Anno2014
AutoriZanetti M.; Maniglio D.; Fasoli C.; Pola M.; Borga E.; Corradi C.; DallaSerra M.; Iannotta S.; Motta A.; Toccoli T.
AbstractWe report the fabrication of a microfluidic apparatus and the realization of a sensors based on PEDOT:PSS, a biocompatible semiconductor polymer used in substitution of standard electrodes for electrophysiological studies and for detection of nanopores in membrane. This gives the possibility to study the mechanisms of ions balance and molecular transport though cell membranes. In particular the apparatus is based on two chambers connected through an aperture in a PTFE sheet where lipid bilayer are formed using Montal-Mueller method, and the pore-forming proteins activity is detected by polymeric electrodes. This methodology could be applied to examine different membrane proteins for the purpose of biosensing, drug screening and nanopore technologies. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
RivistaElectroanalysis (n.y.n.y.)
ISSN1040-0397
Impact factor0
Volume26
Pagina inizio1653
Pagina fine1659
Autori IBFMauro DALLA SERRA, Manuela ZANETTI
Linee di Ricerca IBFMD.P01.028.001
Sedi IBFIBF.TN