Personal Card



Donatella Bulone

Research staff

Donatella Bulone graduated in Physics at the University of Palermo, Italy, in 1981. She is currently senior researcher at the Institute of Biophysics of the National Research Council. She had been Visiting Scientist at Physics Dept. Union College, Schenectady, NY (USA) and at Molecular Structure” del National Institute for Medical Research of London, UK. Her research activity concerns the mechanisms responsible for the biomolecular aggregation with particular reference to protein involved in pathological aggregation and functional biopolymers. She is author of more than 100 international ISI publications journals.

orcid://0000-0002-5841-9133,

Contact:

- Email donatella.bulone@ibf.cnr.it
- Phone +39-091-6809320
- Location Palermo

Research interests:

- Structure and Functionality of Molecular chaperones (Principal investigator)
- Polysaccharides Substitutes for Gluten-Free Baking (Principal investigator)
- Study of natural and chemically modified natural polymers for biotechnological applications
- Development of bio-adhesives for wet environments from marine mussels
- Laboratory of protein engineering for production of recombinant proteins.
- Biomolecular Aggregation Processes
- Protein aggregation and the onset of neurodegenerative diseases
- Extraction and characterization of polyphenols from complex systems of agri-food origin; study of antioxidant properties and of neuroprotective and anti-amyloidogenic effects in neurodegenerative processes

Further collaborations:

- M. Leone (Dip. Scienze Fisiche ed Astronomiche, Università di Palermo)
- G. Giammona (Cnr-Ibf, Palermo e Facoltà di Farmacia - Dip. STEBICEF, Università di Palermo)
- F. Cappello (Dipartimento di biomedicina sperimentale e neuroscienze cliniche, Università di Palermo)
- J. Newman (Dept. of Physics, Union College, Schenectady, NY, USA)
- A. Pastore (Basic and Clinical Neuroscience, King’s College, London, UK)
- T. Coviello (Dip. Farmacia e Tecnologie del Farmaco, Università di Roma, La Sapienza)
- R.M. Negri (NQUIMAE and Departamento de Química Inorgánica, Analítica y Química Física, University of Buenos Aires, AG)
- C. Dispenza (Dip. Innovazione Industriale e Digitale (DIID) - Ingegneria Chimica, Gestionale, Informatica, Meccanica, Università di Palermo)
- F. Robb (Dept. of Microbiology and Immunology, Baltimore, MD, USA)
- A.J.L. Macario (Dept. of Microbiology and Immunology, Baltimore, MD, USA)
- G. Taglialatela (Dept. of Neuroscience, University of Texas Medical Branch, Galvestone, TX, USA)
- M.E. Monge (Centro de Investigaciones en Bionanociencias, CONICET, Buenos Aires, AG)

Financial support:

- Avviso 11/2017 Rafforzare l'occupabilità nel sistema R&S e la nascita di spin off di ricerca in Sicilia – P.O. FSE 2014/2020

Key publications:

Bulone D, San Biagio PL, Quinones-Ruix T, Alomar MR, Lednev IK, Robb FT, Conway de Macario E, Macario A (2019) A multipronged method for assessing the effects of mutations on chaperone molecules causing human chaperonopathies, Methods in Molecular Biology 1873:69-92. doi:10.1007/978-1-4939-8820-4_5

Vilasi S, Bulone D, Caruso Bavisotto C, Campanella C., Marino Gammazza A, San Biagio P.L., Cappello F., Conway de Macario E., Macario A (2018) Chaperonin of Group I: Oligomeric Spectrum and Biochemical and Biological Implications. Frontiers in molecular biosciences 4:99. doi:10.3389/fmolb.2017.00099

Dispenza C, Todaro S, Bulone D, Sabatino MA, Ghersi G, San Biagio PL, Lo Presti C (2017) Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction. Materials Science & Engineering C-Materials for Biological Applications 70: 745-752. doi: 10.1016/j.msec.2016.09.045

Todaro S, Dispenza C, Sabatino MA, Ortore MG, Passantino R, San Biagio PL, Bulone D (2015) Temperature-induced self-assembly of degalactosylated xyloglucan at low concentration. J. Polymer Science Part. B-Polymer Physics 53:1727-1735. doi: 10.1002/polb.23895

Carrotta R, Canale C, Diaspro A, Trapani A, San Biagio PL, Bulone D (2012) Inhibiting effect of alpha (s1)-casein on A beta(1-40) fibrillogenesis. Biochim. Biophys. ACTA-General Subjects 1820: 124-132. doi: 10.1016/j.bbagen.2011.11.010

Publications (94):

Moringa oleifera leaf powder as functional additive in cookies to protect sh-sy5y cells
Nuzzo D.; Picone P.; Sanchez J.L.; Borras-Linares I.; Guiducci A.; Muscolino E.; Biagio P.L.S.; Dispenza C.; Bulone D.; Giacomazza D.; Lapasin R.
Applied sciences, 2021
DOI: 10.3390/app11219995

Synaptosomes: new vesicles for neuronal mitochondrial transplantation
Picone Pasquale; Porcelli Gaetana; Bavisotto Celeste Caruso; Nuzzo Domenico; Galizzi Giacoma; San Biagio Pier Luigi; Bulone Donatella; Di Carlo Marta;
Journal of nanobiotechnology, 2021
DOI: 10.1186/s12951-020-00748-6

Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Dispenza Clelia; Todaro Simona; Sabatino Maria Antonietta; Martino Delia; Martorana Vincenzo; San Biagio Pier Luigi; Maffei Paola and Bulone Donatella
Cellulose (Lond.), 2020
DOI: 10.1007/s10570-020-03004-0

The degree of compactness of the incipient High Methoxyl Pectin networks. A rheological insight at the sol-gel transition
L.A. Ditta (a), D. Bulone (a), P.L. San Biagio (a), R. Marino, D (b). Giacomazza (a), R. Lapasin (c)
International journal of biological macromolecules, 2020
DOI: 10.1016/j.ijbiomac.2020.05.019

Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Dispenza, Clelia; Todaro, Simona; Sabatino, Maria Antonietta; Martino, Delia; Martorana, Vincenzo; San Biagio, Pier Luigi; Maffei, Paola; Bulone, Donatella
Cellulose (Lond.), 2020
DOI: 10.1007/s10570-020-03004-0

Recombinant mussel protein Pvfp-5beta: a potential tissue bioadhesive
Santonocito R, Venturella F, Dal Piaz F, Morando MA, Provenzano A, Rao E, Costa MA, Bulone D, San Biagio PL, Giacomazza D, Sicorello A, Alfano C, Passantino R, Pastore A
Journal of biological chemistry (Online), 2019
DOI: 10.1074/jbc.RA119.009531

Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics
Caruso Bavisotto C, Cipolla C, Graceffa G, Barone R, Bucchieri F, Bulone D, Cabibi D, Campanella C, Marino Gammazza A, Pitruzzella A, Porcasi R, San Biagio PL, Tomasello G, Conway de Macario E, Macario AJL, Cappello F, Rappa F
International journal of molecular sciences (Online), 2019
DOI: 10.3390/ijms20184496

Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus indica and its potential biological activity
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K
Phytochemistry, 2018
DOI: 10.1016/j.phytochem.2018.06.015

Data concerning the rheological behavior of high methoxyl pectin during gelation process
Giacomazza D, Bulone D, San Biagio PL, Marino R, Lapasin R
Data in brief, 2018
DOI: 10.1016/j.dib.2018.04.064

Chaperonin of Group I: Oligomeric spectrum and biochemical and biological implications
Vilasi S, Bulone D, Caruso Bavisotto C, Campanella C, Marino Gammazza A, San Biagio PL, Cappello F, Conway de Macario E, Macario AJL
Frontiers in Molecular Biosciences, 2018
DOI: 10.3389/fmolb.2017.00099

The role of sucrose concentration in self-assembly kinetics of high methoxyl pectin
Giacomazza D, Bulone D, San Biagio PL, Marino R, Lapasin R
International journal of biological macromolecules, 2018
DOI: 10.1016/j.ijbiomac.2018.02.103

Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 2017
DOI: 10.1039/c7ra05300b

Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction
Dispenza C, Todaro S, Bulone D, Sabatino MA, Ghersi G, San Biagio PL, Lo Presti C
Materials science & engineering. C, Biomimetic materials, sensors and systems (Print), 2017
DOI: 10.1016/j.msec.2016.09.045

Pectin from Opuntia ficus indica: Optimization of microwave-assisted extraction and preliminary characterization
Lefsih K, Giacomazza D, Dahmoune F, Mangione MR, Bulone D, San Biagio PL, Passantino R, Costa MA, Guarrasi V, Madani K
Food chemistry, 2017
DOI: 10.1016/j.foodchem.2016.10.073

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog
Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT
Biochemistry and Biophysics Reports, 2017
DOI: 10.1016/j.bbrep.2017.07.011

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, C. and Ortore, M.G. and Vilasi, S. and Carrotta, R. and Mangione, M.R. and Bulone, D. and Librizzi, F. and Spinozzi, F. and Burgio, G. and Amenitsch, H. and San Biagio, P.L.
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Multi-functional nanogels for tumor targeting and redox sensitive drug and siRNA delivery
Adamo G, Grimaldi N, Campora S, Bulone D, Bondì ML, Al-Sheikhly M, Sabatino MA, Dispenza C, Ghersi G
Molecules (Basel, Online), 2016
DOI: 10.3390/molecules21111594

Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects (Print), 2016
DOI: 10.1016/j.bbagen.2016.07.019

The complex mechanism of HM pectin self-assembly: A rheological investigation
Giacomazza D.; Bulone D.; San Biagio P.L.; Lapasin R.
Carbohydrate polymers, 2016
DOI: 10.1016/j.carbpol.2016.03.046

Temporal control of xyloglucan self-assembly into layered structures by radiation-induced degradation
Todaro S, Sabatino MA, Mangione MR, Picone P, Di Giacinto ML, Bulone D, Dispenza C
Carbohydrate polymers, 2016
DOI: 10.1016/j.carbpol.2016.07.005

Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.010

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry (Print), 2016
DOI: 10.1016/j.bpc.2015.07.006

Temperature-induced self-assembly of degalactosylated xyloglucan at low concentration
Todaro S.; Dispenza C.; Sabatino M.A.; Ortore M.G.; Passantino R.; San Biagio P.L.; Bulone D.
Journal of polymer science. Part B, Polymer physics (Online), 2015
DOI: 10.1002/polb.23895

insertion in liposomes containing GM1-cholesterol domains
Nicastro, M. C. Spigolon, D. Librizzi, F. Moran, Oscar Ortore, M. G. Bulone, D. San Biagio, P. L. Carrotta, R.
Biophysical chemistry (Print), 2015
DOI: 10.1016/j.bpc.2015.07.010

Temperature-induced self-assembly of degaloctosylated xyloglucan at low concentration
Todaro, S. Dispenza, C. Sabatino, M. A. Ortore, M. G. Passantino, R. San Biagio, P. L. Bulone, D.
Journal of polymer science. Part B, Polymer physics (Online), 2015

Photo-inhibition of Ab fibrillation mediated by a newly designed fluorinated oxadiazole
M.R. Mangione1, A. Palumbo Piccionello1,2,3, C. Marino1,4, M.G. Ortore5, P. Picone6, S. Vilasi1, M. Di Carlo6, S. Buscemi1,2, D. Bulone1 and P.L. San Biagio1
RSC advances, 2015
DOI: 10.1039/c4ra13556c

Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans
Todaro, S.; Sabatino, M. A.; Walo, M.; Mangione, M. R.; Bulone, D.; Dispenza, C.
Radiation physics and chemistry (1993), 2014
DOI: 10.1016/j.radphyschem.2013.05.055

Oligonucleotides-Decorated-Poly(N-vinyl pyrrolidone) Nanogels for Gene Delivery
Clelia Dispenza, Giorgia Adamo, Maria Antonietta Sabatino, Natascia Grimaldi, Donatella Bulone, Maria Luisa Bondi', Salvatrice Rigogliuso, Giulio Ghersi
Journal of applied polymer science (Online), 2014
DOI: 10.1002/APP.39774

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Davide; Piccionello, Antonio Palumbo; Zummo, Giovanni; Bulone, Donatella; de Macario, Everly Conway; Macario, Alberto J. L.; San Biagio, Pier Luigi; Cappello, Francesco
PloS one, 2014
DOI: 10.1371/journal.pone.0097657

alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes
Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi
The journal of physical chemistry letters, 2014
DOI: 10.1021/jz501570m

High-energy radiation processing, a smart approach to obtain PVP-graft-AA nanogels.
N. Grimaldi, M.A. Sabatino, G. Przybytniak, I. Kaluska, M.L. Bondì, D. Bulone, S. Alessi, G. Spadaro, C. Dispenza
Radiation physics and chemistry (1993), 2014
DOI: 10.1016/j.radphyschem.2013.04.012

Different effects of Alzheimer's peptide A beta(1-40) oligomers and fibrils on supported lipid membranes
Canale, Claudio; Seghezza, Silvia; Vilasi, Silvia; Carrotta, Rita; Bulone, Donatella; Diaspro, Alberto; Biagio, Pier Luigi San; Dante, Silvia
Biophysical chemistry (Print), 2013
DOI: 10.1016/j.bpc.2013.07.010

Structure of e-beam sculptured poly(N-vinylpyrrolidone) networks across different length-scales, from macro to nano
Sabatino MA; Bulone D; Veres M; Spinella A; Spadaro G; Dispenza C
Polymer (Guildford), 2013

Structure and biological evaluation of amino-functionalized PVP nanogels for fast cellular internalization
C. Dispenza, S. Rigogliuso, N. Grimaldi, M.A. Sabatino, D. Bulone, M.L. Bondì, G. Ghersi
Reactive & functional polymers (Print), 2013
DOI: 10.1016/j.reactfunctpolym.2013.04.011

Minimalism in Radiation-synthesis of Biomedical Functional Nanogels
Dispenza C; Sabatino MA; Grimaldi N; Bulone D; Bondi ML; Casaletto MP; Rigogliuso S; Adamo G; Ghersi G
Biomacromolecules, 2012
DOI: 10.1021/bm3003144

Studies of network organization and dynamics of e-beam crosslinked PVPs: From macro to nano
Dispenza C; Grimaldi N; Sabatino MA; Todaro S; Bulone D; Giacomazza D; Przybytniak G; Alessi A; Spadaro G
Radiation physics and chemistry (1993), 2012
DOI: 10.1016/j.radphyschem.2011.11.057

Inhibiting effect of alpha(s1)-casein on A beta(1-40) fibrillogenesis
Carrotta R; Canale C; Diaspro A; Trapani A; San Biagio PL; Bulone D
Biochimica et biophysica acta. G, General subjects (Print), 2012
DOI: 10.1016/j.bbagen.2011.11.010

alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
The journal of physical chemistry. B, 2012
DOI: 10.1021/jp307417x

Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter (Print), 2012
DOI: 10.1088/0953-8984/24/24/244103

Multivariate data analysis of thermally treated Sicilian extravirgin olive oils. Coupling of electronic nose, gas chromatography-mass spectroscopy and rheology techniques
M. Amenta, M.E. Monge, L. Lizzarraga, D. Giacomazza, V. Guarrasi, P.L. San Biagio, D. Bulone
The Open food science journal, 2012
DOI: 10.2174/1874256401206010024

E-beam irradiation and UV photocrosslinking of microemulsion-laden poly(N-vinyl-2-pyrrolidone) hydrogels for "in situ" encapsulation of volatile hydrophobic compounds
Dispenza, C.; Ricca, M.; LoPresti, C.; Battaglia, G.; La Valle, M.; Giacomazza, D.; Bulone, D.
Polymer chemistry (Print), 2011
DOI: 10.1039/c0py00161a

Quantification of underivatized fatty acids from vegetable oils by HPLC with UV Detection
Guarrasi V.; Mangione M.R.; Sanfratello V.; Martorana V.; Bulone D.
Journal of chromatographic science, 2010
DOI: 10.1093/chromsci/48.8.663

Irreversible gelation of thermally unfolded lysozyme: structural and mechanical properties of lysozyme aggregates
Raccosta S.; Manno M. (1); Bulone D. (1); Giacomazza D. (1); Militello V.; Martorana V. (1); San Biagio P. L. (1)
European biophysics journal, 2010
DOI: 10.1007/s00249-009-0503-4

Synergistic interaction of Locust Bean Gum and Xanthan investigated by rheology and light scattering
Sandolo C.; Bulone D.; Mangione M.R.; Margheritelli S.; Di Meo C.; Alhaique F.; Matricardi P.; Coviello T.
Carbohydrate polymers, 2010
DOI: 10.1016/j.carbpol.2010.05.044

Correlation between rheological properties and limonene release in pectin gels using an electronic nose.
Monge M. E.; Negri M. R.; Giacomazza D. (1); Bulone D. (1)
Food hydrocolloids, 2008
DOI: 10.1016/j.foodhyd.2007.05.004

Kinetics of different processes in human insulin amyloid formation.
Manno M.; Craparo E.F.; Podestà A.; Bulone D.; Carrotta R.; Martorana V.; Milani P.; Tiana G.; San Biagio P.L.
Journal of Molecular Biology, 2007
DOI: 10.1016/j.jmb.2006.11.008

A statistical light scattering approach to separating fast and slow dynamics.
Barthès J.; D. Bulone(1); M. Manno(1); V. Martorana (1); P. L. San Biagio. (1)
European biophysics journal, 2007
DOI: 10.1007/s00249-007-0163-1

Relation between structural and release properties in a polysaccharide gel system.
Mangione M. R.(1); D. Giacomazza (1); G. Cavallaro; D. Bulone (1); V. Martorana (1); P. L. San Biagio (1).
Biophysical chemistry (Print), 2007
DOI: 10.1016/j.bpc.2007.04.013

Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation.
Manno M.; Craparo E.F.; Martorana V.; Bulone D.; San Biagio P.L.
Biophysical journal (Print), 2006
DOI: 10.1529/biophysj.105.077636

The interplay between polyQ and protein context delays aggregation by forming a reservoir of protofibrils
Bulone Donatella (2); Masino Laura (1); Thomas David J. (3); San Biagio Pier Luigi (2); Pastore Annalisa (1);
PloS one, 2006
DOI: 10.1371/journal.pone.0000111

Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.
Carrotta R.; Manno M.; Bulone D.; Martorana V.; San Biagio P.L.;
The Journal of biological chemistry (Print), 2005
DOI: 10.1074/jbc.M500052200

K+ and Na+ effects on the gelation properties of k-Carrageenan.
Mangione M.R. (1); Giacomazza D. (1); Bulone D. (1); Martorana V. (1); Cavallaro G.; San Biagio P.L. (1)
Biophysical chemistry (Print), 2005
DOI: 10.1016/j.bpc.2004.08.005

Role of charges and solvent on the conformational properties of poly(galacturonic acid) chains: a Molecular Dynamics study.
Noto R.; Martorana V.; Bulone D.; San Biagio P. L.
Biomacromolecules, 2005
DOI: 10.1021/bm050280g

Electronic Nose screening of limonene release from multicomponent essential oils encapsulated in pectin gels.
Bulone Donatella (2); GIACOMAZZA DANIELA (2); Monge María Eugenia (1); Negri R. M. (1); Bernik Delia L. (1)
Combinatorial chemistry & high throughput screening (Print), 2004
DOI: 10.2174/1386207043328689

Detection of flavour release from pectin gels using electronic noses.
Monge M.E.; Bulone D. (1); Giacomazza D. (1); Bernik D.L.; Negri R.M.
Sensors and actuators. B, Chemical (Print), 2004
DOI: 10.1016/j.snb.2004.02.019

Ordering of agarose near the macroscopic gelation point.
Bulone D.; Giacomazza D.; Martorana V.; Newman J.; San Biagio P.L.
Physical review. E, Statistical, nonlinear, and soft matter physics (Print), 2004
DOI: 10.1103/PhysRevE.69.041401

electronic nose screening of limonene release from multicomponent essential oils encapsulated in pectin gels
Monge ME; Bulone D; Giacomazza D; Negri MR; Bernik DL
Combinatorial chemistry & high throughput screening (Print), 2004

Thermodynamic instability and off-critical slowing down in supersaturated lysozyme solutions
Manno M. (1); Bulone D. (1); Martorana V. (1); San Biagio P. L. (1)
Journal of physics. Condensed matter (Print), 2004
DOI: 10.1088/0953-8984/16/42/017

Ergodic to non-ergodic transition monitored by scattered light intensity statistics
Manno M. (1); Bulone D. (1); Martorana V. (1); San Biagio P. L. (1)
Physica. A (Print), 2004
DOI: 10.1016/j.physa.2004.04.107

Deposito della beta-amiloide sulla membrana cellulare: ruolo degli ioni metallici e dei radicali liberi
Gianfranco Menestrina, Mauro Dalla Serra, Massimiliano Comai, Rossella Tomazzoli, Cristina Potrich, Pier Luigi San Biagio, Mauro Manno, Donatella Bulone, Antonella Graiff, Floriana Giraudo, Lorenzo Gasperi
Punto Omega, 2004

Thermodynamic instability in supersaturated lysozyme solutions: effect of salt and role of concentration fluctuations.
Manno M. 1, Xiao C. 2, Bulone D. 1, Martorana V. 1, San_Biagio P.L. 1
Physical review. E, Statistical, nonlinear and soft matter physics (Online), 2003
DOI: 10.1103/PhysRevE.68.011904

Thermoreversible gelation of k-Carrageenan: relation between conformational transition and aggregation.
Mangione M.R. 1,2, Giacomazza D. 1, Bulone D. 1, Martorana V. 1, San Biagio P.L. 1
Biophysical chemistry (Print), 2003
DOI: 10.1016/S0301-4622(02)00341-1

Role of sucrose in pectin gelation: Static and dynamic light scattering experiments
Bulone D. 1, Martorana V. 1, Xiao C. 2, San Biagio P.L. 1
Macromolecules (Print), 2002
DOI: 10.1021/ma0205109

Salt effects on gelation of agarose aqueous solutions
Newman J., Martorana V., Bulone D., San Biagio P. L.
Biophysical journal (Print), 2002

Effects of intermediates on aggregation of native bovine serum albumin.
Bulone D., Martorana V., San Biagio PL.
Biophysical chemistry (Print), 2001
DOI: 10.1016/S0301-4622(01)00155-7

Interaction of processes on different length scales in a bioelastomer capable of performing energy conversion.
Manno, M., A. Emanuele, V. Martorana, P. L. San Biagio, D. Bulone, M. B. Palma-Vittorelli, D. T. McPherson, J. Xu, T. M. Parker, and D. W. Urry
Biopolymers (Print), 2001

Nel mondo dei biopolimeri
Bulone, D., M. Dalla Serra, R. Felicioli, M. Gonnelli, G. Menestrina, and P. L. San Biagio
Sapere (Bari), 2001

Novel hydrogels based on a polyasparthydrazide. Synthesis and characterization
Pitarresi, G., G. Cavallaro, B. Carlisi, G. Giammona, D. Bulone, and P. L. San Biagio
Macromolecular chemistry and physics (Print), 2000

Potential of mean force between two ions in a sucrose rich aqueous solution
Martorana, V., L. La Fata, D. Bulone, and P. L. San Biagio
Chemical physics letters (Print), 2000

Effects of electric charges on hydrophobic forces II
Bulone D., Martorana V., San Biagio P.L., Palma-Vittorelli M.B.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2000

Multiple interactions between molecular and supramolecular ordering
Manno M., Emanuele A., Martorana V., Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1999

Below the threshold of macroscopic gelation
Bulone D., Martorana V., San Biagio P.L.
Trends in Chemical Physics, 1999

Effects of solvent perturbation on gelation driven by spinodal demixing
Bulone D., Emanuele A., San Biagio P.L.
Biophysical chemistry (Print), 1999

Solvent-induced free energy landscape and solute-solvent dynamic coupling in a multielement solute
San Biagio P.L., Martorana V., Bulone D., Palma-Vittorelli M.B., Palma M.U.
Biophysical journal (Print), 1999

Interacting processes in protein coagulation
San Biagio P.L., Martorana V., Emanuele A., Vaiana S.M., Manno M., Bulone D., Palma-Vittorelli M.B., Palma M.U.
Proteins (Print), 1999

Actin filaments are structurally weakened by binding of the N-terminal (S1-3) portion of gelsolin
Lincoln B., San Biagio P.L., Bulone D., Newman J., Selden L.A., Hurwitz C., Kinosian H.J., Estes J.E., Gershman L.C.
Biophysical journal (Print), 1998

Physics and biophysics of solvent induced forces: hydrophobic interactions and context-dependent hydration
San Biagio P.L., Bulone D., Martorana V., Palma-Vittorelli M.B., Palma M.U.
European Biophysical Journal, 1998

Collective properties of hydration: long range and specificity of hydrophobic interactions
Martorana V., Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Biophysical journal (Print), 1997

Mesoscopic gels at low agarose concentration: perturbation effects on ethanol
Bulone D., Newman J., San Biagio P.L.
Biophysical journal (Print), 1997

Effects of electric charges on hydrophobic forces
Bulone D., Martorana V., San Biagio P.L., Palma-Vittorelli M.B.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1997

Self-assembly of biopolymeric structures below the threshold of random cross-link percolation
San Biagio P.L., Bulone D., Emanuele A., Palma M.U.
Biophysical journal (Print), 1996

Spontaneous symmetry-breaking pathways: Time-resolved study of agarose gelation
San Biagio P.L., Bulone D., Emanuele A., Palma-Vittorelli M.B., Palma M.U.
Food hydrocolloids, 1996

Mesoscopic gel at low agarose concentration in water: a dynamic light scattering study
Bulone D., San Biagio P.L.
Biophysical journal (Print), 1995

Transputer-based upgrading of a differential scanning calorimeter
Bulone D., Fornili L.G., Fornili S.L., Lapis M., San Biagio P.L.
Measurement science & technology (Print), 1994

The role of water in hemoglobin function and stability
Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Science (New York, N.Y.), 1993

The role of solvent-induced forces in bimolecular function and stability
Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Nuovo cimento della Società italiana di fisica. D Condensed matter, atomic, molecular and chemical physics, biophysics (Testo stamp.), 1993

Water-mediated interactions of biosolutes - Aspects of dynamics, structure and configuration lifetime of the solvent
Bulone D., San Biagio P.L., Palma-Vittorelli M.B., Palma M.U.
Journal of molecular liquids (Print), 1993

Enthalpic and Entropic Contributions of Water Molecules to the Functional T-> R Transition of Human Hemoglobin in Solution
Bulone, D., Palma-Vittorelli, M.B., Palma
International journal of quantum chemistry, 1992

Density, Structural Life-time and Entropy of H-bond Cages Promoted by Monohydric Alcohols in Normal and Supercooled Water
D. Bulone, I.D. Donato, M.B. Palma-Vittorelli and M.U. Palma
The Journal of chemical physics, 1991

Microgel regions in dilute agarose solutions: the notion of non-gelling concentration and the role of spinodal demixing
Bulone D., San Biagio P.L.
Chemical physics letters (Print), 1991

Spinodal demixing, percolation and gelation of biostructural polymers
San Biagio P.L., Bulone D., Emanuele A., Madonia F., Di Stefano M., Giacomazza D., Trapanese M., Palma-Vittorelli M.B., Palma M.U.
Makromolekulare Chemie. Theory and simulations, 1990

Viscosity of Aqueous Solutions of Monohydric Alcohols in the Normal and Supercooled States
D. Bulone, C. Spinnato, F. Madonia and M.U. Palma
The Journal of chemical physics, 1989

Interaction Between External Medium and Haem Pocket in Myoglobin Probed by Low Temperature Optical Spectroscopy
L. Cordone, A. Cupane, M. Leone, E. Vitrano and D. Bulone
Journal of Molecular Biology, 1988

Conformational and functional properties of hemoglobin in water-organic cosolvent mixtures: effect of ethylene glycol and glycerol on oxygen affinity
D. Bulone, A. Cupane, L. Cordone
Biopolymers (Print), 1983