Personal Card

Silvia Vilasi

Research staff


- Email
- Phone +39-091-6809338
- Location Palermo

Research interests:

- Extraction and characterization of polyphenols from complex systems of agri-food origin; study of antioxidant properties and of neuroprotective and anti-amyloidogenic effects in neurodegenerative processes
- Amyloid aggregation processes and their inhibition
- Model Membrane Systems and Interaction Studies
- Structure and Functionality of Molecular chaperones

Publications (17):

Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin
Sirangelo, Ivana and Borriello, Margherita and Vilasi, Silvia and Iannuzzi, Clara
International journal of molecular sciences (Online), 2020
DOI: 10.3390/ijms21134636

Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
The journal of physical chemistry. B, 2019
DOI: 10.1021/acs.jpcb.8b11719

Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 2019
DOI: 10.1021/acschemneuro.9b00183

Chaperonin of Group I: Oligomeric spectrum and biochemical and biological implications
Vilasi S, Bulone D, Caruso Bavisotto C, Campanella C, Marino Gammazza A, San Biagio PL, Cappello F, Conway de Macario E, Macario AJL
Frontiers in Molecular Biosciences, 2018
DOI: 10.3389/fmolb.2017.00099

Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 2017
DOI: 10.1039/c7ra05300b

Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.07.008

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging (Albany, N.Y. Online), 2016
DOI: 10.18632/aging.101004

Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, C. and Ortore, M.G. and Vilasi, S. and Carrotta, R. and Mangione, M.R. and Bulone, D. and Librizzi, F. and Spinozzi, F. and Burgio, G. and Amenitsch, H. and San Biagio, P.L.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Photo-inhibition of Ab fibrillation mediated by a newly designed fluorinated oxadiazole
M.R. Mangione1, A. Palumbo Piccionello1,2,3, C. Marino1,4, M.G. Ortore5, P. Picone6, S. Vilasi1, M. Di Carlo6, S. Buscemi1,2, D. Bulone1 and P.L. San Biagio1
RSC advances, 2015
DOI: 10.1039/c4ra13556c

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657

Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes
Canale, Claudio; Seghezza, Silvia; Vilasi, Silvia; Carrotta, Rita; Bulone, Donatella; Diaspro, Alberto; Biagio, Pier Luigi San; Dante, Silvia
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2013.07.010

Unraveling amyloid toxicity pathway in NIH3T3 cells by a combined proteomic and 1H-NMR metabonomic approach
Vilasi A; Vilasi S; Romano R; Acernese F; Barone F; Balestrieri ML; Maritato R; Irace G; Sirangelo I
Journal of cellular physiology (Print), 2013
DOI: 10.1002/jcp.24294

Resolution of the effects induced by W->F substitutions on the conformation and dynamics of the amyloid-forming apomyoglobin mutant W7FW14F
Infusini G; Iannuzzi C; Vilasi S; Birolo L; Pagnozzi D; Pucci P; Irace G; Sirangelo I
European biophysics journal, 2012
DOI: 10.1007/s00249-012-0829-1

alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp307417x

Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter (Print), 2012
DOI: 10.1088/0953-8984/24/24/244103