Personal Card



Rosina Noto

Rosina Noto was born in S. Stefano Quisquina (AG) on 16/01/1956. My recent and main research activity concerns the extracellular vesicles produced by microalgae (production, purification and biophysical studies) and included in Horizon 2020 projects Ves4Us and BOW. From 2001 to present: researcher at CNR-IBF 1990-2000: Tecnical Collaborator Agencies Research at National Research Council, Institute for the Interdisciplinary Application of Physics (now IBF) 1986: Degree in Physics, University of Palermo 1982-1990: training fellowship, ex L.285/77, of National Research Council, biological-medical sector.

orcid://0000-0001-6818-7981,

Research interests:

- Production, Purification, Mutagenesis and Characterization of proteins expressed in E. coli (Principal investigator)

Financial support:

- Percorsi formativi nei settori Biotecnologia, Biomedicina e Agroalimentare. Progetto SPIN OFF N. IBF-BS-001-2018-PA.
- Extracellular vesicles from a natural source for tailor-made nanomaterials (Ves4US). Project ID: 801338. European Union Horizon 2020, FET Open research and innovation actions

Key publications:

Raccosta S, Librizzi F, Jagger AM, Noto R, Martorana V, Lomas DA, Irving JA, Manno M. Scaling Concepts in Serpin Polymer Physics. Materials (Basel). 2021 May 15;14(10). doi: 10.3390/ma14102577

Adamo G, Fierli D, Romancino DP, Picciotto S, Barone ME, Aranyos A, Boži? D, Morsbach S, Raccosta S, Stanly C, Paganini C, Gai M, Cusimano A, Martorana V, Noto R, Carrotta R, Librizzi F, Randazzo L, Parkes R, Capasso Palmiero U, Rao E, Paterna A, Santonicola P, Igli? A, Corcuera L, Kisslinger A, Di Schiavi E, Liguori GL, Landfester K, Kralj-Igli? V, Arosio P, Pocsfalvi G, Touzet N, Manno M, Bongiovanni A. Nanoalgosomes: Introducing extracellular vesicles produced by microalgae. J Extracell Vesicles. 2021 Apr;10(6):e12081. doi: 10.1002/jev2.12081

Picciotto S, Barone ME, Fierli D, Aranyos A, Adamo G, BoŽi? D, Romancino DP, Stanly C, Parkes R, Morsbach S, Raccosta S, Paganini C, Cusimano A, Martorana V, Noto R, Carrotta R, Librizzi F, Capasso Palmiero U, Santonicola P, Igli? A, Gai M, Corcuera L, Kisslinger A, Di Schiavi E, Landfester K, Liguori GL, Kralj-Igli? V, Arosio P, Pocsfalvi G, Manno M, Touzet N, Bongiovanni A. Isolation of extracellular vesicles from microalgae: towards the production of sustainable and natural nanocarriers of bioactive compounds. Biomater Sci. 2021 Apr 21;9(8):2917-2930. doi: 10.1039/d0bm01696a

Martorana V, Raccosta S, Giacomazza D, Ditta LA, Noto R, Biagio PLS, Manno M. Amyloid jams: Mechanical and dynamical properties of an amyloid fibrillar network. Biophys Chem. 2019 Oct;253:106231. doi: 10.1016/j.bpc.2019.106231

Romancino DP, Buffa V, Caruso S, Ferrara I, Raccosta S, Notaro A, Campos Y, Noto R, Martorana V, Cupane A, Giallongo A, d'Azzo A, Manno M, Bongiovanni A. Palmitoylation is a post-translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles. Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2879-2887. doi: 10.1016/j.bbagen.2018.09.004

Publications (26):

Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans
Picciotto Sabrina; Santonicola Pamela; Paterna Angela; Rao Estella; Raccosta Samuele; Romancino Daniele Paolo; Noto Rosina; Touzet Nicolas; Manno Mauro; Di Schiavi Elia; Bongiovanni Antonella; Adamo Giorgia
Frontiers in Bioengineering and Biotechnology, 2022
DOI: 10.3389/fbioe.2022.830189

The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
Pizzo Federica, Mangione Maria Rosalia, Librizzi Fabio, Manno Mauro, Martorana Vincenzo, Noto Rosina and Vilasi Silvia
Life (Basel), 2022
DOI: 10.3390/life12030448

Isolation of Extracellular Vesicles From Microalgae: A Renewable and Scalable Bioprocess
Angela Paterna; Estella Rao; Giorgia Adamo; Samuele Raccosta; Sabrina Picciotto; Daniele Romancino; Rosina Noto; Nicolas Touzet; Antonella Bongiovanni; Mauro Manno
Frontiers in Bioengineering and Biotechnology, 2022
DOI: 10.3389/fbioe.2022.836747

Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto Sabrina; Barone Maria E.; Fierli David; Aranyos Anita; Adamo Giorgia; Bo?i? Darja; Romancino Daniele P.; Stanly Christopher; Parkes Rachel; Morsbach Svenja; Raccosta Samuele; Paganini Carolina; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Capasso Palmiero Umberto; Santonicola Pamela; Igli? Ales; Gai Meiyu; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Landfester Katharina; Liguori Giovanna L.; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Manno Mauro; Touzet Nicolas; Bongiovanni Antonella
Biomaterials science (Print), 2021
DOI: 10.1039/d0bm01696a

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo Giorgia; Fierli David; Romancino Daniele P.; Picciotto Sabrina; Barone Maria E.; Aranyos Anita; Bo?i? Darja; Morsbach Svenja; Raccosta Samuele; Stanly Christopher; Paganini Carolina; Gai Meiyu; Cusimano Antonella; Martorana Vincenzo; Noto Rosina; Carrotta Rita; Librizzi Fabio; Randazzo Loredana; Parkes Rachel; Capasso Palmiero Umberto; Rao Estella; Paterna Angela; Santonicola Pamela; Igli? Ales; Corcuera Laura; Kisslinger Annamaria; Di Schiavi Elia; Liguori Giovanna L.; Landfester Katharina; Kralj-Igli? Veronika; Arosio Paolo; Pocsfalvi Gabriella; Touzet Nicolas; Manno Mauro; Bongiovanni Antonella;
Journal of extracellular vesicles, 2021
DOI: 10.1002/jev2.12081

Scaling concepts in serpin polymer physics
Raccosta S.; Librizzi F.; Jagger A.M.; Noto R.; Martorana V.; Lomas D.A.; Irving J.A.; Manno M.
Materials (Basel), 2021
DOI: 10.3390/ma14102577

N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function
Aguila Sonia; Noto Rosina; Luengo-Gil Gines; Espin Salvador; Bohdan Nataliya; de la Morena-barrio Maria Eugenia; Penas Julia; Rodenas Maria Carmen; Vicente Vicente; Corral Javier; Manno Mauro; Martinez-Martinez Irene
International journal of molecular sciences (Online), 2021
DOI: 10.3390/ijms22020516

Amyloid jams: Mechanical and dynamical properties of an amyloid fibrillar network
Martorana V, Raccosta S, Giacomazza D, Ditta LA, Noto R, Biagio PLS, Manno M
Biophysical chemistry (Print), 2019
DOI: 10.1016/j.bpc.2019.106231

Palmitoylation is a post -translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles
Romancino, Daniele P.; Buffa, Valentina; Caruso, Stefano; Ferrara, Ines; Raccosta, Samuele; Notaro, Antonietta; Campos, Yvan; Noto, Rosina; Martorana, Vincenzo; Cupane, Antonio; Giallongo, Agata; d'Azzo, Alessandra; Manno, Mauro; Bongiovanni, Antonella
Biochimica et biophysica acta. G, General subjects (Print), 2018
DOI: 10.1016/j.bbagen.2018.09.004

Embelin binds to human neuroserpin and impairs its polymerisation
Saga, Giorgia; Sessa, Fabio; Barbiroli, Alberto; Santambrogio, Carlo; Russo, Rosaria; Sala, Michela; Raccosta, Samuele; Martorana, Vincenzo; Caccia, Sonia; Noto, Rosina; Moriconi, Claudia; Miranda, Elena; Grandori, Rita; Manno, Mauro; Bolognesi, Martino; Bolognesi, Martino; Ricagno, Stefano
Scientific reports (Nature Publishing Group), 2016
DOI: 10.1038/srep18769

Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics
Noto, Rosina; Santangelo, Maria Grazia; Levantino, Matteo; Cupane, Antonio; Mangione, Maria Rosalia; Parisi, Daniele; Ricagno, Stéfano; Bolognesi, Martino; Manno, Mauro; Martorana, Vincenzo
Biochimica et biophysica acta. Proteins and proteomics, 2015
DOI: 10.1016/j.bbapap.2014.10.002

The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop
Noto R.; Randazzo L.; Raccosta S.; Caccia S.; Moriconi C.; Miranda E.; Martorana V.; Manno M.
Scientific reports (Nature Publishing Group), 2015
DOI: 10.1038/srep13666

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum
Moriconi C, Ordoñez A, Lupo G, Gooptu B, Irving JA, Noto R, Martorana V, Manno M, Timpano V, Guadagno NA, Dalton L, Marciniak SJ, Lomas DA, Miranda E
The FEBS journal (Online), 2015
DOI: 10.1111/febs.13517

On the molecular structure of human neuroserpin polymers
Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M
Proteins (Print), 2012
DOI: 10.1002/prot.23197

The Tempered Polymerization of Human Neuroserpin
Noto R; Santangelo MG; Ricagno S; Mangione MR; Levantino M; Pezzullo M; Martorana V; Cupane A; Bolognesi M; Manno M
PloS one, 2012
DOI: 10.1371/journal.pone.0032444

Density Functional Theory Study of the Trans-Trans-Cis (TTC) --> Trans-Trans-Trans (TTT) Isomerization of a Photochromic Spiropyran Merocyanine
Cottone, G; R. Noto; G. La Manna.
Molecules (Basel, Online), 2008
DOI: 10.3390/molecules13061246

Role of charges and solvent on the conformational properties of poly(galacturonic acid) chains: a Molecular Dynamics study.
Noto R.; Martorana V.; Bulone D.; San Biagio P. L.
Biomacromolecules, 2005
DOI: 10.1021/bm050280g

Theoretical study of spiropyran-merocyanine thermal isomerization.
Cottone G.; Noto R.: La Manna G.
Chemical physics letters (Print), 2004
DOI: 10.1016/j.cplett.2004.03.016

Ab initio study on the photoisomers of a nitro-substituted spiropyran
Cottone, Grazia; Noto, Rosina; La Manna, Gianfranco; Fornili, Sandro Luciano
Chemical physics letters (Print), 2000

Water interaction with ?,?-trehalose: molecular dynamics simulation
Giovanni Bonanno, Rosina Noto and Sandro L. Fornili
J. Chem. Soc . Faraday Trans., 1998
DOI: 10.1039/A804257H

Ab initio calculations and vibrational spectroscopy on the phenylendiamine isomers
R. Noto, M. Leone, G. La Manna, F. Bruge' and S.L. Fornili
Journal of molecular structure. Theochem (Print), 1998
DOI: 10.1016/S0166-1280(97)00068-7

Interaction of water with the phenylenediamine isomers - Ab initio potential evaluation and molecular dynamics simulation
Cottone, G; Noto, R; Fornili, SL
Journal of the Chemical Society. Faraday transactions (Print), 1998
DOI: 10.1039/a802815j

Microscopic aspects of solute-solute interactions induced by the solvent
Bruge, F; Cottone, G; Noto, R; Fornili, ZL
J Chim Phys JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE, 1996

Comparison of the water perturbations induced by two small organic solutes: ab initio calculations and molecular dynamics simulation
Rosina Noto, Vincenzo Martorana, Antonio Emanuele, Sandro L Fornili
Journal of the Chemical Society. Faraday transactions (Print), 1995

Hydration of the Ammonium Ion: Monte Carlo Simulation
R. Noto (1), V. Martorana (1), M. Migliore (1), S.L. Fornili (1,2)
Zeitschrift für Naturforschung. Teil a, Physik, physikalische Chemie, Kosmophysik, 1991

Solute-induced water structure: computer simulation on a model system.
R. Noto, M. Migliore, F. Sciortino and S.L. Fornili
Molecular simulation (Print), 1988
DOI: 10.1080/08927028808080945