Matteo De Rosa


2013-2015 Postdoc, Dep. of Biosciences, University of Milano, Italy
2010-2013 Postdoc, IGC, Oeiras, Portugal
2008-2009 Postdoc, ITQB, University of Lisbon, Portugal
2004-2007 PhD in Molecular and Cell Biology, University of Milano, Italy
2004 MSc in Biological Sciences (biomolecular program)



- Email
- Phone +39-02-50314890
- Site Milano


Research interests:

- Gelsolin physiopathology (Principal investigator)

- Structure-based drug discovery on viral proteins

- Structural analysis of proteins involved in various human diseases and research of new therapeutic strategies

- Structure-based drug discovery

Further collaborations:

- Michela Bollati, Federica Cossu (IBF-CNR)
- Alberto Barbiroli, Maria A. Vanoni, Fabio Fornara, Vittoria Brambilla (Università di Milano)
- Luisa Diomede (Istituto di ricerche farmacologiche Mario Negri)
- Francesca Arnoldi, Oscar Burrone (International centre for genetic engineering and biotechnology)

Financial support:

- From protein structure to novel drugs against Agel amyloidosis: a fast and cost-effective route to the development of new therapeutics, Research Grant 2018, Amyloidosis foundation .
- Characterization of recently identified gelsolin variants responsible for a novel renal amyloidosis and in silico screening of drug candidates, GEP15070, Fondazione Telethon.

Key publications:

Le Marchand T, de Rosa M, Salvi N, Sala BM, Andreas LB, Barbet-Massin E, Sormanni P, Barbiroli A, Porcari R, Sousa Mota C, de Sanctis D, Bolognesi M, Emsley L, Bellotti V, Blackledge M, Camilloni C, Pintacuda G, Ricagno S. ( 2018) Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity. Nat Commun. Apr 25;9(1):1658. doi: 10.1038/s41467-018-04078-y

Bonì F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M. (2018) Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein. Hum Mol Genet. Jan 1;27(1):53-65. doi: 10.1093/hmg/ddx383

Bonì F, Milani M, Porcari R, Barbiroli A, Ricagno S, de Rosa M. (2016) Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant. Sci Rep. Sep 16;6:33463. doi: 10.1038/srep33463

de Rosa M, Zacarias S, Athanasiadis A. (2013) Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ. Nucleic Acids Res. Nov;41(21):9924-33. doi: 10.1093/nar/gkt743. Epub 2013 Aug 23

de Rosa M, de Sanctis D, Rosario AL, Archer M, Rich A, Athanasiadis A, Carrondo MA. (2010) Crystal structure of a junction between two Z-DNA helices. Proc Natl Acad Sci U S A. May 18;107(20):9088-92. doi: 10.1073/pnas.1003182107

Publication list