| Sigla | MD.P01.002.001 |
| Inizio | 2009 |
| Termine | 2014 |
| Commessa | MD.P01.002 |
| Responsabile | Pier Luigi San Biagio |
| Tematiche di ricerca | Le tematiche della commessa comprendono lo studio di diversi tipi di aggregazione biomolecolare che avvengono su una scala di lunghezze intermedia tra quella macro e quella microscopica. Diverse forme di aggregazione di biomolecole portano ad una significativa varieta’ di strutture sopramolecolari piu’ o meno ordinate: associazione di proteine, formazione di fibrille polipeptidiche, gelificazione (jamming) di biopolimeri, cristallizzazione di proteine. Vengono studiati gli effetti di diversi fattori capaci di controllare l’aggregazione, quali i cambiamenti di conformazione molecolare, le proprieta’ del solvente, la presenza di ioni in soluzione. L’interesse di tali studi risiede nel fatto che i processi di aggregazione biomolecolare interessano campi diversi della scienza che vanno dalla food technology (nuovi additivi per controllare la consistenza dei cibi) alla industria farmaceutica (biopolimeri adatti al trasporto mirato di farmaci), dalla microelettronica (DNA chip e nuovi materiali biopolimerici adatti alla costruzione di memorie ottiche) alla medicina (processi di aggregazione di proteine con effetti tossici come nel caso di alcune malattie neurodegenerative: Alzheimer, BSE, ecc.). |
| Personale di Ricerca (33) | ||
|---|---|---|
| Nome COGNOME | Struttura | Ruolo |
| Donatella Bulone | IBF-PA | Personale di ricerca |
| Silvestre Buscemi | IBF-PA | Personale associato |
| Luna Cangialosi | IBF-PA | Personale collaboratore |
| Francesco Cappello | IBF-PA | Personale associato |
| Rita Carrotta | IBF-PA | Personale di ricerca |
| Francesco Cavarretta | IBF-PA | Personale collaboratore |
| Maria Cupane | IBF-PA | Personale collaboratore |
| Alberto Diaspro | IBF-PA | Personale associato |
| Clelia Dispenza | IBF-PA | Personale associato |
| Fulvio Ferrante | IBF-PA | Personale collaboratore |
| Daniela Giacomazza | IBF-PA | Personale di ricerca |
| Gaetano Giammona | IBF-PA | Personale associato |
| Valeria Guarrasi | IBF-PA | Personale collaboratore |
| Maurizio Leone | IBF-PA | Personale associato |
| Paola Leone | IBF-PA | Personale collaboratore |
| Fabio Librizzi | IBF-PA | Personale di ricerca |
| Maria Rosalia Mangione | IBF-PA | Personale di ricerca |
| Mauro Manno | IBF-PA | Personale di ricerca |
| Vincenzo Martorana | IBF-PA | Personale di ricerca |
| Cristina Miliano | IBF-PA | Personale in formazione |
| Valeria Militello | IBF-PA | Personale associato |
| Marta Moschetti | IBF-PA | Personale in formazione |
| Maria Carmela Nicastro | IBF-PA | Personale collaboratore |
| Rosina Noto | IBF-PA | Personale di ricerca |
| Estefania Nunez Carmona | IBF-PA | Personale collaboratore |
| Antonio Piccionello Palumbo | IBF-PA | Personale associato |
| Giacoma Cinzia Rappa | IBF-PA | Personale in formazione |
| Pier Luigi San Biagio | IBF-PA | Personale di ricerca |
| Dario Spigolon | IBF-PA | Personale in formazione |
| Simona Todaro | IBF-PA | Personale collaboratore |
| Valeria Vetri | IBF-PA | Personale associato |
| Silvia Vilasi | IBF-PA | Personale di ricerca |
| Giulia Zambotti | IBF-PA | Personale in formazione |
| Pubblicazioni (54) | |
|---|---|
| Anno | Autori/Titolo/Rivista |
| 2012 | Settanni L; Palazzolo E; Guarrasi V; Aleo A; Mammina C; Moschetti G; Germanà MA Inhibition of foodborne pathogen bacteria by essential oils extracted from citrus fruits cultivated in Sicily Food Control |
| 2012 | Noto R; Santangelo MG; Ricagno S; Mangione MR; Levantino M; Pezzullo M; Martorana V; Cupane A; Bolognesi M; Manno M The Tempered Polymerization of Human Neuroserpin Plos One |
| 2012 | Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M On the molecular structure of human neuroserpin polymers Proteins |
| 2012 | Dispenza C; Grimaldi N; Sabatino MA; Todaro S; Bulone D; Giacomazza D; Przybytniak G; Alessi A; Spadaro G Studies of network organization and dynamics of e-beam crosslinked PVPs: From macro to nano Radiation Physics And Chemistry |
| 2012 | Carrotta R; Canale C; Diaspro A; Trapani A; San Biagio PL; Bulone D Inhibiting effect of alpha(s1)-casein on A beta(1-40) fibrillogenesis Biochimica Et Biophysica Acta. G, General Subjects |
| 2012 | Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process The Journal Of Physical Chemistry. B |
| 2012 | Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL Entrapment of A Beta 1-40 peptide in unstructured aggregates Journal Of Physics. Condensed Matter |
| 2012 | Di Carlo M, Giacomazza D, Picone P, Nuzzo D, San Biagio PL. Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases? Free Radical Research |
| 2012 | M Di Carlo, D Giacomazza, P L San Biagio Alzheimer's disease: biological aspects, therapeutic perspectives and diagnostic tools Journal Of Physics. Condensed Matter |
| 2012 | Dispenza C; Sabatino MA; Chmielewska DK; Lo Presti C; Battaglia G Inherently fluorescent polyaniline nanoparticles in a dynamic landscape Reactive & Functional Polymers |
| 2012 | Dispenza C; Sabatino MA; Grimaldi N; Bulone D; Bondi ML; Casaletto MP; Rigogliuso S; Adamo G; Ghersi G Minimalism in Radiation-synthesis of Biomedical Functional Nanogels Biomacromolecules |
| 2012 | Infusini G; Iannuzzi C; Vilasi S; Birolo L; Pagnozzi D; Pucci P; Irace G; Sirangelo I Resolution of the effects induced by W->F substitutions on the conformation and dynamics of the amyloid-forming apomyoglobin mutant W7FW14F European Biophysics Journal |
| 2012 | Martorana A; Pace A; Buscemi S; Palumbo Piccionello A Synthesis of Tetrasubstituted 4,4 '-Biimidazoles Organic Letters |
| 2012 | Pitarresi G; Giacomazza D; Triolo D; Giammona G; San Biagio PL Rheological characterization and release properties of inulin-based hydrogels Carbohydrate Polymers |
| 2012 | Raccosta S; Martorana V; Manno M Thermodynamic versus Conformational Metastability in Fibril-Forming Lysozyme Solutions The Journal Of Physical Chemistry. B |
| 2012 | Schirò G; Vetri V; Frick B; Militello V; Leone M; Cupane A Neutron Scattering Reveals Enhanced Protein Dynamics in Concanavalin A Amyloid Fibrils The Journal Of Physical Chemistry Letters |
| 2011 | Navarra G, Cannas M, D’Amico M, Giacomazza D, Militello V, Vaccaro L, Leone M Thermal oxidative process in extra-virgin olive oils studied by FTIR, rheology and time-resolved luminescence Food Chemistry (00520j0) |
| 2011 | Carrotta R, Vetri V, Librizzi F, Martorana V, Militello V, Leone M Amyloid fibrils formation of concanavalin A at basic pH Journal Of Physical Chemistry B (11903j0) |
| 2011 | Fiorica C, Senior RA, Pitarresi G, Palumbo FS, Giammona G, Deshpande P, MacNeil S Biocompatible hydrogels based on hyaluronic acid cross-linked with a polyaspartamide derivative as delivery systems for epithelial limbal cells International Journal Of Pharmaceutics (01047j0) |
| 2011 | Vetri V, D'Amico M, Foder? V, Leone M, Ponzoni A, Sberveglieri G, Militello V Bovine Serum Albumin protofibril-like aggregates formation: solo but not simple mechanism Archives Of Biochemistry And Biophysics (13420j0) |
| 2011 | D'Amico M, Raccosta S, Cannas M, Martorana V, Manno M Existence of metastable intermediate lysozyme conformation highlights the role of alcohols in altering protein stability Journal Of Physical Chemistry B (11903j0) |
| 2011 | Picone P, Giacomazza D, Vetri V, Carrotta R, Militello V, San Biagio PL, Di Carlo M Insulin-activated Akt rescues A? oxidative stress-induced cell death by orchestrating molecular trafficking Aging Cell (14057j0) |
| 2011 | Licciardi M, Cavallaro G, Di Stefano M, Fiorica C, Giammona G Polyaspartamide-graft-polymethacrylate nanoparticles for doxorubicin delivery Macromolecular Bioscience (13642j0) |
| 2010 | Cavallaro G, Licciardi M, Scirè S, Di Stefano M, Giammona G New pegylated polyaspartamide-based polyplexes as gene delivery vectors. Nanomedicine (00088nn) |
| 2010 | Licciardi M, Cavallaro G, Di Stefano M, Pitarresi G, Fiorica C, Giammona G New self-assembling polyaspartylhydrazide copolymer micelles for anticancer drug delivery. International Journal Of Pharmaceutics (01047j0) |
| 2010 | Licciardi M, Grassi M,Di Stefno M, Feruglio L, Giuliano G, Valenti S, Cappelli A, Giammona G Peg-Benzofulvene copolymer hydrogels for antibody delivery. International Journal Of Pharmaceutics (01047j0) |
| 2010 | Giacomazza D Preface to special issue for the XIX meeting of the Italian Society of Pure and Applied Biophysics European Biophysics Journal With Biophysics Letters (05881j0) |
| 2010 | Ricca ME, Foderà V, Giacomazza D, Leone M, Spadaro G, Dispenza C Probing the internal environment f PVP network generated by irradiation of different sources Colloid And Polymer Science (29394j0) |
| 2010 | Guarrasi V, Mangione MR, Sanfratello V, Martorana V, Bulone D Quantification of underivatized fatty acids from vegetable oils by HPLC-UV Journal Of Chromatographic Science (52294j0) |
| 2010 | Pitarresi G, Palumbo FS, Albanese A, Fiorica C, Picone P, Giammona G Self-assembled amphiphilic hyaluronic acid graft copolymers for targeted release of antitumoral drug. Journal Of Drug Targeting (10731j0) |
| 2010 | Palumbo FS, Pitarresi G, Albanese A, Calascibetta F, Giammona G Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure Acta Biomaterialia (00167nn) |
| 2010 | Ferkinghoff-Borg J, Fonslet J, Andersen CB, Krishna S, Pigolotti S, Yagi H, Goto Y, Otzen D, Jensen MH Stop-and-go kinetics in amyloid fibrillation. Physical Review E (10204j0) |
| 2010 | Sandolo C, Bulone D, Mangione MR, Margheritelli S, Di Meo C, Alhaique F, Matricardi P, Coviello T Synergistic interaction of Locust Bean Gum and Xanthan investigated by rheology and light scattering Carbohydrate Polymers (04402j0) |
| 2010 | Ricagno S, Pezzullo M, Barbiroli A, Manno M, Levantino M, Santangelo MG, Bonomi F, Bolognesi M Two latent and two hyperstable polymeric froms of human neuroserpin Biophysical Journal (20372j0) |
| 2010 | Andersen CB, Manno M, Rischel C, Thórólfsson M, Martorana V Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress Protein Science (09853j0) |
| 2010 | Manno M, Giacomazza D, Newman J, Martorana V, San Biagio PL Amyloid gels: precocious appearance of elastic properties during the formation of an insulin fibrillar network Langmuir (06350j0) |
| 2010 | Pedersen JS, Andersen CB, Otzen DE Amyloid structure - one but not the same: the many levels of fibrillar polymorphism Febs Journal (36036j0) |
| 2010 | Bondì ML, Craparo EF, Giammona G, Drago F Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution Nanomedicine (00088nn) |
| 2010 | Vetri V, Carrotta R, Picone P, Di Carlo M, Militello V Concanavalin A aggregation and toxicity on cell cultures Biochimica Et Biophysica Acta-proteins And Proteomics (13884j0) |
| 2010 | Pitarresi G, Palumbo FS, Fiorica C, Calascibetta F, Giammona G Electrospinning of a,b-poly(N.2-hydroxyethyl)-DL-aspertamide-graft-polylactic acid to produce-a fibrillar scaffold. European Polymer Journal (36212j0) |
| 2010 | Licciardi M, Paolino D, Celia C, Giammona G, Cavallaro G, Fresta M Folate-Targeted supramolecular vesicular aggregates based on polyaspartyl – hydrazide copolymers for the selective delivery of antitumoral drugs. Biomaterials (03087j0) |
| 2010 | Andersen CB, Hicks MR, Vetri V, Vandahl B, Rahbek-Nielsen H, Thogersen H, Thogersen IB, Enghild JJ, Serpell LC, Rischel C, Otzen A Glucagon Fibril Polymorphism Reflects Differences in Protofilament Backbone Structure Journal Of Molecular Biology (57772j0) |
| 2010 | Di Carlo M, Picone P, Carrotta R, Giacomazza D, San Biagio PL Insulin promotes survival of amyloid-beta oligomers neuroblastoma damaged cells via caspase 9 inhibition and Hsp70 upregulation Journal Of Biomedicine And Biotechnology (00027nn) |
| 2010 | Raccosta S, Manno M, Bulone D, Giacomazza D, Militello V, Martorana V, San Biagio PL Irreversible gelation of thermally unfolded lysozyme: structural and mechanical properties of lysozyme aggregates European Biophysics Journal With Biophysics Letters (05881j0) |
| 2009 | Picone P, Carrotta R, Montana G, Nobile MR, San Biagio PL, Di Carlo M Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. Biophysical Journal (20372j0) |
| 2009 | Andersen CB, Yagi H, Manno M, Martorana V, Ban T, Christiansen G, Otzen DE, Goto Y, Rischel C Branching in amyloid fibril growth. Biophysical Journal (20372j0) |
| 2009 | Concina I, Falasconi M, Gobbi E, Bianchi F, Musci M, Mattarozzi M, Pardo M, Mangia A, Careri M, Sberveglieri G Early detection of microbial contamination in processed tomatoes by electronic nose Food Control (10758j0) |
| 2009 | D'Amico M, Messina F, Cannas M, Leone M, Boscaino R Inhomogeneous width of oxygen-deficient centers induced by electron irradiation of silica Physical Review B (76373j0) |
| 2009 | D'Amico M, Messina F, Cannas A, Leone M, Boscaino R Photoluminescence spectral dispersion as a probe of structural inhomogeneity in silica Journal Of Physics-condensed Matter (07657j0) |
| 2009 | Pitarresi G, Calabrese R, Palumbo FS, Licciardi M, Giammona G Polysaccharide/polyaminoacid composite scaffolds for modified DNA release International Journal Of Pharmaceutics (01047j0) |
| 2009 | Carrotta R, Manno M, Giordano FM, Longo A, Portale G, Martorana V, Biagio PL Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin. Physical Chemistry Chemical Physics (12860j0) |
| 2009 | Foderà V, Librizzi F, Cataldo S, Pignataro B, Spiccia P, Leone M Self-organization pathways and spatial hetereogeneity in insulin amyloid fibrils formation Journal Of Physical Chemistry B (11903j0) |
| 2009 | Pellicanò M, Picone P, Cavalieri V, Carrotta R, Spinelli G, Di Carlo M The sea urchin embryo: a model to study Alzheimer's beta amyloid induced toxicity. Archives Of Biochemistry And Biophysics (13420j0) |
| 2009 | Navarra G, Giacomazza D, Leone M, Librizzi F, Militello V, San Biagio PL Thermal aggregation and ion-induced cold-gelation of Bovine Serum Albumin European Biophysics Journal With Biophysics Letters (05881j0) |
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