Alessandra Picollo


Degree in Physics, University of Genova
PhD Istituto di Biofisica, CNR, Genova
Post doc University of Iowa, IA, USA
Post doc Weill Cornell Medical College, New York, NY USA

orcid://0000-0003-2980-7951, ncbi://56650231


- Email
- Phone +39-010-6475649
- Site Genova

Research interests:

- Functional and structural studies of human CLC protein complexes involved in genetic diseases (Principal investigator)

- Quantitative single molecule localizations of channel proteins by using fluorescence super resolution tecniques

Further collaborations:

- Cristina Sobacchi (Istituto di riceca genetica e biomendica, CNR)

Financial support:

- Studi strutturali e funzionali dei complessi proteici CLC coinvolti in malattie genetiche. TCP 14008.Dulbecco Telethon Career Award.
- Functional and structural studies of human CLC chloride proteins involved in genetic disease. TCP14008 Dulbecco Telethon Career Award.

Key publications:

Picollo A, Malvezzi M, and Accardi A. (2015) TMEM16 Proteins: Unknown Structure and Confusing Functions. J Mol Biol Jan; 16: 94-105

Terashima H*, Picollo A* and Accardi A. (2013). Purified TMEM16A is sufficient to form Ca2+ activated Cl- channels. PNAS 110:19354-9

Malvezzi M, Chalat M.N, Janjusevic R, Picollo A, Terashima H, Menon A.K, Accardi A (2013). A TMEM16 ion channel that mediates Ca2+-dependent phospholipid scrambling. Nature Communication 4:2367

Picollo A, Malvezzi M , Houtman J and Accardi A. (2009). Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters. Nat Struct Mol Biol. 16:1294-301

Picollo A and Pusch M. (2005). Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature. 21, 420-3.

Publication list