Personal Card

Eloise Mastrangelo

Research staff

I gradueted in Chemistry at the University of Florence, and obtained my PhD in Molecular and Cellular Biology at the the Department of Biomolecular Sciences and Biotechnology of the University of Milan.
After four years (2001-2005 ) in pharmaceutical companies (AlfaWasserman-Bologna e SienaBiotech-Siena), in June 2005 I became researcher at CNR-IBF.
Manager of IBF - Milano since 2018, I am currently a group leader for a team of more than 15 employees.
My main research interest concerns the development of new drugs through structural and functional studies of proteins involved in human pathologies among which tumors, rare diseases, virus infections and neuro-degenerative diseases. My studies integrates X-ray crystallography, Small-angle X-ray Scattering (SAXS) and, more-recently, Cryo-electron microscopy together with computational biology and AI methods and protein biochemistry and biophysics, to address biological questions related to different human diseases and to explore novel therapeutic strategies.
31.01.2024: 67 scientific publications, 3 patents. Scopus: h-index: 26

orcid://0000-0002-5968-8386, ncbi://14066347900


- Email
- Phone +39-02-23699540
- Location Milano


Research interests:

- Structure-based drug discovery (Principal investigator)
- Therapeutic effects of retromer stabilization in Amyotrophic Lateral Sclerosis (Principal investigator)
- Structural and biochemical bases of the pathogenicity of the Apoptosis Inducing Factor (AIF)
- Structure-based drug discovery on viral proteins
- Gelsolin physiopathology
- Structural analysis of proteins involved in various human diseases and research of new therapeutic strategies

Further collaborations:

- Le attività di ricerca vengono svolte in collaborazione con vari gruppi, locali, nazionali ed internazionali. Fra questi:
- -Laboratorio di Virologia Molecolare, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste
- -Laboratory of Molecular Virology and Antiviral Research, Dept. of Clinical and Biological Sciences, Università of Torino
- -Université de la Méditerranée, Unité des Virus Emergents, Marseille, France
- -Katholieke Universiteit Leuven, Laboratory of Virology, and Center for Drug Design & Development, Leuven, Belgium
- -Global Phasing Ltd., Cambridge, UK
- -Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Université Paris Sud 11, France
- -Laboratorio di Chimica Organica, Dipartimento di Chimica, Università di Milano
- -Department of Pharmaceutical Sciences, Università di Perugia
- -Divisione di Immunologia Molecolare, Istituto Tumori IRCSS, Milano
- -Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano
- -Istituto di neurologia sperimentale, Ospedale San Raffaele IRCCS, Milano
- -Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari
- -Ann Romney Center for Neurologic Diseases, Boston, USA

Financial support:


Key publications:

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. Mastrangelo E, Pezzullo M, De Burghgraeve T, Kaptein S, Pastorino B, Dallmeier K, de Lamballerie X, Neyts J, Hanson AM, Frick DN, Bolognesi M, Milani M. J Antimicrob Chemother. 2012;67(8):1884-94.

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment. Cossu F, Milani M, Mastrangelo E*, Lecis D*. *co-corresponding author. Comput Struct Biotechnol J. 2019;17:142-150. doi: 10.1016/j.csbj.2019.01.009.

Structure and activity of Kunjin virus NS3 helicase domain in relation to the low resolution structure of the full length NS3 protein. E. Mastrangelo, M. Milani, M. Bollati, B. Selisko, F. Peyrane, V. Pandini, G. Sorrentino, B. Canard, P. V. Konarev, D. I. Svergun and M. Bolognesi J. Mol. Biol. 2007; 372, 444-455.

Structure-based inhibition of Norovirus RNA-dependent RNA polymerases. Mastrangelo E, Pezzullo M, Tarantino D, Petazzi R, Germani F, Kramer D, Robel I, Rohayem J, Bolognesi M, Milani M. J Mol Biol. 2012; 419(3-4):198-210.

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis. Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci & Gianvito Martino. Nature Communications 2020, volume 11, Article number: 3848

Publications (66):

New Class of Benzodiazepinone Derivatives as Pro-Death Agents Targeting BIR Domains in Cancer Cells
Fiore M.; Mosconi M.; Boni F.; Parodi A.; Salis A.; Tasso B.; Mastrangelo E.; Millo E.; Cossu F.
Molecules (Basel, Online), 2023
DOI: 10.3390/molecules28010446

Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses
Bonotto R.M.; Boni F.; Milani M.; Chaves-Sanjuan A.; Franze S.; Selmin F.; Felicetti T.; Bolognesi M.; Konstantinidou S.; Poggianella M.; Marquez C.L.; Dattola F.; Zoppe M.; Manfroni G.; Mastrangelo E.; Marcello A.
Viruses, 2022
DOI: 10.3390/v14061157

Synthesis and Characterization of Novel Mono- And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult
Gornati D.; Ciccone R.; Vinciguerra A.; Ippati S.; Pannaccione A.; Petrozziello T.; Pizzi E.; Hassan A.; Colombo E.; Barbini S.; Milani M.; Caccavone C.; Randazzo P.; Muzio L.; Annunziato L.; Menegon A.; Secondo A.; Mastrangelo E.; Pignataro G.; Seneci P.
Journal of medicinal chemistry (Online), 2021
DOI: 10.1021/acs.jmedchem.1c00305

A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation
Bollati, Michela; Diomede, Luisa; Giorgino, Toni; Natale, Carmina; Fagnani, Elisa; Boniardi, Irene; Barbiroli, Alberto; Alemani, Rebecca; Beeg, Marten; Gobbi, Marco; Fakin, Ana; Mastrangelo, Eloise; Milani, Mario; Presciuttini, Gianluca; Gabellieri, Edi; Cioni, Patrizia; de Rosa, Matteo
Computational and Structural Biotechnology Journal, 2021
DOI: 10.1016/j.csbj.2021.11.025

Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative Analysis of the Redox-Dependent Interaction of the Apoptosis-Inducing Factor (AIF) with Its Protein Partner
Cocomazzi P.; Tarantino D.; Mastrangelo E.; Aliverti A.
Methods in molecular biology (Clifton N.J.), 2021
DOI: 10.1007/978-1-0716-1286-6_12

Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors
Milani M.; Donalisio M.; Bonotto R.M.; Schneider E.; Arduino I.; Boni F.; Lembo D.; Marcello A.; Mastrangelo E.
Antiviral research (Print), 2021
DOI: 10.1016/j.antiviral.2021.105055

Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-kappa B pathway
Cossu, Federica and Camelliti, Simone and Lecis, Daniele and Sorrentino, Luca and Majorini, Maria Teresa and Milani, Mario and Mastrangelo, Eloise
Computational and Structural Biotechnology Journal, 2021
DOI: 10.1016/j.csbj.2021.11.034

The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties
De Rosa Matteo; Barbiroli Alberto; Bonì Francesco; Scalone Emanuele; Mattioni Davide; Vanoni Maria A.; Patrone Marco; Bollati Michela; Mastrangelo Eloise; Giorgino Toni; Milani Mario
European biophysics journal, 2020
DOI: 10.1007/s00249-019-01409-9

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase
Cannalire, Rolando and Chan, Kitti Wing Ki and Burali, Maria Sole and Gwee, Chin Piaw and Wang, Sai and Astolfi, Andrea and Massari, Serena and Sabatini, Stefano and Tabarrini, Oriana and Mastrangelo, Eloise and Barreca, Maria Letizia and Cecchetti, Violetta and Vasudevan, Subhash G. and Manfroni, Giuseppe
ACS medicinal chemistry letters, 2020
DOI: 10.1021/acsmedchemlett.9b00619

Modulation of guanylate cyclase activating protein 1 (Gcap1) dimeric assembly by ca2+ or mg2+: Hints to understand protein activity
Francesco Bonì; Valerio Marino; Carlo Bidoia; Eloise Mastrangelo; Alberto Barbiroli; Daniele Dell'Orco and Mario Milani
Biomolecules, 2020
DOI: 10.3390/biom10101408

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
Muzio L.; Sirtori R.; Gornati D.; Eleuteri S.; Fossaghi A.; Brancaccio D.; Manzoni L.; Ottoboni L.; Feo L.D.; Quattrini A.; Mastrangelo E.; Sorrentino L.; Scalone E.; Comi G.; Marinelli L.; Riva N.; Milani M.; Seneci P.; Martino G.
Nature communications, 2020
DOI: 10.1038/s41467-020-17524-7

Comprehensive response to usutu virus following first isolation in blood donors in the friuli venezia giulia region of italy: Development of recombinant ns1-based serology and sensitivity to antiviral drugs
Caracciolo I.; Mora-Cardenas E.; Aloise C.; Carletti T.; Segat L.; Burali M.S.; Chiarvesio A.; Totis V.; Avsic-zupanc T.; Mastrangelo E.; Manfroni G.; D'Agaro P.; Marcello A.
PLoS neglected tropical diseases, 2020
DOI: 10.1371/journal.pntd.0008156

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase
Cannalire R.; Ki Chan K.W.; Burali M.S.; Gwee C.P.; Wang S.; Astolfi A.; Massari S.; Sabatini S.; Tabarrini O.; Mastrangelo E.; Barreca M.L.; Cecchetti V.; Vasudevan S.G.; Manfroni G.
ACS medicinal chemistry letters, 2020
DOI: 10.1021/acsmedchemlett.9b00619

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro
Dragoni F.; Boccuto A.; Picarazzi F.; Giannini A.; Giammarino F.; Saladini F.; Mori M.; Mastrangelo E.; Zazzi M.; Vicenti I.
Antiviral research (Print), 2020
DOI: 10.1016/j.antiviral.2020.104708

Computational and experimental characterization of NF023, a candidate anticancer compound inhibiting cIAP2/TRAF2 assembly
Cossu Federica; Sorrentino Luca; Fagnani Elisa; Zaffaroni Mattia; Milani Mario; Giorgino Toni; Mastrangelo Eloise
Journal of chemical information and modeling (Online), 2020
DOI: 10.1021/acs.jcim.0c00518

Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage
Antonio Coluccia, Michela Puxeddu, Marianna Nalli, Chih-Ku Wei, Yu-Hsuan Wu, Eloise Mastrangelo, Tasneem Elamin, Delia Tarantino, Joachim Jakob Bugert, Benno Schreiner, Juliane Nolte, Frank Schwarze, Giuseppe La Regina, Jin-Ching Lee, Romano Silvestri
ACS medicinal chemistry letters, 2020
DOI: 10.1021/acsmedchemlett.9b00405

An alternative non-proteolytic mechanism may underlie AGel amyloidosis
Bonì F, Milani M, Mastrangelo E, Babiroli A, Diomede L, de Rosa M
Amyloid (Online), 2019
DOI: 10.1080/13506129.2019.1582510

High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion
Bollati M, Scalone E, Bonì F, Mastrangelo E, Giorgino T, Milani M, de Rosa M
Biochemical and biophysical research communications (Print), 2019
DOI: 10.1016/j.bbrc.2019.08.013

Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant
Giorgino T, Mattioni D, Hassan A, Milani M, Mastrangelo E, Barbiroli A, Verhelle A, Gettemans J, Barzago MM, Diomede L, de Rosa M
Biochimica et biophysica acta. Molecular basis of disease, 2019
DOI: 10.1016/j.bbadis.2019.01.010

Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1
Sorrentino L, Cossu F, Milani M, Malkoc B, Huang WC, Tsay SC, Ru Hwu J, Mastrangelo E
ChemistryOpen, 2019
DOI: 10.1002/open.201900059

Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa
Uruburu M, Mastrangelo E, Bolognesi M, Ferrara S, Bertoni G, Milani M
Journal of structural biology (Print), 2019
DOI: 10.1016/j.jsb.2018.12.004

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment
Cossu F, Milani M, Mastrangelo E, Lecis D
Computational and Structural Biotechnology Journal, 2019
DOI: 10.1016/j.csbj.2019.01.009

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions
Cannalire R, Tarantino D, Piorkowski G, Carletti T, Massari S, Felicetti T, Barreca ML, Sabatini S, Tabarrini O, Marcello A, Milani M, Cecchetti V, Mastrangelo E, Manfroni G, Querat G
Antiviral research (Print), 2019
DOI: 10.1016/j.antiviral.2019.03.004

A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea
Van Dycke J, Arnoldi F, Papa G, Vandepoele J, Burrone OR, Mastrangelo E, Tarantino D, Heylen E, Neyts J, Rocha-Pereira J
The journal of infectious diseases (Online. University of Chicago Press), 2018
DOI: 10.1093/infdis/jiy398

Role and inhibition of GLI1 protein in cancer
Mastrangelo E, Milani M
Lung cancer (Auckl.), 2018
DOI: 10.2147/LCTT.S124483

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs
Corti A, Milani M, Lecis D, Seneci P, de Rosa M, Mastrangelo E, Cossu F
The FEBS journal (Print), 2018
DOI: 10.1111/febs.14616

Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles
Eichwald C, De Lorenzo G, Schraner EM, Papa G, Bollati M, Swuec P, de Rosa M, Milani M, Mastrangelo E, Ackermann M, Burrone OR, Arnoldi F
Journal of virology (Print), 2018
DOI: 10.1128/JVI.01943-17

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase
Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V
European journal of medicinal chemistry (Online), 2018
DOI: 10.1016/j.ejmech.2017.10.064

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein
Bonì F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M
Human molecular genetics online, 2018
DOI: 10.1093/hmg/ddx383

Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor
Sorrentino L, Cossu F, Milani M, Aliverti A, Mastrangelo E
Biochemical and biophysical research communications (Print), 2017
DOI: 10.1016/j.bbrc.2017.06.156

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor
Tarantino D, Cannalire R, Mastrangelo E, Croci R, Querat G, Barreca ML, Bolognesi M, Manfroni G, Cecchetti V, Milani M
Antiviral research (Print), 2016
DOI: 10.1016/j.antiviral.2016.09.007

Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin
Croci R, Bottaro E, Chan KW, Watanabe S, Pezzullo M, Mastrangelo E, Nastruzzi C
International Journal of Biomaterials (Print), 2016
DOI: 10.1155/2016/8043983

NF023 binding to XIAP-BIR1: Searching drugs for regulation of the NF-kappa B pathway
Cossu, Federica; Milani, Mario; Grassi, Serena; Malvezzi, Francesca; Corti, Alessandro; Bolognesi, Martino; Mastrangelo, Eloise
Proteins (Print), 2015
DOI: 10.1002/prot.24766

The activator of apoptosis Smac-DIABLO acts as a tetramer in solution
Mastrangelo E.; Vachette P.; Cossu F.; Malvezzi F.; Bolognesi M.; Milani M.
Biophysical journal (Print), 2015
DOI: 10.1016/j.bpj.2014.11.3471

Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase
Tarantino, Delia; Pezzullo, Margherita; Mastrangelo, Eloise; Croci, Romina; Rohayem, Jacques; Robel, Ivonne; Bolognesi, Martino; Milani, Mario
Antiviral research (Print), 2014
DOI: 10.1016/j.antiviral.2013.11.016

PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases
Croci, Romina; Tarantino, Delia; Milani, Mario; Pezzullo, Margherita; Rohayem, Jacques; Bolognesi, Martino; Mastrangelo, Eloise
FEBS letters (Print), 2014
DOI: 10.1016/j.febslet.2014.03.021

STructural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds
Croci, Romina; Pezzullo, Margherita; Tarantino, Delia; Milani, Mario; Tsay, Shwuchen; Sureshbabu, Radhakrishnan; Tsai, Yijin; Mastrangelo, Eloise; Rohayem, Jacques; Bolognesi, Martino C.; Hwu, Jihru
PloS one, 2014
DOI: 10.1371/journal.pone.0091765

Delivery of Suramin as an Antiviral Agent through Liposomal Systems
Mastrangelo, Eloise; Mazzitelli, Stefania; Fabbri, Jacopo; Rohayem, Jacques; Ruokolainen, Janne; Nykanen, Antti; Milani, Mario; Pezzullo, Margherita; Nastruzzi, Claudio; Bolognesi, Martino
ChemMedChem (Print), 2014
DOI: 10.1002/cmdc.201300563

One hundred years of X-ray diffraction, 50 years of structural biology
Mastrangelo E, Nardini M, Bolognesi M
Rendiconti lincei. Scienze fisiche e naturali, 2013
DOI: 10.1007/s12210-012-0214-0

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
Mastrangelo E; Pezzullo M; De Burghgraeve T; Kaptein S; Pastorino B; Dallmeier K; de Lamballerie X; Neyts J; Hanson AM; Frick DN; Bolognesi M; Milani M
Journal of antimicrobial chemotherapy (Print), 2012
DOI: 10.1093/jac/dks147

Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases
Mastrangelo E; Pezzullo M; Tarantino D; Petazzi R; Germani F; Kramer D; Robel I; Rohayem J; Bolognesi M; Milani M
Journal of Molecular Biology, 2012
DOI: 10.1016/j.jmb.2012.03.008

Flaviviral helicase: Insights into the mechanism of action of a motor protein
Mastrangelo E; Bolognesi M; Milani M
Biochemical and biophysical research communications (Print), 2012
DOI: 10.1016/j.bbrc.2011.11.060

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents
Bianchi A; Ugazzi M; Ferrante L; Lecis D; Scavullo C; Mastrangelo E; Seneci P
Bioorganic & medicinal chemistry letters (Print), 2012
DOI: 10.1016/j.bmcl.2012.01.098

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis
Leonardo Manzoni; Laura Belvisi; Aldo Bianchi; Annalisa Conti; Carmelo Drago; Marilenia de Matteo; Luca Ferrante; Eloise Mastrangelo; Paola Perego; Donatella Potenza; Carlo Scolastico; Federica Servida; Gabriele Timpano; Francesca Vasile; Vincenzo Rizzo; Pierfausto Seneci
Bioorganic & medicinal chemistry (Print), 2012
DOI: 10.1016/j.bmc.2012.09.020

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.
Daniele Lecis; Eloise Mastrangelo; Laura Belvisi; Martino Bolognesi; Monica Civera; Federica Cossu; Michelandrea De Cesare; Domenico Delia; Carmelo Drago; Giacomo Manenti; Leonardo Manzoni; Mario Milani; Elisabetta Moroni; Paola Perego; Donatella Potenza; Vincenzo Rizzo; Cinzia Scavullo; Carlo Scolastico; Federica Servida; Francesca Vasile; Pierfausto Seneci
Bioorganic & medicinal chemistry (Print), 2012
DOI: 10.1016/j.bmc.2012.09.041

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic
Cossu F; Milani M; Vachette P; Malvezzi F; Grassi S; Lecis D; Delia D; Drago C; Seneci P; Bolognesi M; Mastrangelo E
PloS one, 2012
DOI: 10.1371/journal.pone.0049527

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1
Cossu F.; Malvezzi F.; Canevari G.; Mastrangelo E.; Lecis D.; Delia D.; Seneci P.; Scolastico C.; Bolognesi M.; Milani M.
Protein science (Print), 2010
DOI: 10.1002/pro.523

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib
Lecis, D.; Drago, C.; Manzoni, L.; Seneci, P.; Scolastico, C.; Mastrangelo, E.; Bolognesi, M.; Anichini, A.; Kashkar, H.; Walczak, H.; Delia, D.
British Journal of Cancer, 2010
DOI: 10.1038/sj.bjc.6605687

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Bollati M.; K. Alvarez; R. Assenberg; C. Baronti; B. Canard; S. Cook; B. Coutard; E. Decroly; X. de Lamballerie; E.A. Gould; G. Grard; J.M. Grimes; R. Hilgenfeld; A.M. Jansson; H. Malet; E.J. Mancini; E. Mastrangelo; A. Mattevi; M. Milani; G. Moureau, J.
Antiviral research (Print), 2010
DOI: 10.1016/j.antiviral.2009.11.009

Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication.
Assenberg R; Mastrangelo E; Walter TS; Verma A; Milani M; Owens RJ; Stuart DI; Grimes JM; Mancini EJ.
Journal of virology (Print), 2009
DOI: 10.1128/JVI.00942-09

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition.
Milani M; Mastrangelo E; Bollati M; Selisko B; Decroly E; Bouvet M; Canard B; Bolognesi M
Antiviral research (Print), 2009
DOI: 10.1016/j.antiviral.2009.03.001

Crystal structure of a methyltransferase from a no-known-vector Flavivirus.
Bollati M; Milani M; Mastrangelo E; de Lamballerie X; Canard B; Bolognesi M.
Biochemical and biophysical research communications (Print), 2009
DOI: 10.1016/j.bbrc.2009.03.008

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus.
Bollati M; Milani M; Mastrangelo E; Ricagno S; Tedeschi G; Nonnis S; Decroly E; Selisko B; de Lamballerie X; Coutard B; Canard B; Bolognesi M
Journal of Molecular Biology, 2009
DOI: 10.1016/j.jmb.2008.10.028

Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family
Cossu, Federica; Milani, Mario; Mastrangelo, Eloise; Vachette, Patrice; Servida, Federica; Lecis, Daniele; Canevari, Giulia; Delia, Domenico; Drago, Carmelo; Rizzo, Vincenzo; Manzoni, Leonardo; Seneci, Pierfausto; Scolastico, Carlo; Bolognesi, M
Journal of Molecular Biology, 2009
DOI: 10.1016/j.jmb.2009.04.033

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
Seneci, P.; Bianchi, A.; Battaglia, C.; Belvisi, L.; Bolognesi, M.; Caprini, A.; Cossu, F.; de Franco, E.; de Matteo, M.; Delia, D.; Drago, C.; Khaled, A.; Lecis, D.; Manzoni, L.; Marizzoni, M.; Mastrangelo, E.; Milani, M.; Motto, I.
Bioorganic & medicinal chemistry (Print), 2009

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2
Cossu, Federica; Mastrangelo, Eloise; Milani, Mario; Sorrentino, Graziella; Lecis, Danile; Delia, Domenico; Manzoni, Leonardo; Seneci, Pierfausto; Scolastico, Carlo; Bolognesi, Martino
Biochemical and biophysical research communications (Print), 2009
DOI: 10.1016/j.bbrc.2008.10.139

Hemoprotein time-resolved X-ray crystallography
Milani M; Nardini M; Pesce A; Mastrangelo E; Bolognesi M
IUBMB life (Print), 2008
DOI: 10.1002/iub.23

Ebolavirus and Marburgvirus: Insight the Filoviridae family
Ascenzi, P; Bocedi, A; Heptonstall, J; Capobianchi, MR; Di Caro, A; Mastrangelo, E; Bolognesi, M; Ippolito, G
Molecular aspects of medicine, 2008
DOI: 10.1016/j.mam.2007.09.005

Structure and biochemical analysis of Kokobera virus helicase.
Speroni S; De Colibus L; Mastrangelo E; Gould E; Coutard B; Forrester NL; Blanc S; Canard B; Mattevi A
Proteins (Print), 2008
DOI: 10.1002/prot.21812

Targeting the X-Linked Inhibitor of Apoptosis Protein through 4-Substituted Azabicyclo[5.3.0]alkane Smac Mimetics. Structure, Activity, and Recognition Principles
Mastrangelo, E.; Cossu, F.; Milani, M.; Sorrentino, G.; Lecis, D.; Delia, D.; Manzoni, L.; Drago, C.; Seneci, P.; Scolastico C.; Rizzo, V.; Bolognesi, M.
Journal of Molecular Biology, 2008
DOI: 10.1016/j.jmb.2008.09.064

Ferredoxin-NADP(+) reductase from Plasmodium falciparum undergoes NADP(+)-dependent dimerization and inactivation: Functional and crystallographic analysis
Milani M; Balconi E; Aliverti A; Mastrangelo E; Seeber F; Bolognesi M; Zanetti G
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2007.01.005

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2 '-O-methyltransferase
Mastrangelo, E; Bollati, M; Milani, M; Selisko, B; Peyrane, F; Canard, B; Grard, G; de Lamballerie, X; Bolognesi, M
Protein science (Print), 2007
DOI: 10.1110/ps.072758107

Crystal structure and activity of Kunjin virus NS3 helicase; Protease and helicase domain assembly in the full length NS3 protein
Mastrangelo, E; Milani, M; Bollati, M; Selisko, B; Peyrane, F; Pandini, V; Sorrentino, G; Canard, B; Konarev, PV; Svergun, DI; de Lamballerie, X; Coutard, B; Khromykh, AA; Bolognesi, M
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2007.06.055

Preliminary characterization of (nucleoside-2'-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses.
Mastrangelo, E; Bollati, M; Milani, M; De Lamballerie, X; Brisbarre, N; Dalle, K; Lantez, V; Egloff, MP; Coutard, B; Canard, B; Gould, E; Forrester, N; Bolognesi, M
Acta crystallographica. Section F. Structural biology and crystallization communications, 2006

Preliminary crystallographic characterization of an RNA helicase from Kunjin virus
Mastrangelo, E; Bollati, M; Milani, M; Brisbarre, N; de Lamballerie, X; Coutard, B; Canard, B; Khromykh, A; Bolognesi, M
Acta crystallographica. Section F. Structural biology and crystallization communications, 2006

Preliminary characterization of (nucleoside-2 '-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses
Mastrangelo, E; Bollati, M; Milani, M; de Lamballeire, X; Brisbare, N; Dalle, K; Lantez, V; Egloff, MP; Coutard, B; Canard, B; Gould, E; Forrester, N; Bolognesi, M
Acta crystallographica. Section F. Structural biology and crystallization communications, 2006
DOI: 10.1107/S1744309106025553