Ca2+-Activated Chloride Channels and Phospholipid Scramblases

TMEM16A/Ano1 and TMEM16B/Ano2 form Ca2+ -activated Cl– channels that are involved in a variety of physiological functions, such as transepithelial ion transport, olfaction, phototransduction, smooth muscle contraction, nociception, cell proliferation and neuronal excitability.

Despite sharing a similar structural organization, other members of the TMEM16/Anoctamin family have a
completely different molecular function: these so-called Ca2+ dependent phospholipid scramblases mediate the passive transfer of phospholipids between the leaflets of the membrane bilayer, causing the regulated collapse of membrane asymmetry. Mutations in several TMEM16/Anoctamin genes, TMEM16C/Ano3, TMEM16E/Ano5, TMEM16F/Ano6 and TMEM16K/Ano10, cause various genetic diseases, however their molecular physio-pathology is not established yet.

Following the recent progress on this unique protein family and with new techniques becoming available, these are exciting times to study all aspects of TMEM16 physiology.

This Special Issue calls for original research, full reviews, and perspectives that address the current knowledge in the field of Ca2+-activated chloride channels and scramblases.


Deadline for manuscript submissions: 31 March 2021

Dr. Anna Boccaccio

Institute of Biophysics, National
Research Council, I-16149
Genova, Italy

Dr. Simone Pifferi

Department of Experimental and
Clinical Medicine, Università
Politecnica delle Marche, I-60126
Ancona, Italy