Oscar Moran

Researcher

BSc in Biology (1978) e MSc in Biophysics (1979), Universidad Peruana Cayetano Heredia, Lima.
PhSc Physiology and Biophysics, Instituto Venezolano de Investigaciones Cientificas, Caracas.

orcid://0000-0003-1287-6176, ncbi://47761049

Contact:

- Email oscar.moran@ge.ibf.cnr.it
- Phone +39-010-6475558
- Site Genova

Research interests:

- Genetic diseases caused by mutations of the auxiliary subunits of the sodium channel (Principal investigator)

- Molecular pharmacology of cystic fibrosis (Principal investigator)

- Model Membrane Systems and Interaction Studies

- Liposome as drug delivery system

Further collaborations:

- Rita Carrotta (IBF Palermo)
- Loretta Ferrera (Istituto Giannina Gaslini, Genova)
- Mary Diaz (Biomedical Sciences, University of Edinburgh, UK)
- Luis J.V. Galietta (Tigem, Napoli)

Financial support:

- Identification of the binding sites of CFTR correctors. Progetto FFC#8/2016, Fondazione per la Ricerca sulla Fibrosi Cistica
- Transmembrane anion transporters as new chemotherapeutics for the treatment of cystic fibrosis.
- Grant agreement No 667079, European Union’s Horizon 2020 research and innovation programme.

Key publications:

Baroni D, Picco C, Moran O. A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage dependent sodium channel. Hum Mutat. 2018 Jul 10. doi: 10.1002/humu.23589.

Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R. Small molecule anionophores promote transmembrane anion permeation matching CFTR activity. Sci Rep. 2018 Feb 8;8(1):2608. doi: 10.1038/s41598-018-20708-3.The biophysics, biochemistry and physiology of CFTR. Moran O. Cell Mol Life Sci. 2017 Jan;74(1):1-2. doi: 10.1007/s00018-016-2384-x.

Pollock NL, Satriano L, Zegarra-Moran O, Ford RC, Moran O. Structure of wild type and mutant F508del CFTR: A small-angle X-ray scattering study of the protein-detergent complexes.J Struct Biol. 2016 Apr;194(1):102-11. doi: 10.1016/j.jsb.2016.02.004

Gianotti A, Capurro V, Scudieri P, Galietta LJ, Moran O, Zegarra-Moran O.Pharmacological rescue of mutant CFTR protein improves the viscoelastic properties of CF mucus. J Cyst Fibros. 2016 May;15(3):295-301. doi: 10.1016/j.jcf.2015.11.003.

Baroni D, Moran O. On the multiple roles of the voltage gated sodium channel beta1 subunit in genetic diseases. Front Pharmacol. 2015 May 18;6:108. doi: 10.3389/fphar.2015.00108

Publication list