Anno2015
AutoriBaroni, Debora; Moran, Oscar
AbstractVoltage-gated sodium channels are intrinsic plasma membrane proteins that initiate the action potential in electrically excitable cells. They are composed of a pore-forming alpha-subunit and associated beta-subunits. The beta1-subunit was the first accessory subunit to be cloned. It can be important for controlling cell excitability and modulating multiple aspects of sodium channel physiology. Mutations of beta1 are implicated in a wide variety of inherited pathologies, including epilepsy and cardiac conduction diseases. This review summarizes beta1-subunit related channelopathies pointing out the current knowledge concerning their genetic background and their underlying molecular mechanisms.
RivistaFrontiers In Pharmacology
ISSN1663-9812
Impact factor0
Volume6
Pagina inizio108
Pagina fine
Autori IBFOscar MORAN, Debora BARONI
Linee di Ricerca IBFMD.P01.009.001
Sedi IBFIBF.GE