Anno2014
AutoriTorres, Eva; Leiva, Rosana; Gazzarrini, Sabrina; Rey-Carrizo, Matias; Frigole-Vivas, Marta; Moroni, Anna; Naesens, Lieve; Vazquez, Santiago
AbstractThe synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
RivistaAcs Medicinal Chemistry Letters
ISSN1948-5875
Impact factor0
Volume5
Pagina inizio831
Pagina fine836
Autori IBFAnna MORONI
Linee di Ricerca IBFMD.P01.005.001
Sedi IBFIBF.MI