Michele Fiore

Research staff

Degree in biology (2006), Clinical Pathology graduate school (2014)

Contact:

- Email michele.fiore@ibf.cnr.it
- Phone +39-010-6475555
- Location Genova

Research interests:

- Molecular pharmacology of cystic fibrosis
- Functional and structural studies of human CLC protein complexes involved in genetic diseases
- Neurotoxic effect of per- and polyfluoroalkyl substances (PFAS)
- Synaptic transmission and plasticity

Key publications:

Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada Small molecule anionophores promote transmembrane anion permeation matching CFTR activity Scientific Reports volume 8, Article number: 2608 (2018)

Rebeca Vindas?Smith, Michele Fiore, Melissa Vásquez, Patricia Cuenca, Gerardo Del Valle, Laura Lagostena, Héctor Gaitán?Peñas, Raúl Estevez, Michael Pusch, Fernando Morales Identification and Functional Characterization of CLCN1 Mutations Found in Nondystrophic Myotonia Patients Hum Mutat. 2016 Jan;37(1).

Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy Front. Pharmacol., 07 August 2018

Michele Fiore, Claudia Cossu, Valeria Capurro, Cristiana Picco, Alessandra Ludovico, Marcin Mielczarek, Israel Carreira?Barral, Emanuela Caci, Debora Baroni, Roberto Quesada, Oscar Moran Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis Br. J. Pharmacol. 2019, 176, 1764–1779.

Ambra Gianotti, Valeria Capurro, Livia Delpiano, Marcin Mielczarek, María García-Valverde, Israel Carreira-Barral, Alessandra Ludovico, Michele Fiore, Debora Baroni, Oscar Moran, Roberto Quesada, Emanuela Caci Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia nt. J. Mol. Sci. 2020, 21(4), 1488

Publications (11):

Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra and Capurro, Valeria and Delpiano, Livia and Mielczarek, Marcin and Garcia-Valverde, Maria and Carreira-Barral, Israel and Ludovico, Alessandra and Fiore, Michele and Baroni, Debora and Moran, Oscar and Quesada, Roberto and Caci, Emanuela
International journal of molecular sciences (Online), 2020
DOI: 10.3390/ijms21041488

Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore Michele; Picco Cristiana and Moran Oscar
Scientific reports (Nature Publishing Group), 2020
DOI: 10.1038/s41598-020-65287-4

The different anion transport capability of prodiginine- and tambjamine-like molecules
Fiore M.; Garcia-Valverde M.; Carreira-Barral I.; Moran O.
European journal of pharmacology, 2020
DOI: 10.1016/j.ejphar.2020.173592

Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore M.; Picco C.; Moran O.
Scientific reports (Nature Publishing Group), 2020
DOI: 10.1038/s41598-020-65287-4

Small molecule anion carriers correct abnormal airway surface liquid properties in cystic fibrosis airway epithelia
Gianotti A.; Capurro V.; Delpiano L.; Mielczarek M.; Garcia-valverde M.; Carreira-barral I.; Ludovico A.; Fiore M.; Baroni D.; Moran O.; Quesada R.; Caci E.
International journal of molecular sciences (Print), 2020
DOI: 10.3390/ijms21041488

Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 2019
DOI: 10.1111/bph.14649

Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 2018
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R
Scientific reports (Nature Publishing Group), 2018
DOI: 10.1038/s41598-018-20708-3

Gene expression profile in TNF receptor-associated periodic syndrome reveals constitutively enhanced pathways and new players in the underlying inflammation
Borghini, S.; Ferrera, D.; Prigione, I.; Fiore, M.; Ferraris, C.; Mirisola, V.; Amaro, A. A.; Gueli, I.; Zammataro, L.; Gattorno, M.; Pfeffer, U.; Ceccherini, I.
Clinical and Experimental Rheumatology (Testo stamp.), 2016

Identification and Functional Characterization of CLCN1 Mutations Found in Nondystrophic Myotonia Patients
Vindas-Smith R.; Fiore M.; Vasquez M.; Cuenca P.; del Valle G.; Lagostena L.; Gaitan-Penas H.; Estevez R.; Pusch M.; Morales F.
Human mutation, 2016
DOI: 10.1002/humu.22916

The biophysics of piezo1 and piezo2 mechanosensitive channels
Soattin L.; Fiore M.; Gavazzo P.; Viti F.; Facci P.; Raiteri R.; Difato F.; Pusch M.; Vassalli M.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.06.013