Carlo Musio
Research staff
1988: Degree in Biological Sciences (UniPisa);
1991: CNR-MISM Fellowship in Biophysics (ICIB-CNR Arco Felice, Naples);
1994-1998: CNR Researcher TD;
1998-today: CNR Researcher (permanent);
since 2016: Advisory Editor of the journal "Biophysical Chemistry" Elsevier;
since 2011: Associate Editor of the journal "Photochemistry and Photobiology" Wiley;
2012-2016: President of SIBPA - Italian Society of Pure and Applied Biophysics (to date Past-President)
since 2010: Appointed Member of the Scientific Advisory Board of the European Society for Photobiology (ESP).
Expertize: Biophysics of Neural and Sensory Systems; Ionic Channels; Sensory photobiology; optogenetics; Neurobiology; Bio-hybrid systems; Cell models of neurodegenerative diseases.
orcid://0000-0003-2106-9931,
Contact:
- Email carlo.musio@ibf.cnr.it
- Phone +39-0461-314157
- Location Trento
Research interests:
- Ion channels in neurodegenerative disease (Principal investigator)
- Bio-hybrid interfaces to study neuromorphic functionalities (Principal investigator)
- Visual and non-visual photoreceptors (Principal investigator)
- Host-Pathogen Interaction
Further collaborations:
- Silvia Caponi (Cnr-Iom, Perugia),
- Manuela Basso (CIBIO, Trento)
- Maria Pennuto (Università di Padova)
- Paolo Macchi (CIBIO, Trento)
- Luciano Conti (CIBIO, Trento)
- Cecilia Pederzolli (FBK, Trento)
- Cristina Potrich (FBK, Trento)
- Lorenzo Lunelli ((FBK, Trento)
- Georg Nagel (Julius-Maximilians-Universität Würzburg, D)
Financial support:
- PolyQ Clamp - Characterization, alteration and recovery of the cellular excitability in Spinal and Bulbar muscular Atrophy (SBMA), a polyglutamine neurodegenerative disease. Rif. 2018.0274, Fondazione CARITRO Trento.
- Project MaDEleNA.”Grandi Progetti 2012”. Provincia Autonoma di Trento.
Key publications:
Ricci M, Sagini K, Caponi S, Urbanelli L, Cornella N, Macchi P, Morresi A, Emiliani C, Fioretto D, Musio C, Sassi P (2018) Micro-Raman detection of the differentiation state of SH-SY5Y cells grown on silicon and aluminium substrates. J Raman Spectrosc 49: 1031-1040
Jiménez Garduño AM, Juárez-Hernández LJ, Polanco MJ, Tosatto L, Michelatti D, Arosio D, Basso M, Pennuto M, Musio C (2017) Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modeling SBMA. Biophys Chem 229: 68-76
Roncador A, Jimenez-Garduño AM, Pasquardini L, Giusti G, Cornella N, Lunelli L, Potrich C, Bartali R, Aversa L, Verucchi R, Serra MD, Caponi S, Iannotta S, Macchi P, Musio C (2017) Primary cortical neurons on PMCS TiO2 films towards bio-hybrid memristive device: A morpho-functional study. Biophys Chemistry 229: 115-122
Caponi S, Mattana S, Ricci M, Sagini K, Juarez-Hernandez LJ, Jimenez-Garduño AM, Cornella N, Pasquardini L, Urbanelli L, Sassi P, Morresi A, Emiliani C, Fioretto D, Dalla Serra M, Pederzolli C, Iannotta S, Macchi P, Musio C (2016) A multidisciplinary approach to study the functional properties of neuron-like cell models constituting a living bio-hybrid system: SH-SY5Y cells adhering to PANI substrate. AIP Advances, 6, 111303; doi: 10.1063/1.4966587 (highlighted in: Researchers create living bio-hybrid system AAAS|EurekAlert! Science News 15 Nov 2016 - https://www.eurekalert.org/pub_releases/2016-11/aiop-rcl111016.php)
Santillo S, Orlando P, De Petrocellis L, Cristino L, Guglielmotti V, Musio C (2006) Evolving visual pigments: Hints from the opsin-based proteins in a phylogenetically old eyeless invertebrate. BioSystems 86:3-17
Publications (39):
Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical NeuronsVladimir A Martínez-Rojas1, Francesca Pischedda2, Isabel Romero-Maldonado3, Bouchra Khalaf2, Giovanni Piccoli2, Paolo Macchi2, Carlo Musio1
Life (Basel), 2023
DOI: 10.3390/life13091791
Ion channels and neuronal excitability in polyglutamine neurodegenerative diseases
Juarez-Hernandez L.J., Martinez-Rojas V.A., Musio C.
Biomolecular concepts (Internet), 2022
DOI: 10.1515/bmc-2022-0018
A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells
Alessandro Cutarelli1, Vladimir A. Martínez-Rojas2, Alice Tata1, Ingrid Battistella1, Daniela Rossi3, Daniele Arosio2, Carlo Musio2, Luciano Conti1
Cells, 2021
DOI: 10.3390/cells10051127
Clenbuterol-sensitive delayed outward potassium currents in a cell model of spinal and bulbar muscular atrophy
Vladimir A. Martínez-Rojas 1; Daniele Arosio 1; Maria Pennuto 1; Carlo Musio 1
Pflügers Archiv, 2021
DOI: 10.1007/s00424-021-02559-6
ClC-2-like Chloride Current Alterations in a Cell Model of Spinal and Bulbar Muscular Atrophy, a Polyglutamine Disease
Martinez-Rojas V.A.; Jimenez-Garduno A.M.; Michelatti D.; Tosatto L.; Marchioretto M.; Arosio D.; Basso M.; Pennuto M.; Musio C.
Journal of molecular neuroscience, 2020
DOI: 10.1007/s12031-020-01687-5
Introducing the Italian Society of Pure and Applied Biophysics - SIBPA
Viappiani C, Musio C.
Il Nuovo saggiatore (Testo stamp.), 2020
SIBPA on the crest of the Adriatic Sea wave: Introduction to the SIBPA XXIV (2018 congress) special issue
Giacomazza D.; Viappiani C.; Di Cera E.; Musio C.
Biophysical chemistry (Print), 2019
DOI: 10.1016/j.bpc.2019.106273
Prototyping a memristive-based device to analyze neuronal excitability
L. Lunelli, C. Collini, A.M. Jimenez-Garduño, A. Roncador, G. Giusti, R. Verucchi, L. Pasquardini, S. Iannotta, P. Macchi, L. Lorenzelli, C. Pederzolli, C. Musio, C. Potrich
Biophysical chemistry (Print), 2019
DOI: 10.1016/j.bpc.2019.106212
Micro-Raman detection of the differentiation state of SH-SY5Y cells grown on silicon and aluminium substrates
Ricci M, Sagini K, Caponi S, Urbanelli L, Cornella N, Macchi P, Morresi A, Emiliani C, Fioretto D, Musio C, Sassi P
Journal of Raman spectroscopy (Online), 2018
DOI: 10.1002/jrs.5383
SIBPA under the Tuscan sun: Introduction to the SIBPA XXIII Special Issue
Giacomazza D, Viappiani C, Di Cera E, Musio C
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.08.012
Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modelling SBMA.
Jiménez Garduño AM, Juárez-Hernández LJ, Polanco MJ, Tosatto L, Michelatti D, Arosio D, Basso M, Pennuto M, Musio C
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.05.003
Primary cortical neurons on PMCS TiO2 films towards bio-hybrid memristive device: A morpho-functional study.
Roncador A, Jimenez-Garduño AM, Pasquardini L, Giusti G, Cornella N, Lunelli L, Potrich C, Bartali R, Aversa L, Verucchi R, Serra MD, Caponi S, Iannotta S, Macchi P, Musio C
Biophysical chemistry (Print), 2017
DOI: 10.1016/j.bpc.2017.04.010
A multidisciplinary approach to study the functional properties of neuron-like cell models constituting a living bio-hybrid system: SH-SY5Y cells adhering to PANI substrate
Caponi S, Mattana S, Ricci M, Sagini K, Juarez-Hernandez LJ, Jimenez-Garduno AM, Cornella N, Pasquardini L, Urbanelli L, Sassi P, Morresi A, Emiliani C, Fioretto D, Dalla Serra M, Pederzolli C, Iannotta S, Macchi P, Musio C
AIP advances, 2016
DOI: 10.1063/1.4966587
Raman micro-spectroscopy study of living SH-SY5Y cells adhering on different substrates
Caponi, S.; Mattana, S.; Ricci, M.; Ricci, M.; Sagini, K.; Urbanelli, L.; Sassi, P.; Morresi, A.; Emiliani, C.; Emiliani, C.; Dalla Serra, M.; Iannotta, S.; Musio, C.; Fioretto, D.; Fioretto, D.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.009
Bio-hybrid interfaces to study neuromorphic functionalities: New multidisciplinary evidences of cell viability on poly(anyline) (PANI), a semiconductor polymer with memristive properties
Juarez-Hernandez L.J.; Cornella N.; Pasquardini L.; Battistoni S.; Vidalino L.; Vanzetti L.; Caponi S.; Serra M.D.; Iannotta S.; Pederzolli C.; Macchi P.; Musio C.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.008
Biophysical science in Italy: SIBPA turns 40
Giacomazza D, Musio C
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2013.07.004
Raman micro-spectroscopy: A powerful tool for the monitoring of dynamic supramolecular changes in living cells
S. Caponi, Liguori, L., Giugliarelli, A., Mattarelli, M., Morresi, A., Sassi, P., Urbanelli, L., Musio, C
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2013.06.013
Nitric oxide signaling pathways at neural level in invertebrates: Functional implications in cnidarians
Cristino L.; Guglielmotti V.; Cotugno A.; Musio C.; Santillo S.
Brain research, 2008
DOI: 10.1016/j.brainres.2008.04.056
The effects of pattern shape, subliminal stimulation, and voluntary control on multistable visual perception
Taddei-Ferretti C.; Radilova J.; Musio C.; Santillo S.; Cibelli E.; Cotugno A.; Radil T.
Brain research, 2008
DOI: 10.1016/j.brainres.2008.04.064
Brain and Vision: Editorial
Di Maio V.; Musio C.
Brain research, 2008
Evolving visual pigments: Hints from the opsin-based proteins in a phylogenetically old "eyeless" invertebrate
Santillo S.; Orlando P.; De Petrocellis L.; Cristino L.; Guglielmotti V.; Musio C.
Biosystems (Amst. Print), 2006
DOI: 10.1016/j.biosystems.2006.03.008
Molecular and Functional Diversity of Visual Pigments: Clues from the Photosensitive Opsin-Like Proteins of the Animal Model Hydra
Silvia Santillo, Pierangelo Orlando, Luciano De Petrocellis, Luigia Cristino, Vittorio Guglielmotti, and Carlo Musio
Lecture notes in computer science, 2005
DOI: 10.1007/11565123_23
The photobiology of Hydra's periodic activity
Cloe Taddei-Ferretti; Carlo Musio; Silvia Santillo; Antonio Cotugno
Hydrobiologia (The Hague. Print), 2004
DOI: 10.1007/s10750-004-2680-6
First identification and localization of a visual pigment in Hydra (Cnidaria, Hydrozoa)
Musio C. 1, Santillo S. 2, Taddei-Ferretti C. 3, Robles L.J. 4, Vismara R. 5, Barsanti L. 6, Gualtieri P. 7
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 2001
DOI: 10.1007/s003590100180
Photobehaviour of Hydra (Cnidaria, Hydrozoa) and correlated mechanisms: a case of extraocular photoreception,
Taddei-Ferretti C. & C. Musio
Journal of photochemistry and photobiology. B, Biology (Print), 2000
DOI: 10.1016/S1011-1344(00)00041-5
Sensory and mental access to the mechanism responsible of multistable perception
Taddei-Ferretti C., C. Musio & S. Santillo
Neural net of Hydra and the modulation of its periodic activity
Taddei-Ferretti C. & C. Musio
Lecture notes in computer science, 1999
Conscious and intentional access to unconscious decision-making module in ambiguous visual perception
Taddei-Ferretti C., C. Musio, S. Santillo & A. Cotugno
Lecture notes in computer science, 1999
Il deterioramento mentale senile e la sua valutazione
Martino M. & C. Musio
Sistema nervoso e riabilitazione, 1999
Application of the patch-clamp technique to photoreceptor cells of the crayfish Orconectes limosus
Musio Carlo
The Italian journal of zoology (Modena), 1996
Activity in Aplysia buccal ganglia characterized by signal processing techniques
Fiore L., L. Geppetti & C. Musio
Nuovo cimento della Società italiana di fisica. D Condensed matter, atomic, molecular and chemical physics, biophysics (Online), 1995
Non linearity of the interactions between bottom-up and top-down signals in multistable visual perception
Taddei-Ferretti C., C. Musio & S. Santillo
EXPLAN: a programming language for complex visual stimuli presentation.
Colucci R., C. Musio & C. Taddei-Ferretti
International journal of bio-medical computing, 1994
Suppression of Hydra attenuata period shortening activity by repetitive phase delay
Taddei-Ferretti C., S. Chillemi, V. Di Maio & C. Musio
Temperature effect on rhythmic behaviour and biopotentials in Hydra attenuata
Taddei-Ferretti C. & C. Musio
Cross-correlation study of synaptic input distribution inside the buccal ganglion of a gastropod mollusc.
Fiore, L., L. Geppetti & C. Musio
Biological signals, 1993
MODULATION OF HYDRA-ATTENUATA RHYTHMIC ACTIVITY .6. COMBINED EFFECTS OF BACKGROUND AND PULSE LIGHT WAVELENGTH
TADDEIFERRETTI, C; DIMAIO, V; MUSIO, C; COTUGNO, A
Journal of photochemistry and photobiology. B, Biology (Print), 1992
DOI: 10.1016/1011-1344(92)85137-J
Fine structure and axonal organization in the buccal ganglia nerves of Aplysia (Mollusca, Gastropoda)
Musio C. & C. Bedini
Zoomorphology (Berl., Print), 1990
Cross-correlation analysis of intracellularly recorded synaptic activities: an evaluation of the method through computer simulation
Fiore L., L. Geppetti, C. Musio & A. Simoni
Journal of neuroscience methods, 1986