Carrotta Rita; Paterna Angela; Santonicola Pamela; Di Prima Giulia; Rao Estella; Raccosta Samuele; Zampi Giuseppina; Moran Oscar; Manno Mauro; Di Schiavi Elia; Librizzi Fabio
European biophysics journal, 2023
Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto Sabrina; Barone Maria E.; Fierli David; Aranyos Anita; Adamo Giorgia; Bo?i? Darja; Romancino Daniele P.; Stanly Christopher; Parkes Rachel; Morsbach Svenja; Raccosta Samuele; Paganini Carolina; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Capasso Palmiero Umberto; Santonicola Pamela; Igli? Ales; Gai Meiyu; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Landfester Katharina; Liguori Giovanna L.; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Manno Mauro; Touzet Nicolas; Bongiovanni Antonella
Biomaterials science (Print), 2021
DOI: 10.1039/d0bm01696a
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo Giorgia; Fierli David; Romancino Daniele P.; Picciotto Sabrina; Barone Maria E.; Aranyos Anita; Bo?i? Darja; Morsbach Svenja; Raccosta Samuele; Stanly Christopher; Paganini Carolina; Gai Meiyu; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Randazzo Loredana; Parkes Rachel; Capasso Palmiero Umberto; Rao Estella; Paterna Angela; Santonicola Pamela; Igli? Ales; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Liguori Giovanna L.; Landfester Katharina; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Touzet Nicolas; Manno Mauro; Bongiovanni Antonella;
Journal of extracellular vesicles, 2021
DOI: 10.1002/jev2.12081
Blue autofluorescence in protein aggregates "lighted on" by UV induced oxidation
Fricano A, Librizzi F, Rao E, Alfano C, Vetri V
Biochimica et biophysica acta. Proteins and proteomics, 2019
DOI: 10.1016/j.bbapap.2019.07.011
Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 2019
DOI: 10.1021/acschemneuro.9b00183
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
The journal of physical chemistry. B, 2019
DOI: 10.1021/acs.jpcb.8b11719
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces (Print), 2018
DOI: 10.1016/j.colsurfb.2018.06.032
Dynamical properties of myoglobin in an ultraviscous water-glycerol solvent investigated with elastic neutron scattering and FTIR spectroscopy
Librizzi F, Caliò A, Cupane A
Journal of molecular liquids (Print), 2018
DOI: 10.1016/j.molliq.2018.07.050
The effects of pressure on the energy landscape of proteins
Librizzi F, Carrotta R, Peters J, Cupane A
Scientific reports (Nature Publishing Group), 2018
DOI: 10.1038/s41598-018-20417-x
Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.07.008
Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging (Albany, N.Y. Online), 2016
DOI: 10.18632/aging.101004
Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019
Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.010
Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006
Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657
alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes
Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi
The journal of physical chemistry letters, 2014
DOI: 10.1021/jz501570m
alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp307417x
Amyloid fibrils formation of concanavalin A at basic pH
Carrotta R (1); Vetri V(2); Librizzi F (2); Martorana V (1); Militello V(2); Leone M (2)
The journal of physical chemistry. B (1997 : Online), 2011
Self-organization pathways and spatial heterogeneity in insulin amyloid fibril formation
Vito Foderà; Salvatore Cataldo; Fabio Librizzi; Bruno Pignataro; Paola Spiccia; Maurizio Leone
The journal of physical chemistry. B, 2009
DOI: 10.1021/jp810972y
Elastic neutron scattering of dry and rehydrated trehalose coated carboxy-myoglobin
Librizzi, F; Vitrano, E; Paciaroni, A; Cordone, L
Chemical physics (Print), 2008
Secondary nucleation and accessible surface in insulin amyloid fibril formation
Foderà V., Librizzi F., Groenning M., van de Weert M., and Leone M.
The journal of physical chemistry. B, 2008
Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection.
Foderà, V., M. Groenning, V. Vetri, F. Librizzi, S. Spagnolo, C. Cornett, L. Oltzen, M. Van de Weert, and M. Leone.
The journal of physical chemistry. B, 2008
Amyloid fibrils formation and amorphous aggregation in Concavalin A.
Vetri V., Canale C., Relini A., Librizzi F., Militello V., Gliozzi A., Leone M.
Biophysical chemistry (Print), 2007
Smart hydrogels for novel optical functions.
Dispenza, C., M. Leone, C. Lo Presti, F. Librizzi, V. Vetri, and G. Spadaro.
Macromolecular symposia, 2007
Effects of confinement on insulin amyloid fibrils formation.
Librizzi, F., V. Fodera', V. Vetri, C. Lo Presti, and M. Leone.
European biophysics journal, 2007
Effects of succinylation on thermal induced amyloid formation in Concanavalin A.
Vetri, V., F. Librizzi, V. Militello, and M. Leone.
European biophysics journal, 2007
Thermal aggregation of bovine serum albumin at different pH: comparison with human serum albumin.
Vetri V; Librizzi F; Leone M; Militello V.
European Biophysical Journal, 2007
DOI: 10.1007/s00249-007-0196-5
Optical properties of biocompatible polyaniline nanocomposites
Dispensa C., Leone M., Lo Presti C., Librizzi F., Spadaro G., Vetri V.
Journal of non-crystalline solids, 2006
Fabio Librizzi
Research staff
Since December 2011: Researcher at IBF.
2008-2011: Teacher of Mathematics and Physics at High School.
2004-2008: Post-Doc, Department of Physics, University of Palermo.
2002-2003: Post-Doc, Niels Bohr Institute, University of Copenhagen.
2001: PhD in physics.
1998: Laurea in Physics, University of Palermo, cum laude.
orcid://0000-0003-4900-382X,
Contact:
- Email fabio.librizzi@ibf.cnr.it
- Phone +39-091-6809317
- Location Palermo
Research interests:
- Dynamical properties of proteins (Principal investigator)
- Characterisation of extracellular vescicles
- Amyloid aggregation processes and their inhibition
- Model Membrane Systems and Interaction Studies
- Liposome as drug delivery system
Further collaborations:
- Antonio Cupane (Università degli studi di Palermo)
- Maria Grazia Ortore (Università delle Marche)
- Judith Peters (ILL, Grenoble)
- Valeria Vetri (Università degli studi di Palermo)
Financial support:
- Percorsi formative nei settori Biotecnologia, Biomedicina e Agroalimentare. Progetto FSE 2014/2020
Key publications:
Librizzi F, Caliò A, Cupane A (2018) Dynamical properties of myoglobin in an ultraviscous water-glycerol solvent investigated with elastic neutron scattering and FTIR spectroscopy. J. Mol. Liq. 268: 242-248. doi: 10.1016/j.molliq.2018.07.050
Librizzi F, Carrotta R, Peters J, Cupane A (2018) The effects of pressure on the energy landscape of proteins. Sci. Rep. 8: 2037. doi: 10.1038/s41598-018-20417-x
Librizzi F, Carrotta R, Spigolon D, Bulone D, San Biagio PL (2014) alfa-casein inhibits insulin amyloid formation by preventing the onset of secondary nucleation processes. J. Phys. Chem. Lett. 5: 3043-3048. doi: 10.1021/jz501570m
Foderà V, Librizzi F, Gronning M, van de Weert M, Leone M (2008) Secondary nucleation and accessible surface in insulin amyloid fibril formation. J. Phys. Chem. B. 112: 3853-3858. doi: 10.1021/jp710131u
Librizzi F, Rischel C (2005) The kinetic behavior of insulin fibrillation is determined by heterogeneous nucleation pathways. Protein Sci. 14: 3129-3134. doi: 10.1110/ps.051692305
Publications (28):
alphaS1-Casein administration to a C. elegans model of Alzheimer's disease through proteoliposome deliveryCarrotta Rita; Paterna Angela; Santonicola Pamela; Di Prima Giulia; Rao Estella; Raccosta Samuele; Zampi Giuseppina; Moran Oscar; Manno Mauro; Di Schiavi Elia; Librizzi Fabio
European biophysics journal, 2023
Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto Sabrina; Barone Maria E.; Fierli David; Aranyos Anita; Adamo Giorgia; Bo?i? Darja; Romancino Daniele P.; Stanly Christopher; Parkes Rachel; Morsbach Svenja; Raccosta Samuele; Paganini Carolina; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Capasso Palmiero Umberto; Santonicola Pamela; Igli? Ales; Gai Meiyu; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Landfester Katharina; Liguori Giovanna L.; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Manno Mauro; Touzet Nicolas; Bongiovanni Antonella
Biomaterials science (Print), 2021
DOI: 10.1039/d0bm01696a
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo Giorgia; Fierli David; Romancino Daniele P.; Picciotto Sabrina; Barone Maria E.; Aranyos Anita; Bo?i? Darja; Morsbach Svenja; Raccosta Samuele; Stanly Christopher; Paganini Carolina; Gai Meiyu; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Randazzo Loredana; Parkes Rachel; Capasso Palmiero Umberto; Rao Estella; Paterna Angela; Santonicola Pamela; Igli? Ales; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Liguori Giovanna L.; Landfester Katharina; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Touzet Nicolas; Manno Mauro; Bongiovanni Antonella;
Journal of extracellular vesicles, 2021
DOI: 10.1002/jev2.12081
Blue autofluorescence in protein aggregates "lighted on" by UV induced oxidation
Fricano A, Librizzi F, Rao E, Alfano C, Vetri V
Biochimica et biophysica acta. Proteins and proteomics, 2019
DOI: 10.1016/j.bbapap.2019.07.011
Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 2019
DOI: 10.1021/acschemneuro.9b00183
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
The journal of physical chemistry. B, 2019
DOI: 10.1021/acs.jpcb.8b11719
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces (Print), 2018
DOI: 10.1016/j.colsurfb.2018.06.032
Dynamical properties of myoglobin in an ultraviscous water-glycerol solvent investigated with elastic neutron scattering and FTIR spectroscopy
Librizzi F, Caliò A, Cupane A
Journal of molecular liquids (Print), 2018
DOI: 10.1016/j.molliq.2018.07.050
The effects of pressure on the energy landscape of proteins
Librizzi F, Carrotta R, Peters J, Cupane A
Scientific reports (Nature Publishing Group), 2018
DOI: 10.1038/s41598-018-20417-x
Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.07.008
Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging (Albany, N.Y. Online), 2016
DOI: 10.18632/aging.101004
Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019
Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.010
Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006
Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657
alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes
Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi
The journal of physical chemistry letters, 2014
DOI: 10.1021/jz501570m
alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp307417x
Amyloid fibrils formation of concanavalin A at basic pH
Carrotta R (1); Vetri V(2); Librizzi F (2); Martorana V (1); Militello V(2); Leone M (2)
The journal of physical chemistry. B (1997 : Online), 2011
Self-organization pathways and spatial heterogeneity in insulin amyloid fibril formation
Vito Foderà; Salvatore Cataldo; Fabio Librizzi; Bruno Pignataro; Paola Spiccia; Maurizio Leone
The journal of physical chemistry. B, 2009
DOI: 10.1021/jp810972y
Elastic neutron scattering of dry and rehydrated trehalose coated carboxy-myoglobin
Librizzi, F; Vitrano, E; Paciaroni, A; Cordone, L
Chemical physics (Print), 2008
Secondary nucleation and accessible surface in insulin amyloid fibril formation
Foderà V., Librizzi F., Groenning M., van de Weert M., and Leone M.
The journal of physical chemistry. B, 2008
Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection.
Foderà, V., M. Groenning, V. Vetri, F. Librizzi, S. Spagnolo, C. Cornett, L. Oltzen, M. Van de Weert, and M. Leone.
The journal of physical chemistry. B, 2008
Amyloid fibrils formation and amorphous aggregation in Concavalin A.
Vetri V., Canale C., Relini A., Librizzi F., Militello V., Gliozzi A., Leone M.
Biophysical chemistry (Print), 2007
Smart hydrogels for novel optical functions.
Dispenza, C., M. Leone, C. Lo Presti, F. Librizzi, V. Vetri, and G. Spadaro.
Macromolecular symposia, 2007
Effects of confinement on insulin amyloid fibrils formation.
Librizzi, F., V. Fodera', V. Vetri, C. Lo Presti, and M. Leone.
European biophysics journal, 2007
Effects of succinylation on thermal induced amyloid formation in Concanavalin A.
Vetri, V., F. Librizzi, V. Militello, and M. Leone.
European biophysics journal, 2007
Thermal aggregation of bovine serum albumin at different pH: comparison with human serum albumin.
Vetri V; Librizzi F; Leone M; Militello V.
European Biophysical Journal, 2007
DOI: 10.1007/s00249-007-0196-5
Optical properties of biocompatible polyaniline nanocomposites
Dispensa C., Leone M., Lo Presti C., Librizzi F., Spadaro G., Vetri V.
Journal of non-crystalline solids, 2006