AutoriDi Garbo A, Barbi M, Chillemi S
AbstractThe balance between inhibition and excitation is at the basis of the maintenance of stable and normal brain electrical activity. Experimental results revealed that inhibitory synapses can become depolarizing as the intracellular concentration of Cl-1 of the postsynaptic cells increases. In this work the dynamical behaviour of a network of pyramidal cells coupled to inhibitory fast-spiking interneurons was studied by simulations. In particular, in agreement to the experimental data, it was found that the biophysical properties of the inhibitory/excitatory synapses strongly impact the network dynamics and the transition to seizure.
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Pagina inizio15
Pagina fine23
Autori IBFMichele BARBI, Santi CHILLEMI, Angelo DI GARBO
Linee di Ricerca IBFMD.P01.004.001