Anno2010
AutoriPitarresi G, Palumbo FS, Fiorica C, Calascibetta F, Giammona G
AbstractAbstract: alpha,beta-Poly(N-2-hydroxyethyl)-DL-aspartamide grafted with polylactic acid (PHEA-g-PLA) is a biocompatible and biodegradable amphiphilic copolymer that has been already employed to prepare a drug delivery system. In this study we have prepared for the first time a fibrillar scaffold from PHEA-g-PLA by the electrospinning of a solution of this copolymer in a mixture of N,N-dimethyl formamide (DMF) and acetone (80:20 vol/vol). The average diameter and the morphology of electrospun fibers were detected by scanning electron microscopy. Chemical degradation studies in phosphate buffer solution pH 7.4 have been performed until 15 days in order to obtain a preliminary information about the hydrolytic resistance of the prepared scaffold.
RivistaEuropean Polymer Journal
ISSN
Impact factor
Volume46
Pagina inizio181
Pagina fine184
Autori IBFGaetano GIAMMONA
Linee di Ricerca IBFMD.P01.002.001
Sedi IBFIBF.PA