochlea
Lagostena, L; Cicuttin, A; Inda, J; Kachar, B; Mammano, F
Cell adhesion and communication (Softback), 2001
DOI: 10.3109/15419060109080760
Cholinergic control of membrane conductance and intracellular free Ca2+ in outer hair cells of the guinea pig cochlea
Evans, MG; Lagostena, L; Darbon, P; Mammano, F
Cell calcium (Edinburgh), 2000
DOI: 10.1054/ceca.2000.0145
Frequency dependence of electrical coupling in deiters' cells of the guinea pig cochlea
Lagostena, Laura; Cicuttin, Andres; Inda, Juan; Kachar, Bechara; Mammano, Fabio
Cell adhesion and communication (Softback), 2000
Large-conductance calcium-activated anion channel characteristics in neuroblastoma cells
Nobile, M.; Lagostena, L.
General physiology and biophysics (Tlacené vyd.), 2000
ATP-induced Ca2+ release in cochlear outer hair cells: Localization of an inositol triphosphate-gated Ca2+ store to the base of the sensory hair bundle
Mammano, F; Frolenkov, GI; Lagostena, L; Belyantseva, IA; Kurc, M; Dodane, V; Colavita, A; Kachar, B
The Journal of neuroscience, 1999
Intracellular gradients of free calcium visualized in sensory and neuronal cells by a high-performance fluorescence imaging system
Colavita, A.; Capello, G.; Ijaduola, R. B.; Cunei, A.; Lagostena, L.; Canepari, M.; Mammano, F.
Proceedings of SPIE, the International Society for Optical Engineering, 1999
A discriminant block among K+ channel types by phenytoin in neuroblastoma cells
Nobile, M.; Lagostena, L.
British journal of pharmacology, 1998
DOI: 10.1038/sj.bjp.0702035
Functional aspects of dexamethasone upregulated nicotinic acetylcholine receptors in C2C12 myotubes
Maestrone, E.; Lagostena, L.; Henning, R. H.; Den Hertog, A.; Nobile, Mario
Pharmacological research (Print), 1995
DOI: 10.1016/S1043-6618(05)80019-2
The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells
Nobile, M.; Magnelli, V.; Lagostena, L.; Mochca-Morales, J.; Possani, L. D.; Prestipino, G.
The journal of membrane biology (Print), 1994
DOI: 10.1007/BF00232674