AutoriRaimondo S.; Naselli F.; Fontana S.; Monteleone F.; Lo Dico A.; Saieva L.; Zito G.; Flugy A.; Manno M.; Di Bella M.A.; De Leo G.; Alessandro R.
AbstractNanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing. Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL- mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.
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Pagina inizio19514
Pagina fine19527
Autori IBFMauro MANNO
Linee di Ricerca IBFMD.P01.002.001