Carlo Musio

Research staff

1988: Degree in Biological Sciences (UniPisa);
1991: CNR-MISM Fellowship in Biophysics (ICIB-CNR Arco Felice, Naples);
1994-1998: CNR Researcher TD;
1998-today: CNR Researcher (permanent);
since 2016: Advisory Editor of the journal "Biophysical Chemistry" Elsevier;
since 2011: Associate Editor of the journal "Photochemistry and Photobiology" Wiley;
2012-2016: President of SIBPA - Italian Society of Pure and Applied Biophysics (to date Past-President)
since 2010: Appointed Member of the Scientific Advisory Board of the European Society for Photobiology (ESP).
Expertize: Biophysics of Neural and Sensory Systems; Ionic Channels; Sensory photobiology; optogenetics; Neurobiology; Bio-hybrid systems; Cell models of neurodegenerative diseases.

orcid://0000-0003-2106-9931,

Contact:

- Email carlo.musio@ibf.cnr.it
- Phone +39-0461-314157
- Location Trento

Research interests:

- Ion channels in neurodegenerative disease (Principal investigator)
- Bio-hybrid interfaces to study neuromorphic functionalities (Principal investigator)
- Visual and non-visual photoreceptors (Principal investigator)
- Host-Pathogen Interaction

Further collaborations:

- Silvia Caponi (Cnr-Iom, Perugia),
- Manuela Basso (CIBIO, Trento)
- Maria Pennuto (Università di Padova)
- Paolo Macchi (CIBIO, Trento)
- Luciano Conti (CIBIO, Trento)
- Cecilia Pederzolli (FBK, Trento)
- Cristina Potrich (FBK, Trento)
- Lorenzo Lunelli ((FBK, Trento)
- Georg Nagel (Julius-Maximilians-Universität Würzburg, D)

Financial support:

- PolyQ Clamp - Characterization, alteration and recovery of the cellular excitability in Spinal and Bulbar muscular Atrophy (SBMA), a polyglutamine neurodegenerative disease. Rif. 2018.0274, Fondazione CARITRO Trento.
- Project MaDEleNA.”Grandi Progetti 2012”. Provincia Autonoma di Trento.

Key publications:

Ricci M, Sagini K, Caponi S, Urbanelli L, Cornella N, Macchi P, Morresi A, Emiliani C, Fioretto D, Musio C, Sassi P (2018) Micro-Raman detection of the differentiation state of SH-SY5Y cells grown on silicon and aluminium substrates. J Raman Spectrosc 49: 1031-1040

Jiménez Garduño AM, Juárez-Hernández LJ, Polanco MJ, Tosatto L, Michelatti D, Arosio D, Basso M, Pennuto M, Musio C (2017) Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modeling SBMA. Biophys Chem 229: 68-76

Roncador A, Jimenez-Garduño AM, Pasquardini L, Giusti G, Cornella N, Lunelli L, Potrich C, Bartali R, Aversa L, Verucchi R, Serra MD, Caponi S, Iannotta S, Macchi P, Musio C (2017) Primary cortical neurons on PMCS TiO2 films towards bio-hybrid memristive device: A morpho-functional study. Biophys Chemistry 229: 115-122

Caponi S, Mattana S, Ricci M, Sagini K, Juarez-Hernandez LJ, Jimenez-Garduño AM, Cornella N, Pasquardini L, Urbanelli L, Sassi P, Morresi A, Emiliani C, Fioretto D, Dalla Serra M, Pederzolli C, Iannotta S, Macchi P, Musio C (2016) A multidisciplinary approach to study the functional properties of neuron-like cell models constituting a living bio-hybrid system: SH-SY5Y cells adhering to PANI substrate. AIP Advances, 6, 111303; doi: 10.1063/1.4966587 (highlighted in: Researchers create living bio-hybrid system AAAS|EurekAlert! Science News 15 Nov 2016 - https://www.eurekalert.org/pub_releases/2016-11/aiop-rcl111016.php)

Santillo S, Orlando P, De Petrocellis L, Cristino L, Guglielmotti V, Musio C (2006) Evolving visual pigments: Hints from the opsin-based proteins in a phylogenetically old eyeless invertebrate. BioSystems 86:3-17

Publications (19):

A comprehensive protocol for efficient differentiation of human NPCs into electrically competent neurons
Romito, Elena; Battistella, Ingrid; Plakhova, Vera; Paplekaj, Arteda; Forastieri, Chiara; Toffolo, Emanuela; Musio, Carlo; Conti, Luciano; Battaglioli, Elena; Rusconi, Francesco
JOURNAL OF NEUROSCIENCE METHODS, 410, 2024
DOI: 10.1016/j.jneumeth.2024.110225

Ion channels and neuronal excitability in polyglutamine neurodegenerative diseases
Juarez-Hernandez L.J., Martinez-Rojas V.A., Musio C.
biomolecular concepts (internet), 13, 2022
DOI: 10.1515/bmc-2022-0018

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells
Alessandro Cutarelli1, Vladimir A. Martínez-Rojas2, Alice Tata1, Ingrid Battistella1, Daniela Rossi3, Daniele Arosio2, Carlo Musio2, Luciano Conti1
cellsissn: 2073-4409molecular diversity preservation international, 2021
DOI: 10.3390/cells10051127

Clenbuterol-sensitive delayed outward potassium currents in a cell model of spinal and bulbar muscular atrophy
Vladimir A. Martínez-Rojas 1; Daniele Arosio 1; Maria Pennuto 1; Carlo Musio 1
pflügers archivissn: 0031-6768springer, Volume 473, 2021
DOI: 10.1007/s00424-021-02559-6

ClC-2-like Chloride Current Alterations in a Cell Model of Spinal and Bulbar Muscular Atrophy, a Polyglutamine Disease
Martinez-Rojas, Vladimir A.; Jimenez-Garduno, Aura M.; Michelatti, Daniela; Tosatto, Laura; Marchioretto, Marta; Arosio, Daniele; Basso, Manuela; Pennuto, Maria; Musio, Carlo
Journal Of Molecular Neuroscience, 2020
DOI: 10.1007/s12031-020-01687-5

Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and A beta 1-42-mediated toxicity
Tripathy, Debasmita; Migazzi, Alice; Costa, Federica; Roncador, Alessandro; Gatto, Pamela; Fusco, Federica; Boeri, Lucia; Albani, Diego; Juarez-Hernandez, J. Leon; Musio, Carlo; Colombo, Laura; Salmona, Mario; Wilhelmus, M. M. Micha; Drukarch, Benjamin; P
Neurobiology Of Disease, 140, 2020
DOI: 10.1016/j.nbd.2020.104849

Prototyping a memristive-based device to analyze neuronal excitability
Lunelli L, Collini C, Jimenez-Garduño AM, Roncador A, Giusti G, Verucchi R, Pasquardini L, Iannotta S, Macchi P, Lorenzelli L, Pederzolli C, Musio C, Potrich C
Biophysical chemistry, 253, 2019
DOI: 10.1016/j.bpc.2019.106212

SIBPA on the crest of the Adriatic Sea wave: Introduction to the SIBPA XXIV (2018 congress) special issue
Giacomazza D, Viappiani C, Di Cera E, Musio C
Biophysical chemistry, 255, 2019
DOI: 10.1016/j.bpc.2019.106273

Micro-Raman detection of the differentiation state of SH-SY5Y cells grown on silicon and aluminium substrates
Ricci M, Sagini K, Caponi S, Urbanelli L, Cornella N, Macchi P, Morresi A, Emiliani C, Fioretto D, Musio C, Sassi P
Journal of Raman spectroscopy, 49, 2018
DOI: 10.1002/jrs.5383

Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modelling SBMA.
Jiménez Garduño AM, Juárez-Hernández LJ, Polanco MJ, Tosatto L, Michelatti D, Arosio D, Basso M, Pennuto M, Musio C
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.05.003

Primary cortical neurons on PMCS TiO2 films towards bio-hybrid memristive device: A morpho-functional study.
Roncador A, Jimenez-Garduño AM, Pasquardini L, Giusti G, Cornella N, Lunelli L, Potrich C, Bartali R, Aversa L, Verucchi R, Serra MD, Caponi S, Iannotta S, Macchi P, Musio C
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.04.010

SIBPA under the Tuscan sun: Introduction to the SIBPA XXIII Special Issue
Giacomazza D, Viappiani C, Di Cera E, Musio C
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.08.012

A multidisciplinary approach to study the functional properties of neuron-like cell models constituting a living bio-hybrid system: SH-SY5Y cells adhering to PANI substrate
Caponi S, Mattana S, Ricci M, Sagini K, Juarez-Hernandez LJ, Jimenez-Garduno AM, Cornella N, Pasquardini L, Urbanelli L, Sassi P, Morresi A, Emiliani C, Fioretto D, Dalla Serra M, Pederzolli C, Iannotta S, Macchi P, Musio C
AIP advances American Institute of Physics , 6, 2016
DOI: 10.1063/1.4966587

Bio-hybrid interfaces to study neuromorphic functionalities: New multidisciplinary evidences of cell viability on poly(anyline) (PANI), a semiconductor polymer with memristive properties
Juarez-Hernandez L.J.; Cornella N.; Pasquardini L.; Battistoni S.; Vidalino L.; Vanzetti L.; Caponi S.; Serra M.D.; Iannotta S.; Pederzolli C.; Macchi P.; Musio C.
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.008

Italian biophysics and SIBPA speed-up the pace towards the long and winding road of the interdisciplinary science
Giacomazza D, Musio C
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.10.007

Raman micro-spectroscopy study of living SH-SY5Y cells adhering on different substrates
Caponi, S.; Mattana, S.; Ricci, M.; Ricci, M.; Sagini, K.; Urbanelli, L.; Sassi, P.; Morresi, A.; Emiliani, C.; Emiliani, C.; Dalla Serra, M.; Iannotta, S.; Musio, C.; Fioretto, D.; Fioretto, D.
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.009

Biophysical science in Italy: SIBPA turns 40
Giacomazza D, Musio C
Biophysical chemistry, 182, 2013
DOI: 10.1016/j.bpc.2013.07.004

Raman micro-spectroscopy: A powerful tool for the monitoring of dynamic supramolecular changes in living cells
S. Caponi, Liguori, L., Giugliarelli, A., Mattarelli, M., Morresi, A., Sassi, P., Urbanelli, L., Musio, C
Biophysical chemistry, 182, 2013
DOI: 10.1016/j.bpc.2013.06.013

First identification and localization of a visual pigment in Hydra (Cnidaria, Hydrozoa)
Musio, C; Santillo, S; Taddeiferretti, C; Robles, Lj; Vismara, R; Barsanti, L; Gualtieri, P
JOURNAL OF COMPARATIVE PHYSIOLOGY. A, NEUROETHOLOGY, SENSORY, NEURAL, AND BEHAVIORAL PHYSIOLOGY, 187, 2001
DOI: 10.1007/s003590100180