AutoriTodaro, S.; Sabatino, M. A.; Walo, M.; Mangione, M. R.; Bulone, D.; Dispenza, C.
AbstractThermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to their reversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucans interesting raw materials also in the form of micro/nanoparticles for application as nanoscalar drug delivery devices in cosmetic and pharmaceutical formulations. Owing to their natural source, xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. Co-60 gamma-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiated xyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. The aggregation kinetics at 37 C were studied by dynamic light scattering measurements to confirm the temperature-responsive behavior of this polymer even when dispersed in water at low concentration after gamma-irradiation. Irradiation dose-molecular properties relationship has been sought. (C) 2013 Elsevier Ltd. All rights reserved.
RivistaRadiation Physics And Chemistry (1993)
Impact factor0
Pagina inizio245
Pagina fine248
Autori IBFDonatella BULONE, Maria Rosalia MANGIONE, Simona TODARO, Clelia DISPENZA
Linee di Ricerca IBFMD.P01.002.001