|Autori||M Di Carlo, D Giacomazza, P L San Biagio|
|Abstract||Alzheimer's disease (AD) is the most common form of dementia among older people. |
Dementia is an irreversible brain disorder that seriously affects a person's ability to carry out
daily activities. It is characterized by loss of cognitive functioning and behavioral abilities, to
such an extent that it interferes with the daily life and activities of the affected patients.
Although it is still unknown how the disease process begins, it seems that brain damage
starts a decade or more before problems become evident.
Scientific data seem to indicate that changes in the generation or the degradation of the
amyloid-b peptide (A) lead to the formation of aggregated structures that are the triggering
molecular events in the pathogenic cascade of AD. This review summarizes some
characteristic features of A misfolding and aggregation and how cell damage and death
mechanisms are induced by these supramolecular and toxic structures. Further, some
interventions for the early diagnosis of AD are described and in the last part the potential
therapeutic strategies adoptable to slow down, or better block, the progression of the
pathology are reported.
|Rivista||Journal Of Physics. Condensed Matter|
|Autori IBF||Pier Luigi SAN BIAGIO, Daniela GIACOMAZZA|
|Linee di Ricerca IBF||MD.P01.002.001|