AutoriPusch, Michael; Zifarelli, Giovanni
AbstractCl(-) transport is of fundamental importance in the most diverse physiological contexts and it is mediated by a variety of ion channels and transporters belonging to different protein families. In particular, the recently identified TMEM16 protein family comprises the long sought Ca(2+)-activated Cl(-) channel (CaCC) and the activity of one of its members, TMEM16A, is highly dependent on temperature and is involved in thermal nociception. Among the other protein families mediating Cl(-) transport, CLC proteins are also regulated by temperature although so far the physiological implications of this dependence are unknown.
RivistaCurrent Topics In Membranes
Impact factor0
Pagina inizio213
Pagina fine31
Autori IBFMichael PUSCH, Giovanni ZIFARELLI
Linee di Ricerca IBFMD.P01.009.001