Andrea Mozzarelli

Associate

Full professor in biochemistry since 2000, Department of food and drug sciences, University of Parma. Associated with Cnr, Institute of biophysics, Unit of Pisa, since 2014.
Deputy Director of the Interdepartmental Center SITEIA.PARMA and member of the Biopharmanet-Tec Center, UNIPR. Coordinator of the protein Group, Italian Society of Biochemistry, since 2016.
It carries out scientific activity for the understanding of the relationship structure, dynamics, function and regulation of proteins. He received and receive funding on competitive projects from EU, NIH, Cnr, MIUR. He was PI of the three-year project CNR-RFBR (RUSSIA) on "Methionine gamma lyase as a new antitumor drug”. He has research contracts with pharmaceutical companies.

orcid://0000-0003-3762-0062,

Contact:

- Email andrea.mozzarelli@ibf.cnr.it
- Phone +39-052-1905138
- Location Pisa

Research interests:

- Engineering methionine gamma lyase for anticancer therapy. (Principal investigator)

Further collaborations:

- Tatyana Demidkina (Russian Academy of Science, Mosca, Russia)
- Samanta Raboni (Università di Parma)
- Svetlana Revtovich (Russian Academy of Science, Mosca, Russia)
- Tatyana Demidkina (Russian Academy of Science, Mosca, Russia)
- Paola Storici (Sincrotrone Elettra Trieste)
- Stefano Bettati (Università di Parma)
- Luca Ronda (Università di Parma)
- Stefano Bruno (Università di Parma)
- Barbara Campanini (Università di Parma)
- Annamaria Buschini (Università di Parma)
- Cristiano Viappiani (Università di Parma)
- Chris Cooper (University of Essex, Colchester, UK)
- Simone Sidoli (University of Pennsylvania, Filadelfia, USA)
- William A. Eaton (NIH, Bethesda, USA)

Key publications:

Henry ER, Mozzarelli A, Viappiani C, Abbruzzetti S, Bettati S, Ronda L, Bruno S, Eaton WA (2015)
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models. Biophys. J 109:1264-1272

Pieroni M, Annunziato G, Beato C, Wouters R, Benoni R, Campanini B, Pertinhez TA, Bettati S, Mozzarelli A, Costantino G (2016) Rational Design, Synthesis and Preliminary Structure-Activity Relationships of alpha-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase. J. Med. Chem. 59:2567-2578

Spyrakis F, Ahmed MH, Bayden AS, Cozzini P, Mozzarelli A, Kellogg GE (2017) The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery. J. Med. Chem. 60:6781–6827

Canosa AV, Faggiano S, Marchetti M, Armao A, Bettati S, Bruno S, Percudani P, Campanini B, Mozzarelli A (2018) Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP. Scientific Reports

Raboni S, Revtovich S, Demitri N, Giabbai B, Storici P, Cocconcelli C, Faggiano S, Rosini E, Pollegioni L, Galati S, Buschini A, Morozova E, Kulikova V, Nikulin A, Gabellieri E, Cioni P, Demidkina T, Mozzarelli A (2018) Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity. Biochim Biophys Acta 1866,:1260-1270