Federica Viti

Research staff

2019-2024: Member of IBF Advisory Board
Since 2018: Researcher @ National Research Council - Institute of Biophysics (Genova - Italy)
2018: Collaborator @ Italian Institute of Tecnnology (Genova - Italy)
2014 - 2018: Researcher @ National Research Council - Institute of Biophysics (Genova - Italy)
2010-2013: Post-doc positions @ National Research Council - Institute for Biomedical Technologies (Milano - Italy)
2006 - 2009: PhD in Bioengineering @ National Research Council - Institute for Biomedical Technologies (Milano - Italy) & University of Genova (Genova - Italy)
2004 - 2005: Collaborator @ National Research Council – Institute for Biomedical Technologies (Milano - Italy)
2004: Degree in Biomedical Engineering @ University of Genova (Genova - Italy)

Activity in short
Main scientific activities regard Mechanobiology, in particular regarding biomechanics characterization of cells especially in the context of the sutdy of 'mechanically driven' rare diseases, and Bioinformatics, with specific interest for analysis of data produced by genomic and transcriptomics high-throughput approaches. In addition, I developed interests on application of technology to biological and biomedical fields, exploiting my bioengineering background.

orcid://0000-0002-9651-8896,

Contact:

- Email federica.viti@ibf.cnr.it
- Phone +39-010-6475233
- Location Genova

Website:

http://users.ge.ibf.cnr.it/smml

Research interests:

- Bioinformatics (Principal investigator)
- Mechanobiology (Principal investigator)
- BioPlastics Europe

Further collaborations:

- - Present and/or past collaborations with personnel from other CNR Institutes (ITB in Milano, IMATI in Genova, IEIIT in Genova, IAS in Ganova, IGM in Pavia)
- - University of Genova (DIBRIS - UniGe)
- - University of Glasgow (UK)
- - Ospedale San Martino (IRCCS) in Genova
- - Institute Giannina Gaslini (IRCCS) in Genova
- - Italian Institute of Technology (IIT)
- - University of Milan
- - University of Pisa

Financial support:

- Project "Sviluppo di una strategia di silenziamento genico come terapia per la miopatia viscerale" funded by Liberalità Fondazione Intesa - San Paolo (2023-2024), PI
- Project "Dissection of smooth muscle functionality in clinically-relevant in vitro and in vivo models of visceral myopathy" funded by PRIN 2022 (2023-2025), OU Responsible
- Project "Role of endoplasmic reticulum in cells carrying R257C ACTG2 mutant" funded by Telethon Spring Seed Grant Renewal 2021 (2023-2024), PI
- Member of Regional and National PNRR research initiatives.
- Project "An in vivo model of intractable R257C-ACTG2 Visceral Myopathy to study pathogenesis and to identify new disease targets" funded by Telethon Multiround 2022, Member of the proponent team
- Project "The calcium-triggered molecular scenario underlying mutant ACTG2-caused defective contraction" funded by Telethon Spring Seed Grant 2021 (2021-2022), PI
- Project "European Forum on Visceral Myopathy (EFVM2022)" funded by European Joint Programme on Rare Diseases (EJP-RD) Networking Support Scheme (NSS), PI
- Project "Approccio combinato di genetica molecolare e morfo-meccanica cellulare: uno studio pilota volto allo sviluppo di un possibile trattamento della miopatia viscerale (CIPO)" funded by Fondazione Alessandra Bono (2020-2021)
- Project "Sensori wireless miniaturizzati a basso consumo per l’integrazione in dispositivi indossabili di monitoraggio bio-funzionale" (RLFO18ASSRIC/72/1) on the call "POR-FSE Liguria 2014-2020" funded by the Liguria Region (2020-2022)
- Project "Utilizzo di High Resolution Melting su piattaforma embedded per l’analisi di microsatelliti finalizzata all’identificazione univoca dell’individuo" (RLFO18ASSRIC/73/1) on the call “POR-FSE Liguria 2014 2020” funded by the Liguria Region (2019-2021)
- Project "Whole Genome Sequencing into the diagnostic workflow of rare diseases: a cost-effectiveness evaluation in a heterogeneous population of patients with inconclusive Whole Exome" (RF-2018-12366314) on the call “Ricerca Finalizzata 2018” funded by the Italian Ministry of Health (2020-2023)
- Project "Sviluppo di una piattaforma per lo studio della meccanotrasduzione: dalla singola molecola alla cellula vivente" (RBFR13V4M2) on the call "Futuro in Ricerca 2013" funded by the Italian Ministry of Education, University and Research (2014-2018)

Key publications:

Viti F, Pramotton FM, Martufi M, Magrassi R, Pedemonte N, Nizzari M, Zanacchi FC, De Michele B, Alampi M, Zambito M, Santamaria G, Bajetto A, Sardar S, Tomati V, Gandullia P, Giampietro C, Florio T, Beltrame F, Vassalli M, Ceccherini I. Patient's dermal fibroblasts as disease markers for visceral myopathy. Biomater Adv. 2023 May;148:213355. doi: 10.1016/j.bioadv.2023.213355. Epub 2023 Feb 23. PMID: 36893487.

R. Alfieri, M. Vassalli, F. Viti. Flow-induced mechanotransduction in skeletal cells. Biophysical Reviews. 2019. doi: 10.1007/s12551-019-00596-1. PMID: 31529361

F. Viti, M. Landini, A. Mezzelani, L. Petecchia, L. Milanesi, S. Scaglione. Osteogenic Differentiation of MSC through Calcium Signaling Activation: Transcriptomics and Functional Analysis. PlosOne. 2016. doi: http://dx.doi.org/10.1371/journal.pone.0148173. PMID: 2682858

D. Corrada, F. Viti, I. Merelli, C. Battaglia, L. Milanesi. myMIR: a genome-wide microRNA targets identification and annotation tool. Briefings in Bioinformatics. 2011. doi: 10.1093/bib/bbr062. PMID: 22021901

E. Mosca, R. Alfieri, I. Merelli, F. Viti, A. Calabria, L. Milanesi. A multilevel data integration resource for breast cancer study. BMC Syst Biology. 2010 doi: 10.1186/1752-0509-4-76.
PMID: 20525248

Publications (25):

Development of label-free biophysical markers in osteogenic maturation
Bartolozzi Alice; Viti Federica; De Stefano Silvia; Sbrana Francesca; Petecchia Loredana; Gavazzo Paola; Vassalli Massimo
Journal of the mechanical behavior of biomedical materials (Print), 2020
DOI: 10.1016/j.jmbbm.2019.103581

Flow-induced mechanotransduction in skeletal cells
Alfieri R, Vassalli M, Viti F.
Biophysical reviews (Print), 2019
DOI: 10.1007/s12551-019-00596-1

Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes
La Sala G.; Olieric N.; Sharma A.; Viti F.; de Asis Balaguer Perez F.; Huang L.; Tonra J.R.; Lloyd G.K.; Decherchi S.; Diaz J.F.; Steinmetz M.O.; Cavalli A.
Chem (Cambridge. Print), 2019
DOI: 10.1016/j.chempr.2019.08.022

A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis
Petecchia L, Viti F, Sbrana F, Vassalli M, Gavazzo P
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.05.011

Controlled single-cell cyclic compression and transcription analysis: A pilot study
Gavazzo P, Petecchia L, Facci P, Vassalli M, Viti F
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.07.010

Generation of a Functional Human Neural Network by NDM29 Overexpression in Neuroblastoma Cancer Cells
Alloisio S, Garbati P, Viti F, Dante S, Barbieri R, Arnaldi G, Petrelli A, Gigoni A, Giannoni P, Quarto R, Nobile M, Vassalli M, Pagano A
Molecular neurobiology, 2017
DOI: 10.1007/s12035-016-0161-3

OvMeter: an automated 3D-integrated opto-electronic system for Ostreopsis cf. ovata bloom monitoring
Sbrana F, Landini E, Gjeci N, Viti F, Ottaviani E, Vassalli M
Journal of applied phycology, 2017
DOI: 10.1007/s10811-017-1069-7

Osteogenic differentiation of MSC through calcium signaling activation: transcriptomics and functional analysis
F. Viti, M. Landini, A. Mezzelani, L. Petecchia, L. Milanesi, S. Scaglione
PloS one, 2016
DOI: 10.1371/journal.pone.0148173

The biophysics of piezo1 and piezo2 mechanosensitive channels
Soattin L.; Fiore M.; Gavazzo P.; Viti F.; Facci P.; Raiteri R.; Difato F.; Pusch M.; Vassalli M.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.06.013

Guidelines for managing data and processes in bone and cartilage tissue engineering
Viti, Federica; Scaglione, Silvia; Orro, Alessandro; Milanesi, Luciano
BMC bioinformatics, 2014
DOI: 10.1186/1471-2105-15-S1-S14

SNPranker 2.0: a gene-centric data mining tool for diseases associated SNP prioritization in GWAS
Merelli, Ivan; Calabria, Andrea; Cozzi, Paolo; Viti, Federica; Mosca, Ettore; Milanesi, Luciano
BMC bioinformatics, 2013
DOI: 10.1186/1471-2105-14-S1-S9

IBDsite: a Galaxy-interacting, integrative database for supporting inflammatory bowel disease high throughput data analysis
Merelli I, Viti F, Milanesi L
BMC bioinformatics, 2012
DOI: 10.1186/1471-2105-13-S14-S5

Ontology-based resources for bioinformatics analysis.
Viti F., Merelli I, Calabria A., Cozzi P., Mosca E.,Alfieri R., Milanesi L.
International journal of metadata, semantics and ontologies (Online), 2012

IBDsite: a Galaxy-interacting, integrative database for supporting inflammatory bowel disease high throughput data analysis.
Merelli I , Viti F , Milanesi L.
BMC bioinformatics, 2012

myMIR: a genome-wide microRNA targets identification and annotation tool
Corrada, Dario; Viti, Federica; Merelli, Ivan; Battaglia, Cristina; Milanesi, Luciano
Briefings in bioinformatics, 2011
DOI: 10.1093/bib/bbr062

A multilevel data integration resource for breast cancer study
Mosca E.; Alfieri R.; Merelli I.; Viti F.; Calabria A.; Milanesi L.
BMC systems biology, 2010
DOI: 10.1186/1752-0509-4-76

SNPRanker: a tool for identification and scoring of SNPs associated to target genes.
Calabria A., Mosca E., Viti F., Merelli I., Milanesi L.
Journal of integrative bioinformatics, 2010
DOI: 10.2390/biecoll-jib-2010-138

Semi-automatic identification of punching areas for tissue microarray building: the tubular breast cancer pilot study
Viti F.; Merelli I.; Timmermans M.; den Bakker M.; Beltrame F.; Riegman P.; Milanesi L.
BMC bioinformatics, 2010
DOI: 10.1186/1471-2105-11-566

SNPRanker: a tool for identification and scoring of SNPs associated to target genes.
Calabria, Andrea; Mosca, Ettore; Viti, Federica; Merelli, Ivan; Milanesi, Luciano
Journal of integrative bioinformatics, 2010
DOI: 10.1515/jib-2010-138

Ontology-based, Tissue MicroArray oriented, image centred tissue bank
Viti Federica, Ivan Merelli, Andrea Caprera, Barbara Lazzari, Alessandra Stella, Luciano Milanesi
BMC bioinformatics, 2008

Ontology-based, Tissue MicroArray oriented, image centered tissue bank
Viti, Federica; Merelli, Ivan; Caprera, Andrea; Lazzari, Barbara; Stella, Alessandra; Milanesi, Luciano
BMC bioinformatics, 2008
DOI: 10.1186/1471-2105-9-S4-S4

Tissue MicroArray: a distributed Grid approach for image analysis.
Viti F., Merelli I., Galizia A., D'Agostino D., Clematis A., Milanesi L.
Studies in health technology and informatics (Online), 2007

A Grid based solution for Management and Analysis of Microarrays in distributed experiments
Porro I; Torterolo L; Corradi L; Fato M; Papadimitropoulos A; Scaglione S; Schenone A; Viti F
BMC bioinformatics, 2007

Strategies for comparing gene expression profiles from different microarray platforms: Application to a case-control experiment
Severgnini M, Bicciato S, Mangano E, Scarlatti F, Mezzelani A, Mattioli M, Ghidoni R, Peano C, Bonnal R, Viti F, Milanesi L, De Bellis G, Battaglia C
Analytical biochemistry (Print), 2006

A simple non invasive computerized method for the assessment of bone repair within osteoconductive porous bioceramic grafts
Francesco Beltrame; Ranieri Cancedda; Barbara Canesi; Antonio Crovace; Maddalena Mastrogiacomo; Rodolfo Quarto; Silvia Scaglione; Carmela Valastro; Federica Viti
Biotechnology and bioengineering (Online), 2005