Rosa Passantino
Research staff
1984 - Degree in Biological Science, 110/110 cum laude, University of study of Palermo, Italy 1989 - PhD in Cellular Biology - Cellular Biology and development, University of study of Palermo, Italy. 2001-2013 - Researcher, Istituto di Biomedicina e Immunologia Molecolare – CNR, Palermo, Italy. 2013-present - Researcher, Istituto di Biofisica – CNR, Palermo, Italy
orcid://0000-0001-6598-2664, ncbi://56567737
Contact:
- Email rosa.passantino@ibf.cnr.it
- Phone +39-091-6809540
- Location Palermo
Research interests:
- Development of bio-adhesives for wet environments from marine mussels (Principal investigator)
- Laboratory of protein engineering for production of recombinant proteins. (Principal investigator)
- Study of natural and chemically modified natural polymers for biotechnological applications
- Biomolecular Aggregation Processes
- Protein aggregation and the onset of neurodegenerative diseases
- Structure and Functionality of Molecular chaperones
- Extraction, identification and characterization of naturally occurring compounds and study of their biological activity on cell lines.
Further collaborations:
- Annalisa Pastore (Dipartimento di Medicina Molecolare, Università di Pavia)
- Caterina Alfano (Fondazione Ri.MED, Palermo)
- Clelia Dispenza (Dipartimento di Ingegneria, Università di Palermo)
Key publications:
Ditta, L.A., Rao, E., Provenzano, F., Sánchez, J.L., Santonocito, R., Passantino, R., Costa, M.A., Sabatino, M.A., Dispenza, C., Giacomazza, D., San Biagio, P.L., Lapasin, R.Agarose/?-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds. International Journal of Biological Macromolecules 164 (2020) 2818–2830
Santonocito R, Venturella F, Dal Piaz F, Morando MA, Provenzano A, Rao E, Costa MA, Bulone D, San Biagio PL, Giacomazza D, Sicorello A, Alfano C, Passantino R, Pastore A. Recombinant mussel protein Pvfp-5?: A potential tissue bioadhesive. Volume 294, Issue 34, J Biol Chem. 2019 Aug 23;294(34):12826-12835. doi: 10.1074/jbc.RA119.009531.
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K (2018). Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus indica and its potential cytotoxic activity. Phytochemistry, 154: 47-55.
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D and San Biagio PL (2016). Hsp60, amateur chaperone in amyloid-beta fibrillogenesis. Biochim Biophys Acta, 1860, 2474-83.
Passantino R, Cascio C, Deidda I, Galizzi G, Russo D, Spedale G, Guarneri P (2013). Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Biochim Biophys Acta. Mar;1833(3):529-40.
Publications (28):
Can Be miR-126-3p a Biomarker of Premature Aging? An Ex Vivo and In Vitro Study in Fabry DiseaseLo Curto A; Taverna S; Costa MA; Passantino R; Augello G; Adamo G; Aiello A ; Colomba P; Zizzo C; Zora M; Accardi G; Candore G; Francofonte D; Di Chiara T; Alessandro R; Caruso C; Duro G; Cammarata G;
Cells, 2021
Agarose/ -carrageenan-based hydrogel !lm enriched with natural plant extracts for the treatment of cutaneous wounds
Lorena Anna Ditta (a) , Estella Rao(a) , Fiorenza Provenzano (a) , Jesús Lozano Sánchez (b,c), Radha Santonocito (a), Rosa Passantino (a), Maria Assunta Costa (a), Maria Antonietta Sabatino (d), Clelia Dispenza (a, d), Daniela Giacomazza (a), Pier Luigi San Biagio (a), Romano Lapasin (e)
International journal of biological macromolecules, 2020
DOI: 10.1016/j.ijbiomac.2020.08.170
Water extract of cryphaea heteromalla (Hedw.) d. mohr bryophyte as a natural powerful source of biologically active compounds
Provenzano F, Sánchez JL, Rao E, Santonocito R, Ditta LA, Borrás Linares I, Passantino R, Campisi P, Dia MG, Costa MA, Segura-Carretero A, San Biagio PL, Giacomazza D
International journal of molecular sciences (Print), 2019
DOI: 10.3390/ijms20225560
Recombinant mussel protein Pvfp-5beta: a potential tissue bioadhesive
Santonocito R, Venturella F, Dal Piaz F, Morando MA, Provenzano A, Rao E, Costa MA, Bulone D, San Biagio PL, Giacomazza D, Sicorello A, Alfano C, Passantino R, Pastore A
Journal of biological chemistry (Online), 2019
DOI: 10.1074/jbc.RA119.009531
Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus indica and its potential biological activity
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K
Phytochemistry, 2018
DOI: 10.1016/j.phytochem.2018.06.015
The precious content of the olive mill wastewater: The protective effects of the antioxidant fraction in cell cultures
Giacomazza D, D'Andrea D, Provenzano A, Picone P, Provenzano F, Guarrasi V, Raimondo M, San Biagio PL, Passantino R, Mangione MR, Di Carlo M, Costa MA
CyTA: journal of food (Online), 2018
DOI: 10.1080/19476337.2018.1458752
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces (Print), 2018
DOI: 10.1016/j.colsurfb.2018.06.032
Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection
Presti G, Guarrasi V, Gulotta E, Provenzano F, Provenzano A, Giuliano S, Monfreda M, Mangione MR, Passantino R, San Biagio PL, Costa MA, Giacomazza D
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.09.002
Pectin from Opuntia ficus indica: Optimization of microwave-assisted extraction and preliminary characterization
Lefsih K, Giacomazza D, Dahmoune F, Mangione MR, Bulone D, San Biagio PL, Passantino R, Costa MA, Guarrasi V, Madani K
Food chemistry, 2017
DOI: 10.1016/j.foodchem.2016.10.073
Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019
Temperature-induced self-assembly of degalactosylated xyloglucan at low concentration
Todaro S.; Dispenza C.; Sabatino M.A.; Ortore M.G.; Passantino R.; San Biagio P.L.; Bulone D.
Journal of polymer science. Part B, Polymer physics (Online), 2015
DOI: 10.1002/polb.23895
Expression of vesicle-associated membrane-protein-associated protein B cleavage products in peripheral blood leukocytes and cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis
Deidda, I.; Galizzi, G.; Passantino, R.; Cascio, C.; Russo, D.; Colletti, T.; La Bella, V.; Guarneri, P.
European journal of neurology (Print), 2014
DOI: 10.1111/ene.12334
Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis
Passantino, Rosa; Cascio, Caterina; Deidda, Irene; Galizzi, Giacoma; Russo, Domenica; Spedale, Gianpiero; Guarneri, P.
Biochimica et biophysica acta. Molecular cell research, 2013
DOI: 10.1016/j.bbamcr.2012.10.030
Characterization of a Par j 1/Par j 2 mutant hybrid with reduced allergenicity for immunotherapy of Parietaria allergy.
Bonura A; Passantino R; Costa MA; Montana G; Melis M; Bondì ML; Butteroni C; Barletta B; Corinti S; Di Felice G; Colombo P.
Clinical & experimental allergy (Online), 2012
DOI: 10.1111/j.1365-2222.2011.03938.x.
A retinal proteomics-based study identifies aA-crystallin as a sex steroid-regulated protein
Claudia DAnna; Caterina Cascio; Diego Cigna; Giacoma Galizzi; Irene Deidda; Laura Bianchi; Domenica Russo; Rosa Passantino; Luca Bini, Patrizia Guarneri
Proteomics (Weinh., Print), 2011
DOI: 10.1002/pmic.201000561
Different early ER-stress responses in the CLN8mnd mouse model of neuronal ceroid lipofuscinosis.
Galizzi Giacoma; Russo Domenica; Deidda Irene; Cascio Caterina; Passantino Rosa; Guarneri Rosetta; Bigini Paolo; Mennini Tiziana; Drago Gaspare; Guarneri Patrizia.
Neuroscience letters (Print), 2011
DOI: 10.1016/j.neulet.2010.11.041
17b-estradiol synthesis in the adult male rat retina.
C. Cascio; D. Russo; G. Drago; G. Galizzi; R. Passantino; R. Guarneri; P. Guarneri
Experimental Eye Research, 2007
DOI: 10.1016/j.exer.2007.02.008
The allergens of Parietaria
Colombo P, Bonura A , Costa M. A, Izzo V, Passantino R, Amoroso S, Geraci D.
International archives of allergy and immunology, 2003
DOI: 10.1159/000069520
Conserved structure and promoter sequence similarity in the mouse and human genes encoding the zinc finger factor BERF-1/BFCOL1/ZBP-89
Feo S, Antona V, Cammarata G, Cavaleri F, Passantino R, Rubino P, Giallongo A.
Biochemical and biophysical research communications (Print), 2001
Surface expression of a glycolytic enzyme, alfa-enolase, recognized by autoantibodies in connective tissue disorders
Stefania Moscato1, Federico Pratesi1, Alessandra Sabbatini1, Daniele Chimenti1,Maria Scavuzzo1, Rosa Passantino2, Stefano Bombardieri1, Agata Giallongo2, Paola Migliorini1
European Journal of Immunology, 2000
ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1)
Feo S; Arcuri D; Piddini E; Passantino R; Giallongo A
FEBS letters (Print), 2000
DOI: 10.1016/S0014-5793(00)01494-0
The bldD gene of Streptomyces coelicolor A3(2): a regulatory gene involved in morphogenesis and antibiotic production
Elliot, M; Damji, F; Passantino, R; Chater, K; Leskiw, B
Journal of bacteriology (Print), 1998
Negative regulation of beta enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer.
Passantino R #, Antona V ¶, Barbieri G #, Rubino P #, Melchionna R *, Cossu G *, Feo S ¶, Giallongo A #.
The Journal of biological chemistry (Print), 1998
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A
The Journal of biological chemistry (Print), 1996
DOI: 10.1074/jbc.271.51.32529
Transcription of the human beta enolase gene (ENO-3) is regulated by an intronic muscle-specific enhancer that binds myocyte-specific enhancer factor 2 proteins and ubiquitous G-rich-box binding factors.
Feo S 1-2, Antona V 2, Barbieri G 1, Passantino R 2, Calì L 1, Giallongo A 1.
Molecular and cellular biology (Print), 1995
CLONING AND SEQUENCING OF THE DNAK REGION OF STREPTOMYCES-COELICOLOR A3(2)
BUCCA, G; SMITH, CP; ALBERTI, M; SEIDITA, G; PASSANTINO, R; PUGLIA, AM
Gene (Amst.), 1993
DOI: 10.1016/0378-1119(93)90358-A
ADDITIONAL COPIES OF THE ACTII REGULATORY GENE INDUCE ACTINORHODIN PRODUCTION IN PLEIOTROPIC BLD MUTANTS OF STREPTOMYCES-COELICOLOR-A3(2)
PASSANTINO, R; PUGLIA, AM; CHATER, K
Journal of General Microbiology, 1991
A BREAKDOWN IN MACROMOLECULAR-SYNTHESIS PRECEDING DIFFERENTIATION IN STREPTOMYCES-COELICOLOR A3(2)
GRANOZZI, C; BILLETTA, R; PASSANTINO, R; SOLLAZZO, M; PUGLIA, AM
Journal of General Microbiology, 1990