Samuele Raccosta

Research staff

2011: PhD in Physics (6 months spent in Copenhagen at Prof. Vestergaard’s lab for studies on aSN fibrillation) 2011-2012: fellowship at Biophysics and Nanoscience Centre (Prof. Cannistraro’s lab) 2014: 1 month spent at AppNano for studies on Scanning Thermal Microscopy (Mountain View, California) Since 2014 I work at Institute of Biophysics and my research activity mainly concerns biophysical studies on extracellular vesicles (mechanical properties, composition, functionalization), protein aggregation and protein-protein interaction. Expertise: AFM, Light Scattering, Differential Scanning Calorimetry, Optical spectroscopy, Circular Dichroism. Actually, I’m working on two Horizon2020 projects: Ves4Us (FET-open call) and BOW (FET proactive)

orcid://0000-0001-7775-5928,

Contact:

- Email samuele.raccosta@ibf.cnr.it
- Phone +39-091-6809311
- Location Palermo

Research interests:

- Molecular bases of serpinopathies
- Characterisation of extracellular vescicles
- Laboratory for Advanced and Scattering Technologies (LAST)
- Model Membrane Systems and Interaction Studies
- Cell-based technologies and bioactives for research and innovation (Cell-Tech Hub)

Key publications:

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae. Adamo et al. Journal of Extracellular Vesicles, 2021, 10(6), e12081

Palmitoylation is a post-translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles. Romancino et al. Biochimica et Biophysica Acta - General Subjects, 2018, 1862(12), pp. 2879–2887

Scaling concepts in serpin polymer physics. Raccosta et al. Materials, 2021, 14(10), 2577

Conductive atomic force microscopy study of single molecule electron transport through the Azurin-gold nanoparticle system. Raccosta et al. Applied Physics Letters, 2013, 102(20), 203704

Thermodynamic versus conformational metastability in fibril-forming lysozyme solutions. Raccosta et al. Journal of Physical Chemistry B, 2012, 116(40), pp. 12078–12087

Publications (11):

Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto Sabrina; Barone Maria E.; Fierli David; Aranyos Anita; Adamo Giorgia; Bo?i? Darja; Romancino Daniele P.; Stanly Christopher; Parkes Rachel; Morsbach Svenja; Raccosta Samuele; Paganini Carolina; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Capasso Palmiero Umberto; Santonicola Pamela; Igli? Ales; Gai Meiyu; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Landfester Katharina; Liguori Giovanna L.; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Manno Mauro; Touzet Nicolas; Bongiovanni Antonella
Biomaterials science (Print), 2021
DOI: 10.1039/d0bm01696a

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo Giorgia; Fierli David; Romancino Daniele P.; Picciotto Sabrina; Barone Maria E.; Aranyos Anita; Bo?i? Darja; Morsbach Svenja; Raccosta Samuele; Stanly Christopher; Paganini Carolina; Gai Meiyu; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Randazzo Loredana; Parkes Rachel; Capasso Palmiero Umberto; Rao Estella; Paterna Angela; Santonicola Pamela; Igli? Ales; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Liguori Giovanna L.; Landfester Katharina; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Touzet Nicolas; Manno Mauro; Bongiovanni Antonella;
Journal of extracellular vesicles, 2021
DOI: 10.1002/jev2.12081

Preliminary results of citraves(TM) effects on low density lipoprotein cholesterol and waist circumference in healthy subjects after 12 weeks: A pilot open-label study
Raimondo S.; Nikolic D.; Conigliaro A.; Giavaresi G.; Sasso B.L.; Giglio R.V.; Chianetta R.; Manno M.; Raccosta S.; Corleone V.; Ferrante G.; Citarrella R.; Rizzo M.; De Leo G.; Ciaccio M.; Montalto G. and Alessandro R.
Metabolites, 2021
DOI: 10.3390/metabo11050276

Scaling concepts in serpin polymer physics
Raccosta S.; Librizzi F.; Jagger A.M.; Noto R.; Martorana V.; Lomas D.A.; Irving J.A.; Manno M.
Materials (Basel), 2021
DOI: 10.3390/ma14102577

Biomanufacturing of tomato-derived nanovesicles
Ramesh Bokka; Anna PaulinaRamos; Immacolata Fiume; Mauro Manno; , Samuele Raccosta; , Lilla Turiák; Simon Sugár; Giorgia Adamo; Tamás Csizmadia; Gabriella Pocsfalvi
Foods, 2020
DOI: 10.3390/foods9121852

Palmitoylation is a post -translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles
Romancino, Daniele P.; Buffa, Valentina; Caruso, Stefano; Ferrara, Ines; Raccosta, Samuele; Notaro, Antonietta; Campos, Yvan; Noto, Rosina; Martorana, Vincenzo; Cupane, Antonio; Giallongo, Agata; d'Azzo, Alessandra; Manno, Mauro; Bongiovanni, Antonella
Biochimica et biophysica acta. G, General subjects (Print), 2018
DOI: 10.1016/j.bbagen.2018.09.004

Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: A possible role for exosomal disposal of miR-21
Taverna S.; Giallombardo M.; Pucci M.; Flugy A.; Manno M.; Raccosta S.; Rolfo C.; De Leo G.; Alessandro R.
Oncotarget, 2015
DOI: 10.18632/oncotarget.4204

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
Conigliaro A.; Costa V.; Lo Dico A.; Saieva L.; Buccheri S.; Dieli F.; Manno M.; Raccosta S.; Mancone C.; Tripodi M.; De Leo G.; Alessandro R.
Molecular cancer, 2015
DOI: 10.1186/s12943-015-0426-x

Custom system for single molecule force spectroscopy
1 E. Landini, 2 S. Raccosta, 2 F. D'Anca, 3 M. Zora, 3 S. Mazzola, 2 P.L. Sanbiagio, 2 V. Martorana, 1 M. Vassalli
Microscopie, 2014

Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures
Nielsen SB, Macchi F, Raccosta S, Langkilde AE, Giehm L, Kyrsting A, Pii Svane AS, Manno M, Christiansen G, Nielsen NC, Oddershede L, Vestergaard B, Otzen DE
PloS one, 2013
DOI: 10.1371/journal.pone.0067713

Thermodynamic versus Conformational Metastability in Fibril-Forming Lysozyme Solutions
Raccosta S; Martorana V; Manno M
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp303430g