Lagostena L, Zifarelli G, Picollo A
Journal of the American Society of Nephrology, 2019
DOI: 10.1681/ASN.2018060593
The 2018 correlative microscopy techniques roadmap
Ando Toshio; Bhamidimarri Satya Prathyusha; Brending Niklas; Colin-York, H.; Collinson Lucy; De Jonge Niels; de Pablo P. J.; Debroye Elke; Eggeling Christian; Franck Christian; Fritzsche Marco; Gerritsen Hans; Giepmans Ben N. G.; Grunewald Kay; Hofkens Johan; Hoogenboom Jacob P.; Janssen Kris P. F.; Kaufman Rainer; Klumpermann Judith; Kurniawan Nyoman; Kusch Jana; Liv Nalan; Parekh Viha; Peckys Diana B.; Rehfeldt Florian; Reutens David C.; Roeffaers Maarten B. J.; Salditt Tim; Schaap Iwan A. T.; Schwarz Ulrich S.; Verkade Paul; Vogel Michael W.; Wagner Richard; Winterhalter Mathias; Yuan Haifeng; Zifarelli Giovanni
Journal of physics. D, Applied physics (Print), 2018
DOI: 10.1088/1361-6463/aad055
A tale of two CLCs: Biophysical insights toward understanding ClC-5 and ClC-7 function in endosomes and lysosomes
Zifarelli, G.
Journal of physiology (Lond., Print), 2015
DOI: 10.1113/JP270604
ClC-5: Physiological role and biophysical mechanisms
Pusch M.; Zifarelli G.
Cell calcium (Edinburgh), 2015
DOI: 10.1016/j.ceca.2014.09.007
I-J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes
Gradogna, Antonella; Imbrici, Paola; Zifarelli, Giovanni; Liantonio, Antpnella; Camerino, Diana Conte; Pusch, Michael
Biochimica et biophysica acta. Biomembranes, 2014
DOI: 10.1016/j.bbamem.2014.07.021
Thermal Sensitivity of CLC andTMEM16 Chloride Channelsand Transporters.
Pusch, Michael; Zifarelli, Giovanni
Current topics in membranes, 2014
DOI: 10.1016/B978-0-12-800181-3.00008-7
Patch-Clamp Fluorometry: Electrophysiology meets Fluorescence
Kusch, Jana; Zifarelli, Giovanni
Biophysical journal (Print), 2014
DOI: 10.1016/j.bpj.2014.02.006
A single point mutation reveals gating of the human ClC-5 Cl-/H+ antiporter
De Stefano S, Pusch M, Zifarelli G
Journal of physiology (Lond., Print), 2013
DOI: 10.1113/jphysiol.2013.260240
An optical assay of the transport activity of ClC-7
Zanardi I, Zifarelli G, Pusch M
Scientific reports (Nature Publishing Group), 2013
DOI: 10.1038/srep01231
Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin
Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S, Gasnier B.
Proceedings of the National Academy of Sciences of the United States of America, 2012
GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a CIC-2 Cl- Channel Auxiliary Subunit
Jeworutzki E; López-Hernández T; Capdevila-Nortes X; Bengtsson L; Sirisi S; Montolio M; Zifarelli G; Arnedo T; Müller CS; Schulte U; Nunes V; Martínez A; Jentsch TJ; Gasull X; Pusch M; Estévez R
Neuron (Camb. Mass.), 2012
DOI: 10.1016/j.neuron.2011.12.039
On the mechanism of gating charge movement of ClC-5, a human Cl(-)/H(+) antiporter
Zifarelli G., De Stefano S., Zanardi I., Pusch M.
Biophysical journal (Print), 2012
DOI: 10.1016/j.bpj.2012.03.067
A Kick-Start for CLC Antiporters' Pharmacology
Zifarelli G, Pusch M
Chemistry & biology (Print), 2012
DOI: 10.1016/j.chembiol.2012.10.009
Extracellular Determinants of Anion Discrimination of the Cl-/H+ Antiporter Protein CLC-5
De Stefano S, Pusch M, Zifarelli G
The Journal of biological chemistry (Print), 2011
DOI: 10.1074/jbc.M111.272815
CLC transport proteins in plants
Zifarelli G, Pusch M.
FEBS letters (Print), 2010
The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.
Zifarelli G, Pusch M.
European biophysics journal, 2010
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.
Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini E, Camerino DC, Pusch M
British journal of pharmacology, 2010
DOI: 10.1111/j.1476-5381.2010.00822.x
Relaxing messages from the sarcolemma
Zifarelli G., Pusch M.
It's the proton also in ClC-2.
Pusch M. Zifarelli G.
Conversion of the 2 Cl(-)/1 H(+) antiporter ClC-5 in a NO(3)(-)/H(+) antiporter by a single point mutation.
Giovanni Zifarelli; Michael Pusch
EMBO journal (Print), 2009
DOI: 10.1038/emboj.2008.284
Intracellular regulation of human ClC-5 by adenine nucleotides.
Giovanni Zifarelli; Michael Pusch
EMBO reports (Print), 2009
Determinants of anion-proton coupling in mammalian endosomal CLC proteins.
Anselm A. Zdebik; Giovanni Zifarelli; Eun-Yeong Bergsdorf; Paolo Soliani; Olaf Scheel; Thomas J. Jentsch; Michael Pusch
The Journal of biological chemistry (Print), 2008
DOI: 10.1074/jbc.M708368200
Intracellular proton regulation of ClC-0.
Zifarelli G, Murgia AR, Soliani P, Pusch M.
The Journal of general physiology, 2008
Molecular switch for CLC-K Cl- channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands
Liantonio A1, Picollo A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Laghezza A, Babini E, Zifarelli G, Pusch M, Camerino DC
Proceedings of the National Academy of Sciences of the United States of America, 2008
DOI: 10.1073/pnas.0708977105
Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix.
Macías M.J., Teijido O., Zifarelli G., Martin P., Ramirez-Espain X., Zorzano A., Palacín M., Pusch M., Estévez R.
Biochemical journal (Lond., 1984), 2007
CLC chloride channels and transporters in physiology and pathophysiology.
Giovanni Zifarelli; Michael Pusch
Reviews of physiology, biochemistry and pharmacology, 2007
DOI: 10.1007/11220060605
Channel or transporter? The CLC saga continues
Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E
Experimental physiology (Print), 2006
DOI: 10.1113/expphysiol.2005.031799
Proton sensing of CLC-0 mutant E166D.
Traverso S., Zifarelli G., Aiello R., Pusch M.
Giovanni Zifarelli
Publications (28):
New Insights into the Mechanism of NO3 - Selectivity in the Human Kidney Chloride Channel ClC-Ka and the CLC Protein FamilyLagostena L, Zifarelli G, Picollo A
Journal of the American Society of Nephrology, 2019
DOI: 10.1681/ASN.2018060593
The 2018 correlative microscopy techniques roadmap
Ando Toshio; Bhamidimarri Satya Prathyusha; Brending Niklas; Colin-York, H.; Collinson Lucy; De Jonge Niels; de Pablo P. J.; Debroye Elke; Eggeling Christian; Franck Christian; Fritzsche Marco; Gerritsen Hans; Giepmans Ben N. G.; Grunewald Kay; Hofkens Johan; Hoogenboom Jacob P.; Janssen Kris P. F.; Kaufman Rainer; Klumpermann Judith; Kurniawan Nyoman; Kusch Jana; Liv Nalan; Parekh Viha; Peckys Diana B.; Rehfeldt Florian; Reutens David C.; Roeffaers Maarten B. J.; Salditt Tim; Schaap Iwan A. T.; Schwarz Ulrich S.; Verkade Paul; Vogel Michael W.; Wagner Richard; Winterhalter Mathias; Yuan Haifeng; Zifarelli Giovanni
Journal of physics. D, Applied physics (Print), 2018
DOI: 10.1088/1361-6463/aad055
A tale of two CLCs: Biophysical insights toward understanding ClC-5 and ClC-7 function in endosomes and lysosomes
Zifarelli, G.
Journal of physiology (Lond., Print), 2015
DOI: 10.1113/JP270604
ClC-5: Physiological role and biophysical mechanisms
Pusch M.; Zifarelli G.
Cell calcium (Edinburgh), 2015
DOI: 10.1016/j.ceca.2014.09.007
I-J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes
Gradogna, Antonella; Imbrici, Paola; Zifarelli, Giovanni; Liantonio, Antpnella; Camerino, Diana Conte; Pusch, Michael
Biochimica et biophysica acta. Biomembranes, 2014
DOI: 10.1016/j.bbamem.2014.07.021
Thermal Sensitivity of CLC andTMEM16 Chloride Channelsand Transporters.
Pusch, Michael; Zifarelli, Giovanni
Current topics in membranes, 2014
DOI: 10.1016/B978-0-12-800181-3.00008-7
Patch-Clamp Fluorometry: Electrophysiology meets Fluorescence
Kusch, Jana; Zifarelli, Giovanni
Biophysical journal (Print), 2014
DOI: 10.1016/j.bpj.2014.02.006
A single point mutation reveals gating of the human ClC-5 Cl-/H+ antiporter
De Stefano S, Pusch M, Zifarelli G
Journal of physiology (Lond., Print), 2013
DOI: 10.1113/jphysiol.2013.260240
An optical assay of the transport activity of ClC-7
Zanardi I, Zifarelli G, Pusch M
Scientific reports (Nature Publishing Group), 2013
DOI: 10.1038/srep01231
Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin
Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S, Gasnier B.
Proceedings of the National Academy of Sciences of the United States of America, 2012
GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a CIC-2 Cl- Channel Auxiliary Subunit
Jeworutzki E; López-Hernández T; Capdevila-Nortes X; Bengtsson L; Sirisi S; Montolio M; Zifarelli G; Arnedo T; Müller CS; Schulte U; Nunes V; Martínez A; Jentsch TJ; Gasull X; Pusch M; Estévez R
Neuron (Camb. Mass.), 2012
DOI: 10.1016/j.neuron.2011.12.039
On the mechanism of gating charge movement of ClC-5, a human Cl(-)/H(+) antiporter
Zifarelli G., De Stefano S., Zanardi I., Pusch M.
Biophysical journal (Print), 2012
DOI: 10.1016/j.bpj.2012.03.067
A Kick-Start for CLC Antiporters' Pharmacology
Zifarelli G, Pusch M
Chemistry & biology (Print), 2012
DOI: 10.1016/j.chembiol.2012.10.009
Extracellular Determinants of Anion Discrimination of the Cl-/H+ Antiporter Protein CLC-5
De Stefano S, Pusch M, Zifarelli G
The Journal of biological chemistry (Print), 2011
DOI: 10.1074/jbc.M111.272815
CLC transport proteins in plants
Zifarelli G, Pusch M.
FEBS letters (Print), 2010
The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.
Zifarelli G, Pusch M.
European biophysics journal, 2010
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels.
Zifarelli G, Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR, Babini E, Camerino DC, Pusch M
British journal of pharmacology, 2010
DOI: 10.1111/j.1476-5381.2010.00822.x
Relaxing messages from the sarcolemma
Zifarelli G., Pusch M.
It's the proton also in ClC-2.
Pusch M. Zifarelli G.
Conversion of the 2 Cl(-)/1 H(+) antiporter ClC-5 in a NO(3)(-)/H(+) antiporter by a single point mutation.
Giovanni Zifarelli; Michael Pusch
EMBO journal (Print), 2009
DOI: 10.1038/emboj.2008.284
Intracellular regulation of human ClC-5 by adenine nucleotides.
Giovanni Zifarelli; Michael Pusch
EMBO reports (Print), 2009
Determinants of anion-proton coupling in mammalian endosomal CLC proteins.
Anselm A. Zdebik; Giovanni Zifarelli; Eun-Yeong Bergsdorf; Paolo Soliani; Olaf Scheel; Thomas J. Jentsch; Michael Pusch
The Journal of biological chemistry (Print), 2008
DOI: 10.1074/jbc.M708368200
Intracellular proton regulation of ClC-0.
Zifarelli G, Murgia AR, Soliani P, Pusch M.
The Journal of general physiology, 2008
Molecular switch for CLC-K Cl- channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands
Liantonio A1, Picollo A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Laghezza A, Babini E, Zifarelli G, Pusch M, Camerino DC
Proceedings of the National Academy of Sciences of the United States of America, 2008
DOI: 10.1073/pnas.0708977105
Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix.
Macías M.J., Teijido O., Zifarelli G., Martin P., Ramirez-Espain X., Zorzano A., Palacín M., Pusch M., Estévez R.
Biochemical journal (Lond., 1984), 2007
CLC chloride channels and transporters in physiology and pathophysiology.
Giovanni Zifarelli; Michael Pusch
Reviews of physiology, biochemistry and pharmacology, 2007
DOI: 10.1007/11220060605
Channel or transporter? The CLC saga continues
Pusch M, Zifarelli G, Murgia AR, Picollo A, Babini E
Experimental physiology (Print), 2006
DOI: 10.1113/expphysiol.2005.031799
Proton sensing of CLC-0 mutant E166D.
Traverso S., Zifarelli G., Aiello R., Pusch M.