Anno2014
AutoriLentini R.; Santero S.P.; Chizzolini F.; Cecchi D.; Fontana J.; Marchioretto M.; Del Bianco C.; Terrell J.L.; Spencer A.C.; Martini L.; Forlin M.; Assfalg M.; Serra M.D.; Bentley W.E.; Mansy S.S.
AbstractPrevious efforts to control cellular behaviour have largely relied upon various forms of genetic engineering. Once the genetic content of a living cell is modified, the behaviour of that cell typically changes as well. However, other methods of cellular control are possible. All cells sense and respond to their environment. Therefore, artificial, non-living cellular mimics could be engineered to activate or repress already existing natural sensory pathways of living cells through chemical communication. Here we describe the construction of such a system. The artificial cells expand the senses of Escherichia coli by translating a chemical message that E. coli cannot sense on its own to a molecule that activates a natural cellular response. This methodology could open new opportunities in engineering cellular behaviour without exploiting genetically modified organisms. © 2014 Macmillan Publishers Limited. All rights reserved.
RivistaNature Communications
ISSN2041-1723
Impact factor0
Volume5
Pagina inizio
Pagina fine
Autori IBFMauro DALLA SERRA, Marta MARCHIORETTO
Linee di Ricerca IBFMD.P01.028.001
Sedi IBFIBF.TN